Nicotinic receptor alpha7 expression during tooth morphogenesis reveals functional pleiotropy

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Rogers, Scott W ^a,b   Gahring, Lorise C ^a,b  

^a GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUNGAROTOXIN RECEPTOR; CRE RECOMBINASE; DIPHTHERIA TOXIN; GREEN FLUORESCENT PROTEIN; NICOTINIC RECEPTOR;

AMELOBLAST; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL LINEAGE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ECTODERM; EMBRYO; EMBRYO PATTERN FORMATION; ENAMEL; EPITHELIUM HYPERPLASIA; GENE INACTIVATION; HOMOLOGOUS RECOMBINATION; INNERVATION; MESENCHYME CELL; MOLAR TOOTH; MORPHOGENESIS; MOUSE; NONHUMAN; PLEIOTROPY; PROTEIN EXPRESSION; PROTEIN FUNCTION; TOOTH DEVELOPMENT; ANIMAL; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HISTOLOGY; MESODERM; METABOLISM; TOOTH;

MUS;

ANIMALS; DENTAL ENAMEL; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKOUT TECHNIQUES; GENETIC PLEIOTROPY; MESODERM; MICE; MORPHOGENESIS; RECEPTORS, NICOTINIC; TOOTH;

EID: 84861584384     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036467     Document Type: Article

References (59)

