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Volumn 25, Issue 3-4, 2012, Pages 331-343

Propylthiouracil hepatitis: Report of a case and extensive review of the literature

Author keywords

adolescents; children; hepatitis; methimazole; propylthiouracil; thyrotoxicosis

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; POTASSIUM PERCHLORATE; PREDNISONE; PROPRANOLOL; PROPYLTHIOURACIL; RADIOACTIVE IODINE; SODIUM PERCHLORATE; THIAMAZOLE; THIONAMIDE; VITAMIN K GROUP;

EID: 84861630535     PISSN: 0334018X     EISSN: 21910251     Source Type: Journal    
DOI: 10.1515/jpem-2011-0442     Document Type: Review
Times cited : (7)

References (63)
  • 1
    • 0021328359 scopus 로고
    • Landmark perspective: Treatment of hyperthyroidism
    • Landau RL. Landmark perspective: Treatment of hyperthyroidism. J Am Med Assoc 1984;251:1747-8.
    • (1984) J Am Med Assoc , vol.251 , pp. 1747-1748
    • Landau, R.L.1
  • 2
    • 0021365962 scopus 로고
    • Landmark article May 8, 1943: Treatment of hyperthyroidism with thiourea and thiouracil
    • Astwood EB. Landmark article May 8, 1943: Treatment of hyperthyroidism with thiourea and thiouracil. J Am Med Assoc 1984;251:1743-6.
    • (1984) J Am Med Assoc , vol.251 , pp. 1743-1746
    • Astwood, E.B.1
  • 3
    • 77954985916 scopus 로고    scopus 로고
    • Propylthiouracil (PTU) hepatoxicity in children and recommendations for discontinuation of use
    • Rivkees SA, Mattison DR. Propylthiouracil (PTU) hepatoxicity in children and recommendations for discontinuation of use. Int J Pediatr Endocrinol 2009;2009:132041.
    • (2009) Int J Pediatr Endocrinol , vol.2009 , pp. 132041
    • Rivkees, S.A.1    Mattison, D.R.2
  • 4
    • 1542505460 scopus 로고
    • Toxic manifestations of thiouracil therapy
    • Moore FD. Toxic manifestations of thiouracil therapy. J Am Med Assoc 1946;130:315-9.
    • (1946) J Am Med Assoc , vol.130 , pp. 315-319
    • Moore, F.D.1
  • 5
    • 0039823915 scopus 로고
    • Agranulocytosis and hepatocellular jaundice: Toxic reactions following propylthiouracil therapy
    • Livingston HJ, Livingston SF. Agranulocytosis and hepatocellular jaundice: Toxic reactions following propylthiouracil therapy. J Am Med Assoc 1947;135:422-5.
    • (1947) J Am Med Assoc , vol.135 , pp. 422-425
    • Livingston, H.J.1    Livingston, S.F.2
  • 6
    • 77954893941 scopus 로고    scopus 로고
    • Dissimilar hepatoxicity profiles of propylthiouracil and methimazole on children
    • Rivkees SA, Szarfman A. Dissimilar hepatoxicity profiles of propylthiouracil and methimazole on children. J Clin Endocrinol Metab 2010;95:3260-7.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3260-3267
    • Rivkees, S.A.1    Szarfman, A.2
  • 7
    • 84861611875 scopus 로고    scopus 로고
    • Eunice Kennedy Shriver National Institute of Child Health and Human Development. Hepatic toxicity following treatment for pediatric Graves'disease. Minutes of October 28 2008 meeting. Available at
    • Eunice Kennedy Shriver National Institute of Child Health and Human Development. Hepatic toxicity following treatment for pediatric Graves'disease. Minutes of October 28 2008 meeting. Available at: Http://bpca.nichd.nih.gov/ outreach/index.cfm.
