The dentin organic matrix - Limitations of restorative dentistry hidden on the nanometer scale

Acta Biomaterialia

Volumn 8, Issue 7, 2012, Pages 2419-2433

  Bertassoni, Luiz E ^a   Orgel, Joseph P R ^b   Antipova, Olga ^b   Swain, Michael V ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b Illinois Institute of Technology   (United States)

Author keywords

Adhesion; Bonding; Collagen; Dentin; Polymers

Indexed keywords

COLLAGEN; DENTAL MATERIALS; DENTISTRY; FILLING; MOLECULES; RESTORATION; SUPRAMOLECULAR CHEMISTRY;

'CURRENT; BONDING; DENTAL CARIES; DENTAL RESTORATIONS; DENTINE; NANO-METER-SCALE; ORGANIC MATRIX; RESTORATIVE DENTISTRY; ULTRA-FINES; ULTRAFINE;

RESINS;

ADHESIVE AGENT; BIOMEDICAL AND DENTAL MATERIALS; COLLAGEN FIBRIL; COLLAGEN TYPE 1; MATRIX METALLOPROTEINASE; METHACRYLIC ACID DERIVATIVE; MONOMER; NANOMATERIAL; POLYMER; PROTEINASE; PROTEOGLYCAN; RESIN; TRIETHYLENE GLYCOL DIMETHACRYLATE; WATER;

ADHESION; DENTAL BONDING; DENTAL CARIES; DENTAL ETCHING; DENTIN; ENZYME ACTIVITY; FIBER; HUMAN; HYDROLYSIS; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPARATIVE DENTISTRY; REVIEW;

EID: 84861610026     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.02.022     Document Type: Review

References (148)