1. Albuquerque EX, Pereira EF, Alkondon M, Rogers SW, (2009) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 89: 73-120.
2. Gahring LC, Rogers SW, (2005) Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells. Aaps J 7: E885-894.
3. Atluri P, Fleck MW, Shen Q, Mah SJ, Stadfelt D, et al. (2001) Functional nicotinic acetylcholine receptor expression in stem and progenitor cells of the early embryonic mouse cerebral cortex. Dev Biol 240: 143-156.
4. Thesleff I, Sharpe P, (1997) Signalling networks regulating dental development. Mech Dev 67: 111-123.
5. Thesleff I, (2003) Developmental biology and building a tooth. Quintessence Int 34: 613-620.
6. Tucker A, Sharpe P, (2004) The cutting-edge of mammalian development; how the embryo makes teeth. Nat Rev Genet 5: 499-508.
7. Jussila M, Thesleff I, (2012) Signaling Networks Regulating Tooth Organogenesis and Regeneration, and the Specification of Dental Mesenchymal and Epithelial Cell Lineages. Cold Spring Harb Perspect Biol.
8. Lumsden AG, (1988) Spatial organization of the epithelium and the role of neural crest cells in the initiation of the mammalian tooth germ. Development 103 Supplpp. 155-169.
9. Tucker AS, Sharpe PT, (1999) Molecular genetics of tooth morphogenesis and patterning: the right shape in the right place. J Dent Res 78: 826-834.
10. Jernvall J, Thesleff I, (2000) Reiterative signaling and patterning during mammalian tooth morphogenesis. Mech Dev 92: 19-29.
11. Fried K, Hildebrand C, (1982) Axon number and size distribution in the developing feline inferior alveolar nerve. J Neurol Sci 53: 169-180.
12. Mohamed SS, Atkinson ME, (1983) A histological study of the innervation of developing mouse teeth. J Anat 136: 735-749.
13. Fried K, Nosrat C, Lillesaar C, Hildebrand C, (2000) Molecular signaling and pulpal nerve development. Crit Rev Oral Biol Med 11: 318-332.
14. Kettunen P, Loes S, Furmanek T, Fjeld K, Kvinnsland IH, et al. (2005) Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Development 132: 323-334.
15. Moe K, Kettunen P, Kvinnsland IH, Luukko K, (2008) Development of the pioneer sympathetic innervation into the dental pulp of the mouse mandibular first molar. Arch Oral Biol 53: 865-873.
16. Rogers SW, Tvrdik P, Capecchi MR, Gahring LC, (2012) Ablation of the Nicotinic Receptor alpha7 Cell Lineage Produces Lumbosacral Spina Bifida That is Modified by Maternal Diet. Am J Med Genetics. In Press.
17. Gahring LC, Meyer EL, Rogers SW, (2003) Nicotine-induced neuroprotection against N-methyl-D-aspartic acid or beta-amyloid peptide occur through independent mechanisms distinguished by pro-inflammatory cytokines. J Neurochem 87: 1125-1136.
18. Workman MS, Leamy LJ, Routman EJ, Cheverud JM, (2002) Analysis of quantitative trait locus effects on the size and shape of mandibular molars in mice. Genetics 160: 1573-1586.
19. Leamy LJ, Workman MS, Routman EJ, Cheverud JM, (2005) An epistatic genetic basis for fluctuating asymmetry of tooth size and shape in mice. Heredity 94: 316-325.
20. Li Y, Suggs C, Wright JT, Yuan ZA, Aragon M, et al. (2008) Partial rescue of the amelogenin null dental enamel phenotype. J Biol Chem 283: 15056-15062.
21. Luukko K, Moe K, Sijaona A, Furmanek T, Hals Kvinnsland I, et al. (2008) Secondary induction and the development of tooth nerve supply. Ann Anat 190: 178-187.
22. Byers MR, Schatteman GC, Bothwell M, (1990) Multiple functions for NGF receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity. Development 109: 461-471.
23. Mitsiadis TA, Dicou E, Joffre A, Magloire H, (1992) Immunohistochemical localization of nerve growth factor (NGF) and NGF receptor (NGF-R) in the developing first molar tooth of the rat. Differentiation 49: 47-61.
24. Nosrat CA, Fried K, Lindskog S, Olson L, (1997) Cellular expression of neurotrophin mRNAs during tooth development. Cell Tissue Res 290: 569-580.
25. Loes S, Kettunen P, Kvinnsland H, Luukko K, (2002) Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibers. Anat Embryol (Berl) 205: 187-191.
26. Luukko K, Kvinnsland IH, Kettunen P, (2005) Tissue interactions in the regulation of axon pathfinding during tooth morphogenesis. Dev Dyn 234: 482-488.
27. Tsuzuki H, Kitamura H, (1991) Immunohistochemical analysis of pulpal innervation in developing rat molars. Arch Oral Biol 36: 139-146.
28. Fristad I, Heyeraas KJ, Kvinnsland I, (1994) Nerve fibres and cells immunoreactive to neurochemical markers in developing rat molars and supporting tissues. Arch Oral Biol 39: 633-646.
29. Hildebrand C, Fried K, Tuisku F, Johansson CS, (1995) Teeth and tooth nerves. Prog Neurobiol 45: 165-222.
30. Thesleff I, Jernvall J, (1997) The enamel knot: a putative signaling center regulating tooth development. Cold Spring Harb Symp Quant Biol 62: 257-267.
