Differential effects of escitalopram administration on metabolic parameters of cortical and subcortical brain regions of Wistar rats

Acta Neuropsychiatrica

Volumn 24, Issue 3, 2012, Pages 147-154

  Gonçalves, Cinara L ^a   Rezin, Gislaine T ^a   Ferreira, Gabriela K ^a   Jeremias, Isabela C ^a   Cardoso, Mariane R ^a   Carvalho Silva, Milena ^a   Zugno, Alexandra I ^a   Quevedo, João ^a   Streck, Emilio L ^a  

^a UNIVERSIDADE DO EXTREMO SUL CATARINENSE   (Brazil)

Author keywords

brain; creatine kinase; escitalopram; Krebs cycle; mitochondrial respiratory chain

Indexed keywords

CITRATE SYNTHASE; CREATINE KINASE; ESCITALOPRAM; MALATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN REGION; CEREBELLUM; CITRIC ACID CYCLE; CONTROLLED STUDY; CORPUS STRIATUM; DECAPITATION; ENERGY METABOLISM; ENZYME ACTIVITY; HIPPOCAMPUS; MALE; MITOCHONDRION; NONHUMAN; POSTERIOR CORTEX; PREFRONTAL CORTEX; RAT;

EID: 84861602790     PISSN: 09242708     EISSN: 16015215     Source Type: Journal    
DOI: 10.1111/j.1601-5215.2011.00592.x     Document Type: Article

References (72)

