메뉴 건너뛰기




Volumn 119, Issue 21, 2012, Pages 4908-4918

Human cytomegalovirus-encoded UL33 and UL78 heteromerize with host CCR5 and CXCR4 impairing their HIV coreceptor activity

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C; PROTEIN UL33; PROTEIN UL78; UNCLASSIFIED DRUG;

EID: 84861525744     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-08-372516     Document Type: Article
Times cited : (58)

References (48)
  • 2
    • 0028296439 scopus 로고
    • Cytomegalovirus DNAin arterial walls of patients with atherosclerosis
    • Melnick JL, Hu C, Burek J, Adam E, DeBakey ME. Cytomegalovirus DNAin arterial walls of patients with atherosclerosis. J Med Virol. 1994;42(2):170- 174.
    • (1994) J Med Virol , vol.42 , Issue.2 , pp. 170-174
    • Melnick, J.L.1    Hu, C.2    Burek, J.3    Adam, E.4    DeBakey, M.E.5
  • 3
    • 3042563366 scopus 로고    scopus 로고
    • Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy
    • DOI 10.1016/S0140-6736(04)16500-8, PII S0140673604165008
    • Deayton JR, Sabin CA, Johnson MA, Emery VC, Wilson P, Griffiths PD. Importance of cytomegalovirus viraemia in risk of disease progression and death in HIV-infected patients receiving highly active antiretroviral therapy. Lancet. 2004; 363(9427):2116-2121. (Pubitemid 38844151)
    • (2004) Lancet , vol.363 , Issue.9427 , pp. 2116-2121
    • Deayton, J.R.1    Sabin, C.A.2    Johnson, M.A.3    Emery, V.C.4    Wilson, P.5    Griffiths, P.D.6
  • 4
    • 0037121233 scopus 로고    scopus 로고
    • Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer
    • DOI 10.1016/S0140-6736(02)11524-8
    • Harkins L, Volk AL, Samanta M, et al. Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet. 2002;360(9345):1557-1563. (Pubitemid 35356371)
    • (2002) Lancet , vol.360 , Issue.9345 , pp. 1557-1563
    • Harkins, L.1    Volk, A.L.2    Samanta, M.3    Mikolaenko, I.4    Britt, W.J.5    Bland, K.I.6    Cobbs, C.S.7
  • 5
    • 2642678444 scopus 로고    scopus 로고
    • The cytomegalovirus-encoded chemokine receptor US28 can enhance cell- cell fusion mediated by different viral proteins
    • Pleskoff O, Treboute C, Alizon M. The cytomegalovirus- encoded chemokine receptor US28 can enhance cell-cell fusion mediated by different viral proteins. J Virol. 1998;72(8):6389-6397. (Pubitemid 28323950)
    • (1998) Journal of Virology , vol.72 , Issue.8 , pp. 6389-6397
    • Pleskoff, O.1    Treboute, C.2    Alizon, M.3
  • 6
    • 33646025221 scopus 로고    scopus 로고
    • The human cytomegalovirus-encoded receptor US28 increases the activity of the major immediate- early promoter/enhancer
    • Boomker JM, The TH, de Leij LF, Harmsen MC. The human cytomegalovirus-encoded receptor US28 increases the activity of the major immediate- early promoter/enhancer. Virus Res. 2006: 118(1-2):196-200.
    • (2006) Virus Res , vol.118 , Issue.1-2 , pp. 196-200
    • Boomker, J.M.1    The, T.H.2    De Leij, L.F.3    Harmsen, M.C.4
  • 7
    • 70349524727 scopus 로고    scopus 로고
    • Human cytomegalovirus US28: A functionally selective chemokine binding receptor
    • Vomaske J, Nelson JA, Streblow DN. Human cytomegalovirus US28: a functionally selective chemokine binding receptor. Infect Disord Drug Targets. 2009;9(5):548-556.
