Improved measurement of labile proton concentration-weighted chemical exchange rate (kws) with experimental factor-compensated and T1-normalized quantitative chemical exchange saturation transfer (CEST) MRI

Contrast Media and Molecular Imaging

Volumn 7, Issue 4, 2012, Pages 384-389

  Wu, Renhua ^a,b   Liu, Charng Ming ^c   Liu, Philip K ^c   Sun, Phillip Zhe ^c  

^a THE SECOND AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Amide proton transfer (APT); Chemical exchange saturation transfer (CEST); MRI

Indexed keywords

ARTICLE; CHEMICAL EXCHANGE SATURATION TRANSFER; IN VIVO STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PH; PRIORITY JOURNAL; PROTON TRANSPORT; RADIOFREQUENCY RADIATION; TEMPERATURE;

COMPUTER SIMULATION; MAGNETIC RESONANCE IMAGING; PHANTOMS, IMAGING; PROTONS; SOLUTIONS;

EID: 84861688271     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.505     Document Type: Article

References (38)

1. Wolff SD, Balaban RS. NMR imaging of labile proton exchange. J Magn Reson 1990; 86: 164-169.
2. Ward KM, Balaban RS. Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST). Magn Reson Med 2000; 44: 799-802.
3. Sun PZ, Sorensen AG. Imaging pH using the chemical exchange saturation transfer (CEST) MRI: correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH. Magn Reson Med 2008; 60(2): 390-397.
4. Zhang S, Malloy CR, Sherry AD. MRI thermometry based on PARACEST agents. J Am Chem Soc 2005; 127(50): 17572-17573.
5. van Zijl PCM, Jones CK, Ren J, Malloy CR, Sherry AD. MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci 2007; 104(11): 4359-4364.
6. Shah T, Lu L, Dell KM, Pagel MD, Griswold MA, Flask CA. CEST-FISP: a novel technique for rapid chemical exchange saturation transfer MRI at 7 T. Magn Reson Med 2011; 65(2): 432-437.
7. Longo DL, Dastrù W, Digilio G, Keupp J, Langereis S, Lanzardo S, Prestigio S, Steinbach O, Terreno E, Uggeri F, Aime S. Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: in vivo studies in mice at 7 T. Magn Reson Med 2011; 65(1): 202-211.
8. Gilad AA, McMahon MT, Walczak P, Winnard PT, Jr., Raman V, van Laarhoven HW, Skoglund CM, Bulte JW, van Zijl PC. Artificial reporter gene providing MRI contrast based on proton exchange. Nat Biotechnol 2007; 25(2): 217-219.
9. Li Y, Sheth VR, Liu G, Pagel MD. A self-calibrating PARACEST MRI contrast agent that detects esterase enzyme activity. Contrast Media Mol Imag 2011; 6(4): 219-228.
10. Aime S, Delli Castelli D, Fedeli F, Terreno E. A paramagnetic MRI-CEST agent responsive to lactate concentration. J Am Chem Soc 2002; 124(32): 9364-9365.
11. Vinogradov E, He H, Lubag A, Balschi JA, Sherry AD, Lenkinski RE. MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo. Magn Reson Med 2007; 58(4): 650-655.
12. Li AX, Suchy M, Li C, Gati JS, Meakin S, Hudson RHE, Menon RS, Bartha R. In vivo detection of MRI-PARACEST agents in mouse brain tumors at 9.4 T. Magn Reson Med 2011; 66(1): 67-72.
13. Zhou J, Payen JF, Wilson DA, Traystman RJ, van Zijl PC. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 2003; 9(8): 1085-1090.
14. Jokivarsi KT, Gröhn HI, Gröhn OH, Kauppinen RA. Proton transfer ratio, lactate, and intracellular pH in acute cerebral ischemia. Magn Reson Med 2007; 57(4): 647-653.
15. Sun PZ, Zhou J, Sun W, Huang J, van Zijl PC. Detection of the ischemic penumbra using pH-weighted MRI. J Cereb Blood Flow Metab 2007; 27(6): 1129-1136.
16. Sun PZ, Benner T, Copen W, Sorensen A. Early experience of translating pH-weighted MRI to image human subjects at 3 Tesla. Stroke 2010; 41(suppl 1): S147-S151.
17. Sun PZ, Cheung JS, Wang EF, Lo EH. Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke. J Cereb Blood Flow Metab 2011; 31(8): 1743-1750.
