Relationship between DDAH gene variants and serum ADMA level in individuals with type 1 diabetes

Journal of Diabetes and its Complications

Volumn 26, Issue 3, 2012, Pages 195-198

  Fogarty, Rhys D ^a   Abhary, Sotoodeh ^a   Javadiyan, Shahrbanou ^a   Kasmeridis, Nicholas ^a   Petrovsky, Nikolai ^a   Whiting, Malcolm J ^b   Craig, Jamie E ^a   Burdon, Kathryn P ^a  

^a FLINDERS UNIVERSITY   (Australia)

^b Chemical Pathology Laboratory   (Australia)

Author keywords

ADMA; DDAH1; DDAH2; Diabetes

Indexed keywords

DIMETHYLARGININASE; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1; DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 2; N(G),N(G) DIMETHYLARGININE; UNCLASSIFIED DRUG;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; COHORT ANALYSIS; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AMIDOHYDROLASES; ARGININE; COHORT STUDIES; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 1; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84861621943     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2012.03.022     Document Type: Article

References (35)

1. F. Abbasi, T. Asagmi, J.P. Cooke, C. Lamendola, T. McLaughlin, and G.M. Reaven Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus American Journal of Cardiology 88 10 2001 1201 1203
2. S. Abhary, K.P. Burdon, A. Kuot, S. Javadiyan, M.J. Whiting, and N. Kasmeridis Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes PLoS One 5 3 2010 e9462
3. S. Abhary, N. Kasmeridis, K.P. Burdon, A. Kuot, M.J. Whiting, and W.P. Yew Diabetic retinopathy is associated with elevated serum asymmetric and symmetric dimethylarginines Diabetes Care 32 11 2009 2084 2086
4. V. Achan, M. Broadhead, M. Malaki, G. Whitley, J. Leiper, and R. MacAllister Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase Arteriosclerosis, Thrombosis, and Vascular Biology 23 8 2003 1455 1459
5. A.E. Altinova, M. Arslan, A. Sepici-Dincel, M. Akturk, N. Altan, and F.B. Toruner Uncomplicated type 1 diabetes is associated with increased asymmetric dimethylarginine concentrations Journal of Clinical Endocrinology and Metabolism 92 5 2007 1881 1885
6. M. Anderssohn, E. Schwedhelm, N. Luneburg, R.S. Vasan, and R.H. Boger Asymmetric dimethylarginine as a mediator of vascular dysfunction and a marker of cardiovascular disease and mortality: an intriguing interaction with diabetes mellitus Diabetes & Vascular Disease Research 7 2 2010 105 118
7. J.C. Barrett, B. Fry, J. Maller, and M.J. Daly Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 2 2005 263 265
8. J. Calles-Escandon, and M. Cipolla Diabetes and endothelial dysfunction: a clinical perspective Endocrine Reviews 22 1 2001 36 52
9. S. Dimmeler, V. Rippmann, U. Weiland, J. Haendeler, and A.M. Zeiher Angiotensin II induces apoptosis of human endothelial cells. Protective effect of nitric oxide Circulation Research 81 6 1997 970 976
10. H. Ding, B. Wu, H. Wang, Z. Lu, J. Yan, and X. Wang A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease Circulation Research 106 6 2010 1145 1152
11. Early Treatment Diabetic Retinopathy Study Research Group Grading diabetic retinopathy from stereoscopic color fundus photographs - an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group Ophthalmology 98 5 Suppl 1991 786 806
12. B. Ellger, M.C. Richir, P.A. van Leeuwen, Y. Debaveye, L. Langouche, and I. Vanhorebeek Glycemic control modulates arginine and asymmetrical- dimethylarginine levels during critical illness by preserving dimethylarginine-dimethylaminohydrolase activity Endocrinology 149 6 2008 3148 3157
13. W.L. Greven, J.W. Beulens, D.H. Biesma, S. Faiz, and H.W. de Valk Glycemic variability in inadequately controlled type 1 diabetes and type 2 diabetes on intensive insulin therapy: a cross-sectional, observational study Diabetes Technology & Therapeutics 12 9 2010 695 699
14. K. Hanai, T. Babazono, I. Nyumura, K. Toya, N. Tanaka, and M. Tanaka Asymmetric dimethylarginine is closely associated with the development and progression of nephropathy in patients with type 2 diabetes Nephrology, Dialysis, Transplantation 24 6 2009 1884 1888
