메뉴 건너뛰기




Volumn 60, Issue 7, 2012, Pages 707-714

GABAergic neurosteroids: The "endogenous benzodiazepines" of acute liver failure

Author keywords

Acute liver failure; Gene expression; Hepatic encephalopathy; Neuroinflammation; Neurosteroids; Neurotransmission; Translocator protein (TSPO)

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; AMMONIA; BENZODIAZEPINE; FLUMAZENIL; INTERLEUKIN 1BETA; INTERLEUKIN 6; NEUROSTEROID; PREGNANE X RECEPTOR; PREGNENOLONE; TETRAHYDRODEOXYCORTICOSTERONE; TETRAHYDROPROGESTERONE; TUMOR NECROSIS FACTOR ALPHA; VOLTAGE DEPENDENT ANION CHANNEL;

EID: 84861586481     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2011.10.003     Document Type: Review
Times cited : (30)

References (43)
  • 1
    • 29744466907 scopus 로고    scopus 로고
    • Role of endogenous benzodiazepine ligands and their GABA-A-associated receptors in hepatic encephalopathy
    • S. Ahboucha, and R.F. Butterworth Role of endogenous benzodiazepine ligands and their GABA-A-associated receptors in hepatic encephalopathy Metab. Brain Dis. 20 2005 425 437
    • (2005) Metab. Brain Dis. , vol.20 , pp. 425-437
    • Ahboucha, S.1    Butterworth, R.F.2
  • 2
    • 5444234245 scopus 로고    scopus 로고
    • Pathophysiology of hepatic encephalopathy: A new look at GABA from the molecular standpoint
    • S. Ahboucha, and R.F. Butterworth Pathophysiology of hepatic encephalopathy: a new look at GABA from the molecular standpoint Metab. Brain Dis. 19 2004 331 343
    • (2004) Metab. Brain Dis. , vol.19 , pp. 331-343
    • Ahboucha, S.1    Butterworth, R.F.2
  • 3
    • 33646115813 scopus 로고    scopus 로고
    • An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons
    • S. Ahboucha, L. Coyne, R. Hirakawa, R.F. Butterworth, and R.F. Halliwell An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons Neurochem. Int. 48 2006 703 707
    • (2006) Neurochem. Int. , vol.48 , pp. 703-707
    • Ahboucha, S.1    Coyne, L.2    Hirakawa, R.3    Butterworth, R.F.4    Halliwell, R.F.5
  • 4
    • 0032448780 scopus 로고    scopus 로고
    • Neurosteroids: A novel function of the brain
    • E.E. Baulieu Neurosteroids: a novel function of the brain Psychoneuroendocrinology 23 1998 963 987
    • (1998) Psychoneuroendocrinology , vol.23 , pp. 963-987
    • Baulieu, E.E.1
  • 5
    • 17044382055 scopus 로고    scopus 로고
    • Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure
    • M. Bélanger, P. Desjardins, N. Chatauret, C. Rose, and R.F. Butterworth Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure J. Hepatol. 42 2005 694 699
    • (2005) J. Hepatol. , vol.42 , pp. 694-699
    • Bélanger, M.1    Desjardins, P.2    Chatauret, N.3    Rose, C.4    Butterworth, R.F.5
  • 6
    • 77149125563 scopus 로고    scopus 로고
    • IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure
    • C. Bémeur, H. Qu, P. Desjardins, and R.F. Butterworth IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure Neurochem. Int. 56 2010 213 215
    • (2010) Neurochem. Int. , vol.56 , pp. 213-215
    • Bémeur, C.1    Qu, H.2    Desjardins, P.3    Butterworth, R.F.4
  • 7
    • 0032401018 scopus 로고    scopus 로고
    • Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes
    • A.S. Bender, and M.D. Norenberg Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes J. Neurosci. Res. 54 1998 673 680
    • (1998) J. Neurosci. Res. , vol.54 , pp. 673-680
    • Bender, A.S.1    Norenberg, M.D.2
  • 8
    • 38649113597 scopus 로고    scopus 로고
    • Brain edema in acute liver failure
    • A.T. Blei Brain edema in acute liver failure Crit. Care Clin. 24 2008 99 114
    • (2008) Crit. Care Clin. , vol.24 , pp. 99-114
    • Blei, A.T.1
  • 9
    • 0026087219 scopus 로고
    • Increase in ω3 (peripheral type benzodiazepine) binding sites in the rat cortex and striatum after local injection of interleukin-1, tumour necrosis factor-α and lipopolysaccharide
    • F. Bourdiol, S. Toulmonda, A. Serranoa, J. Benavides, and B. Scattona Increase in ω3 (peripheral type benzodiazepine) binding sites in the rat cortex and striatum after local injection of interleukin-1, tumour necrosis factor-α and lipopolysaccharide Brain Res. 543 1991 194 200