1. Beltran-Aguilar ED, Barker LK, Canto MT, Dye BA, Gooch BF, Griffin SO, et al. Surveillance for dental caries, dental sealants, tooth retention, edentulism, and enamel fluorosis -United States, 1988-1994 and 1999-2002. Surveillance Summaries 54: MMWR. Atlanta, GA: Centers for Disease Control and, Prevention; 2005. p. 1-13.
2. NHEA. National health expenditure projections 2009-2019. Washington, DC: US Department of Health and Human Services; 2006.
3. M. Hannig, and C. Hannig Nanomaterials in preventive dentistry Nat Nanotechnol 5 2010 565 569
4. J.L. Ferracane Resin composite- state of the art Dent Mater 27 2011 29 38
5. D.H. Pashley, F.R. Tay, L. Breschi, L. Tjaderhane, R.M. Carvalho, and M. Carrilho State of the art etch-and-rinse adhesives Dent Mater 27 2011 1 16
6. F.R. Tay, and D.H. Pashley Dental adhesives of the future J Adhes Dent 4 2002 91 103
7. R.M. Vaderhobli Advances in dental materials Dent Clin Nor Am 55 2011 619 625
8. J. Manhart, H. Chen, G. Hamm, and R. Hickel Buonocore Memorial Lecture. Review of the clinical survival of direct and indirect restorations in posterior teeth of the permanent dentition Oper Dent 29 2004 481 508
9. V. Uskoković, and L.E. Bertassoni Nanotechnology in dental sciences: moving towards a finer way of doing dentistry Materials 3 2010 1674 1691
10. L. Breschi, A. Mazzoni, A. Ruggeri, M. Cadenaro, R. Di Lenarda, and E. De Stefano Dorigo Dental adhesion review: aging and stability of the bonded interface Dent Mater 24 2008 90 101
11. Y. Liu, L. Tjaderhane, L. Breschi, A. Mazzoni, N. Li, and J. Mao Limitations in bonding to dentin and experimental strategies to prevent bond degradation J Dent Res 90 2011 953 968
12. G.W. Marshall, S.J. Marshall, J.H. Kinney, and M. Balooch The dentin substrate: structure and properties related to bonding J Dent 25 1997 441 458
13. L.E. Bertassoni, K. Stankoska, and M.V. Swain Insights into the structure and composition of the peritubular dentin organic matrix and the lamina limitans Micron 43 2012 229 236
14. E.P. Katz, and S.T. Li Structure and function of bone collagen fibrils J Mol Biol 80 1973 1 15
15. Katz EP, Wachtel E, Yamauchi M, Mechanic GL. The structure of mineralized collagen fibrils. Connect Tissue Res 1989;21:149-54 [discussion 55-8].
16. W.J. Landis Mineral characterization in calcifying tissues: atomic, molecular and macromolecular perspectives Connect Tissue Res 34 1996 239 246
17. M. Balooch, S. Habelitz, J.H. Kinney, S.J. Marshall, and G.W. Marshall Mechanical properties of mineralized collagen fibrils as influenced by demineralization J Struct Biol 162 2008 404 410
18. W.J. Landis, K.J. Hodgens, M.J. Song, J. Arena, S. Kiyonaga, and M. Marko Mineralization of collagen may occur on fibril surfaces: evidence from conventional and high-voltage electron microscopy and three-dimensional imaging J Struct Biol 117 1996 24 35
19. R.L. Bertolotti Total etch-the rational dentin bonding protocol J Esthet Dent 3 1991 1 6
20. J. Perdigao, P. Lambrechts, B. van Meerbeek, A.R. Tome, G. Vanherle, and A.B. Lopes Morphological field emission-SEM study of the effect of six phosphoric acid etching agents on human dentin Dent Mater 12 1996 262 271
21. N. Nakabayashi, K. Kojima, and E. Masuhara The promotion of adhesion by the infiltration of monomers into tooth substrates J Biomed Mater Res 16 1982 265 273
22. H. Sano, T. Shono, T. Takatsu, and H. Hosoda Microporous dentin zone beneath resin-impregnated layer Oper Dent 19 1994 59 64
23. B. Van Meerbeek, A. Dhem, M. Goret-Nicaise, M. Braem, P. Lambrechts, and G. VanHerle Comparative SEM and TEM examination of the ultrastructure of the resin-dentin interdiffusion zone J Dent Res 72 1993 495 501
24. M. Hashimoto, H. Ohno, H. Sano, M. Kaga, and H. Oguchi In vitro degradation of resin-dentin bonds analyzed by microtensile bond test, scanning and transmission electron microscopy Biomaterials 24 2003 3795 3803
25. H. Sano Microtensile testing, nanoleakage, and biodegradation of resin-dentin bonds J Dent Res 85 2006 11 14