  • 8
    • 78149358765 scopus 로고    scopus 로고
    • 63 years and 715 days to the "boxed warning" : Unmasking of the propylthiouracil problem
    • Rivkees SA. 63 years and 715 days to the "boxed warning" : Unmasking of the propylthiouracil problem. Int J Pediatr Endocrinol 2010;2010:658267.
    • (2010) Int J Pediatr Endocrinol , vol.2010 , pp. 658267
    • Rivkees, S.A.1
  • 9
    • 64349088925 scopus 로고    scopus 로고
    • Ending propylthiouracil-induced liver failure in children
    • Rivkees SA, Mattison DR. Ending propylthiouracil-induced liver failure in children. N Engl J Med 2009;360:1574-5.
    • (2009) N Engl J Med , vol.360 , pp. 1574-1575
    • Rivkees, S.A.1    Mattison, D.R.2
  • 10
    • 67749113754 scopus 로고    scopus 로고
    • The role of propylthiouracil in the management of Graves'disease in adults: Report of a meeting jointly sponsored by the american thyroid association and the food and drug administration
    • Bahn RS, Burch HS, Cooper DS, Garber JR, Greenlee CM, et al. The role of propylthiouracil in the management of Graves'disease in adults: Report of a meeting jointly sponsored by the American Thyroid Association and the Food and Drug Administration. Thyroid 2009;19:673-4.
    • (2009) Thyroid , vol.19 , pp. 673-674
    • Bahn, R.S.1    Burch, H.S.2    Cooper, D.S.3    Garber, J.R.4    Greenlee, C.M.5
  • 12
    • 0021847355 scopus 로고
    • Hepatotoxicity from antithyroid drugs
    • Vitug AC, Goldman JM. Hepatotoxicity from antithyroid drugs. Horm Res 1985;21:229-34.
    • (1985) Horm Res , vol.21 , pp. 229-234
    • Vitug, A.C.1    Goldman, J.M.2
  • 15
    • 0027392519 scopus 로고
    • Propylthiouracil hepatotoxicity. A review and case presentation
    • Levy M. Propylthiouracil hepatotoxicity. A review and case presentation. Clin Pediatr (Phila) 1993;32:25-9.
    • (1993) Clin Pediatr (Phila) , vol.32 , pp. 25-29
    • Levy, M.1
  • 16
    • 0021333903 scopus 로고
    • Propylthiouracil and hepatitis. Two cases and a review of the literature
    • Hanson JS. Propylthiouracil and hepatitis. Two cases and a review of the literature. Arch Intern Med 1984;144:994-6.
    • (1984) Arch Intern Med , vol.144 , pp. 994-996
    • Hanson, J.S.1
  • 17
    • 0016466138 scopus 로고
    • Letter: Hepatitis and propylthiouracil
    • Parker LN. Letter: Hepatitis and propylthiouracil. Ann Intern Med 1975;82:228-9.
    • (1975) Ann Intern Med , vol.82 , pp. 228-229
    • Parker, L.N.1
  • 18
    • 0018571711 scopus 로고
    • Propylthiouracil and hepatitis: A case report
    • Reddy CM. Propylthiouracil and hepatitis: A case report. J Natl Med Assoc 1979;71:1185-6.
    • (1979) J Natl Med Assoc , vol.71 , pp. 1185-1186
    • Reddy, C.M.1
  • 19
    • 0023791212 scopus 로고
    • Propylthiouracil hepatotoxicity: Two pediatric cases and review of the literature
    • Jonas MM, Eidson MS. Propylthiouracil hepatotoxicity: Two pediatric cases and review of the literature. J Pediatr Gastroenterol Nutr 1988;7:776-9.
    • (1988) J Pediatr Gastroenterol Nutr , vol.7 , pp. 776-779
    • Jonas, M.M.1    Eidson, M.S.2
  • 20
    • 0024648460 scopus 로고
    • Unusual complications of antithyroid drug therapy: Four case reports and review of literature
    • Baker B, Shapiro B, Fig LM, Woodbury D, Sisson JC, et al. Unusual complications of antithyroid drug therapy: Four case reports and review of literature. Thyroidology 1989;1:17-26.