    • (1991) Brain Res. , vol.543 , pp. 194-200
    • Bourdiol, F.1    Toulmonda, S.2    Serranoa, A.3    Benavides, J.4    Scattona, B.5
  • 10
    • 58049083992 scopus 로고    scopus 로고
    • Pathophysiology of hepatic encephalopathy: The concept of synergism
    • R.F. Butterworth Pathophysiology of hepatic encephalopathy: the concept of synergism Hepatol. Res. 38 Suppl. 1 2008 S116 S121
    • (2008) Hepatol. Res. , vol.38 , Issue.SUPPL. 1
    • Butterworth, R.F.1
  • 11
    • 79953765823 scopus 로고    scopus 로고
    • Hepatic encephalopathy: A central neuroinflammatory disorder?
    • R.F. Butterworth Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology 53 2011 1372 1376
    • (2011) Hepatology , vol.53 , pp. 1372-1376
    • Butterworth, R.F.1
  • 12
    • 0036096069 scopus 로고    scopus 로고
    • The "peripheral-type" benzodiazepine (omega 3) receptor in hyperammonemic disorders
    • P. Desjardins, and R.F. Butterworth The "peripheral-type" benzodiazepine (omega 3) receptor in hyperammonemic disorders Neurochem. Int. 41 2002 109 114
    • (2002) Neurochem. Int. , vol.41 , pp. 109-114
    • Desjardins, P.1    Butterworth, R.F.2
  • 13
    • 0035576812 scopus 로고    scopus 로고
    • Alterations in expression of genes coding for key astrocytic proteins in acute liver failure
    • P. Desjardins, M. Bélanger, and R.F. Butterworth Alterations in expression of genes coding for key astrocytic proteins in acute liver failure J. Neurosci. Res. 66 2001 967 971
    • (2001) J. Neurosci. Res. , vol.66 , pp. 967-971
    • Desjardins, P.1    Bélanger, M.2    Butterworth, R.F.3
  • 14
    • 0028940632 scopus 로고
    • Flumazenil in the treatment of hepatic encephalopathy in children with fulminant liver failure
    • D. Devictor, C. Tahiri, C. Lanchier, Y. Navelet, P. Durand, and A. Rousset Flumazenil in the treatment of hepatic encephalopathy in children with fulminant liver failure Intensive Care Med. 21 1995 253 256
    • (1995) Intensive Care Med. , vol.21 , pp. 253-256
    • Devictor, D.1    Tahiri, C.2    Lanchier, C.3    Navelet, Y.4    Durand, P.5    Rousset, A.6
  • 17
    • 1242273737 scopus 로고    scopus 로고
    • Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists
    • M. Frosini, M. Valoti, and G. Sgaragli Changes in rectal temperature and ECoG spectral power of sensorimotor cortex elicited in conscious rabbits by i.c.v. injection of GABA, GABA(A) and GABA(B) agonists and antagonists Br. J. Pharmacol. 141 2004 152 162
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 152-162
    • Frosini, M.1    Valoti, M.2    Sgaragli, G.3
  • 18
    • 0034455530 scopus 로고    scopus 로고
    • Neurosteroid levels are increased in vivo after LPS treatment and negatively regulate LPS-induced TNF production
    • P. Ghezzi, E.D. Santo, S. Sacco, C. Foddi, M.L. Barbaccia, and T. Mennini Neurosteroid levels are increased in vivo after LPS treatment and negatively regulate LPS-induced TNF production Eur. Cytokine Network 11 2000 464 469
    • (2000) Eur. Cytokine Network , vol.11 , pp. 464-469
    • Ghezzi, P.1    Santo, E.D.2    Sacco, S.3    Foddi, C.4    Barbaccia, M.L.5    Mennini, T.6
  • 19
    • 0036322095 scopus 로고    scopus 로고
    • The clinical importance of adrenal insufficiency in acute hepatic dysfunction
    • R. Harry, G. Auzinger, and J. Wendon The clinical importance of adrenal insufficiency in acute hepatic dysfunction Hepatology 36 2002 395 402
    • (2002) Hepatology , vol.36 , pp. 395-402
    • Harry, R.1    Auzinger, G.2    Wendon, J.3
  • 20
    • 38349085880 scopus 로고    scopus 로고
    • Neurosteroids in the fetus and neonate: Potential protective role in compromised pregnancies
    • J.J. Hirst, H.K. Palliser, D.M. Yates, T. Yawno, and D.W. Walker Neurosteroids in the fetus and neonate: potential protective role in compromised pregnancies Neurochem. Int. 52 2008 602 610
    • (2008) Neurochem. Int. , vol.52 , pp. 602-610
    • Hirst, J.J.1    Palliser, H.K.2    Yates, D.M.3    Yawno, T.4    Walker, D.W.5
