TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice

Anesthesiology

Volumn 116, Issue 6, 2012, Pages 1299-1311

  James, Michael L ^a   Wang, Haichen ^a   Cantillana, Viviana ^a   Lei, Beilei ^a   Kernagis, Dawn N ^b   Dawson, Hana N ^a   Klaman, Lori D ^c   Laskowitz, Daniel T ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Transition Therapeutics Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHENYL 4 PYRIDIN 4 YL 3 [4 PYRIMIDIN 2 YL PIPERAZIN 1 YL]PYRIDAZINE HYDROCHLORIDE; CENTRAL NERVOUS SYSTEM AGENTS; JANUS KINASE; STAT PROTEIN; TT 301; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN EDEMA; BRAIN HEMORRHAGE; CELL ACTIVATION; CELL VIABILITY; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION; MENTAL FUNCTION; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; TRAUMATIC BRAIN INJURY;

ANIMALS; BLOOD GAS ANALYSIS; BLOOD GLUCOSE; BODY WATER; BRAIN CHEMISTRY; BRAIN INJURIES; CELL COUNT; CELL LINE; CENTRAL NERVOUS SYSTEM; CEREBRAL HEMORRHAGE; CYTOKINES; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICROGLIA; PIPERAZINES; POSTURAL BALANCE; PSYCHOMOTOR PERFORMANCE; PYRIDAZINES; PYRIDINES; REAL-TIME POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

EID: 84861642111     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318253a02a     Document Type: Article

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