Acute exercise activates local bioactive androgen metabolism in skeletal muscle

Steroids

Volumn 75, Issue 3, 2010, Pages 219-223

  Aizawa, Katsuji ^a   Iemitsu, Motoyuki ^b   Maeda, Seiji ^c   Otsuki, Takeshi ^d   Sato, Koji ^c   Ushida, Takashi ^a   Mesaki, Noboru ^e   Akimoto, Takayuki ^a,f  

^a UNIVERSITY OF TOKYO   (Japan)

^b International Pacific University   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d ST CATHERINE UNIVERSITY   (Japan)

^e Teikyo Heisei University   (Japan)

^f WASEDA UNIVERSITY   (Japan)

Author keywords

5 reductase; Acute exercise; Androgen receptor; Dihydrotestosterone; Skeletal muscle; Testosterone

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; PRASTERONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ANDROGEN METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; FEMALE; HORMONE BLOOD LEVEL; MALE; MUSCLE LEVEL; NONHUMAN; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE; SKELETAL MUSCLE; TESTOSTERONE BLOOD LEVEL;

ANDROGENS; ANIMALS; DEHYDROEPIANDROSTERONE; DIHYDROTESTOSTERONE; FEMALE; MALE; MUSCLE, SKELETAL; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; TESTOSTERONE; TESTOSTERONE 5-ALPHA-REDUCTASE;

RATTUS;

EID: 76349111558     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2009.12.002     Document Type: Article

References (32)

