Evidence-based strategies for the optimization of pharmacotherapy in older people

Drugs and Aging

Volumn 29, Issue 6, 2012, Pages 477-494

  Topinková, Eva ^a   Baeyens, Jean Pierre ^b   Michel, Jean Pierre ^c   Lang, Pierre Olivier ^c  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF LUXEMBOURG   (Luxembourg)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Drug utilisation; Elderly; Medication errors; Prescribing

Indexed keywords

DONEPEZIL; NONSTEROID ANTIINFLAMMATORY AGENT; WARFARIN;

AGEISM; ALZHEIMER DISEASE; BEHAVIOR THERAPY; DECISION SUPPORT SYSTEM; DEMENTIA; DRUG EFFICACY; DRUG SAFETY; DRUG TREATMENT FAILURE; ELECTRONIC MEDICAL RECORD; EVIDENCE BASED MEDICINE; GASTROINTESTINAL HEMORRHAGE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GERIATRIC CARE; HEALTH CARE COST; HEALTH CARE PERSONNEL; HEALTH STATUS; HUMAN; INFORMATION TECHNOLOGY; MEDICATION ERROR; PATIENT COMPLIANCE; PERSONALIZED MEDICINE; PHARMACEUTICAL CARE; PHARMACIST; PHARMACOGENETICS; POLYPHARMACY; PRACTICE GUIDELINE; PRESCRIPTION; PRIORITY JOURNAL; PROFESSIONAL COMPETENCE; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SELF MEDICATION; SOCIAL PSYCHOLOGY; UNSPECIFIED SIDE EFFECT;

DRUG PRESCRIPTIONS; DRUG THERAPY; EVIDENCE-BASED MEDICINE; GERIATRICS; HUMANS; MEDICATION ADHERENCE; SELF MEDICATION;

EID: 84861706483     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.2165/11632400-000000000-00000     Document Type: Review

References (97)

