Effects of the val(158)met catechol-O-methyltransferase gene polymorphism on olfactory processing in schizophrenia

Behavioral Neuroscience

Volumn 126, Issue 1, 2012, Pages 209-215

  Kamath, Vidyulata ^a,b   Moberg, Paul J ^a,b   Gur, Raquel E ^a,b   Doty, Richard L ^b   Turetsky, Bruce I ^a,b  

^a Department of Psychiatry   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

COMT; Dopamine; Genetics; Olfaction; Smell

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE; METHIONINE; NEUROLEPTIC AGENT; VALINE;

ADULT; ARTICLE; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; COMT GENE; CONTROLLED STUDY; FEMALE; GENE; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MALE; NEUROMODULATION; OLFACTORY BULB; OLFACTORY SYSTEM; SCHIZOPHRENIA; GENETIC ASSOCIATION; GENETICS; MIDDLE AGED; SINGLE NUCLEOTIDE POLYMORPHISM; SMELLING;

ADULT; CATECHOL O-METHYLTRANSFERASE; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; MIDDLE AGED; OLFACTORY PERCEPTION; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 84861722599     PISSN: 07357044     EISSN: 19390084     Source Type: Journal    
DOI: 10.1037/a0026466     Document Type: Article

References (53)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
2. Andreasen, N. C. (1984a). The Scale for the Assessment of Negative Symptoms (SANS). Iowa City, IA: The University of Iowa.
3. Andreasen, N. C. (1984b). The Scale for the Assessment of Positive Symptoms (SAPS). Iowa City, IA: The University of Iowa.
4. Anholt, R. R. H., & Mackay, T. F. C. (2010). Genetics of olfaction and taste. In Principles of behavioral genetics (pp. 207-230). Amsterdam, the Netherlands: Academic.
5. Bassett, A. S., Caluseriu, O., Weksberg, R., Young, D. A., & Chow, E. W. (2007). Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome. Biological Psychiatry, 61, 1135-1140. doi:10.1016/j.biopsych.2006.07.038
6. Berkowicz, D. A., & Trombley, P. Q. (2000). Dopaminergic modulation at the olfactory nerve synapse. Brain Research, 855, 90-99. doi:10.1016/S0006-8993(99)02342-2
7. Bilder, R. M., Volavka, J., Lachman, H. M., & Grace, A. A. (2004). The catechol-O-methyltransferase polymorphism: Relations to the tonicphasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology, 29, 1943-1961. doi:10.1038/sj.npp.1300542
8. Brewer, W. J., Pantelis, C., Anderson, V., Velakoulis, D., Singh, B., Copolov, D., & McGorry, P. D. (2001). Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosis. American Journal of Psychiatry, 158, 107-115. doi:10.1176/appi.ajp.158.1.107
9. Bromley, S. M., & Doty, R. L. (1995). Odor recognition memory is better under bilateral than unilateral test conditions. Cortex, 31, 25-40.
10. Carstens, M. H. (2002). Development of the facial midline. Journal of Craniofacial Surgery, 13, 129-187. doi:10.1097/00001665-20020100000032
11. Diewert, V. M., Lozanoff, S., & Choy, V. (1993). Computer reconstructions of human embryonic craniofacial morphology showing changes in relations between the face and brain during primary palate formation. Journal of Craniofacial Genetics and Developmental Biology, 13, 193-201.
12. Doty, R. L., Frye, R. E., & Agrawal, U. (1989). Internal consistency reliability of the fractionated and whole University of Pennsylvania Smell Identification Test. Perception and Psychophysics, 45, 381-384. doi:10.3758/BF03210709
13. Doty, R. L., & Risser, J. M. (1989). Influence of the D-2 dopamine receptor agonist quinpirole on the odor detection performance of rats before and after spiperone administration. Psychopharmacology, 98, 310-315. doi: 10.1007/BF00451680
14. Doty, R. L., Shaman, P., & Dann, M. (1984). Development of the University of Pennsylvania Smell Identification Test: A standardized microencapsulated test of olfactory function. Physiology and Behavior, 32, 489-502. doi:10.1016/0031-9384(84)90269-5
15. Doty, R. L., Smith, R., McKeown, D. A., & Raj, J. (1994). Tests of human olfactory function: Principal components analysis suggests that most measure a common source of variance. Perception and Psychophysics, 56, 701-707. doi:10.3758/BF03208363
16. Ennis, M., Zhou, F. M., Ciombor, K. J., Aroniadou-Anderjaska, V., Hayar, A., Borrelli, E.,... Shipley, M. T. (2001). Dopamine D2 receptormediated presynaptic inhibition of olfactory nerve terminals. Journal of Neurophysiology, 86, 2986-2997.