1. Kessler RC, Walters EE., Epidemiology of DSM-III-R major depression and minor depression among adolescents and young adults in the National Comorbidity Survey. Depress Anxiety 1998; 7: 3-14. (Pubitemid 28248515)
2. Turner JR, Gil AG., Psychiatric and substance use disorders in South Florida racial/ethnic and gender contrasts in a young adult cohort. Arch Gen Psychiatry 2002; 59: 43-50. (Pubitemid 34044404)
3. Kessler RC, Berglund P, Demler O, Jin R, Merikans Kr, Walters EE., Lifetime prevalence and age-of-onset distributions of DSM-IV disorder in the national comorbidity survey replication. Arch Gen Psychiatry 2005; 62: 593-768.
4. Rex A, Schickert R, Fink H., Antidepressant-like effect of nicotinamide adenine dinucleotide in the forced swim test in rats. Pharmacol Biochem Behav 2004; 77: 303-307. (Pubitemid 38125162)
5. Kiss JP., Theory of active antidepressants: a nonsynaptic approach to the treatment of depression, Neurochem Int 2008; 52: 34-39. (Pubitemid 350235687)
6. Longone P, Rupprecht R, Manieri GA, Bernardi G, Romeo E, Pasini A., The complex roles of neurosteroids in depression and anxiety disorders. Neurochem Int 2008; 52: 596-601.
7. Greenberg PE, Stiglin LE, Finkelstein SN, Berndt ER, 1993. The economic burden of depression in 1990. J Clin Psychiatry 1990; 54: 405-418. (Pubitemid 24020594)
8. World Health Organization: Programmes and projects/mental health/disorders management/depression. Retrieved March 1, 2010, from URL
9. Cannon TD, Keller MC., Endophenotypes in the genetic analyses of mental disorders. Annu Rev Clin Psychol 2006; 2: 267-290. (Pubitemid 43799806)
10. Skolnick P., Beyond monoamine-based therapies: clues to new approaches. J Clin Psychiatry 2002; 63: 19-23. (Pubitemid 34208793)
11. Charney DS., Monoamine dysfunction and the pathophysiology and treatment of depression. J Clin Psychiatry 1998; 59: 11-14. (Pubitemid 28462383)
12. Brunello N, Mendlewicz J, Kasper S, et al., The role of noradrenaline and selective noradrenaline reuptake inhibition in depression. Eur Neuropsychopharmacology 2002; 12: 461-475.
13. Johnson AM., Paroxetine: a pharmacological review. Int Clin Psychopharmacol 1992; 6: 15-24.
14. Richelson E., Pharmacology of anti-depressants-characteristics of the ideal drug. Mayo Clin Proc 1999; 69: 1069-1081.
15. David DJ, Bourin M, Jego G, Przybylski C, Jolliet P, Gardier AM., Effects of acute treatment with paroxetine, citalopram and venlafaxine in vivo on noradrenaline and serotonin outflow: a microdialysis study in Swiss mice. Br J Pharmacol 2003; 140: 1128-1136. (Pubitemid 37475979)
16. Borsini F, Podhorna J, Marazziti D., Do animal models of anxiety predict anxiolytic-like effects of antidepressants? Psychopharmacology 2002; 163: 121-141. (Pubitemid 35013604)
17. Brennan WA, Bird ED, Aprille JR., Regional mitochondrial respiratory activity in Huntington's disease brain. J Neurochem 1985; 44: 1948.
18. Heales SJ, Bolans JP, Stewart VC, Brookes PS, Land JM, Clark JB., Nitric oxide, mitochondria and neurological disease. Biochim Biophys Acta 1999; 1410: 215-228. (Pubitemid 29078606)
19. Blass JP., Brain metabolism and brain disease: is metabolic deficiency the proximate cause of Alzheimer dementia? J Neurosci Res 2001; 66: 851-856.
20. Schurr A., Energy metabolism, stress hormones and neural recovery from cerebral ischemia/hypoxia. Neurochem Int 2002; 41: 1-8. (Pubitemid 34251400)
21. Monsalve M, Borniquel S, Valle I, Lamas S., Mitochondrial dysfunction in human pathologies. Front Biosci 2007; 12: 1131-1153. (Pubitemid 46850646)
22. Moreira PI, Santos MS, Oliveira CR., Alzheimer's disease: a lesson from mitochondrial dysfunction. Antioxid Redox Signal 2007; 9: 1621-1630. (Pubitemid 47462966)
23. Moreira PI, Santos MS, Seiça R, Oliveira CR., Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. J Neurol Sci 2007; 257: 206-214. (Pubitemid 46856489)
24. Calabrese V, Scapagnini G, Giuffrida-Stella AM, Bates TE, Clark JB., Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochem Res 2001; 26: 739-764. (Pubitemid 32756837)
25. Boekema EJ, Braun HP., Supramolecular structure of the mitochondrial oxidative phosphorylation system. J Biol Chem 2007; 282: 1-4. (Pubitemid 47076588)
26. Kelly D, Gordon J, Alpers R, Strauss AW., The tissue-specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins. Medium chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase. J Biol Chem 1989; 264: 18921-18925. (Pubitemid 19285792)
27. Shepherd D, Garland PB., The kinetic properties of citrate synthase from rat liver mitochondria. Biochem J 1969; 114: 597-610.
28. Labrou NE, Clonis YD., L-Malate dehydrogenase from Pseudomonas stutzeri: purification and characterization. Arch Biochem Biophys 1997; 337: 103-114. (Pubitemid 27198061)
29. Tyler D., The mitochondrion in health and diseases. New York: VCH Publishers, 1992.
30. Rustin P, Munnich A, Rötig A., Succinate dehydrogenase and human diseases: newinsights into a well-known enzyme. Eur J Hum Genet 2002; 10: 289-291. (Pubitemid 34778046)
31. Tomimoto H, Yamamoto K, Homburger HA, Yanagihara T., Immunoelectron microscopic investigation of creatine kinase BB-isoenzyme after cerebral ischemia in gerbils, Acta Neuropathol 1993; 86: 447-455. (Pubitemid 23322244)
32. Hamman BL, Bittl JA, Jacobus WE, et al., Inhibition of the creatine kinase reaction decreases the contractile reserve of isolated rat hearts. Am J Physiol 1995; 269: 1030-1036.
33. Gross WL, Bak MI, Ingwall JS, et al., Nitric oxide inhibits creatine kinase and regulates heart contractile reserve. Proc Natl Acad Sci U S A 1996; 93: 5604-5609. (Pubitemid 26159498)
34. David S, Shoemaker M, Haley BE., Abnormal properties of creatine kinase in Alzheimer's disease brain: correlation of reduced enzyme activity and active site photolabeling with aberrant cytosol-membrane partitioning. Brain Res Mol Brain Res 1998; 54: 276-287. (Pubitemid 28171792)
35. Aksenov M, Aksenova M, Butterfield DA, Markesbery WR., Oxidative modification of creatine kinase BB in Alzheimer's disease brain. J Neurochem 2000; 74: 2520-2527. (Pubitemid 30314229)