1. Stegemann S, Ecker F, Maio M, et al. Geriatric drug therapy: Neglecting the inevitable majority. Ageing Res Rev 2010; 9: 384-398
2. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Final concept paper E7(R1). Studies in support of special populations: Geriatrics. 2008 [online]. Available from URL: Http://www.ich.org/fileadmin/Public-Web-Site/ICH-Products/Guidelines/ Efficacy/E7/Q-As/E7R1-Final-Concept -Paper.pdf [Accessed 2012 Apr 17]
3. O'Connor MN, Gallagher P, O'Mahony D. Inappropriate prescribing: Criteria, detection and prevention. Drugs Aging 2012; 29 (6): 437-452
4. Cherubini A, Corsonello A, Lattanzio F. Underprescription of beneficial medicines in older people: Causes, consequences and prevention. Drugs Aging 2012; 29 (6): 463-475
5. Petrovic M, Van Der Cammen T, Onder G. Adverse drug reactions in older people: Detection and prevention. Drugs Aging 2012; 29 (6): 453-462
6. Spinewine A, Fialova D, Byrne S. The role of the pharmacist in optimizing pharmacotherapy in older people. Drugs Aging 2012; 29 (6): 495-510
7. Hanlon JT, Handler SM, Maher R, et al. Geriatric pharmacotherapy and polypharmacy. In: Fillit H, Rockwood K, Woodhouse K, editors. Brocklehurst's textbook of geriatric medicine. 7th ed. London: Churchill Livingstone, 2010: 880-5
8. Corsonello A, Pedone C, Incalzi RA. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem 2010; 17: 571-584
9. Handler SM, Wright RM, Ruby CM, et al. Epidemiology of medication-related adverse events in nursing homes. Am J Geriatr Pharmacother 2006; 4: 264-272
10. Van Spall HG, Toren A, Kiss A, et al. Eligibility criteria of randomized controlled trials published in high-impact general medical journals: A systematic sampling review. JAMA 2007; 297: 1233-1240
11. Cherubini A, Oristrell J, Pla X, et al. The persistent exclusion of older subjects from ongoing clinical trials in heart failure. Arch Intern Med 2011; 171 (6): 550-6
12. Crome P, Lally F, Cherubini A, et al. Exclusion of older people from clinical trials: Professional views from nine European countries participating in the PREDICT study. Drugs Aging 2011; 28: 1-11
13. PREDICT [online]. Available from URL: Http://www.pre dicteu.org/index. html [Accessed 2012 Apr 12]
14. Cherubini A, Del Signore S, Ouslander J, et al. Fighting against age discrimination in clinical trials. J Am Geriatr Soc 2010; 58 (9): 1791-6
15. Gemmill M. Research note: Chronic disease management in Europe. London: The London School of Economics and Political Sciences, for the Commission, Directorate-General ''Employment, Social Affairs and Equal Opportunities'' Unit E1-Social and Demographic Analysis, 2008
16. Saltvedt I, Spigset O, Ruths S, et al. Patterns of drug prescription in a geriatric evaluation and management unit as compared with the general medical wards: A randomised study. Eur J Clin Pharmacol 2005; 61 (12): 921-8
17. Schmader KE, Hanlon JT, Pieper CF, et al. Effects of geriatric evaluation and management on adverse drug reactions and suboptimal prescribing in the frail elderly. Am J Med 2004; 116: 394-401
18. Busse R, Blümel M, Scheller-Kreinsen D, et al. Tackling chronic disease in Europe: Strategies, interventions and challenges. Observatory Studies Series No. 20. Copenhagen: WHO Regional Office for Europe, on behalf of the European Observatory on Health Systems and Policies, 2010: 111
19. Blum K. Nurse practitioners in Eastern Germany. Health Policy Monitor, 2006 Oct 8 [online]. Available from URL: Http://www.hpm.org/survey/de/b8/3 [Accessed 2011 Aug 28]
20. Bernabei R, Onder G, Landi F. Comprehensive care for older adults: Case management approach. J AmGeriatr Soc 2010; 58 (6): 1202-3
21. Wehling M. Guideline-driven polypharmacy in elderly, multimorbid patients is basically flawed: There are almost no guidelines for these patients. J Am Geriatr Soc 2011; 59 (2): 376-7
22. Van den Akker M, Buntinx F, Metsemakers JF, et al. Multimorbidity in general practice: Prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases. J Clin Epidemiol 1998; 51: 367-375
23. Boyd CM, Darer J, Boult C, et al. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: Implications for pay for performance. JAMA 2005; 294: 716-724
24. Tinetti ME, Bogardus Jr. ST, Agostini JV. Potential pitfalls of disease-specific guidelines for patients with multiple conditions. N Engl J Med 2004; 351: 2870-4
