Modulation of nitric oxide synthase by arginase and methylated arginines during the acute phase of experimental multiple sclerosis

Journal of the Neurological Sciences

Volumn 318, Issue 1-2, 2012, Pages 106-111

  Ljubisavljevic, Srdjan ^a   Stojanovic, Ivana ^a   Pavlovic, Radmila ^a   Sokolovic, Dusan ^a   Pavlovic, Dusica ^a   Cvetkovic, Tatjana ^a   Stevanovic, Ivana ^b  

^a UNIVERSITY OF NI   (Serbia)

^b UNIVERSITY OF DEFENCE   (Serbia)

Author keywords

ADMA; Arginase; EAE; Nitric oxide; SDMA

Indexed keywords

6 N,N' DIMETHYLARGININE; ACETYLCYSTEINE; AMINOGUANIDINE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HINDLIMB; LIMB WEAKNESS; MULTIPLE SCLEROSIS; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; RAT; SPINAL CORD;

ACUTE DISEASE; ANIMALS; ARGINASE; ARGININE; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; MALE; METHYLATION; MULTIPLE SCLEROSIS; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84861637444     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2012.03.015     Document Type: Article

References (40)

1. A.G. Baxter The origin and application of experimental autoimmune encephalomyelitis Nat Rev Immunol 7 2007 904 912
2. B. Barbul Arginine: biochemistry, physiology, and therapeutic implications J Parenter Enteral Nutr 10 1986 227 238
3. G. Wu, and S.M. Morris Arginine metabolism: nitric oxide and beyond Biochem J 336 Pt. 1 1998 1 17
4. D. Cai, K. Deng, W. Mellado, J. Lee, R.R. Ratan, and M.T. Filbin Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro Neuron 35 2002 711 719
5. J. Lee, H. Ryu, R.J. Ferrante, S.M. Morris, and R.R. Ratan Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox Proc Natl Acad Sci U S A 100 2003 4843 4848
6. M. Hesse, M. Modolell, A.C. La Flamme, M. Schito, J.M. Fuentes, and A.W. Cheever Differential regulation of nitric oxide synthase 2 and arginase 1 by type1/type2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L arginine metabolism J Immunol 167 2001 6533 6544
7. C.D. Mills, K. Kincaid, J.M. Alt, M.J. Heilman, and A.M. Hill M-1/M-2 macrophages and the Th1/Th2 paradigm J Immunol 164 2000 6166 6173
8. C. Jack, F. Ruffini, A. Bar-Or, and J.P. Antel Microglia and multiple sclerosis J Neurosci Res 81 2005 363 373
9. S. Ljubisavljevic, I. Stojanovic, D. Pavlovic, D. Sokolovic, and I. Stevanovic Aminoguanidine and N-acetyl-cysteine suppress oxidative and nitrosative stress in EAE rat brains Redox Rep 16 4 2011 166 172
10. A. Pautz, J. Art, S. Hahn, S. Nowag, C. Voss, and H. Kleinert Regulation of the expression of inducible nitric oxide synthase Nitric Oxide 23 2 2010 75 93
11. M. Sajad, J. Zargan, R. Chawla, S. Umar, M. Sadaqat, and H.A. Khan Hippocampal neurodegeneration in experimental autoimmune encephalomyelitis (EAE): potential role of inflammation activated myeloperoxidase Mol Cell Biochem 328 2009 183 188
12. J.A. Navaro-Gonzalvez, C. Garcia-Benayas, and J. Arenas Semiautomated measurement of nitrate in biological fluids Clin Chem 44 1998 679 681
13. Z. Porembska, and M. Kedra Early diagnosis of myocardial infarction by arginase activity determination Clin Chim Acta 60 1975 355 361
14. J. Pi, Y. Kumagai, G. Sun, and N. Shimojo Improved method for simultaneous determination of l-arginine and its mono- and dimethylated metabolites in biological samples by high-performance liquid chromatography J Chromatogr B Biomed Sci Appl 742 1 2000 199 203
15. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with Folin phenol reagent J Biol Chem 193 1951 265 275
16. S. Ljubisavljevic, I. Stojanovic, D. Pavlovic, M. Milojkovic, S. Vojinovic, and D. Sokolovic The nitric oxide level in different CNS regions of EAE rats and its correlation with clinical expression Acta Neurobiol Exp 72 1 2012 33 39
17. M. Munder, K. Eichmann, J.M. Morán, F. Centeno, G. Soler, and M. Modolell Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells J Immunol 163 1999 3771 3777
