Human cytomegalovirus preferentially infects the neoplastic epithelium of colorectal cancer: A quantitative and histological analysis

Journal of Clinical Virology

Volumn 54, Issue 3, 2012, Pages 240-244

  Chen, Hsin Pai ^a   Jiang, Jeng Kai ^a,b   Chen, Cheng Yu ^a   Chou, Teh Ying ^a,b   Chen, Yen Chung ^a   Chang, Ya Ting ^a   Lin, Shiou Fu ^b   Chan, Chia Hao ^a   Yang, Chih Yung ^a,c   Lin, Chi Hung ^a,c   Lin, Jen Kou ^a,b   Cho, Wen Long ^a,d   Chan, Yu Jiun ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c VGH Yang Ming Genome Research Center (VYMGC)   (Taiwan)

^d MACKAY MEDICAL COLLEGE   (Taiwan)

Author keywords

Colorectal cancer; Human cytomegalovirus; In situ hybridization; Polymerase chain reaction

Indexed keywords

GENOMIC DNA; NUCLEIC ACID; VIRUS DNA;

ARTICLE; CANCER PATIENT; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; CYTOPLASM; DNA DETERMINATION; HISTOLOGY; HUMAN; HUMAN CYTOMEGALOVIRUS; HUMAN TISSUE; IN SITU HYBRIDIZATION; INFLAMMATORY INFILTRATE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STROMA; SUBMUCOSA; TUMOR MICROENVIRONMENT; VIRUS TITRATION;

COLORECTAL NEOPLASMS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; EPITHELIUM; HUMANS; IN SITU HYBRIDIZATION; REAL-TIME POLYMERASE CHAIN REACTION; VIRAL LOAD;

EID: 84861696525     PISSN: 13866532     EISSN: 18735967     Source Type: Journal    
DOI: 10.1016/j.jcv.2012.04.007     Document Type: Article

References (36)