    • (1989) Thyroidology , vol.1 , pp. 17-26
    • Baker, B.1    Shapiro, B.2    Fig, L.M.3    Woodbury, D.4    Sisson, J.C.5
  • 22
    • 0025303950 scopus 로고
    • Propylthiouracil-induced hepatic failure and encephalopathy in a child
    • Kirkland JL. Propylthiouracil-induced hepatic failure and encephalopathy in a child. DICP 1990;24:470-1.
    • (1990) DICP , vol.24 , pp. 470-471
    • Kirkland, J.L.1
  • 23
    • 0029780496 scopus 로고    scopus 로고
    • Propylthiouracil-induced fulminant hepatitis: Case report and review of the literature
    • Deidiker R, deMello DE. Propylthiouracil-induced fulminant hepatitis: Case report and review of the literature. Pediatr Pathol Lab Med 1996;16:845-52.
    • (1996) Pediatr Pathol Lab Med , vol.16 , pp. 845-852
    • Deidiker, R.1    DeMello, D.E.2
  • 24
    • 0031159541 scopus 로고    scopus 로고
    • Fifty years of experience with propylthiouracil-associated hepatotoxicity: What have we learned?
    • Williams KV, Nayak S, Becker D, Reyes J, Burmeister LA. Fifty years of experience with propylthiouracil-associated hepatotoxicity: What have we learned? J Clin Endocrinol Metab 1997;82:1727-33.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1727-1733
    • Williams, K.V.1    Nayak, S.2    Becker, D.3    Reyes, J.4    Burmeister, L.A.5
  • 26
    • 0037283083 scopus 로고    scopus 로고
    • Liver transplantation for propylthiouracil-induced acute hepatic failure
    • Testa G, Trevino J, Bogetti D, Layden T, Wiley T, et al. Liver transplantation for propylthiouracil-induced acute hepatic failure. Dig Dis Sci 2003;48:190-1.
    • (2003) Dig Dis Sci , vol.48 , pp. 190-191
    • Testa, G.1    Trevino, J.2    Bogetti, D.3    Layden, T.4    Wiley, T.5
  • 27
    • 33646869291 scopus 로고    scopus 로고
    • Propylthiouracil-associated liver failure presenting as probable autoimmune hepatitis in a child with Graves'disease
    • Sipe WE, Su M, Posselt A, Kim GE, Quiros JA, et al. Propylthiouracil- associated liver failure presenting as probable autoimmune hepatitis in a child with Graves'disease. Pediatr Transplant 2006;10:525-8.
    • (2006) Pediatr Transplant , vol.10 , pp. 525-528
    • Sipe, W.E.1    Su, M.2    Posselt, A.3    Kim, G.E.4    Quiros, J.A.5
  • 30
    • 0014701749 scopus 로고
    • Granulocytopenia, lupus-like syndrome, and other complications of propylthiouracil therapy
    • Amrhein JA, Kenny FM, Ross D. Granulocytopenia, lupus-like syndrome, and other complications of propylthiouracil therapy. J Pediatr 1970;76:54-63.
    • (1970) J Pediatr , vol.76 , pp. 54-63
    • Amrhein, J.A.1    Kenny, F.M.2    Ross, D.3
  • 31
    • 0017385926 scopus 로고
    • Antithyroid drug therapy for toxic diffuse goiter (Graves disease): Thirty years experience in children and adolescents
    • Barnes HV, Blizzard RM. Antithyroid drug therapy for toxic diffuse goiter (Graves disease): Thirty years experience in children and adolescents. J Pediatr 1977;91:313-20.
