Synthesis and evaluation of [ 18F]Fluorobutyl ethacrynic amide: A potential PET tracer for studying glutathione transferase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 3998-4003

  Huang, Ho Lien ^a   Yeh, Chun Nan ^b   Chang, Kang Wei ^c   Chen, Jenn Tzong ^c   Lin, Kun Ju ^b   Chiang, Li Wu ^a   Jeng, Kee Ching ^d   Wang, Wei Ting ^e   Lim, Ken Hong ^e   Chen, Caleb Gonshen ^e   Lin, Kun I ^a,f   Huang, Ying Cheng ^b   Lin, Wuu Jyh ^c   Yen, Tzu Chen ^b   Yu, Chung Shan ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e MACKAY MEMORIAL HOSPITAL   (Taiwan)

^f CHANG BING SHOW CHWAN MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Cholangiocarcinoma; Cold spot; GST ; Imaging; Tumor

Indexed keywords

ETACRYNIC ACID; FLUORINE 18; FLUORINE 18 FLUROBUTYL ETHACRYNIC AMIDE; GLUTATHION TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE; TRACER; UNCLASSIFIED DRUG; AMIDE; DIAGNOSTIC AGENT; FLUORINE; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE ALPHA; ISOENZYME; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; DRUG CONJUGATION; DRUG PURITY; IN VIVO STUDY; LIVER; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RADIOACTIVITY; RAT; ANIMAL; BILE DUCT CARCINOMA; BILE DUCT TUMOR; CHEMICALLY INDUCED DISORDER; CHEMISTRY; INTRAHEPATIC BILE DUCT; METABOLISM; PATHOLOGY; SCINTISCANNING; SYNTHESIS; TISSUE DISTRIBUTION;

RATTUS;

AMIDES; ANIMALS; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CHOLANGIOCARCINOMA; FLUORINE RADIOISOTOPES; GLUTATHIONE; GLUTATHIONE TRANSFERASE; ISOENZYMES; LIVER; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; TISSUE DISTRIBUTION;

EID: 84861571409     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.091     Document Type: Article

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