DHEA administration and exercise training improves insulin resistance in obese rats

Nutrition and Metabolism

Volumn 9, Issue , 2012, Pages

  Sato, Koji ^a   Iemitsu, Motoyuki ^a   Aizawa, Katsuji ^b   Mesaki, Noboru ^c   Ajisaka, Ryuichi ^c   Fujita, Satoshi ^a  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b SENSHU UNIVERSITY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Exercise training; Insulin sensitivity; Obesity; Sex steroid hormone

Indexed keywords

ANDROSTANOLONE; GLUCOSE; INSULIN; PRASTERONE; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CARBOHYDRATE DIET; CONTROLLED STUDY; DIETARY INTAKE; DRUG MUSCLE LEVEL; EPIDIDYMIS FAT; EXERCISE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN SENSITIVITY CHECK INDEX; MALE; MUSCLE MASS; NONHUMAN; OBESITY; PROTEIN DETERMINATION; RAT; STEROIDOGENESIS; TREATMENT DURATION;

RATTUS; RATTUS NORVEGICUS;

EID: 84861536518     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-9-47     Document Type: Article

References (30)

1. Is dehydroepiandrosterone an antiobesity agent? Berdanier CD, Parente JA, McIntosh MK, FASEB J 1993 7 414 419 8462783 (Pubitemid 23108555)
2. Anti-obesity effect of two different levels of dehydroepiandrosterone in lean and obese middle-aged female Zucker rats. Cleary MP, Zisk JF, Int J Obes 1986 10 193 204 2944850 (Pubitemid 16048554)
3. Dehydroepiandrosterone-sulfate (DHEAS) reduces adipocyte hyperplasia associated with feeding rats a high-fat diet. Lea-Currie YR, Wen P, McIntosh MK, Int J ObesRelatMetabDisord 1997 21 1058 1064 (Pubitemid 27462412)
4. Androgens, insulin resistance and vascular disease in men. Kapoor D, Malkin CJ, Channer KS, Jones TH, Clinical Endocrinology 2005 63 239 250 10.1111/j.1365-2265.2005.02299.x 16117808 (Pubitemid 41233438)
5. Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats. Aizawa K, Iemitsu M, Otsuki T, Maeda S, Miyauchi T, Mesaki N, J Appl Physiol 2008 104 67 74 10.1007/s00421-008-0780-0 17975125
6. Acute exercise activates local bioactive androgen metabolism in skeletal muscle. Aizawa K, Iemitsu M, Maeda S, Otsuki T, Sato K, Ushida T, Mesaki N, Akimoto T, Steroids 2010 75 219 223 10.1016/j.steroids.2009.12.002 20045012
7. DHEA improves impaired activation of Akt and PKC /-GLUT4 pathway in skeletal muscle and improves hyperglycaemia in streptozotocin-induced diabetes rats. Sato K, Iemitsu M, Aizawa K, Ajisaka R, Acta Physiol 2009 197 217 225 10.1111/j.1748-1716.2009.02011.x
8. Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice. Coleman DL, Leiter EH, Schwizer RW, Diabetes 1982 31 830 833 10.2337/diabetes.31.9.830 6219024 (Pubitemid 12062875)
9. Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetes-obesity mutants and in aged normal mice. Coleman DL, Schwizer RW, Leiter EH, Diabetes 1984 33 26 32 10.2337/diabetes.33.1.26 6228478 (Pubitemid 14187198)
10. Effect of dehydroepiandrosterone on body weight and food intake in rats. Cleary MP, Shephard A, Zisk J, Schwartz A, NutrBehav 1983 1 127 136 (Pubitemid 14099694)
11. Increased lipolysis to beta-adrenergic stimulation after dehydroepiandrosterone treatment in rats. Tagliaferro AR, Ronan AM, Payne J, Meeker LD, Tse S, Am J Physiol 1995 268 1374 R1380 7611511
12. Effect of short-term DHEA administration on liver metabolism of lean and obese rats. Mohan PF, Cleary MP, Am J Physiol 1988 255 2 E8
13. Effects of dehydroepiandrosterone treatment in rats with diet-induced obesity. Mohan PF, Ihnen JS, Levin BE, Cleary MP, J Nutr 1990 120 1103 1114 2144587 (Pubitemid 20306074)
