Interactive effect of exercise training and growth hormone administration on glucose tolerance and muscle GLUT4 protein expression in rats

Journal of Biomedical Science

Volumn 10, Issue 6 II, 2003, Pages 689-696

  Hou, Chien Wen ^a   Chou, Shih Wei ^b   Ho, Hsin Yi ^a   Lee, Wen Chih ^a   Lin, Ching Hung ^a   Kuo, Chia Hua ^a  

^a UNIVERSITY OF TAIPEI   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Citrate synthase; Glycogen; Insulin resistance; Skeletal muscle; Type 2 diabetes

Indexed keywords

CITRATE SYNTHASE; GLUCOSE TRANSPORTER 4; GLYCOGEN; GROWTH HORMONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXERCISE; GASTROCNEMIUS MUSCLE; GLUCOSE TOLERANCE; GLYCOGEN MUSCLE LEVEL; GLYCOGEN SYNTHESIS; HORMONE ACTION; INJECTION; INSULIN RESISTANCE; INSULIN RESPONSE; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PLANTARIS MUSCLE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CITRATE (SI)-SYNTHASE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 4; GLYCOGEN; GROWTH HORMONE; HOMEOSTASIS; INSULIN RESISTANCE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0348048853     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000073955     Document Type: Article

References (28)

1. Adamson U, Cerasi E. Acute effects of exogenous GH in man: Time- and dose-bound modification of glucose tolerance and glucose-induced insulin release. Acta Endocrinol 80:247-261;1975.
2. Baron AD, Brechtel G, Wallace P, Edelman SV. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol 255:E769-E774;1988.
3. Brozinick JT, Etgen GJ, Yaspelkis BB, Kang HY, Ivy JL. Effects of exercise training on muscle GLUT-4 protein content and translocation in obese Zucker rats. Am J Physiol 265:E419-E427;1993.
4. Cameron CM, Kostyo JL, Adamafio NA, Dunbar JC. Metabolic basis for the diabetogenic action of growth hormone in the obese (ob/ob) mouse. Endocrinology 120:1568-1575;1987.
5. Cartee GD, Bohn EE. Growth hormone reduces glucose transport but not GLUT-1 or GLUT-4 in adult and old rats. Am J Physiol 268:E902-E909;1995.
6. Cartee GD, Bohn EE, Gibson BT, Farrar RP. Growth hormone supplementation increases skeletal muscle mass of old male Fischer 344/brown Norway rats. J Gerontol A Biol Sci Med Sci 51:B214-B219;1996.
7. Cortez MY, Torgan CE, Brozinick JT, Ivy JL. Insulin resistance of obese Zucker rats exercise trained at two different intensities. Am J Physiol 261:E613-E619;1991.
8. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000-1007;1981.
9. Dimitriadis G, Parry-Billings M, Leighton B, Piva T, Dunger D, Calder P, Bond J, Newsholme E. Studies on the effects of GH administration in vivo on the rates of glucose transport and utilization in rat skeletal muscle. Eur J Clin Invest 24:161-165;1994.
10. Henwood MJ, Grimberg A, Moshang T. Expanded spectrum of recombinant human growth hormone therapy. Curr Opin Pediatr 14:437-442;2002.
11. Hettiarachchi M, Watkinson A, Jenkins AB, Theos V, Ho KK, and Kraegen EW. GH-induced insulin resistance and its relationship to lipid availability in the rat. Diabetes 45:415-421;1996.
12. Holloszy JO, Schultz J, Kusnierkiewicz J, Hagberg JM, Ehsani AA. Effects of exercise on glucose tolerance and insulin resistance. Brief review and some preliminary results. Acta Medica Scand 711(suppl):55-65;1986.
13. Husbands S, Ong KK, Gilbert J, Wass JA, Dunger DB. Increased insulin sensitivity in young, growth hormone deficient children. Clin Endocrinol 55:87-92;2001.
14. Ivy JL, Zderic TW, Fogt DL. Prevention and treatment of non-insulin-dependent diabetes mellitus. Exerc Sport Sci Rev 27:1-35;1999.
15. Jorgensen JO, Vahl N, Hansen TB, Thuesen L, Hagen C, Christiansen JS. Growth hormone versus placebo treatment for one year in growth hormone deficient adults: increase in exercise capacity and normalization of body composition. Clin Endocrinol 45:681-688;1996.
16. Kraegen EW, Storlien LH, Jenkins AB, James DE. Chronic exercise compensates for insulin resistance induced by a high-fat diet in rats. Am J Physiol 256:E242-E249;1989.
17. Kuo CH, Browning KS, Ivy JL. Regulation of GLUT4 protein expression and glycogen storage after prolonged exercise. Acta Physiol Scand 165:193-201;1999.
18. MacLean PS, Zheng D, Dohm GL. Muscle glucose transporter (GLUT 4) gene expression during exercise. Exerc Sport Sci Rev 28:148-152;2000.
19. Marshall BA, Mueckler MM. Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice. Am J Physiol 267:E738-E744;1994.
20. Olson AL, Pessin JE. Structure, function, and regulation of the mammalian facilitative glucose transporter gene family. Annu Rev Nutr 16:235-256;1996.
21. Reaven GM, Ho H, Hoffman BB. Attenuation of fructose-induced hypertension in rats by exercise training. Hypertension 12:129-132;1988.
22. Rosenfalck AM, Fisker S, Hilsted J, Dinesen B, Volund A, Jorgensen JO, Christiansen JS, Madsbad S. The effect of the deterioration of insulin sensitivity on beta-cell function in growth-hormone-deficient adults following 4-month growth hormone replacement therapy. Growth Hormone Igf Res 9:96-105;1999.
23. Srere PA. Citrate synthase. Methods Enzymol 230:946-950;1969.
24. Tsao TS, Burcelin R, Katz EB, Huang L, Charron MJ. Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle. Diabetes 45:28-36;1996.
25. Winder WW. Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J Appl Physiol 91:1017-1028;2001.
26. Zachwieja JJ, Toffolo G, Cobelli C, Bier DM, Yarasheski KE. Resistance exercise and growth hormone administration in older men: Effects on insulin sensitivity and secretion during a stable-label intravenous glucose tolerance test. Metabol Clin Exp 45:254-260;1996.
27. Zhao FQ, Moseley WM, Tucker HA, Kennelly JJ. Regulation of glucose transporter gene expression in mammary gland, muscle, and fat of lactating cows by administration of bovine growth hormone and bovine growth hormone-releasing factor. J Anim Sci 74:183-189;1996.
28. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med 6:924-928;2000.