Exposure of flight attendants to pyrethroid insecticides on commercial flights: Urinary metabolite levels and implications

International Journal of Hygiene and Environmental Health

Volumn 215, Issue 4, 2012, Pages 465-473

  Wei, Binnian ^a   Mohan, Krishnan R ^a   Weisel, Clifford P ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

3 PBA; Disinsection; Flight attendant; Metabolite; Permethrin; Pesticide; Pyrethroid

Indexed keywords

INSECTICIDE; PYRETHROID;

ADOLESCENT; ADULT; AGED; AIR POLLUTANT; AIRCRAFT; ARTICLE; ASIA; AUSTRALIA; COMMERCIAL PHENOMENA; ENVIRONMENTAL MONITORING; EUROPE; HUMAN; INDOOR AIR POLLUTION; METHODOLOGY; MIDDLE AGED; NORTH AMERICA; OCCUPATIONAL EXPOSURE; STATISTICS; TRAVEL; URINE;

ADOLESCENT; ADULT; AGED; AIR POLLUTANTS; AIR POLLUTION, INDOOR; AIRCRAFT; ASIA; AUSTRALIA; COMMERCE; ENVIRONMENTAL MONITORING; EUROPE; HUMANS; INSECTICIDES; MIDDLE AGED; NORTH AMERICA; OCCUPATIONAL EXPOSURE; PYRETHRINS; TRAVEL; YOUNG ADULT;

EID: 84861526590     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2011.08.006     Document Type: Article

References (45)