25. Fusco D, Lattanzio F, Tosato M, et al. Development of CRIteria to assess appropriate Medication use among Elderly complex patients (CRIME) project: Rationale and methodology. Drugs Aging. 2009; 26 Suppl. 1: 3-13
26. Vogt-Ferrier N. Reviewing a complicated geriatric regimen. Eur Ger Med 2010; 1: 198-202
27. Pilotto A, Panza F, Seripa D. Pharmacogenetics in geriatric medicine: Challenges and opportunities for clinical practice. Curr Drug Metab 2011; 12: 621-634
28. Roden DM, Altman RB, Benowitz NL, et al., Pharmacogenetics Research Network. Pharmacogenomics: Challenges and opportunities. Ann Intern Med 2006; 145 (10): 749-757
29. Pilotto A, SeripaD, FranceschiM, et al. Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding : Role of cytochrome P450 2C9 polymorphisms. Gastroenterology 2007; 133 (2): 465-471
30. Higashi MK, Veenstra DL, Kondo LM, et al. Association between CYP2C9 genetic variants and anticoagulationrelated outcomes during warfarin therapy. JAMA 2002; 287 (13): 1690-8
31. Pilotto A, Franceschi M, D'Onofrio G, et al. Effect of a CYP2D6 polymorphism on the efficacy of donepezil in Alzheimer's disease patients. Neurology 2009; 73 (10): 761-7
32. Savino M, Seripa D, Gallo AP, et al. Effectiveness of a high-throughput genetic analysis in the identification of responders/non-responders to CYP2D6-metabolized drugs. Clin Lab 2011; 57: 887-893
33. Klotz U. Clinical impact of CYP2C19 polymorphism on the action of proton pump inhibitors: A review of a special problem. Int J Clin Pharmacol Ther 2006; 44 (7): 297-302
34. Ulfvarson J, Rahmer PB, Fastbom J, et al. Medication reviews with computerized expert support: Evaluation of a method to improve the quality of drug utilization in the elderly. Int J Health Care Qul Assur 2010; 23: 571-582
35. Hayes TL, Cobbinah K, Dishongh T, et al. A study of medication-taking and unobtrusive, intelligent reminding. Telemed J E Health 2009; 15 (8): 770-6
36. Handler SM, Hanlon JT. Detecting adverse drug events using nursing home specific trigger tool. Ann Longterm Care 2010; 18 (5): 17-22
37. Hornick TR, Higgins PA, Stollings C, et al. Initial evaluation of a computer-based medication management tool in a geriatric clinic. Am J Geriatr Pharmacother 2006; 4: 62-69
38. Yourman L, Concato J, Agostini JV. Use of computer decision support interventions to improve medication prescribing in older adults: A systematic review. Am J Geriatr Pharmacother 2008; 6: 119-129
39. Gurwitz JH, Field TS, Rochon P, et al. Effect of computerized provider order entry with clinical decision support on adverse drug events in the long-term care setting. J Am Geriatr Soc 2008; 56 (12): 2225-2233
40. Tamblyn R, Huang A, Perreault R, et al. The medical office of the 21st century (MOXXI): Effectiveness of computerized decision-making support in reducing inappropriate prescribing in primary care. CMAJ 2003; 169: 549-556
41. Terrell KM, Perkins AJ, Dexter PR, et al. Computerized decision support to reduce potentially inappropriate prescribing to older emergency department patients: A randomized, controlled trial. J Am Geriatr Soc 2009; 57: 1388-1394
42. Mattison ML, Afonso KA, Ngo LH, et al. Preventing potentially inappropriate medication use in hospitalized older patients with a computerized provider order entry warning system. Arch Intern Med 2010; 170: 1331-6
43. Raebel MA, Charles J, Dugan J, et al. Randomized trial to improve prescribing safety in ambulatory elderly patients. J Am Geriatr Soc 2007; 55 (7): 977-985
44. Van Der Sijs H, Aarts J, Vulto A, et al. Overriding of drug safety alerts in computerized physician order entry. J Am Med Inform Assoc 2006; 130: 138-147
45. Avorn J. Medication use in older patients: Better policy could encourage better practice. JAMA 2010; 304 (14): 1606-7
46. Jansen PA. Specific needs for research in geriatrics [presentation]. Expertisecentre Pharmacotherapy in Old Persons (EPHOR), 2011 [online]. Available from URL: Http://ephor.artsennet.nl/English-website.htm [Accessed 2011 Aug 28]
47. Scott-Cawiezell J, Madsen RW, Pepper GA, et al. Medication safety teams' guided implementation of electronic medication administration records in five nursing homes. Jt Comm J Qual Patient Saf 2009; 35: 29-35
48. Spinewine A, Schmader K, Barber N, et al. Appropriate prescribing in elderly people: How well can it be measured and optimised? Lancet 2007; 370: 73-84