    • (2009) Infect Disord Drug Targets , vol.9 , Issue.5 , pp. 548-556
    • Vomaske, J.1    Nelson, J.A.2    Streblow, D.N.3
  • 8
    • 30344484844 scopus 로고    scopus 로고
    • HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks
    • DOI 10.1016/j.tips.2005.11.006, PII S0165614705003081
    • Vischer HF, Leurs R, Smit MJ. HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks. Trends Pharmacol Sci. 2006;27(1):56-63. (Pubitemid 43063125)
    • (2006) Trends in Pharmacological Sciences , vol.27 , Issue.1 , pp. 56-63
    • Vischer, H.F.1    Leurs, R.2    Smit, M.J.3
  • 9
    • 84941944720 scopus 로고    scopus 로고
    • Cell-dependent mechanisms restrict the HIV type 1 coreceptor activity of US28, a chemokine receptor homolog encoded by human cytomegalovirus
    • DOI 10.1089/088922200309575
    • Ohagen A, Li L, Rosenzweig A, Gabuzda D. Cell-dependent mechanisms restrict the HIV type 1 coreceptor activity of US28, a chemokine receptor homolog encoded by human cytomegalovirus. AIDS Res Hum Retroviruses. 2000;16(1):27-35. (Pubitemid 30036740)
    • (2000) AIDS Research and Human Retroviruses , vol.16 , Issue.1 , pp. 27-35
    • Ohagen, A.1    Li, L.2    Rosenzweig, A.3    Gabuzda, D.4
  • 10
    • 0036312026 scopus 로고    scopus 로고
    • Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities
    • Waldhoer M, Kledal TN, Farrell H, Schwartz TW. Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities. J Virol. 2002;76(16):8161- 8168.
    • (2002) J Virol , vol.76 , Issue.16 , pp. 8161-8168
    • Waldhoer, M.1    Kledal, T.N.2    Farrell, H.3    Schwartz, T.W.4
  • 12
    • 13644262813 scopus 로고    scopus 로고
    • The human cytomegalovirus UL78 gene is highly conserved among clinical isolates, but is dispensable for replication in fibroblasts and a renal artery organ-culture system
    • DOI 10.1099/vir.0.80436-0
    • Michel D, Milotic I, Wagner M, et al. The human cytomegalovirus UL78 gene is highly conserved among clinical isolates, but is dispensable for replication in fibroblasts and a renal artery organ-culture system. J Gen Virol. 2005;86(2):297-306. (Pubitemid 40227940)
    • (2005) Journal of General Virology , vol.86 , Issue.2 , pp. 297-306
    • Michel, D.1    Milotic, I.2    Wagner, M.3    Vaida, B.4    Holl, J.5    Ansorge, R.6    Mertens, T.7
  • 13
    • 69249206623 scopus 로고    scopus 로고
    • G protein-coupled receptor heterodimerization: Contribution to pharmacology and function
    • Milligan G. G protein-coupled receptor heterodimerization: contribution to pharmacology and function. Br J Pharmacol. 2009;158(1):5-14.
    • (2009) Br J Pharmacol , vol.158 , Issue.1 , pp. 5-14
    • Milligan, G.1
  • 14
    • 84874178020 scopus 로고    scopus 로고
    • Biological significance of GPCR heteromerization in the neuro-endocrine system
    • [published online ahead of print, February 2, 2011]. doi:10.3389/fendo. 2011.00002
    • Kamal M, Jockers R. Biological significance of GPCR heteromerization in the neuro-endocrine system [published online ahead of print, February 2, 2011]. Front Endocrin. doi:10.3389/fendo. 2011.00002.
    • Front Endocrin
    • Kamal, M.1    Jockers, R.2
  • 15
    • 78650003293 scopus 로고    scopus 로고
    • Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant- like effects
    • Pei L, Li S, Wang M, et al. Uncoupling the dopamine D1-D2 receptor complex exerts antidepressant- like effects. Nat Med. 2010;16(12):1393- 1395.
