Fifty Years of Experience with Propylthiouracil-Associated Hepatotoxicity: What Have We Learned?

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 6, 1997, Pages 1727-1733

  Williams, Katherine V ^a   Nayak, Sunil ^a   Becker, Dorothy ^a   Reyes, Jorge ^a   Burmeister, Lynn A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROPYLTHIOURACIL;

ADOLESCENT; CASE REPORT; CHEMICALLY INDUCED DISORDER; ENDOCRINOLOGY; FEMALE; HUMAN; LIVER DISEASE; MALE; METHODOLOGY; MIDDLE AGED; REVIEW; THYROTOXICOSIS;

ADOLESCENT; ENDOCRINOLOGY; FEMALE; HUMANS; LIVER DISEASES; MALE; MIDDLE AGED; PROPYLTHIOURACIL; THYROTOXICOSIS;

EID: 0031159541     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.6.1727     Document Type: Article

References (70)

1. Livingston HJ, Livingston SF. 1947 Agranulocytosis and hepatocellular jaundice. JAMA. 135:422-425.
2. Westphal SA. 1994 Hepatotoxicity from propylthiouracil. South Med J. 87:943-947.
3. Levy M. 1993 Propylthiouracil hepatotoxicity: a review and case presentation. Clin Pediatr. 32:85-89.
4. Peter SA. 1991 Propylthiouracil-associated hepatitis. Journal of the National Medical Association. 83:75-77.
5. Kirkland JL. 1990 Propylthiouracil-induced hepatic failure and encephalopathy in a child. DICP Ann Pharmacother. 24:470-471.
6. Hayashida CY, Durate AJS, Sato AE, Yamashiro-Kanashiro EH. 1990 Neonatal hepatitis and lymphocyte sensitization by placental transfer of propylthiouracil. J Endocrinol Invest. 13:937-941.
7. Baker B, Shapiro B, Fig LM, Woodbury D, Sisson JC, Beierwaltes WH. 1989 Unusual complications of antithyroid drug therapy: four case reports and review of literature. Thyroidology. 1:17-26.
8. Morris CV, Goldstein RM, Cofer JB, Solomon H, Klintmalm GB. 1989 An unusual presentation of fulminant hepatic failure secondary to propylthiouracil therapy. Clin Transplants. 311.
9. Jonas MM, Eidson MS. 1988 Propylthiouracil hepatotoxicity: two pediatric cases and review of the literature. J Pediatr Gastroenterol Nutr. 7:776-779.
10. Seidman DS, Livni E, Ilie B, Blum I. 1986 Propylthiouracil-induced cholestatic jaundice. Clin Toxicol. 24:353-360.
11. Bloch CA, Jenski LJ, Balistreri WF, Dolan LM. 1985 Propylthiouracil-associated hepatitis. Arch Intern Med. 145:2129-2130.
12. Garty B, Kauli R, Ben-Ari J, Lubin E, Nitzan M, Laron Z. 1985 Hepatitis associated with propylthiouracil treatment. Drug Intell Clin Pharmacy. 19:740-742.
13. Hanson JS. 1984 Propylthiouracil and hepatitis: two cases and a review of the literature. Arch Intern Med. 144:994-996.
14. Pacini F, Sridama V, Refetoff S. 1982 Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction, and hepatitis with lymphocyte sensitization. J Endocrinol Invest. 5:403-407.
15. Parker WA. 1982 Propylthiouracil-induced hepatotoxicity. Clin Pharmacol. 1:1471-1474.
16. Weiss M, Hassin D, Bank H. 1980 Propylthiouracil-induced hepatic damage. Arch Intern Med. 140:1184-1185.
17. Reddy CM. 1979 Propythiouracil and hepatitis: a case report. Journal of The National Medical Association. 71:1185-1186.
18. Mihas AA, Holley P, Koff RS, Hirschowitz BI. 1976 Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil. Gastroenterology. 70:770-774.
19. Parker LN. 1975 Hepatitis and propylthiouracil. Ann Intern Med. 82:228-229.
20. Fedotin MS, Lefer LG. 1975 Liver disease caused by propylthiouracil. Arch Intern Med. 135:319-321.
21. Limaye A, Rulfolo PR. 1987 Propylthiouracil-induced fatal hepatic necrosis. Am J Gastroenterol. 82:152-154.
22. Safani MM, Tatro DS, Rudd P. 1982 Fatal propylthiouracil-induced hepatitis. Arch Intern Med. 142:838-839.