1. Mooradian A.D., Morley J.E., and Korenman S.G. Biological actions of androgens. Endocr Rev 8 (1987) 1-28
2. Ramamani A., Aruldhas M.M., and Govindarajulu P. Impact of testosterone and oestradiol on region specificity of skeletal muscle-ATP, creatine phosphokinase and myokinase in male and female Wistar rats. Acta Physiol Scand 166 (1999) 91-97
3. Van Der Eerden B.C., Van De Ven J., Lowik C.W., Wit J.M., and Karperien M. Sex steroid metabolism in the tibial growth plate of the rat. Endocrinology 143 (2002) 4048-4055
4. Vianello S., Waterman M.R., Dalla Valle L., and Colombo L. Developmentally regulated expression and activity of 17alpha-hydroxylase/C-17,20-lyase cytochrome P450 in rat liver. Endocrinology 138 (1997) 3166-3174
5. Zwain I.H., and Yen S.S. Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology 140 (1999) 3843-3852
6. Aizawa K., Iemitsu M., Maeda S., Jesmin S., Otsuki T., Mowa C.N., Miyauchi T., and Mesaki N. Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats. Am J Physiol Endocrinol Metab 292 (2007) 577-584
7. Kraemer W.J., Gordon S.E., Fleck S.J., Marchitelli L.J., Mello R., Dziados J.E., Friedl K., Harman E., Maresh C., and Fry A.C. Endogenous anabolic hormonal and growth factor responses to heavy resistance exercise in males and females. Int J Sports Med 12 (1991) 228-235
8. Simpson E.R. Sources of estrogen and their importance. J Steroid Biochem Mol Biol 86 (2003) 225-230
9. Bruchovsky N., and Wilson J.D. The intranuclear binding of testosterone and 5-alpha-androstan-17-beta-ol-3-one by rat prostate. J Biol Chem 243 (1968) 5953-5960
10. Hiipakka R.A., and Liao S. Molecular mechanism of androgen action. Trends Endocrinol Metab 9 (1998) 317-324
11. Russell D.W., and Wilson J.D. Steroid 5 alpha-reductase: two genes/two enzymes. Annu Rev Biochem 63 (1994) 25-61
12. Normington K., and Russell D.W. Tissue distribution and kinetic characteristics of rat steroid 5 alpha-reductase isozymes. Evidence for distinct physiological functions. J Biol Chem 267 (1992) 19548-19554
13. Wigley W.C., Prihoda J.S., Mowszowicz I., Mendonca B.B., New M.I., Wilson J.D., and Russell D.W. Natural mutagenesis study of the human steroid 5 alpha-reductase 2 isozyme. Biochemistry 33 (1994) 1265-1270
14. George F.W., and Noble J.F. Androgen receptors are similar in fetal and adult rabbits. Endocrinology 115 (1984) 1451-1458
15. Antonio J., Wilson J.D., and George F.W. Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles. J Appl Physiol 87 (1999) 2016-2019
16. Yoshioka M., Boivin A., Ye P., Labrie F., and St-Amand J. Effects of dihydrotestosterone on skeletal muscle transcriptome in mice measured by serial analysis of gene expression. J Mol Endocrinol 36 (2006) 247-259
17. Akimoto T., Pohnert S.C., Li P., Zhang M., Gumbs C., Rosenberg P.B., Williams R.S., and Yan Z. Exercise stimulates PGC-1α transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem 280 (2005) 19587-19593
18. Alessio H.M., and Goldfarb A.H. Lipid peroxidation and scavenger enzymes during exercise: adaptive response to training. J Appl Physiol 64 (1988) 1333-1336
19. Staron R.S., Leonardi M.J., Karapondo D.L., Malicky E.S., Falkel J.E., Hagerman F.C., and Hikida R.S. Strength and skeletal muscle adaptations in heavy-resistance-trained women after detraining and retraining. J Appl Physiol 70 (1991) 631-640
20. Willoughby D.S., and Taylor L. Effects of sequential bouts of resistance exercise on androgen receptor expression. Med Sci Sports Exerc 36 (2004) 1499-1506
21. Sinha-Hikim I., Roth S.M., Lee M.I., and Bhasin S. Testosterone-induced muscle hypertrophy is associated with an increase in satellite cell number in healthy, young men. Am J Physiol Endocrinol Metab 285 (2003) 197-205
22. Storer T.W., Magliano L., Woodhouse L., Lee M.L., Dzekov C., Dzekov J., Casaburi R., and Bhasin S. Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. J Clin Endocrinol Metab 88 (2003) 1478-1485
23. Tremblay M.S., Copeland J.L., and Van Helder W. Effect of training status and exercise mode on endogenous steroid hormones in men. J Appl Physiol 96 (2004) 531-539
24. Cureton K.J., Collins M.A., Hill D.W., and McElhannon Jr. F.M. Muscle hypertrophy in men and women. Med Sci Sports Exerc 20 (1988) 338-344
25. Staron R.S., Karapondo D.L., Kraemer W.J., Fry A.C., Gordon S.E., Falkel J.E., Hagerman F.C., and Hikida R.S. Skeletal muscle adaptations during early phase of heavy-resistance training in men and women. J Appl Physiol 76 (1994) 1247-1255
26. Kraemer W.J., Fleck S.J., Dziados J.E., Harman E.A., Marchitelli L.J., Gordon S.E., Mello R., Frykman P.N., Koziris L.P., and Triplett N.T. Changes in hormonal concentrations after different heavy-resistance exercise protocols in women. J Appl Physiol 75 (1993) 594-604
27. Aizawa K., Iemitsu M., Otsuki T., Maeda S., Miyauchi T., and Mesaki N. Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats. J Appl Physiol 104 (2008) 67-74
28. Vingren J.L., Kraemer W.J., Hatfield D.L., Anderson J.M., Volek J.S., Ratamess N.A., Thomas G.A., Ho J.Y., Fragala M.S., and Maresh C.M. Effect of resistance exercise on muscle steroidogenesis. J Appl Physiol 105 (2008) 1754-1760
29. Iemitsu M., Maeda S., Jesmin S., Otsuki T., Kasuya Y., and Miyauchi T. Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise. J Appl Physiol 101 (2006) 151-163
30. Watanabe N., Kamei S., Ohkubo A., Yamanaka M., Ohsawa S., Makino K., and Tokuda K. Urinary protein as measured with a pyrogallol red-molybdate complex, manually and in a Hitachi 726 automated analyzer. Clin Chem 32 (1986) 1551-1554
31. Mora G.R., Prins G.S., and Mahesh V.B. Autoregulation of androgen receptor protein and messenger RNA in rat ventral prostate is protein synthesis dependent. J Steroid Biochem Mol Biol 58 (1996) 539-549
32. Hawkins V.N., Foster-Schubert K., Chubak J., Sorensen B., Ulrich C.M., Stancyzk F.Z., Plymate S., Stanford J., White E., Potter J.D., and McTiernan A. Effect of exercise on serum sex hormones in men: a 12-month randomized clinical trial. Med Sci Sports Exerc 40 (2008) 223-233