    • (2010) Nat Med , vol.16 , Issue.12 , pp. 1393-1395
    • Pei, L.1    Li, S.2    Wang, M.3
  • 16
    • 27144548417 scopus 로고    scopus 로고
    • Dimerization of chemokine receptors and its functional consequences
    • DOI 10.1016/j.cytogfr.2005.05.005, PII S1359610105000663, Chemokines
    • Springael JY, Urizar E, Parmentier M. Dimerization of chemokine receptors and its functional consequences. Cytokine Growth Factor Rev. 2005;16(6):611-623. (Pubitemid 41505520)
    • (2005) Cytokine and Growth Factor Reviews , vol.16 , Issue.6 , pp. 611-623
    • Springael, J.-Y.1    Urizar, E.2    Parmentier, M.3
  • 17
    • 48249131606 scopus 로고    scopus 로고
    • CXCR4-CCR5: A couple modulating T cell functions
    • Contento RL, Molon B, Boularan C, et al. CXCR4-CCR5: a couple modulating T cell functions. Proc Natl Acad Sci U S A. 2008;105(29): 10101-10106.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.29 , pp. 10101-10106
    • Contento, R.L.1    Molon, B.2    Boularan, C.3
  • 18
    • 71449122467 scopus 로고    scopus 로고
    • Heterooligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists
    • Sohy D, Yano H, de Nadai P, et al. Heterooligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists. J Biol Chem. 2009;284(45):31270-31279.
    • (2009) J Biol Chem , vol.284 , Issue.45 , pp. 31270-31279
    • Sohy, D.1    Yano, H.2    De Nadai, P.3
  • 19
    • 85027927015 scopus 로고    scopus 로고
    • Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
    • Wu B, Chien EY, Mol CD, et al. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010; 330(6007):1066-1071.
    • (2010) Science , vol.330 , Issue.6007 , pp. 1066-1071
    • Wu, B.1    Chien, E.Y.2    Mol, C.D.3
  • 20
    • 0031298109 scopus 로고    scopus 로고
    • HIV entry and tropism: The chemokine receptor connection
    • Berger EA. HIV entry and tropism: the chemokine receptor connection. AIDS. 1997;11 (Suppl A):S3- S16.
    • (1997) AIDS , vol.11 , Issue.SUPPL. A
    • Berger, E.A.1
  • 21
    • 0030942063 scopus 로고    scopus 로고
    • Coreceptors: Implications for HIV pathogenesis and therapy
    • DOI 10.1126/science.276.5309.51
    • Moore JP. Coreceptors: implications for HIV pathogenesis and therapy. Science. 1997; 276(5309):51-52. (Pubitemid 27161239)
    • (1997) Science , vol.276 , Issue.5309 , pp. 51-52
    • Moore, J.P.1
  • 23
    • 78650121289 scopus 로고    scopus 로고
    • A fluorescent ligand-binding alternative using Tag-lite(R) technology
    • Zwier JM, Roux T, Cottet M, et al. A fluorescent ligand-binding alternative using Tag-lite(R) technology. J Biomol Screen. 2010;15(10):1248- 1259.
    • (2010) J Biomol Screen , vol.15 , Issue.10 , pp. 1248-1259
    • Zwier, J.M.1    Roux, T.2    Cottet, M.3
  • 24
    • 70350093721 scopus 로고    scopus 로고
    • Improved donor/acceptor BRET couples for monitoring β-arrestin recruitment to G protein-coupled receptors
    • Kamal M, Marquez M, Vauthier V, et al. Improved donor/acceptor BRET couples for monitoring β-arrestin recruitment to G protein-coupled receptors. Biotechnol J. 2009;4(9):1337-1344.
    • (2009) Biotechnol J , vol.4 , Issue.9 , pp. 1337-1344
    • Kamal, M.1    Marquez, M.2    Vauthier, V.3
  • 25
    • 34247341369 scopus 로고    scopus 로고
    • Galactosyl ceramide expressed on dendritic cells can mediate HIV-1 transfer from monocyte derived dendritic cells to autologous T cells
    • DOI 10.1016/j.virol.2006.11.035, PII S004268220600883X
    • Magerus-Chatinet A, Yu H, Garcia S, Ducloux E, Terris B, Bomsel M. Galactosyl ceramide expressed on dendritic cells can mediate HIV-1 transfer from monocyte derived dendritic cells to autologous T cells. Virology. 2007;362(1):67-74. (Pubitemid 46629094)
    • (2007) Virology , vol.362 , Issue.1 , pp. 67-74
    • Magerus-Chatinet, A.1    Yu, H.2    Garcia, S.3    Ducloux, E.4    Terris, B.5    Bomsel, M.6
  • 26
    • 69249086612 scopus 로고    scopus 로고
    • HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: An IgA gene and functional analysis
    • Tudor D, Derrien M, Diomede L, et al. HIV-1 gp41-specific monoclonal mucosal IgAs derived from highly exposed but IgG-seronegative individuals block HIV-1 epithelial transcytosis and neutralize CD4(+) cell infection: an IgA gene and functional analysis. Mucosal Immunol. 2009;2(5): 412-426.