15. International HapMap Project The International HapMap Project Nature 426 6968 2003 789 796
16. A. Ito, P.S. Tsao, S. Adimoolam, M. Kimoto, T. Ogawa, and J.P. Cooke Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase Circulation 99 24 1999 3092 3095
17. K. Krzyzanowska, F. Mittermayer, W. Krugluger, C. Schnack, M. Hofer, and M. Wolzt Asymmetric dimethylarginine is associated with macrovascular disease and total homocysteine in patients with type 2 diabetes Atherosclerosis 189 1 2006 236 240
18. J. Leiper, M. Nandi, B. Torondel, J. Murray-Rust, M. Malaki, and B. O'Hara Disruption of methylarginine metabolism impairs vascular homeostasis Nature Medicine 13 2 2007 198 203
19. J. Leiper, and P. Vallance Biological significance of endogenous methylarginines that inhibit nitric oxide synthases Cardiovascular Research 43 3 1999 542 548
20. J. Li, and L. Ji Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix Heredity 95 3 2005 221 227
21. T.M. Lu, S.J. Lin, M.W. Lin, C.P. Hsu, and M.Y. Chung The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study Cardiovascular Diabetology 10 2011 16
22. M.T. Malecki, A. Undas, K. Cyganek, B. Mirkiewicz-Sieradzka, P. Wolkow, and G. Osmenda Plasma asymmetric dimethylarginine (ADMA) is associated with retinopathy in type 2 diabetes Diabetes Care 30 11 2007 2899 2901
23. T. Nakamura, E. Sato, N. Fujiwara, Y. Kawagoe, T. Suzuki, and Y. Ueda Circulating levels of advanced glycation end products (AGE) and interleukin-6 (IL-6) are independent determinants of serum asymmetric dimethylarginine (ADMA) levels in patients with septic shock Pharmacological Research 60 6 2009 515 518
24. G. Ndrepepa, A. Kastrati, S. Braun, W. Koch, K. Kolling, and J. Mehilli Circulating homocysteine levels in patients with type 2 diabetes mellitus Nutrition, Metabolism, and Cardiovascular Diseases 18 1 2008 66 73
25. D.R. Nyholt A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other American Journal of Human Genetics 74 4 2004 765 769
26. M.J. O'Dwyer, F. Dempsey, V. Crowley, D.P. Kelleher, R. McManus, and T. Ryan Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study Critical Care 10 5 2006 R139
27. S.R. Orth, T. Schroeder, E. Ritz, and P. Ferrari Effects of smoking on renal function in patients with type 1 and type 2 diabetes mellitus Nephrology, Dialysis, Transplantation 20 11 2005 2414 2419
28. F. Palm, M.L. Onozato, Z. Luo, and C.S. Wilcox Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems American Journal of Physiology - Heart and Circulatory Physiology 293 6 2007 H3227 H3245
29. S. Purcell, S.S. Cherny, and P.C. Sham Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits Bioinformatics 19 1 2003 149 150
30. S. Purcell, B. Neale, K. Todd-Brown, L. Thomas, M.A. Ferreira, and D. Bender PLINK: a tool set for whole-genome association and population-based linkage analyses American Journal of Human Genetics 81 3 2007 559 575
31. A.R. Rubio, and M.A. Morales-Segura Nitric oxide, an iceberg in cardiovascular physiology: far beyond vessel tone control Archives of Medical Research 35 1 2004 1 11
32. E. Schwedhelm, J. Tan-Andresen, R. Maas, U. Riederer, F. Schulze, and R.H. Boger Liquid chromatography-tandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma Clinical Chemistry 51 7 2005 1268 1271
33. C. Tymvios, C. Moore, S. Jones, A. Solomon, D. Sanz-Rosa, and M. Emerson Platelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not by endothelial nitric oxide synthase British Journal of Pharmacology 158 7 2009 1735 1742
34. V.P. Valkonen, T.P. Tuomainen, and R. Laaksonen DDAH gene and cardiovascular risk Vascular Medicine 10 Suppl. 1 2005 S45 S48
35. J.G. Zhang, J.X. Liu, Z.H. Li, L.Z. Wang, Y.D. Jiang, and S.R. Wang Dysfunction of endothelial NO system originated from homocysteine-induced aberrant methylation pattern in promoter region of DDAH2 gene Chinese Medical Journal 120 23 2007 2132 2137