The effects of functional polymorphisms in the TGFβ 1 gene on nasopharyngeal carcinoma susceptibility

Otolaryngology - Head and Neck Surgery (United States)

Volumn 146, Issue 4, 2012, Pages 579-584

  Hu, Sunhong ^a   Zhou, Guojin ^a   Zhang, Lei ^a   Jiang, Huifen ^b   Xiao, Mang ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG CANCER HOSPITAL   (China)

Author keywords

nasopharyngeal carcinoma; single nucleotide polymorphism; TGF

Indexed keywords

MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; BIOCHEMISTRY; CANCER CELL CULTURE; CANCER RISK; CANCER SUSCEPTIBILITY; CHINESE; CONTROLLED STUDY; EXON; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; POLYMERASE CHAIN REACTION; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; ANALYSIS OF VARIANCE; CASE CONTROL STUDY; CHI SQUARE DISTRIBUTION; CHINA; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; NASOPHARYNX TUMOR; STATISTICAL MODEL;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHINA; EXONS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84861668791     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1177/0194599811434890     Document Type: Article

References (37)

1. Kiessling R, Wasserman K, Horiguchi S, et al. Tumor-induced immune dysfunction. Cancer Immunol Immunother. 1999 ; 48: 353-362
2. Hellstrom KE, Hellstrom I.. Novel approaches to therapeutic cancer vaccines. Expert Rev Vaccines. 2003 ; 2: 517-532
3. Zheng J, Yu X, Jiang L, et al. Association between the cytotoxic T-lymphocyte antigen 4 +49G > A polymorphism and cancer risk: a meta-analysis. BMC Cancer. 2010 ; 10: 522
4. D'Orazio TJ, Niederkorn JY. A novel role for TGF-beta and IL-10 in the induction of immune privilege. J Immunol. 1998 ; 160: 2089-2098
5. Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 2001 ; 194: 629-44
6. Liyanage UK, Moore TT, Joo HG, et al. Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J Immunol. 2002 ; 169: 2756-2761
7. Kanamaru Y, Nakao A, Mamura M, et al. Blockade of TGF-beta signaling in T cells prevents the development of experimental glomerulonephritis. J Immunol. 2001 ; 166: 2818-2823
8. Dickson RB, Kasid A, Huff KK, et al. Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene. Proc Natl Acad Sci U S A. 1987 ; 84: 837-841
9. Lu SL, Zhang WC, Akiyama Y, et al. Genomic structure of the transforming growth factor beta type II receptor gene and its mutations in hereditary nonpolyposis colorectal cancers. Cancer Res. 1996 ; 56: 4595-4598
10. Park K, Kim SJ, Bang YJ, et al. Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta. Proc Natl Acad Sci U S A. 1994 ; 91: 8772-8776
11. Chung YJ, Song JM, Lee JY, et al. Microsatellite instability-associated mutations associate preferentially with the intestinal type of primary gastric carcinomas in a high-risk population. Cancer Res. 1996 ; 56: 4662-4665
12. Izumoto S, Arita N, Ohnishi T, et al. Microsatellite instability and mutated type II transforming growth factor-beta receptor gene in gliomas. Cancer Lett. 1997 ; 112: 251-256
13. Xiao M, Qi F, Chen X, et al. Functional polymorphism of cytotoxic T-lymphocyte antigen 4 and nasopharyngeal carcinoma susceptibility in a Chinese population. Int J Immunogenet. 2010 ; 37: 27-32
14. Xiao M, Zhang L, Zhu X, et al. Genetic polymorphisms of MDM2 and TP53 genes are associated with risk of nasopharyngeal carcinoma in a Chinese population. BMC Cancer. 2010 ; 10: 147
15. Lehmann T, Biernacka-Lukanty J, Trzeciak WH. Expression of three negative regulators of CYP17 gene transcription in adrenocortical cells. Endocr Res. 2000 ; 26: 1019-1026
16. Jiang L, Zhang C, Li Y, et al. A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population. Breast Cancer Res Treat. 2011 ; 126: 487-495
17. Zheng J, Liu B, Zhang L, et al. The protective role of polymorphism MKK4 -1304 T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus infection status [published online ahead of print June 23, 2011]. Int J Cancer. :
18. Zheng J, Zhang C, Jiang L, et al. Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma. Mol Carcinog. 2011 ; 50: 689-696
19. Piek E, Heldin CH, Ten Dijke P.. Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J. 1999 ; 13: 2105-2124
20. Elliott RL, Blobe GC. Role of transforming growth factor Beta in human cancer. J Clin Oncol. 2005 ; 23: 2078-2093
21. Mishra L, Derynck R, Mishra B.. Transforming growth factor-beta signaling in stem cells and cancer. Science. 2005 ; 310: 68-71
22. Roberts AB, Sporn MB. Differential expression of the TGF-beta isoforms in embryogenesis suggests specific roles in developing and adult tissues. Mol Reprod Dev. 1992 ; 32: 91-98
23. Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily. Science. 2002 ; 296: 1646-1647
24. Tsushima H, Ito N, Tamura S, et al. Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer. Clin Cancer Res. 2001 ; 7: 1258-1262
25. Shariat SF, Kattan MW, Traxel E, et al. Association of pre- and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression. Clin Cancer Res. 2004 ; 10: 1992-1999
26. Domagala-Kulawik J, Hoser G, Safianowska A, et al. Elevated TGF-beta1 concentration in bronchoalveolar lavage fluid from patients with primary lung cancer. Arch Immunol Ther Exp (Warsz). 2006 ; 54: 143-147
27. Wright JA, Turley EA, Greenberg AH. Transforming growth factor beta and fibroblast growth factor as promoters of tumor progression to malignancy. Crit Rev Oncog. 1993 ; 4: 473-492
28. Wojtowicz-Praga S.. Reversal of tumor-induced immunosuppression: a new approach to cancer therapy. J Immunother. 1997 ; 20: 165-177
29. Mocellin S, Wang E, Marincola FM. Cytokines and immune response in the tumor microenvironment. J Immunother. 2001 ; 24: 392-407
30. Lee KM, Park SK, Hamajima N, et al. Genetic polymorphisms of TGF-beta1 & TNF-beta and breast cancer risk. Breast Cancer Res Treat. 2005 ; 90: 149-155
31. Dunning AM, Ellis PD, McBride S, et al. A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer. Cancer Res. 2003 ; 63: 2610-2615
32. Jin Q, Hemminki K, Grzybowska E, et al. Polymorphisms and haplotype structures in genes for transforming growth factor beta1 and its receptors in familial and unselected breast cancers. Int J Cancer. 2004 ; 112: 94-99
33. Hishida A, Iwata H, Hamajima N, et al. Transforming growth factor B1 T29C polymorphism and breast cancer risk in Japanese women. Breast Cancer. 2003 ; 10: 63-69
34. Grainger DJ, Heathcote K, Chiano M, et al. Genetic control of the circulating concentration of transforming growth factor type beta1. Hum Mol Genet. 1999 ; 8: 93-97
35. Jin G, Wang L, Chen W, et al. Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population. Int J Cancer. 2007 ; 120: 1330-1335
36. Chung SJ, Kim JS, Jung HC, et al. Transforming growth factor-[beta]1 -509T reduces risk of colorectal cancer, but not adenoma in Koreans. Cancer Sci. 2007 ; 98: 401-404
37. de Caestecker MP, Piek E, Roberts AB. Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst. 2000 ; 92: 1388-1402