  • 22
    • 77952800717 scopus 로고    scopus 로고
    • Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
    • Hu, J., Zhang, Z., Shen, W.J., Azhar, S., 2010. Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutr. Metab. (Lond.) 1(7), 47.
    • (2010) Nutr. Metab. (Lond.) , vol.1 , Issue.7 , pp. 47
    • Hu, J.1    Zhang, Z.2    Shen, W.J.3    Azhar, S.4
  • 23
    • 0029562295 scopus 로고
    • Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain
    • Y. Itzhak, A. Roig-Cantisano, R.S. Dombro, and M.D. Norenberg Acute liver failure and hyperammonemia increase peripheral-type benzodiazepine receptor binding and pregnenolone synthesis in mouse brain Brain Res. 705 1995 345 348
    • (1995) Brain Res. , vol.705 , pp. 345-348
    • Itzhak, Y.1    Roig-Cantisano, A.2    Dombro, R.S.3    Norenberg, M.D.4
  • 24
    • 7644222090 scopus 로고    scopus 로고
    • Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension
    • R. Jalan, S.W. Olde Damink, N.E. Deutz, P.C. Hayes, and A. Lee Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension Gastroenterology 127 2004 1338 1346
    • (2004) Gastroenterology , vol.127 , pp. 1338-1346
    • Jalan, R.1    Olde Damink, S.W.2    Deutz, N.E.3    Hayes, P.C.4    Lee, A.5
  • 25
    • 65549138899 scopus 로고    scopus 로고
    • Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: Protective effect of hypothermia
    • W. Jiang, P. Desjardins, and R.F. Butterworth Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia J. Cereb. Blood Flow Metab. 29 2009 944 952
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 944-952
    • Jiang, W.1    Desjardins, P.2    Butterworth, R.F.3
  • 26
    • 0030611794 scopus 로고    scopus 로고
    • The involvement of ammonia with the mechanisms that enhance GABAergic neurotransmission in hepatic failure
    • V. (Felipo, S. (Grisolia, Plenum Press New York
    • E.A. Jones, and A.S. Basile The involvement of ammonia with the mechanisms that enhance GABAergic neurotransmission in hepatic failure V. (Felipo, S. (Grisolia, Advances in Cirrhosis, Hyperammonemia and Hepatic Encephalopathy 1997 Plenum Press New York 75 83
    • (1997) Advances in Cirrhosis, Hyperammonemia and Hepatic Encephalopathy , pp. 75-83
    • Jones, E.A.1    Basile, A.S.2
  • 27
    • 0029917867 scopus 로고    scopus 로고
    • Induction of peripheral-type benzodiazepine receptors in mouse brain following thioacetamide-induced acute liver failure
    • Y. Kadota, K. Inoue, R. Tokunaga, and S. Taketani Induction of peripheral-type benzodiazepine receptors in mouse brain following thioacetamide-induced acute liver failure Life Sci. 58 1996 953 959
    • (1996) Life Sci. , vol.58 , pp. 953-959
    • Kadota, Y.1    Inoue, K.2    Tokunaga, R.3    Taketani, S.4
  • 28
    • 0033932980 scopus 로고    scopus 로고
    • Flumazenil in the treatment of acute hepatic encephalopathy in cirrhotic patients: A double blind randomized placebo controlled study
    • M. Laccetti, G. Manes, G. Uomo, M. Lioniello, P.G. Rabitti, and A. Balzano Flumazenil in the treatment of acute hepatic encephalopathy in cirrhotic patients: a double blind randomized placebo controlled study Dig. Liver Dis. 32 2000 335 338
    • (2000) Dig. Liver Dis. , vol.32 , pp. 335-338
    • Laccetti, M.1    Manes, G.2    Uomo, G.3    Lioniello, M.4    Rabitti, P.G.5    Balzano, A.6
  • 29
    • 4444264038 scopus 로고    scopus 로고
    • PXR (NR1I2): Splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators
    • V. Lamba, K. Yasuda, J.K. Lamba, M. Assem, J. Davila, S. Strom, and E.G. Schuetz PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators Toxicol. Appl. Pharmacol. 199 2004 251 265
    • (2004) Toxicol. Appl. Pharmacol. , vol.199 , pp. 251-265
    • Lamba, V.1    Yasuda, K.2    Lamba, J.K.3    Assem, M.4    Davila, J.5    Strom, S.6    Schuetz, E.G.7
  • 31
    • 0032427875 scopus 로고    scopus 로고
    • Astroglial dysfunction in hepatic encephalopathy
    • M.D. Norenberg Astroglial dysfunction in hepatic encephalopathy Metab. Brain Dis. 13 1998 319 335