36. Jayatissa MN, Bisgaard C, Tingström A, Papp M, Wiborg O., Hippocampal cytogenesis correlates to escitalopram-mediated recovery in a chronic mild stress rat model of depression. Neuropsychopharmacology 2006; 31: 2395-2404. (Pubitemid 44607057)
37. Lowry OH, Rosebough NG, Farr AL, Randall RJ., Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
38. Cassina A, Radi R., Differential inhibitory Aation of nitric oxide and peroxynitrite on mitochondrial electron transport. Arch Biochem Biophys 1996; 328: 309-316. (Pubitemid 26160113)
39. Fischer JC, Ruitenbeek W, Berden JA, Trijbels JM., Differential investigation of the capacity of succinate oxidation in human skeletal muscle. Clin Chim Acta 1985; 153: 23-26. (Pubitemid 16200073)
40. Rustin P, Chretien D, Bourgeron T, et al., Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta 1994; 228: 35-51. (Pubitemid 24231224)
41. Kitto GB., Intra- and extramitochondrial malate dehydrogenases from chicken and tuna heart. Methods Enzymol 1969; 8: 106-116.
42. Hughes BP., A method for estimation of serum creatine kinase and its use in comparing creatine kinase and aldolase activity in normal and pathologic sera. Clin Chim Acta 1962; 7: 597-604.
43. Mattson MP, Gleichmann M, Cheng A., Mitochondria in neuroplasticity and neurological disorders. Neuron 2008; 60: 748-766.
44. Retter L, Mayer-Takacs D, Adam-Vizi V., The effect of bovine serum albumin on the membrane potential and reactive oxygen species generation in succinate-supported isolated brain mitochondria. Neurochem Int 2007; 50: 139-147. (Pubitemid 44895358)
45. Petrosillo G, Matera M, Casanova G, Ruggiero FM, Paradies G., Mitochondrial dysfunction in rat brain with aging: involvement of complex I, reactive oxygen species and cardiolipin. Neurochem Int 2008; 53: 126-131.
46. Kanarik M, Matrov D, Kiv K, Eller M, Tnissaar M, Harro J., Changes in regional long-term oxidative metabolism induced by partial serotonergic denervation and chronic variable stress in rat brain. Neurochem Int 2008; 52: 432-437.
47. Stanyer L, Jorgensen W, Hori O, Clark JB, Heales SJ., Inactivation of brain mitochondrial Lon protease by peroxynitrite precedes electron transport chain dysfunction. Neurochem Int 2008; 53: 95-101.
48. Madrigal JL, Olivenza R, Moro M, et al., Glutathione depletion, lipid peroxidation and mitochondrial dysfunction are induced by chronic stress in rat brain. Neuropsychopharmacology 2001; 24: 420-429. (Pubitemid 32157558)
49. Barrett SL, Kelly C, Bell R, King DJ., Gender influences the detection of spatial working memory deficits in bipolar disorder. Bipolar Disord 2008; 10: 647-654. (Pubitemid 352003831)
50. Quraishi S, Walshe M, Mcdonald C, et al., Memory functioning in familial bipolar I disorder patients and their relatives. Bipolar Disord 2009; 11: 209-214.
51. Streck EL, Amboni G, Scaini G, et al., Brain Creatine kinase activity in an animal model of mania. Life Sci 2008; 82: 424-429.
52. Burigo M, Roza CA, Bassani C, et al., Decreased Creatine kinase activity caused by electroconvulsive shock. Neurochem Res 2006; 31: 877-881. (Pubitemid 44134240)
53. +-ATPase activity in rats subjected to an experimental model of depression. Neurochem Res 2003; 28: 1339-1344. (Pubitemid 38113062)
54. Rezin GT, Cardoso MR, Gonçalves CL, et al., Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression. Neurochem Int 2008; 53: 395-400.
55. Ferretti V, Roullet P, Sargolini F, et al., Ventral striatal plasticity and spatial memory. Proc Natl Acad Sci U S A 2010; 107: 7945-7950.
56. Marais L, Stein DJ, Daniels WM., Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats. Metab Brain Dis 2009; 24: 587-597.
57. Gokce O, Runne H, Kuhn A, Luthi-Carter R., Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation. PLoS One 2009; 4: 5292.
58. Duman RS, Monteggia LM., A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006; 59: 1116-1127.
59. Hall J, Whalley HC, Marwick K, et al., Hippocampal function in schizophrenia and bipolar disorder. Psychol Med 2009; 7: 1-10.
60. Hassel S, Almeida JR, Kerr N, et al., Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load. Bipolar Disord 2008; 10: 916-927.
61. Hroudova J, Fisar Z., Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers. Neuroendocrinology Lett 2010; 31: 336-342.
62. Burke WJ, Kratochvil Cj,. Stereoisomers in psychiatry: the case of escitalopra. Prim Care Companion J Clin Psychiatry 2002; 4: 20-24.
63. Mitchell PJ, Hogg S., Beavioural effects of escitalopram predict potent antidepressant activity. Presented at the 7th World Congress of Biological Psychiatry, July 1-6. Berlin, Germany, 2001.
64. Sanchez C, Hogg S., The antidepressant effect of citalopram resides in the S-enantiomer (Lu 26-054). Presented at the 55th annual meeting of the Society of Biological Psychiatry, May 11-13. Chicago, IL, 2000.
65. Mitchell P, Hogg S., Escitalopram: rapid antidepressant activity in rats. Presented at the 7th World Congress of Biological Psychiatry, July 1-6. Berlin, Germany, 2001.
66. Pathak RU, Davey GP., Complex I and energy theresholds in the brain. Biochim Biophys Acta 2008; 1777: 777-782.
67. Barja G, Herrero AJ., Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon. J Bioenerg Biomembr 1998; 30: 235-224.
68. Sherer TB, Betarbet R, Kim Jh, Greenamyre JT., Selective microglial activation in the rat rotenone model of Parkinson's disease. Neurosci Lett 2003; 341: 87-90. (Pubitemid 36398476)
69. Degli EM., Inhibitors of NADH-ubiquinone reductase: an overview. Biochim Biophys Acta 1998; 1364: 222-235.
70. Miyoshi H., Structure-activity relationships of some complex I inhibitors. Biochim Biophys Acta 1998; 1364: 236-244. (Pubitemid 28291842)
71. Don AS, Hogg PJ., Mitochondria as cancer drug targets. Trends Mol Med 2004; 10: 372-378. (Pubitemid 39061138)
72. Scatena R, Bottoni P, Botta G, Martorana GE, Giardina B., The role of mitochondria in pharmacotoxicology: a reevaluation of an old, newly emerging topic. Am J Physiol Cell Physiol 2007; 293: C12-C21. (Pubitemid 47105003)