1. AbouDonia M.B., Wilmarth K.R., Jensen K.F., Oehme F.W., Kurt T.L. Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET, and permethrin: Implications of Gulf War chemical exposures. J. Toxicol. Environ. Health 1996, 48(1):35-56.
2. AQIS/MAFBNZ, 2010. Schedule of aircraft disinsection procedures. Available from: (accessed 21.03.11). http://www.daff.gov.au/aqis/avm/aircraft/disinsection/procedures.
3. Arcury T.A., Grzywacz J.G., Barr D.B., Tapia J., Chen H.Y., Quandt S.A. Pesticide urinary metabolite levels of children in eastern North Carolina farm worker households. Environ. Health Perspect. 2007, 115(8):1254-1260.
4. Barr D.B., Olsson A.O., Wong L.Y., Udunka S., Baker S.E., Whitehead R.D., et al. Urinary concentrations of metabolites of pyrethroid insecticides in the general US population: national health and nutrition examination survey 1999-2002. Environ. Health Perspect. 2010, 118(6):742-748.
5. Berkowitz G.S., Obel J., Deych E., Lapinski R., Godbold J., Liu Z.S., et al. Exposure to indoor pesticides during pregnancy in a multiethnic, urban cohort. Environ. Health Perspect. 2003, 111(1):79-84.
6. Bjorling-Poulsen M., Andersen H.R., Grandjean P. Potential developmental neurotoxicity of pesticides used in Europe. Environ. Health 2008, 7:50.
7. Chen H.Y., Xiao J.G., Hu G., Zhou J.W., Xiao H., Wang X.R. Estrogenicity of organophosphorus and pyrethroid pesticides. J. Toxicol. Environ. Health A 2002, 65(19):1419-1435.
8. Clark J.M., Symington S.B. Pyrethroid action on calcium channels: neurotoxicological implications. Invert. Neurosci. 2007, 7(1):3-16.
9. DeMicco A., Cooper K.R., Richardson J.R., White L.A. Developmental neurotoxicity of pyrethroid insecticides in zebrafish embryos. Toxicol. Sci. 2010, 113(1):177-186.
10. Eadsforth C.V., Bragt P.C., Vansittert N.J. Human dose-excretion studies with pyrethroid insecticides cypermethrin and alphacypermethrin-relevance for biological monitoring. Xenobiotica 1988, 18(5):603-614.
11. Gratz N.G., Steffen R., Cocksedge W. Why aircraft disinsection?. Bull. World Health Organ. 2000, 78(8):995-1004.
12. Hardt J., Angerer J. Biological monitoring of workers after the application of insecticidal pyrethroids. Int. Arch. Occup. Environ. Health 2003, 76(7):492-498.
13. Heudorf U., Angerer J. Metabolites of pyrethroid insecticides in urine specimens: current exposure in an urban population in Germany. Environ. Health Perspect. 2001, 109(3):213-217.
14. Heudorf U., Angerer J., Drexler H. Current internal exposure to pesticides in children and adolescents in Germany: urinary levels of metabolites of pyrethroid and organophosphorus insecticides. Int. Arch. Occup. Environ. Health 2004, 77(1):67-72.
15. Hornung R.W., Reed D.L. Estimation of average concentration in the presence of nondetectable values. Appl. Occup. Environ. Hyg. 1990, 5:46-51.
16. Kakko I., Toimela T., Tahti H. The toxicity of pyrethroid compounds in neural cell cultures studied with total ATP, mitochondrial enzyme activity and microscopic photographing. Environ. Toxicol. Pharmacol. 2004, 15(2-3):95-102.
17. Kim I.Y., Shin J.H., Kim H.S., Lee S.J., Kang I.H., Kim T.S., et al. Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assays. J. Reprod. Dev. 2004, 50(2):245-255.
18. Kolmodin-Hedman B., Swensson A., Akerblom M. Occupational exposure to some synthetic pyrethroids (permethrin and fenvalerate). Arch. Toxicol. 1982, 50:27-33.
19. Leng G., Kuhn K.H., Idel H. Biological monitoring of pyrethroids in blood and pyrethroid metabolites in urine: applications and limitations. Sci. Total Environ. 1997, 199(1-2):173-181.
20. Leng G., Leng A., Kuhn K.H., Lewalter J., Pauluhn J. Human dose-excretion studies with the pyrethroid insecticide cyfluthrin: urinary metabolite profile following inhalation. Xenobiotica 1997, 27(12):1273-1283.
21. Mohan K.R., Weisel C.P. Sampling scheme for pyrethroids on multiple surfaces on commercial aircrafts. J. Expo. Anal. Environ. Epidemiol. 2010, 20(4):320-325.
22. Murawski J. Insecticide use in occupied areas of aircraft. Handbook of Environmental Chemistry 2005, vol. 4 (H). Springer-Verlag, Berlin, Germany, pp. 169-190.
23. Naeher L.P., Tulve N.S., Egeghy P.P., Barr D.B., Adetona O., Fortmann R.C., et al. Organophosphorus and pyrethroid insecticide urinary metabolite concentrations in young children living in a southeastern United States city. Sci. Total Environ. 2010, 408(5):1145-1153.
24. Narahashi T. Neurophysiological effects of insecticides. Handbook of Pesticide Toxicology. Vol. 1: Principles 2001, 335-350. Academic Press, San Diego. R. Krieger, J. Doull, D. Ecobichon (Eds.).
25. OSTPXWEB, 2010. Aircraft disinsection requirements. The Safety and Health Team of the U.S. Department of Transportation. Available from: (accessed 21.03.11). http://ostpxweb.dot.gov/policy/safetyenergyenv/disinsection.htm.
26. Panuwet P., Prapamontol T., Chantara S., Barr D.B. Urinary pesticide metabolites in school students from northern Thailand. Int. J. Hyg. Environ. Health 2009, 212(3):288-297.
27. Ray D.E., Fry J.R. A reassessment of the neurotoxicity of pyrethroid insecticides. Pharmacol. Ther. 2006, 111(1):174-193.
28. Rayman R.B. Aircraft disinsection. Aviat. Space Environ. Med. 2006, 77(7):733-736.
29. Repetto R., Baliga S.S. Pesticides and immunosuppression: the risks to public health. Health Policy Plann. 1997, 12(2):97-106.
30. Sams C., Jones K. Human volunteer studies investigating the potential for toxicokinetic interactions between the pesticides deltamethrin; pirimicarb and chlorpyrifos-methyl following oral exposure at the acceptable daily intake. Toxicol. Lett. 2011, 200(1-2):41-45.
31. Schettgen T., Heudorf U., Drexler H., Angerer E. Pyrethroid exposure of the general population-is this due to diet?. Toxicol. Lett. 2002, 134(1-3):141-145.
32. Schettgen T., Koch H.M., Drexler H., Angerer J. New gas chromatographic-mass spectrometric method for the determination of urinary pyrethroid metabolites in environmental medicine. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2002, 778(1-2):21-130.
33. Shafer T.J., Meyer D.A. Effects of pyrethroids on voltage-sensitive calcium channels: a critical evaluation of strengths, weaknesses, data needs, and relationship to assessment of cumulative neurotoxicity. Toxicol. Appl. Pharmacol. 2004, 196(2):303-318.
34. Shafer T.J., Meyer D.A., Crofton K.M. Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs. Environ. Health Perspect. 2005, 113(2):123-136.
35. Smith A.J. Cabin air quality in aircraft: what is the problem. What is being done or what can be done about it? Who can do it and how?. J. Air Law Comm. 1996, 721-754.
36. Soderlund D.M., Clark J.M., Sheets L.P., Mullin L.S., Piccirillo V.J., Sargent D., et al. Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. Toxicology 2002, 171(1):3-59.
37. Sullivan W.N., Azurin J.C., Wright J.W., Gratz N.G. Studies on aircraft disinsection at " blocks away" in tropical areas. Bull. World Health Organ. 1964, 30:113-118.
38. Sullivan W.N., Pal R., Wright J.W., Azurin J.C., Okamoto R., Mcguire J.U., Waters R.M. Worldwide studies on aircraft disinsection at " blocks away" . Bull. World Health Organ. 1972, 46:485-491.
39. Sutton P.M., Vergara X., Beckman J., Nicas M., Das R. Pesticide illness among flight attendants due to aircraft disinsection. Am. J. Ind. Med. 2007, 50(5):345-356.
40. Tomalik-Scharte D., Lazar A., Meins J., Bastian B., Ihrig M., Wachall B., et al. Dermal absorption of permethrin following topical administration. Eur. J. Clin. Pharmacol. 2005, 61(5-6):399-404.
41. Tuomainen A., Kangas J., Liesivuori J., Manninen A. Biological monitoring of deltamethrin exposure in greenhouses. Int. Arch. Occup. Environ. Health 1996, 69(1):62-64.
42. WHO/HQ, 1995. Report of the informal consultation on aircraft disinsection. International Programme on Chemical Safety, World Health Organization, Geneva. Available from: (accessed 21.03.11). http://whqlibdoc.who.int/HQ/1995/WHO_PCS_95.51_Rev.pdf.
43. Whyatt R.M., Camann D.E., Kinney P.L., Reyes A., Ramirez J., Dietrich J., et al. Residential pesticide use during pregnancy among a cohort of urban minority women. Environ. Health Perspect. 2002, 110(5):507-514.
44. Wilkes M.F., Woollen B.H., Marsh J.R., Batten P.L., Chester G. Biological monitoring for pesticide exposure-the role of human volunteer studies. Int. Arch. Occup. Environ. Health 1993, 65(1):S189-S192.
45. Woollen B.H., Marsh J.R., Laird W.J.D., Lesser J.E. The metabolism of cypermethrin in man-differences in urinary metabolite profiles following oral and dermal administration. Xenobiotica 1992, 22(8):983-991.