The impact of medication regimen factors on adherence to chronic treatment: A review of literature

Journal of Behavioral Medicine

Volumn 31, Issue 3, 2008, Pages 213-224

  Ingersoll, Karen S ^a   Cohen, Jessye ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Adherence; Chronic illness; HIV AIDS; Medication compliance

Indexed keywords

ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; CONTRACEPTIVE AGENT; FLUNISOLIDE; FLUTICASONE PROPIONATE; GLIBENCLAMIDE; GLICLAZIDE; GLIPIZIDE; LAMIVUDINE; METHADONE; STAVUDINE; SULFONYLUREA; THEOPHYLLINE;

ASTHMA; CARDIOVASCULAR DISEASE; CHRONIC DISEASE; CONTRACEPTION; DIABETES MELLITUS; DOSAGE SCHEDULE COMPARISON; DRUG DOSE COMPARISON; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERTENSION; LONG TERM CARE; MENTAL DISEASE; PAIN; PATIENT COMPLIANCE; REVIEW; TREATMENT DURATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-HIV AGENTS; CHRONIC DISEASE; CONTRACEPTION BEHAVIOR; COST OF ILLNESS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; HIV INFECTIONS; HUMANS; MOTIVATION; PATIENT COMPLIANCE;

EID: 44449148293     PISSN: 01607715     EISSN: 15733521     Source Type: Journal    
DOI: 10.1007/s10865-007-9147-y     Document Type: Review

References (72)