17. Feron, F., Vincent, A., & Mackay-Sim, A. (1999). Dopamine promotes differentiation of olfactory neuron in vitro. Brain Research, 845, 252-259. doi:10.1016/S0006-8993(99)01959-9
18. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1995). Structured Clinical Interview for DSM-IV-Nonpatient Edition (SCID- NP, Version 2.0). New York, NY: New York State Psychiatric Institute.
19. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1996). Structured Clinical Interview for DSM-IV-Patient Edition (SCID-P, Version 2.0). New York, NY: New York State Psychiatric Institute.
20. Hedner, M., Larsson, M., Arnold, N., Zucco, G. M., & Hummel, T. (2010). Cognitive factors in odor detection, odor discrimination, and odor identification tasks. Journal of Clinical and Experimental Neuropsychology, 32, 1062-1067. doi:10.1080/13803391003683070
21. Hsia, A. Y., Vincent, J. D., & Lledo, P. M. (1999). Dopamine depresses synaptic inputs into the olfactory bulb. Journal of Neurophysiology, 82, 1082-1085.
22. Huisman, E., Uylings, H. B., & Hoogland, P. V. (2004). A 100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease. Movement Disorders, 19, 687-692. doi:10.1002/mds.10713
23. Ishizuka, K., Tajinda, K., Colantuoni, C., Morita, M., Winicki, J., Le, C.,... Cascella, N. G. (2010). Negative symptoms of schizophrenia correlate with impairment on the University of Pennsylvania smell identification test. Neuroscience Research, 66, 106-110. doi:10.1016/j.neures.2009.10.001
24. Karayiorgou, M., Morris, M. A., Morrow, B., Shprintzen, R. J., Goldberg, R., Borrow, J.,...Housman, D. E. (1995). Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proceedings of the National Academy of Sciences of the United States of America, 92, 7612-7616. doi:10.1073/pnas.92.17.7612
25. Kurnianingsih, Y. A., Kuswanto, C. N., McIntyre, R. S., Qiu, A., Ho, B. C., & Sim, K. (2011). Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder. Journal of Neural Transmission.
26. Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y. M., Szumlanski, C. L., & Weinshilboum, R. M. (1996). Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6, 243-250. doi:10.1097/00008571-199606000-00007
27. Levinson, D. F., Duan, J., Oh, S., Wang, K., Sanders, A. R., Shi, J.,... Gejman, P. V. (2011). Copy number variants in schizophrenia: Confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. American Journal of Psychiatry, 168, 302-316. doi:10.1176/appi.ajp.2010.10060876
28. Malaspina, D., Coleman, E., Goetz, R. R., Harkavy-Friedman, J., Corcoran, C., Amador, X.,... Gorman, J. M. (2002). Odor identification, eye tracking and deficit syndrome schizophrenia. Biological Psychiatry, 51, 809-815. doi:10.1016/S0006-3223(01)01319-1
29. McLean, J. H., & Shipley, M. T. (1988). Postmitotic, postmigrational expression of tyrosine hydroxylase in olfactory bulb dopaminergic neurons. Journal of Neuroscience, 8, 3658-3669.
30. Meechan, D. W., Maynard, T. M., Tucker, E. S., & LaMantia, A. S. (2011). Three phases of DiGeorge/22q11 deletion syndrome pathogenesis during brain development: Patterning, proliferation, and mitochondrial functions of 22q11 genes. International Journal of Developmental Neuroscience, 29, 283-294. doi:10.1016/j.ijdevneu.2010.08.005
31. Meechan, D. W., Tucker, E. S., Maynard, T. M., & LaMantia, A. S. (2009). Diminished dosage of 22q11 genes disrupts neurogenesis and cortical development in a mouse model of 22q11 deletion/DiGeorge syndrome. Proceedings of the National Academy of Sciences of the United States of America, 106, 16434-16445. doi:10.1073/pnas.0905696106
32. Moberg, P. J., Arnold, S. E., Doty, R. L., Gur, R. E., Balderston, C. C., Roalf, D. R.,... Turetsky, B. I. (2006). Olfactory functioning in schizophrenia: Relationship to clinical, neuropsychological, and volumetric MRI measures. Journal of Clinical and Experimental Neuropsychology, 28, 1444-1461. doi:10.1080/13803390500434409
33. Moberg, P. J., Roalf, D. R., Gur, R. E., & Turetsky, B. I. (2004). Smaller nasal volumes as stigmata of aberrant neurodevelopment in schizophrenia. American Journal of Psychiatry, 161, 2314-2316. doi:10.1176/appi.ajp.161.12.2314
34. Murphy, K. C. (2002, February 2). Schizophrenia and velo-cardio-facial syndrome. Lancet, 359, 426-430. doi:10.1016/S0140-6736(02)07604-3