23. Eisen MJ. 1953 Fulminant hepatitis during treatment with propylthiouracil. N Engl J Med. 249:814-816.
24. Colwell AR, Sando DE. 1952 Propylthiouracil-induced agranulocytosis, tosic hepatitis, and death. JAMA. 148:639-641.
25. Romaldini JH, Werner MC, Bromberg N, Werner RS. 1991 Adverse effects related to antithyroid drugs and their dose regimen. Exp Clin Endocinol. 97:261-264.
26. Buckingham BA, Costin G, Roe TF, Weitzman JJ, Kogut MD. 1981 Hyperthyrodism in children: a reevaluation of treatment. Am J Dis Child. 135:112-117.
27. Maddrey CW, Boitnott JK. 1977 Drug-induced chronic liver disease. Gastroenterology. 72:1348-1353.
28. Amrhein JA, Kenny FM, Ross D. 1970 Granulocytopenia, lupus-like syndrome and other complications of propylthiouracil therapy. J Pediatr. 76:54-63.
29. Moore FD. 1946 Toxic manifestations of thiouracil therapy. JAMA. 130:315-319.
30. Cooper DS. 1996 Treatment of thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid, 7th ed. Philadelphia: Lippincott-Raven; 713-734.
31. Liaw YF, Huang MJ, Fan KD, Li KL, Wu SS, Chen TJ. 1993 Hepatic injury during propylthiouracil therapy in patients with hyperthyroidism: a cohort study. Ann Intern Med. 118:424-428.
32. Cooper DS. 1984 Antithyroid drugs. N Engl J Med. 311:1353-1362.
33. Vanderpump MPJ, Tunbridge WMG. 1996 The epidemiology of thyroid disease. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid, 7th ed. Phildelphia: Lippincott-Raven; 474-482.
34. O'Grady JG, Alexander GJM, Hayllar KM. 1989 Early indicators of prognosis in fulminant hepatic failure. Gastroenterology. 97:439.
35. Hughes RD, Wendon J, Gimson AES. 1991 Acute liver failure. Gut. 35:S86-S91.
36. Gordon RD, Van Thiel DH, Starzl TE. 1995 Orthotopic liver transplantation. In: Haubrich WS, Schaffner F, Berk JE, eds. Bockus gastroenterology, 5th ed. Philadelphia: Saunders; 2509-2544.
37. O'Grady JG, Gimson AES, O'Brien CJ, Pucknell A, Hughes RD, Williams R. 1988 Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. Gastroenterology. 94:1186-1192.
38. Ross DS, Daniels GH, Dienstag JL, Ridgway EC. 1983 Elevated thyroxine levels due to increased thyroxine-binding globulin in acute hepatitis. Am J Med. 74:564-569.
39. Burmeister LA. 1995 Reverse T3 does not reliably differentiate hypothyroid sick syndrome from euthyroid sick syndrome. Thyroid. 5:435-441.
40. Wartofsky L, Burman KD. 1982 Alterations in thyroid function in patients with systemic illness: The "euthyroid sick syndrome." Endocr Rev. 3:164-217.
41. Chopra IJ, Teco GNC, Nguyen AH, Solomon DH. 1979 In search of an inhibitor of thyroid hormone binding to serum proteins in nonthyroidal illnesses. J Clin Endocrinol Metab. 49:63-69.
42. Lim C, Docter R, Visser TJ, et al. 1993 Inhibition of thyroxine transport into cultured rat hepatocytes by serum of nonuremic critically ill patients: effects of bilirubin and nonesterified fatty acids. J Clin Endocrinol Metab. 76:1165-1171.
43. Lum SMC, Kaptein EM, Nicoloff JT. 1983 Influence of nonthyroidal illnesses on serum thyroid hormone indices in hyperthyroidism. West J Med. 138:670-675.
44. Archambeaud-Mouveroux F, Dejax C, DeBuhan B, Bonnaud F. 1989 Hyperthyroidism without elevated levels of thyroxine and triiodothyronine in a patient with pulmonary tuberculosis. South Med J. 82:907-910.
45. Wartofsky L. 1996 Thyrotoxic storm. In: Braverman LE, Utiger RD, eds. Werner and Ingbar's the thyroid. Philadelphia: Lippincott-Raven; 701-707.
46. Philippou G, Koutras DA, Piperingos G, Souvatzoglou A, Moulopoulos SD. 1992 The effect of iodide on serum thyroid hormone levels in normal persons, in hyperthyroid patients, and in hypothyroid patients on thyroxine replacement. Clin Endocrinol (Oxf). 36:573-578.