26. F.R. Tay, M. Hashimoto, D.H. Pashley, M.C. Peters, S.C. Lai, and C.K. Yiu Aging affects two modes of nanoleakage expression in bonded dentin J Dent Res 82 2003 537 541
27. H. Sano, T. Takatsu, B. Ciucchi, J.A. Horner, W.G. Matthews, and D.H. Pashley Nanoleakage: leakage within the hybrid layer Oper Dent 20 1995 18 25
28. M. Goldberg, and M. Takagi Dentine proteoglycans: composition, ultrastructure and functions Histochem J 25 1993 781 806
29. A. Linde, and S.P. Robins Quantitative assessment of collagen crosslinks in dissected predentin and dentin Coll Relat Res 8 1988 443 450
30. A.L. Boskey The role of extracellular matrix components in dentin mineralization Crit Rev Oral Biol Med 2 1991 369 387
31. J.H. Kinney, J.A. Pople, G.W. Marshall, and S.J. Marshall Collagen orientation and crystallite size in human dentin: a small angle X-ray scattering study Calcif Tissue Int 69 2001 31 37
32. C.P. Lin, W.H. Douglas, and S.L. Erlandsen Scanning electron microscopy of type I collagen at the dentin-enamel junction of human teeth J Histochem Cytochem 41 1993 381 388
33. J. Perdigao, J.Y. Thompson, M. Toledano, and R. Osorio An ultra-morphological characterization of collagen-depleted etched dentin Am J Dent 12 1999 250 255
34. L. Breschi, P. Gobbi, M. Lopes, C. Prati, M. Falconi, and G. Teti Immunocytochemical analysis of dentin: a double-labeling technique J Biomed Mater Res A 67 2003 11 17
35. L. Breschi, J. Perdigao, P. Gobbi, G. Mazzotti, M. Falconi, and M. Lopes Immunocytochemical identification of type I collagen in acid-etched dentin J Biomed Mater Res A 66 2003 764 769
36. R.K. Nalla, A.E. Porter, C. Daraio, A.M. Minor, V. Radmilovic, and E.A. Stach Ultrastructural examination of dentin using focused ion-beam cross-sectioning and transmission electron microscopy Micron 36 2005 672 680
37. S. Habelitz, M. Balooch, S.J. Marshall, G. Balooch, and G.W. Marshall In situ atomic force microscopy of partially demineralized human dentin collagen fibrils J Struct Biol 138 2002 227 236
38. G.W. Marshall Jr., M. Balooch, J.H. Kinney, and S.J. Marshall Atomic force microscopy of conditioning agents on dentin J Biomed Mater Res 29 1995 1381 1387
39. G.W. Marshall, M. Balooch, R.J. Tench, J.H. Kinney, and S.J. Marshall Atomic force microscopy of acid effects on dentin Dent Mater 9 1993 265 268
40. L.E. Bertassoni, S. Habelitz, M. Pugach, P.C. Soares, S.J. Marshall, and G.W. Marshall Evaluation of surface structural and mechanical changes following remineralization of dentin Scanning 32 2010 312 319
41. M.A. Vargas, D.S. Cobb, and G.E. Denehy Interfacial micromorphology and shear bond strength of single-bottle primer/adhesives Dent Mater 13 1997 316 324
42. R. Garberoglio, and M. Brannstrom Scanning electron microscopic investigation of human dentinal tubules Arch Oral Biol 21 1976 355 362
43. D.H. Pashley Clinical correlations of dentin structure and function J Prosthet Dent 66 1991 777 781
44. J.K. Avery Oral development and histology 1988 B.C. Dekker Inc. Toronto, Canada
45. P. Fratzl Collagen: strucutre and mechanics 2008 Springer Boston, MA
46. JP. Orgel, JD. San Antonio, and O. Antipova Molecular and structural mapping of collagen fibril interactions Connect Tissue Res 52 2011 2 17
47. JP. Orgel, O. Antipova, I. Sagi, A. Bitler, D. Qiu, and R. Wang Collagen fibril surface displays a constellation of sites capable of promoting fibril assembly, stability, and hemostasis Connect Tissue Res 52 2011 18 24
48. J.P. Orgel, A. Eid, O. Antipova, J. Bella, and J.E. Scott Decorin core protein (decoron) shape complements collagen fibril surface structure and mediates its binding PLoS One 4 2009 e7028
49. S. Perumal, O. Antipova, and J.P. Orgel Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis Proc Natl Acad Sci USA 105 2008 2824 2829
50. J.P. Orgel, T.C. Irving, A. Miller, and T.J. Wess Microfibrillar structure of type I collagen in situ Proc Natl Acad Sci USA 103 2006 9001 9005
