Specific immune response to a synthetic peptide derived from outer surface protein C of Borrelia burgdorferi predicts protective borreliacidal antibodies

FEMS Immunology and Medical Microbiology

Volumn 29, Issue 1, 2000, Pages 15-21

  Ikushima, Masako ^a   Matsui, Katsuhiko ^b   Yamada, Fumiya ^a   Kawahashi, Sachie ^a   Nishikawa, Akemi ^b  

^a SAITAMA INSTITUTE OF PUBLIC HEALTH   (Japan)

^b Meiji Pharmaceutical U ^*  (Japan)

Author keywords

Borreliacidal activity; Lyme disease; Outer surface protein C; Synthetic peptide; Vaccination

Indexed keywords

BACTERIUM ANTIBODY; IMMUNOGLOBULIN M; OUTER MEMBRANE PROTEIN; SYNTHETIC PEPTIDE;

ADOLESCENT; ANTIBODY RESPONSE; ARTICLE; BACTERICIDAL ACTIVITY; BORRELIA AFZELII; BORRELIA BURGDORFERI; BORRELIA GARINII; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMORAL IMMUNITY; LYME DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BORRELIA BURGDORFERI GROUP; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNE SERA; IMMUNOGLOBULIN M; LYME DISEASE; MICE; NEUTRALIZATION TESTS; PEPTIDES; PREDICTIVE VALUE OF TESTS; VACCINATION;

EID: 0033844574     PISSN: 09288244     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-8244(00)00181-4     Document Type: Article

References (41)

