The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Gαi proteins, and constitutively impairs CXCR4 functioning

Journal of Biological Chemistry

Volumn 285, Issue 38, 2010, Pages 29632-29641

  Nijmeijer, Saskia ^a   Leurs, Rob ^a   Smit, Martine J ^a   Vischer, Henry F ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ENERGY TRANSFER; ENZYME ACTIVITY; PHYSIOLOGICAL MODELS; PROTEINS; VIRUSES;

BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELLULAR SIGNALING NETWORKS; CHEMOKINE RECEPTORS; CO-EXPRESSION; COMPLEMENTATION; EPSTEIN-BARR VIRUS; EXTRACELLULAR STIMULI; G PROTEIN; G-PROTEIN COUPLED RECEPTORS; HETERODIMERIC COMPLEXES; HETEROMERIC COMPLEXES; INTRACELLULAR SIGNALING; OLIGOMERIC COMPLEXES; PHYSIOLOGICAL RESPONSE;

SIGNALING;

CHEMOKINE RECEPTOR CXCR4; G PROTEIN COUPLED RECEPTOR; HISTAMINE; HISTAMINE H4 RECEPTOR; MUTANT PROTEIN; PROTEIN BILF1; PROTEIN GALPHAI; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; BILF1 PROTEIN, EPSTEIN-BARR VIRUS; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN BINDING; VIRUS PROTEIN;

ARTICLE; CONTROLLED STUDY; EMBRYO; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; CELL LINE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION;

HUMAN HERPESVIRUS 4;

CELL LINE; CHEMOKINE CXCL12; ENZYME-LINKED IMMUNOSORBENT ASSAY; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; MICROSCOPY, FLUORESCENCE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECEPTORS, CXCR4; RECEPTORS, G-PROTEIN-COUPLED; VIRAL PROTEINS;

EID: 77956553602     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.115618     Document Type: Article

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