51. J.P. Orgel, A. Miller, T.C. Irving, R.F. Fischetti, A.P. Hammersley, and T.J. Wess The in situ supermolecular structure of type I collagen Structure 9 2001 1061 1069
52. J.P. Orgel, T.J. Wess, and A. Miller The in situ conformation and axial location of the intermolecular cross-linked non-helical telopeptides of type I collagen Structure 8 2000 137 142
53. M. Raspanti, T. Congiu, and S. Guizzardi Tapping-mode atomic force microscopy in fluid of hydrated extracellular matrix Matrix Biol 20 2001 601 604
54. M. Raspanti, V. Ottani, and A. Ruggeri Different architectures of the collagen fibril: morphological aspects and functional implications Int J Biol Macromol 11 1989 367 371
55. Pace RJ, Datyner A. Model of sorption of simple molecules in polymers. J Polym Sci Polym Phys 1980;18.
56. T. Pioch, H.J. Staehle, H. Duschner, and F. Garcia-Godoy Nanoleakage at the composite-dentin interface. a review Am J Dent 14 2001 252 258
57. Bella J, Eaton M, Brodsky B, Berman HM. Crystal and molecular structure of a collagen-like peptide at 1.9 Å resolution. Science 1994;266:75-81.
58. Petruska JA, Hodge AJ. A subunit model for the tropocollagenmacromolecule. Proc Natl Acad Sci USA 1964;51:871-6.
59. J.W. Smith Molecular pattern in native collagen Nature 219 1968 157 158
60. Voet D, Judith GV, Charlotte WP. Biochemistry. 3rd ed. Hoboken, NJ: Wiley; 2008.
61. V. Ottani, M. Raspanti, and A. Ruggeri Collagen structure and functional implications Micron 32 2001 251 260
62. J.P. Orgel, J.D. San Antonio, and O. Antipova Molecular and structural mapping of collagen fibril interactions Connect Tissue Res 52 2011 2 17
63. J.E. Scott Proteoglycan: collagen interactions and subfibrillar structure in collagen fibrils. Implications in the development and ageing of connective tissues J Anat 169 1990 23 35
64. S. Yamamoto, H. Hashizume, J. Hitomi, M. Shigeno, S. Sawaguchi, and H. Abe The subfibrillar arrangement of corneal and scleral collagen fibrils as revealed by scanning electron and atomic force microscopy Arch Histol Cytol 63 2000 127 135
65. M. Raspanti, M. Viola, M. Sonaggere, M.E. Tira, and R. Tenni Collagen fibril structure is affected by collagen concentration and decorin Biomacromolecules 8 2007 2087 2091
66. F.H. Silver, K.H. Langley, and R.L. Trelstad Type I collagen fibrillogenesis: initiation via reversible linear and lateral growth steps Biopolymers 18 1979 2523 2535
67. O. Antipova, and J.P. Orgel In situ D-periodic molecular structure of type II collagen J Biol Chem 285 2010 7087 7096
68. D.J. Hulmes, and A. Miller Quasi-hexagonal molecular packing in collagen fibrils Nature 282 1979 878 880
69. S.M. Sweeney, J.P. Orgel, A. Fertala, J.D. McAuliffe, K.R. Turner, and G.A. Di Lullo Candidate cell and matrix interaction domains on the collagen fibril, the predominant protein of vertebrates J Biol Chem 283 2008 21187 21197
70. T. Twardowski, A. Fertala, J.P. Orgel, and J.D. San Antonio Type I collagen and collagen mimetics as angiogenesis promoting superpolymers Curr Pharm Des 13 2007 3608 3621
71. D.J. Hulmes, T.J. Wess, D.J. Prockop, and P. Fratzl Radial packing, order, and disorder in collagen fibrils Biophys J 68 1995 1661 1670
72. J. Bella, B. Brodsky, and H.M. Berman Hydration structure of a collagen peptide Structure 3 1995 893 906
73. R.D.B. Fraser, and T.P. MacRae Conformation in fibrous proteins 1973 Academic Press New York
74. H.J.C. Berendsen, and C. Migchelsen Hydration structure of fibrous macromolecules Ann NY Acad Sci 125 1965 365 379
75. J.R. Grigera, and H.J.C. Berendsen The molecular details of collagen hydration Biopolymers 18 1979 47 57
76. S. Nomura, A. Hiltner, J.B. Lando, and E. Baer Interaction of water with native collagen Biopolymers 16 1977 231 246
77. S. Cusack, and S. Lees Variation of longitudinal acoustic velocity at gigahertz frequencies with water content in rat-tail tendon fibers Biopolymers 23 1984 337 351
78. S. Peto, P. Gillis, and V.P. Henri Structure and dynamics of water in tendon from NMR relaxation measurements Biophys J 57 1990 71 84
