The involvement of ammonia with the mechanisms that enhance gaba-ergic neurotransmission in hepatic failure

Advances in Experimental Medicine and Biology

Volumn 420, Issue , 1997, Pages 75-83

  Jones, E Anthony ^a   Basile, Anthony S ^b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; AMMONIA; 4 AMINOBUTYRIC ACID RECEPTOR; DIAZEPAM; NORDAZEPAM;

ANIMAL; BLOOD; HEPATIC ENCEPHALOPATHY; HUMAN; LIVER FAILURE; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; SYNAPTIC TRANSMISSION; AMMONIA BLOOD LEVEL; CONFERENCE PAPER; ELECTROPHYSIOLOGY; HYPERAMMONEMIA; INHIBITORY POSTSYNAPTIC POTENTIAL; LIGAND BINDING; NEUROTOXICITY; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL;

AMMONIA; ANIMALS; GAMMA-AMINOBUTYRIC ACID; HEPATIC ENCEPHALOPATHY; HUMANS; LIVER FAILURE; SYNAPTIC TRANSMISSION;

EID: 0030611794     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-5945-0_5     Document Type: Article

References (29)

1. G. Gabuzda, G.B Phillips, and C.S. Davidson, Reversible toxic manifestations in patients with cirrhosis of the liver given cation-exchange resins, New Engl. J. Med. 246:124 (1952).
2. D.F. Schafer and E.A. Jones, Hepatic encephalopathy and the γ-aminobutyric-acid neurotransmitter system. Lancet i:18 (1982).
3. A response in dissociated rat cortical neurons, Neurosci. Lett. 151:51 (1993).
4. A receptor complex by ammonia: implications for the pathogenesis of hyperammonemic syndromes, Brain Res. 720:35 (1996).
5. D.L. Coulter and R.J. Allen, Secondary hyperammonemia: A possible mechanism of valproate encephalopathy. Lancet i:1310 (1980).
6. D.B. Flannery, Y.E. Hsia, and B. Wolf, Current status of hyperammonemia syndromes, Hepatol. 2: 495 (1982).
7. F. Vergara, F. Plum, and T.E. Duffy, α-Ketoglutaramate: increased concentrations in the cerebrospinal fluid of patients in hepatic coma, Science 183:81 (1974).
8. L.T. Oei, J. Kuys, A.J.P. Lombarts, C. Goor, L.J. Endtz, Cerebrospinal fluid glutamine levels and EEG findings in patients with hepatic encephalopathy, Clin. Neurol. Neurosurg. 81:59 (1979).
9. H.O. Conn, and M.M. Lieberthal, The Hepatic Coma Syndromes and Lactulose. Williams & Wilkins, Baltimore, (1978).
10. J. Stahl, Studies of the blood ammonia in liver disease: Its diagnostic, prognostic and therapeutic significance. Ann. Int. Med. 58: 1 (1963).
11. H.O. Conn, Cirrhosis, in: Diseases of the Liver, L. Schiff and E.R. Schiff, eds., Lippincott, Philadelphia, (1987).
12. M. Ehrlich, F. Plum, and T.E. Duffy, Blood and brain ammonia concentrations after portacaval anastomosis: effects of acute ammonia loading, J. Neurochem. 34: 1538 (1980).
13. P. Opolon, Large-pore hemodialysis in fulminant hepatic failure, in: Artificial Liver Support, G. Brunner and F.W. Schmidt, eds., Springer Verlag, Berlin, (1980).
14. L. T. Webster and G.J. Gabuzda, Ammonium uptake by the extremities and brain in hepatic coma, J. Clin. Invest. 39:414 (1958).
15. A.H. Lockwood, R.D. Finn, J.A. Campbell, and T.B. Richman, Factors that affect the uptake of ammonia by the brain: the blood-brain pH gradient, Brain Res. 181:259 (1980)
16. 13N ammonia from blood to brain, Circ. Res. 48:913 (1981).
17. A.H. Lockwood, J.M. MacDonald, R.E. Reiman, A.S. Gelbard, J.S. Laughlin, T.E. Duffy, and F. Plum, The dynamics of ammonia metabolism in man: effects of liver disease and hyperammonemia, J. Clin. Invest. 63: 449 (1979).
18. B. Hindfelt, F. Plum and T.E. Duffy, Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts, J. Clin. Invest. 59:386 (1977).
19. R.F. Butterworth, Neurobiology of hepatic encephalopathy, Sem. Liver Dis. In press, (1996).
20. C. Torda, Ammonium ion content and electrical activity of the brain during the preconvulsive and convulsive phases induced by various convulsants. J. Pharm. Exp. Ther. 107: 197 (1953).
21. W. Raabe, Neurophysiology of ammonia intoxication, in: Hepatic Encephalopathy. Pathophysiology and Treatment, R.Butterworth and G. Pomier Layrargues, eds., Humana Press, Clifton, NJ, (1989).
22. H.D. Lux, Ammonium and chloride extrusion: Hyperpolarizing synaptic inhibition in spinal motoneurons, Science 173:555 (1971).
23. H.D. Lux, E. Loracher, and E. Neher, The action of ammonium on postsynaptic inhibition of cat spinal motoneurons, Exp. Brain Res., 11:431 (1970).
24. S.C. Pappas, P. Ferenci, D.F. Schafer, and E.A. Jones, Visual evoked potentials in a rabbit model of hepatic encephalopathy. II Comparison of hyperammonemic encephalopathy, postictal coma, and coma induced by synergistic neurotoxins, Gastroenterol. 86:546 (1984).
25. J.F. Iles and J.J.B. Jack, Ammonia: assessment of its action on postsynaptic inhibition as a cause of convulsions, Brain 103:555 (1983).
26. A.S. Basile, E.A. Jones, and P. Skolnick, The pathogenesis of hepatic encephalopathy: evidence for the involvement of benzodiazepine receptor ligands, Pharmacol. Rev. 43:27 (1991).
27. A.S. Basile, R. Hughes, P. Harrison, R. Murata, L. Pannel, E.A. Jones, R. Williams, and P. Skolnick, Brain concentrations of 1,4 benzodiazepines are elevated in patients with fulminant hepatic failure, New Engl. J. Med. 325: 473 (1991).
28. C. Yurdaydin, T.J. Walsh, H. Engler, J-H. Ha, Y. Li, E.A. Jones, and A.S. Basile, The role of gut bacteria in the accumulation of benzodiazepine receptor ligands in a rat model of hepatic encephalopathy, Brain Res. 679:42 (1995).
29. M.R. Ferreira, S.H. Gammal, and E.A. Jones, Hepatic encephalopathy: evidence of increased GABA-mediated neurotransmission in a rat model of fulminant hepatic failure, Hepato-Gastroenterol. In press (1996).