    • (2009) Mucosal Immunol , vol.2 , Issue.5 , pp. 412-426
    • Tudor, D.1    Derrien, M.2    Diomede, L.3
  • 28
    • 61849099861 scopus 로고    scopus 로고
    • CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface
    • Achour L, Scott MG, Shirvani H, et al. CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface. Blood. 2009;113(9):1938-1947.
    • (2009) Blood , vol.113 , Issue.9 , pp. 1938-1947
    • Achour, L.1    Scott, M.G.2    Shirvani, H.3
  • 32
    • 27144487749 scopus 로고    scopus 로고
    • Chemokine receptor internalization and intracellular trafficking
    • DOI 10.1016/j.cytogfr.2005.05.008, PII S1359610105000705, Chemokines
    • Neel NF, Schutyser E, Sai J, Fan GH, Richmond A. Chemokine receptor internalization and intracellular trafficking. Cytokine Growth Factor Rev. 2005;16(6): 637-658. (Pubitemid 41505521)
    • (2005) Cytokine and Growth Factor Reviews , vol.16 , Issue.6 , pp. 637-658
    • Neel, N.F.1    Schutyser, E.2    Sai, J.3    Fan, G.-H.4    Richmond, A.5
  • 33
    • 0021720872 scopus 로고
    • T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
    • DOI 10.1038/312767a0
    • Klatzmann D, Champagne E, Chamaret S, et al. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature. 1984; 312(5996):767-768. (Pubitemid 15195925)
    • (1984) Nature , vol.312 , Issue.5996 , pp. 767-768
    • Klatzmann, D.1    Champagne, E.2    Chamaret, S.3
  • 34
    • 33750502435 scopus 로고    scopus 로고
    • Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers
    • DOI 10.1038/sj.embor.7400838, PII 7400838
    • Levoye A, Dam J, Ayoub MA, Guillaume JL, Jockers R. Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers. EMBO Rep. 2006;7(11):1094-1098. (Pubitemid 44660563)
    • (2006) EMBO Reports , vol.7 , Issue.11 , pp. 1094-1098
    • Levoye, A.1    Dam, J.2    Ayoub, M.A.3    Guillaume, J.-L.4    Jockers, R.5
  • 36
    • 77956553602 scopus 로고    scopus 로고
    • The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Galphai proteins, and constitutively impairs CXCR4 functioning
    • Nijmeijer S, Leurs R, Smit MJ, Vischer HF. The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Galphai proteins, and constitutively impairs CXCR4 functioning. J Biol Chem. 2010;285(38):29632-29641.
    • (2010) J Biol Chem , vol.285 , Issue.38 , pp. 29632-29641
    • Nijmeijer, S.1    Leurs, R.2    Smit, M.J.3    Vischer, H.F.4
  • 37
    • 53149113005 scopus 로고    scopus 로고
    • An escort for GPCRs: Implications for regulation of receptor density at the cell surface
    • Achour L, Labbe-Jullie C, Scott MG, Marullo S. An escort for GPCRs: implications for regulation of receptor density at the cell surface. Trends Pharmacol Sci. 2008;29(10):528-535.
