Molecular recognition of Candida albicans (1→2)-β-mannan oligosaccharides by a protective monoclonal antibody reveals the immunodominance of internal saccharide residues

Journal of Biological Chemistry

Volumn 287, Issue 22, 2012, Pages 18078-18090

  Johnson, Margaret A ^a   Cartmell, Jonathan ^a   Weisser, Nina E ^b   Woods, Robert J ^b,c   Bundle, David R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RECOGNITION; CANDIDA ALBICANS; CHEMICAL MAPPING; COMPUTATIONAL STUDIES; FRAMESHIFT; GLOBAL MINIMA; GLYCOCONJUGATE VACCINES; GLYCOCONJUGATES; HELICAL CONFORMATION; IMMUNODOMINANCE; IMMUNODOMINANT EPITOPES; LIGAND INTERACTIONS; MINIMAL LENGTHS; MOLECULAR RECOGNITION PATTERN; OBSERVATION POINT; POLYCLONAL; REDUCING ENDS; SATURATION TRANSFER; SELF-CONSISTENT MODEL; STRONG BINDING; TETRASACCHARIDES;

ANTIGENS; CANDIDA; CHEMICAL MODIFICATION; MOLECULAR RECOGNITION; MONOCLONAL ANTIBODIES; OLIGOMERS; YEAST;

OLIGOSACCHARIDES;

BETA MANNAN OLIGOSACCHARIDE DERIVATIVE; CARBOHYDRATE; DISACCHARIDE; EPITOPE; GLYCOCONJUGATE; HAPTEN; MANNOSE OLIGOSACCHARIDE; MANNOSIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY C3.1; OLIGOMER; POLYCLONAL ANTIBODY; TRISACCHARIDE; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CANDIDA ALBICANS; CHEMICAL MODIFICATION; CONTROLLED STUDY; ENZYME CONFORMATION; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RABBIT;

ANTIBODIES, MONOCLONAL; CANDIDA ALBICANS; CARBOHYDRATE SEQUENCE; COMPUTER SIMULATION; IMMUNODOMINANT EPITOPES; MANNANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;

CANDIDA ALBICANS; MUS; ORYCTOLAGUS CUNICULUS;

EID: 84861566843     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.355578     Document Type: Article

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