1. Amico, K. R., Harman, J. J., & Johnson, B. T. (2006). Efficacy of antiretroviral therapy adherence interventions: A research synthesis of trials, 1996 to 2004. Journal of Acquired Immune Deficiency Syndrome, 41(3), 285-297.
2. Ammassari, A. A., Starace, F., Aloisi, M. S., Trotta, M. P., Murri, R., D'Arminio Monforte, A., & Antinori, A. (2003). Medication adherence among HIV+ adults: Effects of cognitive dysfunction and regimen complexity. Neurology, 61, 723-724.
3. Balint, S., & O'Donnell, R. (2007). Beyond compliance. Occupational Health & Safety (Waco, Tex.), 76(6), 104, 106-107.
4. Bedell, S. E., Jabbout, S., Goldberg, R., Glaser, H., Gobble, S., & Young-Xu, Y., et al. (2000). Discrepancies in the use of medications: Their extent and predictors in an outpatient practice. Archives of Internal Medicine, 160, 2129-2134.
5. Burke, W. J., & McArthur-Miller, D. A. (2001). Exploring treatment alternatives: Weekly dosing of fluoxetine for the continuation phase of major depressive disorder. Journal of Clinical Psychiatry, 62(Suppl), 38-42.
6. Burkman, R. T. (2002). The transdermal contraceptive patch: A new approach to hormonal contraception. International Journal of Fertility Womens' Medicine, 47, 69-76.
7. Chapman, R. H., Benner, J. S., Petrilla, A. A., Tierce, J. C., Collins, S. R., Battleman, D. S., et al. (2005). Predictors of adherence with antihypertensive and lipid-lowering therapy. Archives of Internal Medicine, 165, 1147-1152.
8. Chengappa, K. N., Parepally, H., Brar, J. S., Mullen, J., Shilling, A., & Goldstein, J. M. (2003). A random-assignment, double-blind, clinical trial of once- vs twice-daily administration of quetiapine fumarate in patients with schizophrenia or schizoaffective disorder: A pilot study. Canadian Journal of Psychiatry, 48, 187-194.
9. Claxton, A. J., Cramer, J., & Pierce, C. (2001). A systematic review of the associations between dose regimens and medication compliance. Clinical Therapy, 23, 1296-1310.
10. Dezii, C. M., Kawabata, H., & Tran, M. (2002). Effects of once-daily and twice-daily dosing on adherence with prescribed glipizide oral therapy for type 2 diabetes. Southern Medical Journal, 95, 68-71.
11. Dieben, T. O., Roumen, F. J., & Apter, D. (2002). Efficacy, cycle control, and user acceptability of a novel combined contraceptive vaginal ring. Obstetrics and Gynecology, 100, 585-593.
12. Dittrich, R., Parker, L., Rosen, J. B., Shangold, G., Creasy, G. W., Fisher, A. C., & Ortho Evra/Evra 001 Study Group (2002). Transdermal contraception: Evaluation of three transdermal norelgestromin/ethinyl estradiol doses in a randomized, multicenter, dose-response study. American Journal of Obstetrics and Gynecology, 186, 15-20.
13. Dolce, J. J., Crisp, C., Manzella, B., Richards, J. M., Hardin, J. M., & Bailey, W. C. (1991). Medication adherence patterns in chronic obstructive pulmonary disease. Chest, 99, 837-841.
14. Donnan, P. T., MacDonald, T. M., & Morris, A. D. (1996). Adherence to prescribed oral hypoglycaemic medication in a population of patients with type 2 diabetes: A retrospective cohort study. Diabetic Medicine, 19, 270-284.
15. Dunbar-Jacob J., Bohachick P., Mortimer M. K., Sereika S. M., & Foley S. M. (2003). Medication adherence in persons with cardiovascular disease. Journal of Cardiovascular Nursing, 18, 209-218.
16. Eisen, S. A., Miller, D. K., & Woodward, R. S. (1990). The effect of prescribed daily dose frequency on patient medication compliance. Archives of Internal Medicine, 150, 1881-1884.
17. Eldred, L. J., Wu, A. W., Chaisson, R. E., & Moore, R. D. (1998). Adherence to antiretroviral and Pneumocystis prophylaxis in HIV disease. Journal of Acquired Immune Deficiency Syndrome, 18, 117-125.
18. Eron, J. J., Yetzer, E. S., Ruane, P. J., et al. (2000). Efficacy, safety, and adherence with a twice daily combination lamivudine/zidovudine tablet formulation, plus a protease inhibitor, in HIV infection. AIDS, 14, 671-681.
