Synthesis of [11C]dehydropravastatin, a PET probe potentially useful for studying OATP1B1 and MRP2 transporters in the liver

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 12, 2012, Pages 3703-3709

  Ijuin, Ryosuke ^a   Takashima, Tadayuki ^a   Watanabe, Yasuyoshi ^a   Sugiyama, Yuichi ^b   Suzuki, Masaaki ^a  

^a RIKEN   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

C C Coupling; Positron emission tomography; Rapid reaction; Transporter

Indexed keywords

2 METHYL 3 (4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)ACRYLIC ACID; 2',3' DEHYDROPRAVASTATIN C 11; 3 [(TERT BUTYLDIMETHYLSILYL)OXY] 8 [2 [4 [(TERT BUTYLDIMETHYLSILYL)OXY] 6 OXOTETRAHYDRO 2H PYRAN 2 YL]ETHYL] 7 METHYL 1,2,3,7,8,8A HEXAHYDRONAPHTHALEN 1 YL 2 METHYL 3 (4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)ACRYLIC ACID; 3 [(TERT BUTYLDIMETHYLSILYL)OXY] 8 [2 [4 [(TERT BUTYLDIMETHYLSILYL)OXY] 6 OXOTETRAHYDRO 2H PYRAN 2 YL]ETHYL] 7 METHYL 1,2,3,7,8,8A HEXAHYDRONAPHTHALEN 1 YL 2 METHYLBUT 2 ENOATE; 3 HYDROXY 8 [2 (4 HYDROXY 6 OXOTETRAHYDRO 2H PYRAN 2 YL)ETHYL] 7 METHYL 1,2,3,7,8,8A HEXAHYDRONAPHTHALEN 1 YL 2 METHYLBUT 2 ENOATE; 3,5 DIHYDROXY 7 [6 HYDROXY 2 METHYL 8 [(2 METHYLBUT 2 ENOYL)OXY] 1,2,6,7,8,8A HEXAHYDRONAPHTHALEN 1 YL]HEPTANOATE; CARBON 11; DEHYDROPRAVASTATIN C 11; MEVINOLIN; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER P1B1; PALLADIUM; RADIOPHARMACEUTICAL AGENT; RIFAMPICIN; SIMVASTATIN; SODIUM 3,5 DIHYDROXY 7 [6 HYDROXY 2 METHYL 8 [(1 2 METHYLBUT 2 ENOYL)OXY] 1,2,6,7,8,8A HEXAHYDRONAPHTHALEN 1 YL]HEPTANOATE C 11; TERT BUTYL 2 METHYL 3 (4,4,5,5 TETRAMETHYL 1,3,2 DIOXABOROLAN 2 YL)ACRYLIC ACID; TERT BUTYL 2,3 DIBROMO 2 METHYLPROPANOIC ACID; TERT BUTYL 3 BROMO 2 METHYL ACRYLIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CROSS COUPLING REACTION; DEPROTECTION REACTION; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ISOTOPE LABELING; MALE; METHYLATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIATION DOSE DISTRIBUTION; RADIOACTIVITY; RADIOCHEMISTRY; RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; LIVER; MALE; ORGANIC ANION TRANSPORTERS; POSITRON-EMISSION TOMOGRAPHY; PRAVASTATIN; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84861575094     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.051     Document Type: Conference Paper

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