    • (1998) Metab. Brain Dis. , vol.13 , pp. 319-335
    • Norenberg, M.D.1
  • 32
    • 0030833288 scopus 로고    scopus 로고
    • The peripheral benzodiazepine receptor and neurosteroids in hepatic encephalopathy
    • M.D. Norenberg, Y. ltzhak, and A.S. Bender The peripheral benzodiazepine receptor and neurosteroids in hepatic encephalopathy Adv. Exp. Med. Biol. 420 1997 95 111
    • (1997) Adv. Exp. Med. Biol. , vol.420 , pp. 95-111
    • Norenberg, M.D.1    Ltzhak, Y.2    Bender, A.S.3
  • 33
    • 0026710093 scopus 로고
    • Interleukin-1-β and tumor necrosis factor-α increase peripheral-type benzodiazepine binding sites in cultured polygonal astrocytes
    • Y.J. Oh, J.W. Francis, G.J. Markelonis, and T.H. Oh Interleukin-1-β and tumor necrosis factor-α increase peripheral-type benzodiazepine binding sites in cultured polygonal astrocytes J. Neurochem. 58 1992 2131 2138
    • (1992) J. Neurochem. , vol.58 , pp. 2131-2138
    • Oh, Y.J.1    Francis, J.W.2    Markelonis, G.J.3    Oh, T.H.4
  • 34
    • 0036020325 scopus 로고    scopus 로고
    • Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines
    • A.A. Palmer, M.R. Moyer, J.C. Crabbe, and T.J. Phillips Initial sensitivity, tolerance and cross-tolerance to allopregnanolone- and ethanol-induced hypothermia in selected mouse lines Psychopharmacology (Berl.) 162 2002 313 322
    • (2002) Psychopharmacology (Berl.) , vol.162 , pp. 313-322
    • Palmer, A.A.1    Moyer, M.R.2    Crabbe, J.C.3    Phillips, T.J.4
  • 35
    • 35348973583 scopus 로고    scopus 로고
    • Downregulation of the 18-kDa translocator protein: Effects on the ammonia-induced mitochondrial permeability transition and cell swelling in cultured astrocytes
    • K.S. Panickar, A.R. Jayakumar, K.V. Rama Rao, and M.D. Norenberg Downregulation of the 18-kDa translocator protein: effects on the ammonia-induced mitochondrial permeability transition and cell swelling in cultured astrocytes Glia 55 2007 1720 1727
    • (2007) Glia , vol.55 , pp. 1720-1727
    • Panickar, K.S.1    Jayakumar, A.R.2    Rama Rao, K.V.3    Norenberg, M.D.4
  • 37
    • 77957748402 scopus 로고    scopus 로고
    • Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes
    • Rama Rao, K.V., Jayakumar, A.R., Tong, X., Alvarez, V.M., Norenberg, M.D., 2010. Marked potentiation of cell swelling by cytokines in ammonia-sensitized cultured astrocytes. J. Neuroinflamm. 13(7), 66.
    • (2010) J. Neuroinflamm. , vol.13 , Issue.7 , pp. 66
    • Rama Rao, K.V.1    Jayakumar, A.R.2    Tong, X.3    Alvarez, V.M.4    Norenberg, M.D.5
  • 39
    • 0034102769 scopus 로고    scopus 로고
    • Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure
    • C. Rose, A. Michalak, M. Pannunzio, N. Chatauret, A. Rambaldi, and R.F. Butterworth Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure Hepatology 31 2000 872 877
    • (2000) Hepatology , vol.31 , pp. 872-877
    • Rose, C.1    Michalak, A.2    Pannunzio, M.3    Chatauret, N.4    Rambaldi, A.5    Butterworth, R.F.6
  • 40
    • 0033198566 scopus 로고    scopus 로고
    • Neuroactive steroids: Mechanisms of action and neuropsychopharmacological perspectives
    • R. Rupprecht, and F. Holsboer Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives Trends Neurosci. 22 1999 410 416
    • (1999) Trends Neurosci. , vol.22 , pp. 410-416
    • Rupprecht, R.1    Holsboer, F.2
  • 41
    • 27144492341 scopus 로고    scopus 로고
    • The pathophysiologic basis of hepatic encephalopathy: Central role for ammonia and inflammation
    • D. Shawcross, and R. Jalan The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation Cell. Mol. Life Sci. 62 19-20 2005 2295 2304
    • (2005) Cell. Mol. Life Sci. , vol.62 , Issue.1920 , pp. 2295-2304
    • Shawcross, D.1    Jalan, R.2
  • 43
    • 0025041686 scopus 로고
    • Endogenous steroids and pathogenesis of hepatic encephalopathy
    • S.H. Zaman Endogenous steroids and pathogenesis of hepatic encephalopathy Lancet 336 1990 573 574
    • (1990) Lancet , vol.336 , pp. 573-574
    • Zaman, S.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.