79. C.A. Hoeve, and P.C. Lue The structure of water absorbed in collagen. I. The dielectric properties Biopolymers 13 1974 1661 1680
80. J.L. Ferracane Hygroscopic and hydrolytic effects in dental polymer networks Dent Mater 22 2006 211 222
81. G.J. Christensen Bonding to dentin and enamel where does it stand in 2005? J Am Dent Assoc 136 2005 1299 1302
82. A. Peutzfeldt Resin composites in dentistry: the monomer systems Eur J Oral Sci 105 1997 97 116
83. S. Venz, and B. Dickens NIR-spectroscopic investigation of water sorption characteristics of dental resins and composites J Biomed Mater Res 25 1991 1231 1248
84. J.P. Santerre, L. Shajii, and H. Tsang Biodegradation of commercial dental composites by cholesterol esterase J Dent Res 78 1999 1459 1468
85. E.C. Munksgaard, and M. Freund Enzymatic hydrolysis of (di)methacrylates and their polymers Scand J Dent Res 98 1990 261 267
86. T.A. Bean, W.C. Zhuang, P.Y. Tong, J.D. Eick, and D.M. Yourtee Effect of esterase on methacrylates and methacrylate polymers in an enzyme simulator for biodurability and biocompatibility testing J Biomed Mater Res 28 1994 59 63
87. J.P. Santerre, L. Shajii, and B.W. Leung Relation of dental composite formulations to their degradation and the release of hydrolyzed polymeric-resin-derived products Crit Rev Oral Biol Med 12 2001 136 151
88. Y. Finer, and J.P. Santerre The influence of resin chemistry on a dental composite's biodegradation J Biomed Mater Res A 69 2004 233 246
89. B. Willershausen, A. Callaway, C.P. Ernst, and E. Stender The influence of oral bacteria on the surfaces of resin-based dental restorative materials-an in vitro study Int Dent J 49 1999 231 239
90. G.J. Pearson Long term water sorption and solubility of composite filling materials J Dent 7 1979 64 68
91. M. Toledano, R. Osorio, E. Osorio, V. Fuentes, C. Prati, and F. Garcia-Godoy Sorption and solubility of resin-based restorative dental materials J Dent 31 2003 43 50
92. H. Oysaed, and I.E. Ruyter Water sorption and filler characteristics of composites for use in posterior teeth J Dent Res 65 1986 1315 1318
93. L. Musanje, M. Shu, and B.W. Darvell Water sorption and mechanical behaviour of cosmetic direct restorative materials in artificial saliva Dent Mater 17 2001 394 401
94. J.L. Ferracane Elution of leachable components from composites J Oral Rehabil 21 1994 441 452
95. M. Braden, E.E. Causton, and R.L. Clarke Diffusion of water in composite filling materials J Dent Res 55 1976 730 732
96. P. Milleding, S. Karlsson, and L. Nyborg On the surface elemental composition of non-corroded and corroded dental ceramic materials in vitro J Mater Sci Mater Med 14 2003 557 566
97. J.L. Ferracane Water sorption and solubility of experimental dental composites Polymer Preprints 38 1997 116 117
98. Y. Nishitani, M. Yoshiyama, A.M. Donnelly, K.A. Agee, J. Sword, and F.R. Tay Effects of resin hydrophilicity on dentin bond strength J Dent Res 85 2006 1016 1021
99. F.T. Sadek, C.S. Castellan, R.R. Braga, S. Mai, L. Tjaderhane, and D.H. Pashley One-year stability of resin-dentin bonds created with a hydrophobic ethanol-wet bonding technique Dent Mater 26 2010 380 386
100. M. Ferrari, and F.R. Tay Technique sensitivity in bonding to vital, acid-etched dentin Oper Dent 28 2003 3 8
101. D.H. Pashley, F.R. Tay, C. Yiu, M. Hashimoto, L. Breschi, and R.M. Carvalho Collagen degradation by host-derived enzymes during aging J Dent Res 83 2004 216 221
102. M.R. Carrilho, S. Geraldeli, F. Tay, M.F. de Goes, R.M. Carvalho, and L. Tjaderhane In vivo preservation of the hybrid layer by chlorhexidine J Dent Res 86 2007 529 533
103. F. Garcia-Godoy, F.R. Tay, D.H. Pashley, A. Feilzer, L. Tjaderhane, and E.L. Pashley Degradation of resin-bonded human dentin after 3 years of storage Am J Dent 20 2007 109 113
104. R. Visse, and H. Nagase Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry Circ Res 92 2003 827 839
