Determination of total and unbound concentrations of valproic acid in human plasma by liquid chromatography-tandem mass spectrometry

Journal of Liquid Chromatography and Related Technologies

Volumn 35, Issue 9, 2012, Pages 1171-1183

  Fernandez Campos F ^a   Calpena, A ^a   Soy, D ^b   Colom, H ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

free fraction; LC MS; plasma; total VPA; validation; valproic acidper

Indexed keywords

FREE FRACTION; LC-MS; TOTAL VPA; VALIDATION; VALPROIC ACIDPER;

CARBOXYLIC ACIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMAS;

PLASMA (HUMAN);

BENZOIC ACID; VALPROIC ACID;

ACCURACY; ANALYTIC METHOD; ARTICLE; BIOASSAY; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STABILITY; HUMAN; INTERRATER RELIABILITY; INTRARATER RELIABILITY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; SOLID PHASE EXTRACTION; SPIKE WAVE; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION;

EID: 84861520352     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.619027     Document Type: Article

References (20)

1. Macdonald, R. L.; Kelly, K. M. Epilepsia 1995, 36 (2), 2.
2. Park, H. M.; Kang, S. S.; Lee, Y. B.; Shin, D. J.; Kim, O. N.; Lee, S. B.; Yim, D. S. J. Clin. Pharm. Ther. 2002, 27, 419.
3. Sproule, B.; Nava-Ocampo, A. A.; Kapur, B. Ther. Drug Monit. 2006, 28, 714.
4. Cloyd, J. C.; Dutta, S.; Cao, G.; Walch, J. K.; Collins, S. D.; Granneman, G. R. Epilepsy Res. 2003, 53, 19.
5. Grandison, M. K.; Boudinot, F. D. Clin. Pharmacokinet. 2000, 38, 271.
6. Haroldson, J. A.; Kramer, L. E.; Wolff, D. L.; Lake, K. D. Ann. Pharmacother. 2000, 34, 183.
7. hen, L. C.; Chou, M. H.; Lin, M. F.; Yang, L. L. J. Clin. Pharm. Ther. 2000, 25, 453.
8. Chan, K.; Beran, R. G. Seizure. 2008, 17, 572.
9. Kishore, P.; Kumar, V. R.; Satyanarayana, V.; Krishna, D. R. Pharmazie 2003, 58, 378.
10. Liu, H.; Forman, L. J.; Montoya, J.; Eggers, C.; Barham, C.; Delgado, M. J. Chromatogr. 1992, 15, 163.
11. Lin, M. C.; Kou, H. S.; Chen, C. C.; Wu, S. M.; Wu, H. L. J. Chromatogr. B 2004, 810, 169.
12. Hara, S.; Kamura, M.; Inoue, K.; Fukuzawa, M.; Ono, N.; Kuroda, T. Biol. Pharm. Bull. 1999, 22, 975.
13. Bousquet, E.; Tirendi, S.; Santagati, N. A.; Salvo, M.; Castello, P. M.P. Pharmazie 1991, 46, 257.
14. Yu, D.; Gordon, J. D.; Zheng, J.; Panesar, S. K.; Riggs, K. W.; Rurak, D. W. J. Chromatogr. B Biomed. Appl. 1995, 666, 269.
15. Kassahun, K.; Burton, R. Biomed. Environ. Mass. Spectrom. 1989, 18, 918.
16. Ramakrishna, N. V.; Vishwottam, K. N.; Manoj, S.; Koteshwara, M.; Santosh, M.; Chidambara, J.; Kumar, B. R. Rapid Commun. Mass Spectrom. 2005, 19, 1970.
17. Matsuura, K.; Ohmori, T.; Nakamura, M.; Itoh, Y.; Hirano, K. Biomed. Chromatogr. 2008, 22, 387.
18. Pucci, V.; Monteagudo, E.; Bonelli, F. Rapid Commun. Mass Spectrom. 2005, 19, 3713.
19. U.S. FDA-Guidance for Industry Bioanalytical Method Validation, 2001, U.S. Department of Health and Human Services, Rockville, MD, USA.
20. Guideline on Bioanalytical Method Validation, 2009, European Medicines Agency, London, UK.