35. Nurnberger, J. I., Jr., Blehar, M. C., Kaufmann, C. A., York-Cooler, C., Simpson, S. G., Harkavy-Friedman, J.,... Reich, T. (1994). Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Archives of General Psychiatry, 51, 849-859.
36. O'Callaghan, E., Larkin, C., Kinsella, A., & Waddington, J. L. (1991). Familial, obstetric, and other clinical correlates of minor physical anomalies in schizophrenia. American Journal of Psychiatry, 148, 479-483.
37. Rawson, N. E., Lischka, F. W., Yee, K. K., Peters, A. Z., Tucker, E. S., Meechan, D. W.,... LaMantia, A. S. (2010). Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons. Developmental Dynamics, 239, 1723-1738. doi:10.1002/dvdy.22315
38. Rhoades, H. M., & Overall, J. E. (1988). The semistructured BPRS interview and rating guide. Psychopharmacology Bulletin, 24, 101-104.
39. Romanos, M., Renner, T. J., Schecklmann, M., Hummel, B., Roos, M., von Mering, C.,... Gerlach, M. (2008). Improved odor sensitivity in attention-deficit/hyperactivity disorder. Biological Psychiatry, 64, 938-940. doi:10.1016/j.biopsych.2008.08.013
40. Romanos, M., Schecklmann, M., Kraus, K., Fallgatter, A. J., Warnke, A., Lesch, K. P., & Gerlach, M. (2011). Olfactory deficits in deletion syndrome 22q11.2. Schizophrenia Research, 129, 220-221. doi: 10.1016/j.schres.2010.12.015
41. Sallaz, M., & Jourdan, F. (1992). Apomorphine disrupts odour-induced patterns of glomerular activation in the olfactory bulb. Neuroreport, 3, 833-836. doi:10.1097/00001756-199210000-00003
42. Schecklmann, M., Schaldecker, M., Aucktor, S., Brast, J., Kirchgüβner, K., Mühlberger, A.,... Romanos, M. (2011). Effects of methylphenidate on olfaction and frontal and temporal brain oxygenation in children with ADHD. Journal of Psychiatric Research, 45, 1463-1470.
43. Skagerberg, G., Lindvall, O., & Bjorklund, A. (1984). Origin, course and termination of the mesohabenular dopamine pathway in the rat. Brain Research, 307, 99-108. doi:10.1016/0006-8993(84)90465-7
44. Sobin, C., Kiley-Brabeck, K., Dale, K., Monk, S. H., Khuri, J., & Karayiorgou, M. (2006). Olfactory disorder in children with 22q11 deletion syndrome. Pediatrics, 118, e697-703. doi:10.1542/peds.2005-3114
45. Tan, H. Y., Callicott, J. H., & Weinberger, D. R. (2007). Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia. Cerebral Cortex, 17(Suppl 1), i171-181. doi:10.1093/cercor/bhm069
46. Turetsky, B. I., Crutchley, P., Walker, J., Gur, R. E., & Moberg, P. J. (2009). Depth of the olfactory sulcus: A marker of early embryonic disruption in schizophrenia? Schizophrenia Research, 115, 8-11. doi: 10.1016/j.schres.2009.09.005
47. Turetsky, B. I., Glass, C. A., Abbazia, J., Kohler, C. G., Gur, R. E., & Moberg, P. J. (2007). Reduced posterior nasal cavity volume: A genderspecific neurodevelopmental abnormality in schizophrenia. Schizophrenia Research, 93, 237-244.
48. Turetsky, B. I., Moberg, P. J., Yousem, D. M., Doty, R. L., Arnold, S. E., & Gur, R. E. (2000). Reduced olfactory bulb volume in patients with schizophrenia. American Journal of Psychiatry, 157, 828-830. doi: 10.1176/appi.ajp.157.5.828
49. Vacic, V., McCarthy, S., Malhotra, D., Murray, F., Chou, H. H., Peoples, A.,... Sebat, J. (2011, March 24). Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia. Nature, 471, 499-503. doi:10.1038/nature09884
50. Vollmecke, T., & Doty, R. L. (1985). Development of the Picture Identification Test (PIT): A research companion to the University of Pennsylvania Smell Identification Test. Chemical Senses, 10, 413-414.
51. Vorstman, J. A., Turetsky, B. I., Sijmens-Morcus, M. E., de Sain, M. G., Dorland, B., Sprong, M.,... Kemner, C. (2009). Proline affects brain function in 22q11DS children with the low activity COMT 158 allele. Neuropsychopharmacology, 34, 739-746. doi:10.1038/npp.2008.132
52. Wachowiak, M., & Shipley, M. T. (2006). Coding and synaptic processing of sensory information in the glomerular layer of the olfactory bulb. Seminars in Cell and Developmental Biology, 17, 411-423. doi:10.1016/j.semcdb.2006.04.007
53. Wishart, H. A., Roth, R. M., Saykin, A. J., Rhodes, C. H., Tsongalis, G. J., Pattin, K. A.,... McAllister, T. W. (2011). COMT val158met genotype and individual differences in executive function in healthy adults. Journal of the International Neuropsychological Society, 17, 174-180. doi:10.1017/S1355617710001402