    • (1977) J Pediatr , vol.91 , pp. 313-320
    • Barnes, H.V.1    Blizzard, R.M.2
  • 32
    • 0021857474 scopus 로고
    • Management of hyperthyroidism in children and adolescents
    • Hamburger JI. Management of hyperthyroidism in children and adolescents. J Clin Endocrinol Metab 1985;60:1019-24.
    • (1985) J Clin Endocrinol Metab , vol.60 , pp. 1019-1024
    • Hamburger, J.I.1
  • 33
    • 0023227143 scopus 로고
    • Hyperthyroidism in children treated with long term medical therapy: Twenty-five percent remission every two years
    • Lippe BM, Landaw EM, Kaplan SA. Hyperthyroidism in children treated with long term medical therapy: Twenty-five percent remission every two years. J Clin Endocrinol Metab 1987;64:1241-5.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 1241-1245
    • Lippe, B.M.1    Landaw, E.M.2    Kaplan, S.A.3
  • 34
    • 0032752647 scopus 로고    scopus 로고
    • Outcome of pediatric Graves'disease after treatment with antithyroid medication and radioiodine
    • Ward L, Huot C, Lambert R, Deal C, Collu R, et al. Outcome of pediatric Graves'disease after treatment with antithyroid medication and radioiodine. Clin Invest Med 1999;22:132-9.
    • (1999) Clin Invest Med , vol.22 , pp. 132-139
    • Ward, L.1    Huot, C.2    Lambert, R.3    Deal, C.4    Collu, R.5
  • 36
    • 40949125710 scopus 로고    scopus 로고
    • Predicting the likelihood of remission in children with Graves'disease: A prospective, multicenter study
    • Organization of Pediatric Endocrinologists of Northern California Collaborative Graves'Disease Study Group
    • Glaser NS, Styne DM, Organization of Pediatric Endocrinologists of Northern California Collaborative Graves'Disease Study Group. Predicting the likelihood of remission in children with Graves'disease: A prospective, multicenter study. Pediatrics 2008;121:e481-8.
    • (2008) Pediatrics , vol.121
    • Glaser, N.S.1    Styne, D.M.2
  • 38
    • 79959386478 scopus 로고    scopus 로고
    • Comparison of methimazole and propylthiouracil in the management of children and adolescents with Graves'disease: Efficacy and adverse reactions during initial treatment and long-term outcome
    • Sato H, Minagawa M, Sasaki N, Sugihara S, Kazukawa I, et al. Comparison of methimazole and propylthiouracil in the management of children and adolescents with Graves'disease: Efficacy and adverse reactions during initial treatment and long-term outcome. J Pediatr Endocrinol Metab 2011;24:257-63.
    • (2011) J Pediatr Endocrinol Metab , vol.24 , pp. 257-263
    • Sato, H.1    Minagawa, M.2    Sasaki, N.3    Sugihara, S.4    Kazukawa, I.5
  • 39
    • 77955329997 scopus 로고    scopus 로고
    • Liver failure due to antithyroid drugs: Report of a case and literature review
    • Livadas S, Xyrafis X, Economou F, Boutzios G, Christou M, et al. Liver failure due to antithyroid drugs: Report of a case and literature review. Endocrine 2010;38:24-8.
    • (2010) Endocrine , vol.38 , pp. 24-28
    • Livadas, S.1    Xyrafis, X.2    Economou, F.3    Boutzios, G.4    Christou, M.5
  • 41
    • 14544296973 scopus 로고    scopus 로고
    • Antithyroid drugs
    • Cooper DS. Antithyroid drugs. N Engl J Med 2005;352:905-17.
    • (2005) N Engl J Med , vol.352 , pp. 905-917
    • Cooper, D.S.1
  • 43
    • 0028279469 scopus 로고
    • Sequential liver and bone biochemical changes in hyperthyroidism: Prospective controlled follow-up study
    • Huang MJ, Li KL, Wei JS, Wu SS, Fan KD, et al. Sequential liver and bone biochemical changes in hyperthyroidism: Prospective controlled follow-up study. Am J Gastroenterol 1994;89:1071-6.