1. Steere A.C. Lyme disease. New Engl. J. Med. 321:1989;586-596.
2. Steere A.C., Bartenhagen N.H., Craft J.E., Hutchinson G.J., Newman J.H., Rahn D.W., Sigal L.H., Spieler P.N., Stenn K.S., Malawista S.E. The early clinical manifestations of Lyme disease. Ann. Intern. Med. 99:1983;76-82.
3. Pachner A.R., Steere A.C. The triad of neurologic manifestations of Lyme disease: meningitis, cranial neuritis, and radiculoneuritis. Neurology. 35:1985;47-53.
4. Steere A.C., Schoen R.T., Taylor E. The clinical evolution of Lyme arthritis. Ann. Intern. Med. 107:1987;725-731.
5. Johnson R.C., Kodner C., Russell M. Passive immunization of hamsters against experimental infection with the Lyme disease spirochete. Infect. Immun. 53:1986;713-714.
6. Schmitz J.L., Schell R.F., Hejka A.G., England D.M. Passive immunization prevents induction of Lyme arthritis in LSH hamsters. Infect. Immun. 58:1990;144-148.
7. Schmitz J.L., Schell R.F., Lovrich S.D., Callister S.M., Coe J.E. Characterization of the protective antibody response to Borrelia burgdorferi in experimentally infected LSH hamsters. Infect. Immun. 59:1991;1916-1921.
8. Callister S.M., Schell R.F., Case K.L., Lovrich S.D., Day S.P. Characterization of the borreliacidal antibody response to Borrelia burgdorferi in humans: a serodiagnostic test. J. Infect. Dis. 167:1993;158-164.
9. Fikrig E., Bockenstedt L.K., Barthold S.W., Chen M., Tao H., Ali-Salaam P., Telford S.R., Flavell R.A. Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. J. Infect. Dis. 169:1994;568-574.
10. Lovrich S.D., Callister S.M., DuChateau B.K., Lim L.C.L., Winfrey J., Day S.P., Schell R.F. Abilities of OspA proteins from different seroprotective groups of Borrelia burgdorferi to protect hamsters from infection. Infect. Immun. 63:1995;2113-2119.
11. Lovrich S.D., Callister S.M., Lim L.C.L., DuChateau B.K., Schell R.F. Seroprotective groups of Lyme borreliosis spirochetes from North America and Europe. J. Infect. Dis. 170:1994;115-121.
12. Probert W.S., LeFebvre R.B. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen. Infect. Immun. 62:1994;1920-1926.
13. Simon M.M., Schaible U.E., Kramer M.D., Eckerskorn C., Museteanu C., Müller-Hermelink H.K., Wallich R. Recombinant outer surface protein A from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice. J. Infect. Dis. 164:1991;123-132.
14. Fikrig E., Barthold S.W., Kantor F.S., Flavell R.A. Long-term protection of mice from Lyme disease by vaccination with OspA. Infect. Immun. 60:1992;773-777.
15. Fikrig E., Barthold S.W., Marcantonio N., Deponte K., Kantor F.S., Flavell R.A. Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect. Immun. 60:1992;657-661.
16. Schaible E.U., Kramer M.D., Eichmann K., Modolell M., Museteanu C., Simon M.M. Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc. Natl. Acad. Sci. USA. 87:1990;3768-3772.
17. Preac-Mursic V., Wilske B., Patsouris E., Jauris S., Will G., Soutschek E., Rainhardt S., Lehnert G., Klockmann U., Mehraein P. Active immunization of pC protein of Borrelia burgdorferi protects gerbils against B. burgdorferi infection. Infection. 20:1992;342-349.
18. Scriba M., Ebrahim J.S., Schlott T., Eiffert H. The 39-kilodalton protein of Borrelia burgdorferi: a target for bactericidal human monoclonal antibodies. Infect. Immun. 61:1993;4523-4526.
19. Sambri V., Armati S., Cevenini R. Animal and human antibodies reactive with the outer surface protein A and B of Borrelia burgdorferi are borreliacidal, in vitro, in the presence of complement. FEMS Immunol. Med. Microbiol. 7:1993;67-72.
20. Ma J., Gingrich-Baker C., Franchi P.M., Bulger P., Coughlin R.T. Molecular analysis of neutralizing epitopes on outer surface proteins A and B of Borrelia burgdorferi. Infect. Immun. 63:1995;2221-2227.
21. Aydintug M.K., Gu Y., Philipp M.T. Borrelia burgdorferi antigens that are targeted by antibody-dependent, complement-mediated killing in the rhesus monkey. Infect. Immun. 62:1994;4929-4937.
22. Moskophidis M., Luther B. Monoclonal antibodies with in vitro borreliacidal activities define the outer surface proteins A and B of Borrelia burgdorferi. Zbl. Bakt. 279:1993;201-213.
23. Coleman J.L., Rogers R.C., Benach J.L. Selection of an escape variant of Borrelia burgdorferi by use of bactericidal monoclonal antibodies to OspB. Infect. Immun. 60:1992;3098-3104.
24. Rousselle J.C., Callister S.M., Schell R.F., Lovrich S.D., Jobe D.A., Marks J.A., Wieneke C.A. Borreliacidal antibody production against outer surface protein C of Borrelia burgdorferi. J. Infect. Dis. 178:1998;733-741.
25. Ikushima M., Kawahashi S., Ohzeki Y., Okuyama Y., Isogai E., Arai T., Matsui K. A new specific serodiagnosis system for Lyme disease: use of synthetic peptides derived from outer surface protein C of Borrelia burgdorferi. Opport. Path. 9:1997;21-25.
26. Fukunaga M., Hamase A. Outer surface protein C gene sequence analysis of Borrelia burgdorferi sensu lato isolates from Japan. J. Clin. Microbiol. 33:1995;2415-2420.
27. Ma J., Coughlin R.T. A simple, colorimetric microtiter assay for borreliacidal activity of antisera. J. Microbiol. Methods. 17:1993;145-153.
28. Probert W.S., Crawford M., Cadiz R.B., LeFebvre R.B. Immunization with outer surface protein (Osp) A, but not OspC, provides cross-protection of mice challenged with North American isolates of Borrelia burgdorferi. J. Infect. Dis. 175:1997;400-405.
29. Gilmore R.D. Jr., Kappel K.J., Dolan M.C., Burkot T.R., Johnson B.J. Outer surface protein C (OspC), but not p39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC. Infect. Immun. 64:1996;2234-2239.
30. Fikrig E., Telford S.R., Barthold S.W., Kantor F.S., Spielman A., Flavell R.A. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc. Natl. Acad. Sci. USA. 89:1992;5418-5421.
31. Johnson B.J.B., Sviat S.L., Happ C.M., Dunn J.J., Frantz J.C., Mayer L.W., Piesman J. Incomplete protection of hamsters vaccinated with unlipidated OspA from Borrelia burgdorferi infection is associated with low levels of antibody to an epitope defined by mAb LA-2. Vaccine. 13:1995;1086-1094.
32. Padilla M.L., Callister S.M., Schell R.F., Bryant G.L., Jobe D.A., Lovrich S.D., DuChateau B.K., Jensen J.R. Characterization of the protective borreliacidal antibody response in humans and hamsters after vaccination with a Borrelia burgdorferi outer surface protein A vaccine. J. Infect. Dis. 174:1996;739-746.
33. Jauris-Heipke S., Liegl G., Preac-Mursic V., Rößler D., Schwab E., Soutschek E., Will G., Wilske B. Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to OspA genotype and evidence of lateral gene exchange of OspC. J. Clin. Microbiol. 33:1995;1860-1866.
34. Stevenson B., Barthold S.W. Expression and sequence of outer surface protein C among North American isolates of Borrelia burgdorferi. FEMS Microbiol. Lett. 124:1994;367-372.
35. Livey I., Gibbs C.P., Schuster R., Dorner F. Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia. Mol. Microbiol. 18:1995;257-269.
36. Schwan T.G., Piesman J., Golde W.T., Dolan M.C., Rosa P.A. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc. Natl. Acad. Sci. USA. 92:1995;2909-2913.
37. Ikushima M., Yamada F., Kawahashi S., Okuyama Y., Matsui K. Antibody response to OspC-I synthetic peptide derived from outer surface protein C of Borrelia burgdorferi in sera from Japanese forestry workers. Epidemiol. Infect. 122:1999;429-433.
38. Gilmore R.D. Jr., Mbow M.L. Conformational nature of the Borrelia burgdorferi B31 outer surface protein C protective epitope. Infect. Immun. 67:1999;5463-5469.
39. Callister S.M., Schell R.F., Lovrich S.D. Lyme disease assay which detects killed Borrelia burgdorferi. J. Clin. Microbiol. 29:1991;1773-1776.
40. Callister S.M., Schell R.F., Lim L.C.L., Jobe D.A., Case K.L., Bryant G.L., Molling P.E. Detection of borreliacidal antibodies by flow cytometry: an accurate, highly specific serodiagnostic test for Lyme disease. Arch. Intern. Med. 154:1994;1625-1632.
41. Callister S.M., Jobe D.A., Schell R.F., Pavia C.S., Lovrich S.D. Sensitivity and specificity of the borreliacidal-antibody test during early Lyme disease: a gold standard? Clin. Diagn. Lab. Immunol. 3:1996;399-402.