47. Emerson CH, Anderson AJ, Howard WJ, Utiger RD. 1975 Serum thyroxine and triiodothyronine concentrations during iodide treatment of hyperthyroidism. J Clin Endocrinol Metab. 40:33-36.
48. Orrego H, Blake JE, Blendis LM, Compton KV, Israel Y. 1987 Long-term treatment of alcoholic liver disease with propylthiouracil. N Engl J Med. 317:1421-1427.
49. Huang MJ, Li KL, Wei JS, Wu SS, Fan KD, Liaw YF. 1994 Sequential liver and bone biochemical changes in hyperthyroidism: prospective controlled follow-up study. Am J Gastroenterol. 89:1071-1076.
50. Cooper DS, Kaplan MM, Ridgway EC. 1979 Alkaline phosphatase isoenzyme patterns in hyperthyroidism. Ann Intern Med. 90:164-168.
51. Tibi L, Patrick AW, Leslie P, Toft AD, Smith AF. 1989 Alkaline phosphatase isoenzymes in plasma in hyperthyroidism. Clin Chem. 357:1427-1430.
52. Myers J, Brannon E, Holland B. 1950 A correlative study of the cardiac output and the hepatic circulation in hyperthyroidism. J Clin Invest. 29:1069-1077.
53. Barker S, Klitgaard H. 1952 Metabolism of tissues excised from thyroxine-injected rats. Am J Physiol. 170:81-86.
54. Arab DM, Malatjalian DA, Rittmaster RS. 1995 Severe cholestatic jaundice in uncomplicated hyperthyroidism treated with methimazole. J Clin Endocrinol Metab. 80:1083-1085.
55. Ozenne G, Manchon ND, Doucet J, Hemet J, Schrub JC, Bercoff E. 1989 Carbimazole-induced acute cholestatic hepatitis. J Clin Gastroenterol. 11:95-97.
56. Ayensa C, Diaz De Otazu R, Cia JM. 1986 Carbimazole-induced cholestatic hepatitis. Arch Intern Med. 146:1455.
57. Schmidt G, Borsch G, Muller KM, Wegener M. 1986 Methimazole-associated cholestatic liver injury: case report and brief literature review. Hepatogastroenterology. 33:244-246.
58. Blom H, Stolk J, Schreuder HB. 1985 A case of Carbimazole-induced intraheptic cholestasis: an immune-mediated reaction? Arch Intern Med. 145:1513-1515.
59. Dinsmore WW, O'Hara MD, Callender ME. 1983 Postanesthetic carbimazole jaundice. N Engl J Med. 309:438.
60. Lunzer M, Huang S, Ginsburg J, Ahmed M, Sherlock S. 1975 Jaundice due to carbimazole. Gut. 16:913-917.
61. Fischer MG, Nayer HR, Miller A. 1973 Methimazole-induced jaundice. JAMA. 223:1028-1029.
62. Martinez-Lopez JI, Greenberg SE, Kling RR. 1962 Drug-induced hepatic injury duing methimazole therapy. Gastroenterology. 43:84-87.
63. Shipp JC. 1953 Jaundice during methimazole administration. Ann Intern Med. 42:701-706.
64. Rosenbaum H, Reveno WS. 1953 Agranulocytosis and toxic hepatitis from methimazole. JAMA. 152:27.
65. Tennenbaum JI, Dreskin OH. 1962 Toxic hepatitis during treatment with methimazole: report of a case with apparent recovery. Ohio State Med J. 58:306-307.
66. Sadoul JL, Canivet B, Freychet P. 1993 Toxic hepatitis induced by antithyroid drugs: tour cases including one with cross-reactivity between carbimazole and benzylthiouracil. Eur J Med. 2:473-477.
67. Jenkins RM, Evans DMD. 1981 Carbimazole hypersensitivity and liver damage. Br J Clin Pract. 415-417.
68. Jansen PLM, Froeling PGAM, Schade RWB, Kloppenborg PWC, Yap SH, Van Haelst UJG. 1982 Intrahepatic cholestasis in hyperthyroidism and the effect of antithyroid and beta-blocking drugs. Neth J Med. 25:318-324.
69. Kang H, Choi JD, Jung IG, et al. 1990 A case of methimazole-induced acute hepatic failure in a patient with chronic hepatitis B carrier. Korean J Intern Med. 5:69-73.
70. Becker CE, Gorden P, Robbins J. 1968 Hepatitis from methimazole during adrenal steroid therapy for malignant exopthalmos. JAMA. 206:1787-1789.