18. Jin T, Wang P, Zong X, Kim S-G. Magnetic resonance imaging of the Amine Proton EXchange (APEX) dependent contrast. Neuroimage 2012; 59(2): 1218-1827.
19. Zhou J, Tryggestad E, Wen Z, Lal B, Zhou T, Grossman R, Wang S, Yan K, Fu D-X, Ford E, Tyler B, Blakeley J, Laterra J, van Zijl PCM. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med 2011; 17(1): 130-134.
20. Jia G, Abaza R, Williams JD, Zynger DL, Zhou J, Shah ZK, Patel M, Sammet S, Wei L, Bahnson RR, Knopp MV. Amide proton transfer MR imaging of prostate cancer: a preliminary study. J Magn Reson Imag 2011; 33(3): 647-654.
21. Jones CK, Schlosser MJ, van Zijl PCM, Pomper GM, Golay X, Zhou J. Amide proton transfer imaging of human brain tumors at 3T. Magn Reson Med 2006; 56(3): 585-592.
22. Dula AN, Asche EM, Landman BA, Welch EB, Pawate S, Sriram S, Gore JC, Smith SA. Development of chemical exchange saturation transfer at 7 T. Magn Reson Med 2011; 66(3): 831-838.
23. Sun PZ, van Zijl PCM, Zhou J. Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments. J Magn Reson 2005; 175(2): 193-200.
24. McMahon M, Gilad A, Zhou J, Sun PZ, Bulte J, van Zijl PC. Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): pH calibration for poly- l-lysine and a starburst dendrimer. Magn Reson Med 2006; 55(4): 836-847.
25. ws) with RF saturation time dependent ratiometric analysis (QUESTRA): normalization of relaxation and RF irradiation spillover effects for improved quantitative chemical exchange saturation transfer (CEST) MRI. Magn Reson Med 2011; doi: 10.1002/mrm.23068.
26. Woessner DE, Zhang S, Merritt ME, Sherry AD. Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI. Magn Reson Med 2005; 53(4): 790-799.
27. Sun PZ, Zhou J, Huang J, van Zijl P. Simplified quantitative description of amide proton transfer (APT) imaging during acute ischemia. Magn Reson Med 2007; 57(2): 405-410.
28. Zaiss M, Schmitt B, Bachert P. Quantitative separation of CEST effect from magnetization transfer and spillover effects by Lorentzian-line-fit analysis of z-spectra. J Magn Reson 2011; 211(2): 149-155.
29. Murase K, Tanki N. Numerical solutions to the time-dependent Bloch equations revisited. Magn Reson Imag 2011; 29(1): 126-131.
30. Sun PZ, Farrar CT, Sorensen AG. Correction for artifacts induced by B0 and B1 field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging. Magn Reson Med 2007;58(6):1207-1215.
31. Kim M, Gillen J, Landman BA, Zhou J, van Zijl PCM. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med 2009; 61(6): 1441-1450.
32. Dixon TW, Ren J, Lubag AJM, Ratnakar J, Vinogradov E, Hancu I, Lenkinski RE, Sherry AD. A concentration-independent method to measure exchange rates in PARACEST agents. Magn Reson Med 2010; 63(3): 625-632.
33. Sun PZ. Simultaneous determination of labile proton concentration and exchange rate utilizing optimal RF power: radio frequency power (RFP) dependence of chemical exchange saturation transfer (CEST) MRI. J Magn Reson 2010; 202(2): 155-161.
34. Aime S, Calabi L, Biondi L, Miranda MD, Ghelli S, Paleari L, Rebaudengo C, Terreno E. Iopamidol: exploring the potential use of a well-established x-ray contrast agent for MRI. Magn Reson Med 2005; 53(4): 830-834.
35. Soesbe TC, Merritt ME, Green KN, Rojas-Quijano FA, Sherry AD. T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation. Magn Reson Med 2011; 66(6): 1697-1703.
36. Jin T, Autio J, Obata T, Kim S-G. Spin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons. Magn Reson Med 2011; 65(5): 1448-1460.
37. Trott O, Palmer AG. R1[rho] relaxation outside of the fast-exchange limit. J Magn Reson 2002; 154(1): 157-160.
38. Sun PZ. Simplified and scalable numerical solution for describing multi-pool chemical exchange saturation transfer (CEST) MRI contrast. J Magn Reson 2010; 205(2): 235-241.