49. Kaur S, Mitchell G, Vitetta L, et al. Interventions that can reduce inappropriate prescribing in the elderly: A systematic review. Drugs Aging 2009; 26 (12): 1013-1028
50. Steinman MA, Hanlon JT. Managing medications in clinically complex elders. JAMA 2010; 304 (14): 1592-1601
51. Marcum ZA, Handler SV, Wright R, et al. Interventions to improve suboptimal prescribing in nursing homes: A narrative review. Am J Geriatr Pharmacother 2010; 8 (3): 183-200
52. Loganathan M, Singh S, Franklin BD, et al. Interventions to optimize prescribing in care homes: Systematic review. Age Ageing 2011; 40: 150-162
53. Trivalle C, Cartier T, Verny C, et al., for the IMEPAG GROUP. Identifying and preventing adverse drug events in elderly hospitalised patients: A randomised trial of a program to reduce adverse drug effects. J Nutr Health Aging 2010; 14: 57-61
54. Crotty M, Halbert J, Rowett D, et al. An outreach geriatric medication advisory service in residential aged care: A randomised controlled trial of case conferencing. Age Ageing 2004; 33: 612-7
55. Strandberg TE, Pitkala KH, Berglind S, et al. Multifactorial intervention to prevent recurrent cardiovascular events in patients 75 years or older: The Drugs and Evidence-Based Medicine in the Elderly (DEBATE) study. A randomised controlled trial. Am Heart J 2006; 152: 585-592
56. Tulner LR, Van Campen JP, Frankfort SV, et al. Changes in under-treatment after comprehensive geriatric assessment: An observational study. Drugs Aging 2010; 27: 831-843
57. Lampela P, Hartikainen S, Lavikainen P, et al. Effects of medication assessment as part of a comprehensive geriatric assessment on drug use over a 1-year period: A populationbased intervention study. Drugs Aging 2010; 27: 507-521
58. Lutters M, Harbarth S, Janssens JP, et al. Impact of a comprehensive, multidisciplinary, educational program on the use of antibiotics in a geriatric university hospital. J Am Geriatr Soc 2004; 52: 112-6
59. Hughes CM. Medication non-Adherence in the elderly: How big is the problem? Drugs Aging 2004; 21 (12): 793-811
60. World Health Organization (WHO). Adherence to longterm therapies: Evidence for action. Geneva: WHO, 2003 [online]. Available from URL: Http://whqlibdoc.who.int/publications/2003/9241545992.pdf [Accessed 2011 Aug 28]
61. Cooper C, Carpenter I, Katona C, et al. The AdHOC Study of older adults' adherence to medication in 11 countries. Am J Geriatr Psychiatry 2005; 13 (12): 1067-1076
62. Gellad WF, Grenard JL, Marcum ZA. A systematic review of barriers to medication adherence in the elderly: Iooking beyond cost and regimen complexity. Am J Geriatr Pharmacother 2011; 9: 11-23
63. Conn VS, Hafdahl AR, Cooper PS, et al. Interventions to improve medication adherence among older adults: Metaanalysis of adherence outcomes among randomized controlled trials. Gerontologist 2009; 49 (4): 447-62
64. Haynes R, Ackloo E, Sahota N, et al. Interventions for enhancing medication adherence. Cochrane Database Syst Rev 2008; (4): CD000011
65. Malhotra S, Karan RS, Pandhi P, et al. Drug related medical emergencies in the elderly: Role of adverse drug reactions and non-compliance. Postgrad Med 2001; 77: 703-7
66. Topinkova E, Fialova D, Carpenter GI, et al. Cross-national comparison of drug compliance and non-compliance associated factors in the elderly with polypharmacotherapy. Cas Lek Cesk 2006; 145 (9): 726-32
67. Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: A review of literature. J Behav Med 2008; 31: 213-24
68. Briesacher BA, Gurwitz JH, Soumerai SB. Patients at-risk for cost-related medication nonadherence: A review of the literature. J Gen Intern Med 2007; 22: 864-71
69. Doggrell SA. Adherence to medicines in the older-Aged with chronic conditions. Drugs Aging 2010; 27 (3): 239-54
70. George J, Elliot RA, Stewart DC. A systematic review of interventions to improve medication taking in elderly patients prescribed multiple medications. Drugs Aging 2008; 25 (4): 307-24
71. Williams A, Manias E, Walker R. Interventions to improve medication adherence in people with multiple chronic conditions: A systematic review. J Adv Nurs 2008; 63 (2): 132-43
72. Hawe P, Higgins G. Can medication education improve the drug compliance of the elderly? Evaluation of an inhospital program. Patient Educ Couns 1990; 16: 151-60