19. Ferguson, T. F., Stewart, K. E., Funkhouser, E., Tolson, J., Westfall, A. O., & Saag, M. S. (2002). Patient-perceived barriers to antiretroviral adherence: Associations with race. AIDS Care, 14, 607-617.
20. Flandre, P., Peytavin, G., Meiffredy, V., Saidi, Y., Descomps, D., Delagnes, M., Brun-Vezinet, F., & Roffi, F. (2002). Adherence to antiretroviral therapy and outcomes in HIV-infected patients enrolled in an induction/maintenance randomized trial. Antiviral Therapy, 7, 113-121.
21. Fogarty, L., Roter, D., Larson, S., Burke, J., Gillespie, J., & Levy, R. (2002). Patient adherence to HIV medication regimens: A review of published and abstract reports. Patient Education and Counseling, 46, 93-108.
22. Gallo, M. F., Grimes, D. A., & Schulz, K. F. (2003). Skin patch and vaginal ring versus combined oral contraceptives for contraception. Cochrane Database of Systematic Reviews, 1, CD003552.
23. George, J., Phun, Y. T., Bailey, M. J., Kong, D. C., & Stewart, K. (2004). Development and validation of the medication regimen complexity index. The Annals of Pharmacotherapy, 38, 1369-1376.
24. George, J., & Shalansky, S. J. (2007). Predictors of refill non-adherence in patients with heart failure. British Journal of Clinical Pharmacology, 63, 488-493.
25. Gerald, L. B., McClure, L. A., Harrington, K. F., Mangan, J. M., Gibson, L., Atchison, J., et al. (2007). Design of the supervised asthma therapy study: Implementing an adherence intervention in urban elementary schools. Contemporary Clinical Trials, in press.
26. Golden, R. N., Nemeroff, C. B., McSorley, P., et al. (2002). Efficacy and tolerability of controlled-release and immediate release paroxetine in the treatment of depression. Journal of Clinical Psychiatry, 63, 577-584.
27. Golin, C. E., Liu, H., Hays, R. D., Miller, L. G., Beck, C. K., Ickovics, J., Kaplan, A. H., & Wenger, N. S. (2002). A prospective study of predictors of adherence to combination antiretroviral medication. Journal of General Internal Medicine, 17, 756-765.
28. Grant, R. W., Devita, N. G, Singer, D. E., & Meigs, J. B. (2003). Polypharmacy and medication adherence in patients with type 2 diabetes. Diabetes Care, 26, 1408-1412.
29. Halkitis, P. N., Parsons, J. T., Wolitski, R. J., & Remien, R. H. (2003). Characteristics of HIV antiretroviral treatments, access and adherence in an ethnically diverse sample of men who have sex with men. AIDS Care, 15, 89-102.
30. Hanchak, N. A., Patel, M. B., Berlin, J. A., & Strom, B. L. (1996). Patient misunderstanding of dosing instructions. Journal General Internal Medicine, 11, 325-328.
31. Hays, H., Hagen, N., Thirlwell, M., Dhaliwal, H., Babul, N., Harsanyi, Z., & Darke, A. C. (1994). Comparative clinical efficacy and safety of immediate release and controlled release hydromorphone for chronic severe cancer pain. Cancer, 74, 1808-1816.
32. Haynes, R. B., McDonald, H. P., & Garg, A. X. (2002). Helping patients follow prescribed treatment: Clinical applications. Journal of the American Medical Association, 288, 2880-2883.
33. Hinkin, C. H., Castellon, S. A., Durvasula, R. S., Hardy, D. J., Lam, M. N., Mason, K. I., Thrasher, D., Goetz, M. B., & Stefaniak, M. (2002). Medication adherence among HIV+ adults: Effects of cognitive dysfunction and regimen complexity. Neurology, 59, 1944-1950.
34. Ickovics, J. R., & Meisler, A. W. (1997). Adherence in AIDS clinical trials: A framework for clinical research and clinical care. Journal of Clinical Epidemiology, 50, 385-391.
35. Iskedjian, M., Einarson, T. R., MacKeigan, L. D., Shear, N., Addis, A., Mittmann, N., & Ilersich, A. L. (2002). Relationship between daily dose frequency and adherence to antihypertensive pharmacotherapy: Evidence from a meta-analysis. Clinical Therapy, 24, 302-316.
36. Kane, S. V. (2006). Systematic review: Adherence issues in the treatment of ulcerative colitis. Alimentary Pharmacology and Therapeutics, 23, 577-585.
