Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs

Laboratory Investigation

Volumn 92, Issue 6, 2012, Pages 802-811

  Yen, Hai Yun ^a   Gabet, Yankel ^b,d   Liu, Ying ^b   Martin, Anthony ^b   Wu, Nancy L ^a   Pike, Malcolm C ^b,c   Frenkel, Baruch ^b   Maxson, Robert ^a   Dubeau, Louis ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

BRCA1; familial cancer predisposition; hormonal carcinogenesis; mouse model; ovarian cancer

Indexed keywords

BRCA1 PROTEIN; ESTROGEN; GONADOTROPIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE STRENGTH; CANCER RISK; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; CONTROLLED STUDY; DIAPHYSIS; ESTROGEN RESPONSIVE ELEMENT; ESTROGEN SYNTHESIS; FAMILIAL CANCER; FEMALE; FEMUR; GENE INACTIVATION; GENE MUTATION; GRANULOSA CELL; HORMONAL REGULATION; MENSTRUAL CYCLE; MOUSE; MYOMETRIUM; NONHUMAN; OSTEOCLAST; OVARY CANCER; PRIORITY JOURNAL; PROESTRUS; PROTEIN EXPRESSION; SPLEEN CELL; TRABECULAR BONE;

EID: 84861641993     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2012.58     Document Type: Article

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