    • (2008) Trends Pharmacol Sci , vol.29 , Issue.10 , pp. 528-535
    • Achour, L.1    Labbe-Jullie, C.2    Scott, M.G.3    Marullo, S.4
  • 39
    • 0031913208 scopus 로고    scopus 로고
    • The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infection
    • Beisser PS, Vink C, Van Dam JG, Grauls G, Vanherle SJ, Bruggeman CA. The R33 G protein-coupled receptor gene of rat cytomegalovirus plays an essential role in the pathogenesis of viral infection. J Virol. 1998;72(3):2352-2363. (Pubitemid 28100796)
    • (1998) Journal of Virology , vol.72 , Issue.3 , pp. 2352-2363
    • Beisser, P.S.1    Vink, C.2    Van Dam, J.G.3    Grauls, G.4    Vanherle, S.J.V.5    Bruggeman, C.A.6
  • 40
    • 38949138811 scopus 로고    scopus 로고
    • Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: Ablation of constitutive signaling is associated with an attenuated phenotype in vivo
    • DOI 10.1128/JVI.02550-06
    • Case R, Sharp E, Benned-Jensen T, Rosenkilde MM, Davis-Poynter N, Farrell HE. Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo. J Virol. 2008;82(4):1884-1898. (Pubitemid 351222436)
    • (2008) Journal of Virology , vol.82 , Issue.4 , pp. 1884-1898
    • Case, R.1    Sharp, E.2    Benned-Jensen, T.3    Rosenkilde, M.M.4    Davis-Poynter, N.5    Farrell, H.E.6
  • 42
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M, Libert F, Doranz BJ, et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 1996;382(6593):722-725.
    • (1996) Nature , vol.382 , Issue.6593 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3
  • 43
    • 0030712312 scopus 로고    scopus 로고
    • Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5delta32
    • DOI 10.1074/jbc.272.49.30603
    • Benkirane M, Jin DY, Chun RF, Koup RA, Jeang KT. Mechanism of transdominant inhibition of CCR5- mediated HIV-1 infection by ccr5delta32. J Biol Chem. 1997;272(49):30603-30606. (Pubitemid 27527488)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.49 , pp. 30603-30606
    • Benkirane, M.1    Jin, D.-Y.2    Chun, R.F.3    Koup, R.A.4    Jeang, K.-T.5
  • 44
    • 0030861904 scopus 로고    scopus 로고
    • Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression
    • Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study
    • Smith MW, Dean M, Carrington M, et al. Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study. Science. 1997;277(5328):959-965.
    • (1997) Science , vol.277 , Issue.5328 , pp. 959-965
    • Smith, M.W.1    Dean, M.2    Carrington, M.3
  • 45
    • 79251526530 scopus 로고    scopus 로고
    • HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV
    • Cicala C, Arthos J, Fauci AS. HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV. J Transl Med. 2011;9 Suppl 1:S2.
    • (2011) J Transl Med , vol.9 , Issue.SUPPL. 1
    • Cicala, C.1    Arthos, J.2    Fauci, A.S.3
  • 46
    • 0026069801 scopus 로고
    • Cytomegalovirus as a possible cofactor in HIV disease progression
    • Webster A. Cytomegalovirus as a possible cofactor in HIV disease progression. J Acquir Immune Defic Syndr. 1991;4 (Suppl 1):S47-S52.
    • (1991) J Acquir Immune Defic Syndr , vol.4 , Issue.SUPPL. 1
    • Webster, A.1
  • 47
    • 0028362809 scopus 로고
    • Human cytomegalovirus-mediated enhancement of human immunodeficiency virus type-1 production in monocyte-derived macrophages
    • DOI 10.1006/viro.1994.1101
    • Lathey JL, Spector DH, Spector SA. Human cytomegalovirus- mediated enhancement of human immunodeficiency virus type-1 production in monocyte-derived macrophages. Virology. 1994; 199(1):98-104. (Pubitemid 24170428)
    • (1994) Virology , vol.199 , Issue.1 , pp. 98-104
    • Lathey, J.L.1    Spector, D.H.2    Spector, S.A.3
  • 48
    • 33746801911 scopus 로고    scopus 로고
    • Human cytomegalovirus modulation of CCR5 expression on myeloid cells affects susceptibility to human immunodeficiency virus type 1 infection
    • DOI 10.1099/vir.0.81452-0
    • King CA, Baillie J, Sinclair JH. Human cytomegalovirus modulation of CCR5 expression on myeloid cells affects susceptibility to human immunodeficiency virus type 1 infection. J Gen Virol. 2006;87(8):2171-2180. (Pubitemid 44178095)
    • (2006) Journal of General Virology , vol.87 , Issue.8 , pp. 2171-2180
    • King, C.A.1    Baillie, J.2    Sinclair, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.