37. Kardas, P. (2005). The DIACOM study (effect of Dosing frequency of oral Antidiabetic agents on the COMpliance and biochemical control of type 2 diabetes). Diabetes, Obesity and Metabolism, 7, 722-728.
38. Katlama, C., Clumeck, N., Fenske, S., et al. (2001). Use of trizivir to simplify therapy in HAART-experienced patients with long-term suppression of HIV-RNA: TRIZIAL study (AZL 30002) 24-week results. Presented at the 8th Conference on Retroviruses and Opportunistic Infections, Chicago, Feb. 4-8, 2001, Abstract 316.
39. Kelloway, J. S., Wyatt, R. A., & Adlis, S. A. (1994). Comparison of patients' compliance with prescribed oral and inhaled asthma medications. Archieves of Intern Medicine, 154, 1349-1352.
40. Kubacka, R. T., & Juhl, R. P. (1985). Attitudes of patients with hypertension or arthritis toward the frequency of medication administration. American Journal of Hospital Pharmacy, 42, 2499-2501.
41. Lee, J. Y., Kusek, J. W., Greene, P. G., Bernhard, S., Norris, K., Smith, D., Wilkening, B., & Wright, J. T. Jr. (1996). Assessing medication adherence by pill count and electronic monitoring in the African American Study of Kidney Disease and Hypertension (AASK) Pilot Study. American Journal of Hypertension, 9, 719-725.
42. Lee, M., Kemp, J. A., Canning, A., Egan, C., Tataronis, G., & Farraye, F. A. (1999). A randomized controlled trial of an enhanced patient compliance program for Helicobacter pylori therapy. Archives of Internal Medicine, 159, 2312-2316.
43. Mai, L., & Eng, J. (2007). Community-based elder care: A model for working with the marginally housed elderly. Care Management Journals, 8(2), 96-99.
44. Mann, E., Eliasson, O., Patel, K., & ZuWallack, R. L. (1992). A comparison of the effects on bid and qid dosing on compliance with inhaled flunisolide. Chest, 101, 496-499.
45. Martin, S., Wolters, P. L., Calabrese, S. K., Toledo-Tamula, M. A., Wood, L. V., Roby, G., et al. (2007). The Antiretroviral Regimen Complexity Index: A novel method of quantifying regimen complexity. Journal of Acquired Immune Deficiency Syndrome, 45, 1-10.
46. Masand, P. S. (2003). Tolerability and adherence issues in antidepressant therapy. Clinical Therapy, 25, 2289-2304.
47. McDonald, H. P., Garg, A. X., & Haynes, R. B. (2002). Interventions to enhance patient adherence to medication prescriptions: Scientific review. Journal of the American Medical Association, 288, 2868-2879.
48. McNabb, J. J., Nicolau, D. P., Stoner, J. A., & Ross, J. (2003). Patterns of adherence to antiretroviral medications: The value of electronic monitoring. AIDS, 17, 1763-1767.
49. Misra, A., & Ganda, O. P. (2007). Migration and its impact on adiposity and type 2 diabetes. Nutrition (Burbank, Los Angeles County, Calif.), 23(9), 696-708.
50. Molassiotis, A., Lopez-Nahas, V., Chung, W. Y., & Lam, S. W. (2003). A pilot study of the effects of a behavioural intervention on treatment adherence in HIV-infected patients. AIDS Care, 15, 125-135.
51. Morley, J. S., Bridson, J., Nash, T. P., Miles, J. B., White, S., & Makin, M. K. (2003). Low-dose methadone has an analgesic effect in neuropathic pain: A double-blind randomized controlled crossover trial. Palliative Medicine, 17, 576-587.
52. Murphy, D. A., Roberts, K. J., Martin, D. J., Marelich, W., & Hoffman, D. (2000). Barriers to antiretroviral adherence among HIV-infected adults. AIDS Patient Care and STDs, 14, 47-58.
53. O'Shea, S. D., Taylor, N. F., & Paratz, J. D. (2007). But watch out for the weather: Factors affecting adherence to progressive resistance exercise for persons with COPD. Journal of Cardiopulmonary Rehabilitation and Prevention, 27(3), 166-174; quiz 175-176.
54. Paes, A. H., Bakker, A., & Soe-Agnie, C. J. (1997). Impact of dosage frequency on patient compliance. Diabetes Care, 20, 1512-1517.