73. Hanlon JT, Weinberger M, Samsa GP, et al. A randomised, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy. Am J Med 1996; 100: 428-37
74. Bernsten C, Bjorkman I, Caramona M, et al. Improving the well-being of elderly patients via community pharmacybased provision of pharmaceutical care: A multicentre study in seven European countries. Drugs Aging 2001; 18 (1): 63-77
75. Grymonpre RE, Williamson DA, Montgomery PR. Impact of a pharmaceutical care model for non-institutionalised elderly: Results of a randomised controlled trial. Int J Pharm Prac 2001; 9: 235-41
76. Nazareth I, Burton A, Shulman S, et al. A pharmacy discharge plan for hospitalized elderly patients - A randomized controlled trial. Age Ageing 2001; 30 (1): 33-40
77. Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care programme on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: A randomized controlled trial. J Am Med Assoc 2006; 296 (21): 2563-2571
78. Sturgess IK, McElnay JC, Hughes CM, et al. Community pharmacy based provision of pharmaceutical care to older patients. Pharm World Sci 2003; 25 (5): 218-26
79. Volume CI, Farris KB, Kassam R, et al. Pharmaceutical care research and education project: Patient outcomes. J Am Pharm Assoc (Wash) 2001; 41: 411-20
80. Wu JYF, Leung WY, Chang S, et al. Effectiveness of telephone counselling by a pharmacist in reducing mortality in patients receiving polypharmacy: Randomised controlled trial. Br Med J 2006; 333 (7567): 522-7
81. Hayes TL, Larimer N, Adami A, et al. Medication adherence in healthy elders: Small cognitive changes make a big difference. J Aging Health 2009; 21: 567-80
82. Insel K, Morrow D, Brewer B, et al. Executive function, working memory, and medication adherence among older adults. J Gerontol 2006; 61: P102-7
83. Arlt S, Lindner R, Rösler A, et al. Adherence to medication in patients with dementia: Predictors and strategies for improvement. Drugs Aging 2008; 25 (12): 1033-1047
84. Applegate WB, Blass JP, Williams TF. Instruments for functional assessment of older patients. N Engl J Med 1990; 322: 1207-1214
85. Elliott RA, Marriott JL. Standardized assessment of patients' capacity to manage medications: A systematic review of published instruments. BMC Geriatr 2009; 9: 27. doi: 10.1186/1471-2318-9-27
86. Farris KB, Phillips BB. Instruments assessing capacity to manage medications. Ann Pharmacother 2008; 42: 1026-1036
87. Edelberg HK, Shallenberger E, Wei JY. Medication management capacity in highly functioning community-living older adults: Detection of early deficits. J Am Geriatr Soc 1999; 47: 592-6
88. Orwig D, Brandt N, Gruber-Baldini AL. Medication management assessment for older adults in the community. Gerontologist 2006; 46: 661-8
89. Patterson TL, Lacro J, McKibbin CL, et al. Medication management ability assessment: Results from a performance-based measure in older outpatients with schizophrenia. J Clin Psychopharmacol 2002; 22: 11-19
90. Schmidt KS, Lieto JM. Validity of the Medication Administration Test among older adults with and without dementia. Am J Geriatr Pharmacother 2005; 3: 255-61
91. Tran T, Elliott RA, Taylor SE, et al. A self-Administration of medications program to identify and address potential barriers to adherence in elderly patients. Ann Pharmacother. Epub 2011 Jan 12
92. Lam P, Elliot RA, George J. Impact of a self-Administration of medications programme on elderly inpatients' competence to manage medications: A pilot study. J Clin Pharm Ther 2011; 36 (1): 80-86
93. Huisman-Baron M, Van Der Veen L, Jansen PA, et al. Criteria for drug selection in frail elderly persons. Drugs Aging 2011; 28 (5): 391-402
94. Nolte E, McKee M. Integration and chronic care: A review. In: Nolte E, McKee M, editors. Caring for people with chronic conditions: A health system perspective. Maidenhead: Open University Press, 2008: 64-91
95. O'Neil D. Dialogue at Davos for and aging world. J Am Geriatr Soc 2011; 59: 1540-1
96. Patterson SM, Hughes CM, Lapane K. Assessment of a United States pharmaceutical care model for nursing homes in the United Kingdom. Pharm World Sci 2007; 29: 517-25
97. European Commission. i2010 - A European information society for growth and employment. Brussels: European Commission, 2009 [online]. Available from URL: Http://ec.europa.eu/information-society/eeurope/i2010/index-en. htm [Accessed 2011 Aug 28]