14. Holloszy JO.DHEA treatment reduces fat accumulation and protects against insulin resistance in male rats.J Gerontol A BiolSci. Han DH, Hansen PA, Chen MM, Med Sci 1998 53 19 24
15. Fasting-induced hepatic production of DHEA is regulated by PGC-1[alpha], ERR[alpha], and HNF4 [alpha]. Grasfeder LL, Gaillard S, Hammes SR, Ilkayeva O, Newgard CB, Hochberg RB, Dwyer MA, Chang CY, McDonnell DP, Mol Endocrinol 2009 23 1171 1182 10.1210/me.2009-0024 19389810
16. Biosynthesis and action of neurosteroids. Mellon SH, Griffin LD, Compagnone NA, Brain Res Rev 2001 37 3 12 10.1016/S0165-0173(01)00109-6 11744070 (Pubitemid 34020717)
17. Production of sex steroid hormones from DHEA in articular chondrocyte of rats. Takeuchi S, Mukai N, Tateishi T, Miyakawa S, Am J Physiol 2007 293 410 E415
18. Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle. Sato K, Iemitsu M, Aizawa K, Ajisaka R, Am J Physiol 2008 294 961 E968
19. Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats. Commerford SR, Ferniza JB, Bizeau ME, Thresher JS, Willis WT, Pagliassotti MJ, Am J Physiol 2002 283 545 E555
20. Dietary n-3 polyunsaturated fatty acids decrease hepatic triglycerides in Fischer 344 rats. Levy JR, Clore JN, Stevens W, Hepatology 2004 39 608 616 10.1002/hep.20093 14999679 (Pubitemid 38337640)
21. QUICKI is a useful index of insulin sensitivity in subjects with hypertension. Chen H, Sullivan G, Yue LQ, Katz A, Quon MJ, Am J Physiol 2003 4 804 E812
22. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ, J clin Endocrinol Metab 2000 85 2402 2410 10.1210/jc.85.7.2402 10902785 (Pubitemid 32269192)
23. Effects of AICAR and exercise on insulin-stimulated glucose uptake, signalling, and GLUT4 content in rat muscles. Jessen N, Pold R, Buhl ES, Jensen LS, Schmitz O, Lund S, J Appl Physiol 2003 94 1373 1379 12496137 (Pubitemid 36348812)
24. Interactive effect of exercise training and growth hormone administration on glucose tolerance and muscle GLUT4 protein expression in rats. Hou CW, Chou SW, Ho HY, Lee WC, Lin CH, Kuo CH, J Biomed Sci 2003 10 689 696 10.1007/BF02256320 14631107
25. Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinaemia. Yamaguchi Y, Tanaka S, Yamakawa T, Kimura M, Ukawa K, Yamada Y, Ishihara M, Sekihara H, Clin Endocrinol 1998 49 377 383 10.1046/j.1365-2265. 1998.00533.x (Pubitemid 28448949)
26. Ageing, exercise and food restriction: effects on skeletal glucose uptake. Ivy JL, Young JC, Craig BW, Kohrt WM, Holloszy JO, Mech Ageing Dev 1991 61 123 133 10.1016/0047-6374(91)90011-N 1824119
27. Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity. Sanchez J, Heredia FP, Priego T, Portillo MP, Zamora S, Garaulet M, Palou A, J Nutr Biochem 2008 19 809 818 10.1016/j.jnutbio.2007.10. 005 18482832
28. Dehydroepiandrosterone replacement in health men with age-related decline of DHEA-S: effects of fat distribution, insulin sensitivity and lipid metabolism. Jedrzejuk D, Medras M, Milewicz A, Demissie M, Aging male 2003 6 151 156 14628495 (Pubitemid 37411885)
29. Effect of DHEA on abdominal fat and insulin action in elderly women and men. Villareal DT, Hollszy JO, JAMA 2004 292 2243 2248 10.1001/jama.292.18.2243 15536111 (Pubitemid 39473162)
30. DHEA in elderly women and DHEA or testosterone in elderly men. Nair KS, Rizza RA, O'Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton LJ, Smith GE, Khosla S, Jensen MD, N Engl J Med 2006 355 1647 1659 10.1056/NEJMoa054629 17050889 (Pubitemid 44583955)