55. Paterson, D. L., Swindells, S., Mohr, J., Brester, M., Vergis, E. N., Squier, C., Wagener, M. M., & Singh, N. (2000). Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Annals of Internal Medicine, 133, 21-30.
56. Peterson, A. M., Takiya, L., & Finley, R. (2003). Meta-analysis of trials of interventions to improve medication adherence. American Journal of Health System Pharmacy, 60, 657-665.
57. Pinter, B. (2002). Continuation and compliance of contraceptive use. European Journal of Contraception and Reproductive Health Care, 7, 178-183.
58. Portsmouth, S. D., Osorio, J., McCormick, K., Gazzard, B. G., & Moyle, G. J. (2005). Better maintained adherence on switching from twice-daily to once-daily therapy for HIV: A 24-week randomized trial of treatment simplification using prolonged-release capsules. HIV Medicine, 6, 185-190.
59. Purucker, M. E., Rosebraugh, C. J., Zhou, F., & Meyer, R. J. (2003). Inhaled fluticasone propionate by diskus in the treatment of asthma: A comparison of the efficacy of the same nominal dose given either once or twice a day. Chest, 124, 1584-1593.
60. Richter, A., Anton, S. E., Koch, P., & Dennett, S. L. (2003). The impact of reducing dose frequency on health outcomes. Clinical Therapy, 25, 2307-2335.
61. Rueda, S., Park-Wyllie, L. Y., Bayoumi, A. M., Tynan, A. M., Antoniou, T. A., Rourke, S. B., & Glazier, R. H. (2006). Patient support and education for promoting adherence to highly active antiretroviral therapy for HIV/AIDS. Cochrane Database Systematic Review, 3, CD001442.
62. Sankar, A. P., Nevedal, D. C., Neufeld, S., & Luborsky, M. R. (2007). What is a missed dose? Implications for construct validity and patient adherence. AIDS Care, 19(6), 775-780.
63. Shoptaw, S., Reback, C. J., & Freese, T. E. (2002). Patient characteristics, HIV serostatus, and risk behaviors among gay and bisexual males seeking treatment for methamphetamine abuse and dependence in Los Angeles. Journal of Addictive Diseases, 21, 91-105.
64. Sicat, B. L. (2003). Ortho Evra, a new contraceptive patch. Pharmacotherapy, 23, 472-480.
65. Simoni, J. M., Pearson, C. R., Pantalone, D. W., Marks, G., & Crepaz, N. (2006). Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load. Journal of Acquired Immune Deficiency Syndrome, 43, S1, S23-S35.
66. Stone, V. E., Hogan, J. W., Schuman, P., Rompalo, A. M., Howard, A. A., Korkontzelou, C., & Smith, D. K. (2001). Antiretroviral regimen complexity, self-reported adherence, and HIV patients' understanding of their regimens: Survey of women in the HER study. Journal of Acquired Immune Deficiency Syndromes, 28, 124-131.
67. Trotta, M. P., Ammassari, A., Melzi, S., Zaccarelli, M., Ladisa, N., Sighinolfi, L., Mura, M. S., d'Arminio Monforte, A., Antinori, A., & AdICoNA Study Group (2002). Treatment-related factors and highly active antiretroviral therapy adherence. Journal of Acquired Immune Deficiency Syndromes, 31(Suppl 3), S128-131.
68. Wilson, I. B., Tchetgen, E., & Spiegelman, D. (2001). Patterns of adherence with antiretroviral medications: An examination of between-medication differences. Journal of Acquired Immune Deficiency Syndromes, 28, 259-263.
69. Witteveen, E., & van Ameijden, E. J. (2002). Drug users and HIV-combination therapy (HAART): Factors which impede or facilitate adherence. Substance Use and Misuse, 37, 1905-1925.
70. Wohl, D. A., Stephenson, B. L., Golin, C. E., Kiziah, C. N., Rosen, D., Ngo B., Liu, H., & Kaplan, A. H. (2003). Adherence to directly observed antiretroviral therapy among human immunodeficiency virus-infected prison inmates. Clinical Infectious Diseases, 36, 1572-1576.
71. World Health Organization (WHO). (2003). Adherence to long-term therapies: Evidence for action. Geneva, Switzerland: WHO.
72. Yiannakopoulou, E. C., Papadopulos, J. S., Cokkinos, D. V., & Mountokalakis, T. D. (2005). Adherence to antihypertensive treatment: A critical factor for blood pressure control. European Journal of Cardiovascular Prevention and Rehabilitation, 12, 243-249.