18. J.B. Ochoa, A.C. Bernard, W.E. O'Brien, M.M. Griffen, M.E. Maley, and A.K. Rockich Arginase I expression and activity in human mononuclear cells after injury Ann Surg 233 2001 393 399
19. A.L. Mellor, and D.H. Munn Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 20 1999 469 473
20. A.L. Mellor, and D.H. Munn Tryptophan catabolism prevents maternal T cells from activating lethal anti-fetal immune responses J Reprod Immunol 52 2001 5 13
21. F. Esch, K.I. Lin, A. Hills, K. Zaman, J.M. Baraban, and S. Chatterjee Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide independent inhibition of neuronal apoptosis J Neurosci 18 1998 4083 4095
22. D.T. Efron, S.J. Kirk, M.C. Regan, H.L. Wasserkrug, and A. Barbul Nitric Oxide generation from l-arginine is required for optimal human peripheral blood lymphocyte DNA synthesis Surgery 110 1991 327 334
23. V. Bansal, and J.B. Ochoa Arginine availability, arginase, and the immune response Curr Opin Clin Nutr 6 2003 223 228
24. M. Mori, and T. Gotoh Regulation of nitric oxide production by arginine metabolic enzymes Biochem Biophys Res Commun 275 2000 715 719
25. M. Mori, and T. Gotoh Arginine metabolic enzymes, nitric oxide and infection J Nutr 134 2004 2820S 2825S
26. B. Nicholson, C.K. Manner, J. Kleeman, and C.L. MacLeod Sustained nitric oxide production in macrophages requires the arginine transporter CAT2 J Biol Chem 276 2001 15881 15885
27. J.B. Ochoa, J. Strange, P. Kearney, G. Gellin, E. Endean, and E. Fitzpatrick Effects of l-arginine on the proliferation of T lymphocyte subpopulations JPEN J Parenter Enteral Nutr 25 2001 23 29
28. X.U. Lingyun, B. Hilliard, R.J. Carmody, G. Tsabary, H. Shin, and D.W. Christianson Arginase and autoimmune inflammation in the central nervous system Immunology 110 2003 141 148
29. J.L. Boucher, C. Moali, and J.P. Tenu Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for l-arginine utilization Cell Mol Life Sci 55 1999 1015 1028
30. K.J. Baek, B.A. Thiel, Lucas, and S.D.J. Stuehr Macrophage nitric oxide synthase subunits. purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme J Biol Chem 268 1993 21120 21129
31. V. Bronte, and P. Zanovello Regulation of immune responses by l-arginine metabolism Nat Rev Immunol 5 2005 641 654
32. Salimuddin, A. Nagasaki, T. Gotoh, H. Isobe, and M. Mori Regulation of the genes for arginase isoforms and related enzymes in mouse macrophages by lipopolysaccharide Am J Physiol Endocrinol Metab 277 1 Pt 1 1999 E110 E117
33. L. Santhanam, H.K. Lim, H.K. Lim, V. Miriel, T. Brown, and M. Patel Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction Circ Res 101 2007 692 702
34. J. Leiper, and P. Vallance Biological significance of endogenous methylargininesthat inhibit nitric oxide synthases Cardiovasc Res 43 1999 542 548
35. J. Bełtowski, and A. Kedra Asymmetric dimethylarginine (ADMA) as a target for pharmacotherapy Pharmacol Rep 58 2006 159 178
36. C.A. Robertson, B.G. Green, L. Niedzwiecki, R.K. Harrison, and S.K. Grant Effect of nitric oxide synthase substrate analog inhibitors on rat liver arginase Biochem Biophys Res Commun 197 1993 523 528
37. A. Hrabak, T. Bajor, and A. Temesi Comparison of substrate and inhibitor specificity of arginase and nitric oxide (NO) synthase for arginine analogues and related compounds in murine and rat macrophages Biochem Biophys Res Commun 198 1994 206 212
38. D. Owczarek, D. Cibor, and T. Mach Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), arginine, and 8-iso-prostaglandin F2a (8-iso-PGF2a) level in patients with inflammatory bowel diseases Inflamm Bowel Dis 16 2010 52 57
39. K. Pahan, F.G. Sheikh, A.M.S. Namboodiri, and I. Singh N-acetyl cysteine inhibits induction of NO production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes Free Radic Biol Med 24 1 1998 39 48
40. J. Malabendu, and P. Kalipada Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytes Free Radic Biol Med 39 2005 823 831