105. L. Tjaderhane, H. Larjava, T. Sorsa, V.J. Uitto, M. Larmas, and T. Salo The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions J Dent Res 77 1998 1622 1629
106. A.J. van Strijp, D.C. Jansen, J. DeGroot, J.M. ten Cate, and V. Everts Host-derived proteinases and degradation of dentine collagen in situ Caries Res 37 2003 58 65
107. Y. Nishitani, M. Yoshiyama, B. Wadgaonkar, L. Breschi, F. Mannello, and A. Mazzoni Activation of gelatinolytic/collagenolytic activity in dentin by self-etching adhesives Eur J Oral Sci 114 2006 160 166
108. F.R. Tay, D.H. Pashley, R.J. Loushine, R.N. Weller, F. Monticelli, and R. Osorio Self-etching adhesives increase collagenolytic activity in radicular dentin J Endod 32 2006 862 868
109. W.W. Brackett, S. Ito, F.R. Tay, L.D. Haisch, and D.H. Pashley Microtensile dentin bond strength of self-etching resins: effect of a hydrophobic layer Oper Dent 30 2005 733 738
110. J. De Munck, B. Van Meerbeek, Y. Yoshida, S. Inoue, M. Vargas, and K. Suzuki Four-year water degradation of total-etch adhesives bonded to dentin J Dent Res 82 2003 136 140
111. S.R. Armstrong, M.A. Vargas, I. Chung, D.H. Pashley, J.A. Campbell, and J.E. Laffoon Resin-dentin interfacial ultrastructure and microtensile dentin bond strength after five-year water storage Oper Dent 29 2004 705 712
112. P. Siljander, and R. Lassila Studies of adhesion-dependent platelet activation: distinct roles for different participating receptors can be dissociated by proteolysis of collagen Arterioscler Thromb Vasc Biol 19 1999 3033 3043
113. M.H. Zaman, L.M. Trapani, A.L. Sieminski, D. Mackellar, H. Gong, and R.D. Kamm Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis Proc Natl Acad Sci USA 103 2006 10889 10894
114. L. Chung, D. Dinakarpandian, N. Yoshida, J.L. Lauer-Fields, G.B. Fields, and R. Visse Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis Embo J 23 2004 3020 3030
115. C.M. Stultz Localized unfolding of collagen explains collagenase cleavage near imino-poor sites J Mol Biol 319 2002 997 1003
116. G. Orsini, A. Mazzoni, M. Orciani, A. Putignano, M. Procaccini, and M. Falconi Matrix metalloproteinase-2 expression induced by two different adhesive systems on human pulp fibroblasts J Endod 37 2011 1663 1667
117. G.E. Davis Identification of an abundant latent 94-kDa gelatin-degrading metalloprotease in human saliva which is activated by acid exposure: implications for a role in digestion of collagenous proteins Arch Biochem Biophys 286 1991 551 554
118. I.L. Tersariol, S. Geraldeli, C.L. Minciotti, F.D. Nascimento, V. Paakkonen, and M.T. Martins Cysteine cathepsins in human dentin-pulp complex J Endod 36 2010 475 481
119. F.D. Nascimento, C.L. Minciotti, S. Geraldeli, M.R. Carrilho, D.H. Pashley, and F.R. Tay Cysteine cathepsins in human carious dentin J Dent Res 90 2011 506 511
120. A. Al-Ammar, J.L. Drummond, and A.K. Bedran-Russo The use of collagen cross-linking agents to enhance dentin bond strength J Biomed Mater Res B Appl Biomater 91 2009 419 424
121. G.V. Macedo, M. Yamauchi, and A.K. Bedran-Russo Effects of chemical cross-linkers on caries-affected dentin bonding J Dent Res 88 2009 1096 1100
122. A.K. Bedran-Russo, K.J. Yoo, K.C. Ema, and D.H. Pashley Mechanical properties of tannic-acid-treated dentin matrix J Dent Res 88 2009 807 811
123. A.K. Bedran-Russo, C.M. Vidal, P.H. Dos Santos, and C.S. Castellan Long-term effect of carbodiimide on dentin matrix and resin-dentin bonds J Biomed Mater Res B Appl Biomater 94 2010 250 255
124. C.S. Castellan, P.N. Pereira, R.H. Grande, and A.K. Bedran-Russo Mechanical characterization of proanthocyanidin-dentin matrix interaction Dent Mater 26 2010 968 973
125. C.S. Castellan, P.N. Pereira, G. Viana, S.N. Chen, G.F. Pauli, and A.K. Bedran-Russo Solubility study of phytochemical cross-linking agents on dentin stiffness J Dent 38 2010 431 436
126. A. Tezvergil-Mutluay, M.M. Mutluay, K.A. Agee, R. Seseogullari-Dirihan, T. Hoshika, and M. Cadenaro Carbodiimidecross-linking inactivates soluble and matrix-bound MMPs, in vitro J Dent Res 91 2012 192 196