    • (1994) Am J Gastroenterol , vol.89 , pp. 1071-1076
    • Huang, M.J.1    Li, K.L.2    Wei, J.S.3    Wu, S.S.4    Fan, K.D.5
  • 46
    • 0015432563 scopus 로고
    • Prolonged intraoperative bleeding caused by propylthiouracil-induced hypoprothrombinemia
    • Gotta AW, Sullivan CA, Seaman J, Jean-Gilles B. Prolonged intraoperative bleeding caused by propylthiouracil-induced hypoprothrombinemia. Anesthesiology 1972;37:562-3.
    • (1972) Anesthesiology , vol.37 , pp. 562-563
    • Gotta, A.W.1    Sullivan, C.A.2    Seaman, J.3    Jean-Gilles, B.4
  • 47
    • 0017288352 scopus 로고
    • Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil
    • Mihas AA, Holley P, Koff RS, Hirschowitz BI. Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil. Gastroenterology 1976;70(Pt 1):770-4.
    • (1976) Gastroenterology , vol.70 , Issue.PART 1 , pp. 770-774
    • Mihas, A.A.1    Holley, P.2    Koff, R.S.3    Hirschowitz, B.I.4
  • 48
    • 0000868965 scopus 로고
    • Fulminant hepatitis during treatment with propylthiouracil
    • Eisen MJ. Fulminant hepatitis during treatment with propylthiouracil. N Engl J Med 1953;249:814-6.
    • (1953) N Engl J Med , vol.249 , pp. 814-816
    • Eisen, M.J.1
  • 49
    • 0020117454 scopus 로고
    • Fatal propylthiouracil-induced hepatitis
    • Safani MM, Tatro DS, Rudd P. Fatal propylthiouracil-induced hepatitis. Arch Intern Med 1982;142:838-9.
    • (1982) Arch Intern Med , vol.142 , pp. 838-839
    • Safani, M.M.1    Tatro, D.S.2    Rudd, P.3
  • 50
    • 0023122943 scopus 로고
    • Propylthiouracil-induced fatal hepatic necrosis
    • Limaye A, Ruffolo PR. Propylthiouracil-induced fatal hepatic necrosis. Am J Gastroenterol 1987;82:152-4.
    • (1987) Am J Gastroenterol , vol.82 , pp. 152-154
    • Limaye, A.1    Ruffolo, P.R.2
  • 51
    • 0018900202 scopus 로고
    • Propylthiouracil-induced hepatic damage
    • Weiss M, Hassin D, Bank H. Propylthiouracil-induced hepatic damage. Arch Intern Med 1980;140:1184-5.
    • (1980) Arch Intern Med , vol.140 , pp. 1184-1185
    • Weiss, M.1    Hassin, D.2    Bank, H.3
  • 52
    • 0016678183 scopus 로고
    • Liver disease caused by propylthiouracil
    • Fedotin MS, Lefer LG. Liver disease caused by propylthiouracil. Arch Intern Med 1975;135:319-21.
    • (1975) Arch Intern Med , vol.135 , pp. 319-321
    • Fedotin, M.S.1    Lefer, L.G.2
  • 53
    • 0013147466 scopus 로고
    • Propylthiouracil-induced agranulocytosis, toxic hepatitis, and death
    • Colwell AR Jr, Sando DE, Lang SJ. Propylthiouracil-induced agranulocytosis, toxic hepatitis, and death. J Am Med Assoc 1952;148:639-41.
    • (1952) J Am Med Assoc , vol.148 , pp. 639-641
    • Colwell Jr., A.R.1    Sando, D.E.2    Lang, S.J.3
  • 54
    • 0020282915 scopus 로고
    • Multiple complications of propylthiouracil treatment: Granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization
    • Pacini F, Sridama V, Refetoff S. Multiple complications of propylthiouracil treatment: Granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitization. J Endocrinol Invest 1982;5:403-7.
