Enhancement of immune response towards non-lipidized Borrelia burgdorferi recombinant OspC antigen by binding onto the surface of metallochelating nanoliposomes with entrapped lipophilic derivatives of norAbuMDP

Journal of Controlled Release

Volumn 160, Issue 2, 2012, Pages 374-381

  Křupka, Michal ^a   Mašek, Josef ^b   Bartheldyová, Eliška ^b   Knötigová, Pavlína Turánek ^b   Plocková, Jana ^b   Korvasová, Zina ^b   Škrabalová, Michaela ^b   Koudelka, Štěpán ^b   Kulich, Pavel ^b   Zachová, Kateřina ^a   Czerneková, Lýdie ^a   Strouhal, Ondřej ^a   Horynová, Milada ^a   Šebela, Marek ^a   Miller, Andrew D ^d,e   Ledvina, Miroslav ^c   Raška, Milan ^a   Turánek, Jaroslav ^b  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b VETERINARY RESEARCH INSTITUTE   (Czech Republic)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Borrelia burgdorferi OspC; MDP; Metallochelating liposomes; nor Abu MDP; Vaccine

Indexed keywords

BORRELIA; BORRELIA BURGDORFERI; CELL ACTIVATION; IMMUNE RESPONSE; IMMUNE SYSTEMS; LYME DISEASE; MDP; NANOLIPOSOMES; NOR-ABU-MDP; PHAGOCYTIC CELLS;

CHEMICAL ACTIVATION; IMMUNOLOGY; LIPOSOMES; VACCINES;

RECOMBINANT PROTEINS;

ANTIGEN; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; LIPOSOME; NANOLIPOSOME; OSPC ANTIGEN; UNCLASSIFIED DRUG; VACCINE;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; BORRELIA BURGDORFERI; ESCHERICHIA COLI; FEMALE; IMMUNE RESPONSE; IMMUNITY; IMMUNIZATION; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BORRELIA BURGDORFERI; CALORIMETRY, DIFFERENTIAL SCANNING; CHELATING AGENTS; DRUG CARRIERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; LIGHT; LIPOSOMES; LYME DISEASE VACCINES; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; SCATTERING, RADIATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84861680486     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.02.017     Document Type: Article

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