127. A. Cova, L. Breschi, F. Nato, A. Ruggeri Jr., M. Carrilho, and L. Tjaderhane Effect of UVA-activated riboflavin on dentin bonding J Dent Res 90 2011 1439 1445
128. A. Mazzoni, D.H. Pashley, Y. Nishitani, L. Breschi, F. Mannello, and L. Tjaderhane Reactivation of inactivated endogenous proteolytic activities in phosphoric acid-etched dentine by etch-and-rinse adhesives Biomaterials 27 2006 4470 4476
129. M.G. Brackett, F.R. Tay, W.W. Brackett, A. Dib, F.A. Dipp, and S. Mai In vivo chlorhexidine stabilization of hybrid layers of an acetone-based dentin adhesive Oper Dent 34 2009 379 383
130. J. De Munck, P.E. Van den Steen, A. Mine, K.L. Van Landuyt, A. Poitevin, and G. Opdenakker Inhibition of enzymatic degradation of adhesive-dentin interfaces J Dent Res 88 2009 1101 1106
131. J.E. Scott, and A.M. Thomlinson The structure of interfibrillar proteoglycan bridges (shape modules) in extracellular matrix of fibrous connective tissues and their stability in various chemical environments J Anat 192 3 1998 391 405
132. J. Bella, K.L. Hindle, P.A. McEwan, and S.C. Lovell The leucine-rich repeat structure Cell Mol Life Sci 65 2008 2307 2333
133. J.E. Scott Supramolecular organization of extracellular matrix glycosaminoglycans, in vitro and in the tissues Faseb J 6 1992 2639 2645
134. J.E. Scott Elasticity in extracellular matrix 'shape modules' of tendon, cartilage, etc. A sliding proteoglycan-filament model J Physiol 553 2003 335 343
135. J.E. Scott Cartilage is held together by elastic glycan strings. Physiological and pathological implications Biorheology 45 2008 209 217
136. A.K. Bedran-Russo, P.N. Pereira, W.R. Duarte, K. Okuyama, and M. Yamauchi Removal of dentin matrix proteoglycans by trypsin digestion and its effect on dentin bonding J Biomed Mater Res B Appl Biomater 85 2008 261 266
137. P.N. Pereira, A.K. Bedran-de-Castro, W.R. Duarte, and M. Yamauchi Removal of noncollagenous components affects dentin bonding J Biomed Mater Res B Appl Biomater 80 2007 86 91
138. A. Mazzoni, D.H. Pashley, A. Ruggeri, F. Vita, M. Falconi, and R. Di Lenarda Adhesion to chondroitinase ABC treated dentin J Biomed Mater Res B Appl Biomater 86 2008 228 236
139. E. Hadler-Olsen, B. Fadnes, I. Sylte, L. Uhlin-Hansen, and J.O. Winberg Regulation of matrix metalloproteinase activity in health and disease FEBS J 278 2011 28 45
140. M. Raspanti, M. Viola, A. Forlino, R. Tenni, C. Gruppi, and M.E. Tira Glycosaminoglycans show a specific periodic interaction with type I collagen fibrils J Struct Biol 164 2008 134 139
141. E. Coutinho, M.V. Cardoso, C.P. Fernandes, A.A. Neves, C.V. Gouvea, and K.L. Van Landuyt Nanoleakage distribution at adhesive-dentin interfaces in 3D J Dent Res 90 2011 1019 1025
142. V. Ottani, D. Martini, M. Franchi, A. Ruggeri, and M. Raspanti Hierarchical structures in fibrillar collagens Micron 33 2002 587 596
143. J.M. Powers, and R.L. Sakaguchi Craig's restorative dental materials 12th ed. 2006 Mosby St Louis, MO
144. A. Gautieri, S. Vesentini, A. Redaelli, and M.J. Buehler Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up Nano Lett 11 2010 757 766
145. P.G. Scott, P.A. McEwan, C.M. Dodd, E.M. Bergmann, P.N. Bishop, and J. Bella Crystal structure of the dimeric protein core of decorin, the archetypal small leucine-rich repeat proteoglycan Proc Natl Acad Sci USA 101 2004 15633 15638
146. W.T. Winter, S. Arnott, D.H. Isaac, and E.D. Atkins Chondroitin 4-sulfate: the structure of a sulfated glycosaminoglycan J Mol Biol 125 1978 1 19
147. N. Lehmann, R. Debret, A. Romeas, H. Magloire, M. Degrange, and F. Bleicher Self-etching increases matrix metalloproteinase expression in the dentin-pulp complex J Dent Res 88 2009 77 82
148. A. Mazzoni, M. Carrilho, V. Papa, L. Tjaderhane, P. Gobbi, and C. Nucci MMP-2 assay within the hybrid layer created by a two-step etch-and-rinse adhesive: biochemical and immunohistochemical analysis J Dent 39 2011 470 477