    • (1982) J Endocrinol Invest , vol.5 , pp. 403-407
    • Pacini, F.1    Sridama, V.2    Refetoff, S.3
  • 56
    • 3242773744 scopus 로고    scopus 로고
    • Graves'disease accompanied by anti-myeloperoxidase antibody-related nephropathy and autoimmune hepatitis
    • Nagai T, Imamura M, Kamiya Y, Mori M. Graves'disease accompanied by anti-myeloperoxidase antibody-related nephropathy and autoimmune hepatitis. Intern Med 2004;43:516-20.
    • (2004) Intern Med , vol.43 , pp. 516-520
    • Nagai, T.1    Imamura, M.2    Kamiya, Y.3    Mori, M.4
  • 57
    • 0030917822 scopus 로고    scopus 로고
    • Liver tests in hyperthyroidism: Effect of antithyroid therapy
    • Gürlek A, Cobankara V, Bayraktar M. Liver tests in hyperthyroidism: Effect of antithyroid therapy. J Clin Gastroenterol 1997; 24:180-3.
    • (1997) J Clin Gastroenterol , vol.24 , pp. 180-183
    • Gürlek, A.1    Cobankara, V.2    Bayraktar, M.3
  • 59
    • 0027179361 scopus 로고
    • Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy
    • Dolman KM, Gans RO, Vervaat TJ, Zevenbergen G, Maingay D, et al. Vasculitis and antineutrophil cytoplasmic autoantibodies associated with propylthiouracil therapy. Lancet 1993;342:651-2.
    • (1993) Lancet , vol.342 , pp. 651-652
    • Dolman, K.M.1    Gans, R.O.2    Vervaat, T.J.3    Zevenbergen, G.4    Maingay, D.5
  • 60
    • 0028357601 scopus 로고
    • Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis as a complication of treatment with propylthiouracil in children
    • Vogt BA, Kim Y, Jennette JC, Falk RJ, Burke BA, et al. Antineutrophil cytoplasmic autoantibody-positive crescentic glomerulonephritis as a complication of treatment with propylthiouracil in children. J Pediatr 1994;124:986-8.
    • (1994) J Pediatr , vol.124 , pp. 986-988
    • Vogt, B.A.1    Kim, Y.2    Jennette, J.C.3    Falk, R.J.4    Burke, B.A.5
  • 61
    • 0023099607 scopus 로고
    • Adverse immunologic effects of antithyroid drugs
    • Wing SS, Fantus IG. Adverse immunologic effects of antithyroid drugs. CMAJ 1987;136:121-7.
    • (1987) CMAJ , vol.136 , pp. 121-127
    • Wing, S.S.1    Fantus, I.G.2
  • 62
    • 0020566588 scopus 로고
    • Serum propylthiouracil concentration in patients with Graves'disease with various clinical course
    • Sato K, Mimura H, Kato S, Isozaki O, Tsushima T, et al. Serum propylthiouracil concentration in patients with Graves'disease with various clinical course. Acta Endocrinol (Copenh) 1983;104:189-94.
    • (1983) Acta Endocrinol (Copenh) , vol.104 , pp. 189-194
    • Sato, K.1    Mimura, H.2    Kato, S.3    Isozaki, O.4    Tsushima, T.5
  • 63
    • 78650274525 scopus 로고    scopus 로고
    • Pharmacological treatment of hyperthyroidism during lactation: Review of the literature and novel data
    • Karras S, Tzotzas T, Kaltsas T, Krassas GE. Pharmacological treatment of hyperthyroidism during lactation: Review of the literature and novel data. Pediatr Endocrinol Rev 2010;8:25-33.
    • (2010) Pediatr Endocrinol Rev , vol.8 , pp. 25-33
    • Karras, S.1    Tzotzas, T.2    Kaltsas, T.3    Krassas, G.E.4


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