31. Thesleff I, Keranen S, Jernvall J, (2001) Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation. Adv Dent Res 15: 14-18.
32. Laurikkala J, Kassai Y, Pakkasjarvi L, Thesleff I, Itoh N, (2003) Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot. Dev Biol 264: 91-105.
33. Miletich I, Sharpe PT, (2003) Normal and abnormal dental development. Hum Mol Genet 12 Spec No 1: R69-73.
34. Thesleff I, (2006) The genetic basis of tooth development and dental defects. Am J Med Genet A 140: 2530-2535.
35. Picciotto MR, Caldarone BJ, Brunzell DH, Zachariou V, Stevens TR, et al. (2001) Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol Ther 92: 89-108.
36. Jones IW, Wonnacott S, (2005) Why doesn't nicotinic ACh receptor immunoreactivity knock out? Trends Neurosci 28: 343-345.
37. Simmer JP, Fincham AG, (1995) Molecular mechanisms of dental enamel formation. Crit Rev Oral Biol Med 6: 84-108.
38. Simmer JP, Papagerakis P, Smith CE, Fisher DC, Rountrey AN, et al. (2010) Regulation of dental enamel shape and hardness. J Dent Res 89: 1024-1038.
39. Simmer JP, Hu JC, (2002) Expression, structure, and function of enamel proteinases. Connect Tissue Res 43: 441-449.
40. Arredondo J, Nguyen VT, Chernyavsky AI, Bercovich D, Orr-Urtreger A, et al. (2003) Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis. Life Sci 72: 2063-2067.
41. Xu M, Scott JE, Liu KZ, Bishop HR, Renaud DE, et al. (2008) The influence of nicotine on granulocytic differentiation-inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release. BMC Cell Biol 9: 19.
42. Eastoe JE, (1979) Enamel protein chemistry-past, present and future. J Dent Res 58: 753-764.
43. Robinson RM, Taylor RE, Birkedal-Hansen H, (1984) Evidence for an extracellular plasmin-dependent proteolytic system in mineralizing matrices. Calcif Tissue Int 36: 31-38.
44. Smith CE, (1998) Cellular and chemical events during enamel maturation. Crit Rev Oral Biol Med 9: 128-161.
45. Shore RC, Robinson C, Kirkham J, Brookes SJ, (1995) The control of ingress of albumin into developing enamel from adjacent dentine of the rat incisor. Connect Tissue Res 33: 151-155.
46. Brunzell DH, Russell DS, Picciotto MR, (2003) In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice. J Neurochem 84: 1431-1441.
47. Gubbins EJ, Gopalakrishnan M, Li J, (2010) Alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells. Brain Res 1328: 1-11.
48. Li Q, Zhou XD, Kolosov VP, Perelman JM, (2011) Nicotine reduces TNF-alpha expression through a alpha7 nAChR/MyD88/NF-kB pathway in HBE16 airway epithelial cells. Cell Physiol Biochem 27: 605-612.
49. Arredondo J, Chernyavsky AI, Jolkovsky DL, Pinkerton KE, Grando SA, (2007) Receptor-mediated tobacco toxicity: alterations of the NF-kappaB expression and activity downstream of alpha7 nicotinic receptor in oral keratinocytes. Life Sci 80: 2191-2194.
50. Yoshikawa H, Kurokawa M, Ozaki N, Nara K, Atou K, et al. (2006) Nicotine inhibits the production of proinflammatory mediators in human monocytes by suppression of I-kappaB phosphorylation and nuclear factor-kappaB transcriptional activity through nicotinic acetylcholine receptor alpha7. Clin Exp Immunol 146: 116-123.
51. Trombino S, Cesario A, Margaritora S, Granone P, Motta G, et al. (2004) Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway. Cancer Res 64: 135-145.
52. Tulin S, Stathopoulos A, (2010) Extending the family table: Insights from beyond vertebrates into the regulation of embryonic development by FGFs. Birth Defects Res C Embryo Today 90: 214-227.
53. Xu W, Orr-Urtreger A, Nigro F, Gelber S, Sutcliffe CB, et al. (1999) Multiorgan autonomic dysfunction in mice lacking the beta2 and the beta4 subunits of neuronal nicotinic acetylcholine receptors. J Neurosci 19: 9298-9305.
54. Khan MA, Provenza DV, Seibel W, (1981) The effects of nicotine on mouse first molar tooth germs in organ culture. J Biol Buccale 9: 335-348.
55. Saad AY, (1991) Postnatal effects of nicotine on first molar development in the CD-1 mouse. Acta Anat (Basel) 140: 269-272.
56. Chowdhury IG, Bromage TG, (2000) Effects of fetal exposure to nicotine on dental development of the laboratory rat. Anat Rec 258: 397-405.
57. Ross RG, Stevens KE, Proctor WR, Leonard S, Kisley MA, et al. (2010) Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia. J Child Psychol Psychiatry 51: 535-549.
58. Nomikos GG, Schilstrom B, Hildebrand BE, Panagis G, Grenhoff J, et al. (2000) Role of alpha7 nicotinic receptors in nicotine dependence and implications for psychiatric illness. Behav Brain Res 113: 97-103.
59. Rajchgot H, Fathalli F, Rajchgot P, Menezes N, Joober R, et al. (2009) Decreased tooth size in schizophrenia. Schizophr Res 110: 194-196.