1. Staras S.A., Dollard S.C., Radford K.W., Flanders W.D., Pass R.F., Cannon M.J. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis 2006, 43(9):1143-1151.
2. Fisher R.A. Cytomegalovirus infection and disease in the new era of immunosuppression following solid organ transplantation. Transpl Infect Dis 2009, 11(3):195-202.
3. Ives D.V. Cytomegalovirus disease in AIDS. AIDS 1997, 11(15):1791-1797.
4. Reusser P. Cytomegalovirus infection and disease after bone marrow transplantation: epidemiology, prevention, and treatment. Bone Marrow Transplant 1991, 7(Suppl 3):52-56.
5. Castillo J.P., Kowalik T.F. Human cytomegalovirus immediate early proteins and cell growth control. Gene 2002, 290(1-2):19-34.
6. Cinatl J., Cinatl J., Vogel J.U., Rabenau H., Kornhuber B., Doerr H.W. Modulatory effects of human cytomegalovirus infection on malignant properties of cancer cells. Intervirology 1996, 39(4):259-269.
7. Powers C., DeFilippis V., Malouli D., Fruh K. Cytomegalovirus immune evasion. Curr Top Microbiol Immunol 2008, 325:333-359.
8. Cobbs C.S., Harkins L., Samanta M., Gillespie G.Y., Bharara S., King P.H., et al. Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res 2002, 62(12):3347-3350.
9. Giraldo G., Beth E., Huang E.S. Kaposi's sarcoma and its relationship to cytomegalovirus (CMNV). III. CMV DNA and CMV early antigens in Kaposi's sarcoma. Int J Cancer 1980, 26(1):23-29.
10. Huang G., Yan Q., Wang Z., Chen X., Zhang X., Guo Y., et al. Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease. Int J Oncol 2002, 21(1):31-36.
11. Pacsa A.S., Kummerlander L., Pejtsik B., Pali K. Herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls. J Natl Cancer Inst 1975, 55(4):775-781.
12. Sanford E.J., Geder L., Laychock A., Rohner T.J., Rapp F. Evidence for the association of cytomegalovirus with carcinoma of the prostate. J Urol 1977, 118(5):789-792.
13. Huang E.S., Roche J.K. Cytomegalovirus D.N.A. and adenocarcinoma of the colon: Evidence for latent viral infection. Lancet 1978, 1(8071):957-960.
14. Akintola-Ogunremi O., Luo Q., He T.C., Wang H.L. Is cytomegalovirus associated with human colorectal tumorigenesis?. Am J Clin Pathol 2005, 123(2):244-249.
15. Boguszakova L., Hirsch I., Brichacek B., Faltyn J., Fric P., Dvorakova H., et al. Absence of cytomegalovirus, Epstein-Barr virus, and papillomavirus DNA from adenoma and adenocarcinoma of the colon. Acta Virol 1988, 32(4):303-308.
16. Brichacek B., Hirsch I., Zavadova H., Prochazka M., Faltyn J., Vonka V. Absence of cytomegalovirus DNA from adenocarcinoma of the colon. Intervirology 1980, 14(3-4):223-227.
17. Hart H., Neill W.A., Norval M. Lack of association of cytomegalovirus with adenocarcinoma of the colon. Gut 1982, 23(1):21-30.
18. Aquino V.H., Figueiredo L.T. High prevalence of renal transplant recipients infected with more than one cytomegalovirus glycoprotein B genotype. J Med Virol 2000, 61(1):138-142.
19. Arav-Boger R., Willoughby R.E., Pass R.F., Zong J.C., Jang W.J., Alcendor D., et al. Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-alpha and beta-chemokine receptors in congenital CMV disease. J Infect Dis 2002, 186(8):1057-1064.
20. Chen H.P., Lin J.C., Yang S.P., Lan Y.C., Weng W.S., Tsai C.H., et al. The type-2 variant of human cytomegalovirus glycoprotein N (gN-2) is not the rarest in the Chinese population of Taiwan: influence of primer design. J Virol Methods 2008, 151(1):161-164.
21. Castillo J.P., Yurochko A.D., Kowalik T.F. Role of human cytomegalovirus immediate-early proteins in cell growth control. J Virol 2000, 74(17):8028-8037.
22. Boldogh I., AbuBakar S., Albrecht T. Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection. Science 1990, 247(4942):561-564.
23. Hagemeier C., Walker S.M., Sissons P.J., Sinclair J.H. The 72K IE1 and 80K IE2 proteins of human cytomegalovirus independently trans-activate the c-fos, c-myc and hsp70 promoters via basal promoter elements. J Gen Virol 1992, 73(Pt 9):2385-2393.
24. Johnson R.A., Ma X.L., Yurochko A.D., Huang E.S. The role of MKK1/2 kinase activity in human cytomegalovirus infection. J Gen Virol 2001, 82(Pt 3):493-497.
25. Johnson R.A., Wang X., Ma X.L., Huong S.M., Huang E.S. Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling. J Virol 2001, 75(13):6022-6032.
26. Yurochko A.D., Kowalik T.F., Huong S.M., Huang E.S. Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters. J Virol 1995, 69(9):5391-5400.
27. Harkins L., Volk A.L., Samanta M., Mikolaenko I., Britt W.J., Bland K.I., et al. Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet 2002, 360(9345):1557-1563.
28. Koshiba M., Ogawa K., Hamazaki S., Sugiyama T., Ogawa O., Kitajima T. The effect of formalin fixation on DNA and the extraction of high-molecular-weight DNA from fixed and embedded tissues. Pathol Res Pract 1993, 189(1):66-72.
29. Rogers B.B., Alpert L.C., Hine E.A., Buffone G.J. Analysis of DNA in fresh and fixed tissue by the polymerase chain reaction. Am J Pathol 1990, 136(3):541-548.
30. Ferrer I., Armstrong J., Capellari S., Parchi P., Arzberger T., Bell J., et al. Effects of formalin fixation, paraffin embedding, and time of storage on DNA preservation in brain tissue: a BrainNet Europe study. Brain Pathol 2007, 17(3):297-303.
31. Rollo F., Ermini L., Luciani S., Marota I., Olivieri C. Studies on the preservation of the intestinal microbiota's DNA in human mummies from cold environments. Med Secoli 2006, 18(3):725-740.
32. Esclatine A., Bellon A., Michelson S., Servin A.L., Quero A.M., Geniteau-Legendre M. Differentiation-dependent redistribution of heparan sulfate in epithelial intestinal Caco-2 cells leads to basolateral entry of cytomegalovirus. Virology 2001, 289(1):23-33.
33. Jarvis M.A., Wang C.E., Meyers H.L., Smith P.P., Corless C.L., Henderson G.J., et al. Human cytomegalovirus infection of caco-2 cells occurs at the basolateral membrane and is differentiation state dependent. J Virol 1999, 73(6):4552-4560.
34. Furukawa T. A variant of human cytomegalovirus derived from a persistently infected culture. Virology 1984, 137(1):191-194.
35. Ogura T., Tanaka J., Kamiya S., Sato H., Ogura H., Hatano M. Human cytomegalovirus persistent infection in a human central nervous system cell line: production of a variant virus with different growth characteristics. J Gen Virol 1986, 67(Pt 12):2605-2616.
36. Reeves M., Sinclair J. Aspects of human cytomegalovirus latency and reactivation. Curr Top Microbiol Immunol 2008, 325:297-313.