Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release

Cell Calcium

Volumn 51, Issue 6, 2012, Pages 452-458

  Mekahli, D ^a,b   Sammels, E ^c   Luyten, T ^a   Welkenhuyzen, K ^a   van den Heuvel, L P ^b   Levtchenko, E N ^b   Gijsbers, R ^d   Bultynck, G ^a   Parys, J B ^a   De Smedt, H ^a   Missiaen, L ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c Groep T Leuven Engineering College   (Belgium)

^d DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

Author keywords

ADPKD; Endoplasmic reticulum; Inositol 1,4,5 trisphosphate receptor; Polycystin

Indexed keywords

CALCIUM; INOSITOL TRISPHOSPHATE; INOSITOL TRISPHOSPHATE RECEPTOR; LENTIVIRUS VECTOR; MICRORNA; POLYCYSTIN 1; POLYCYSTIN 2; RECEPTOR; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL IMMORTALIZATION; CELL MEMBRANE; CELL PERMEABILIZATION; CONTROLLED STUDY; CYTOSOL; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

EID: 84861481586     PISSN: 01434160     EISSN: 15321991     Source Type: Journal    
DOI: 10.1016/j.ceca.2012.03.002     Document Type: Article

References (41)

1. Chang M.Y., Ong A.C. Autosomal dominant polycystic kidney disease: recent advances in pathogenesis and treatment. Nephron Physiol. 2008, 108:1-7.
2. Harris P.C., Torres V.E. Polycystic kidney disease. Annu. Rev. Med. 2009, 60:321-337.
3. Chapin H.C., Caplan M.J. The cell biology of polycystic kidney disease. J. Cell Biol. 2010, 191:701-710.
4. Hofherr A., Kottgen M. TRPP channels and polycystins. Adv. Exp. Med. Biol. 2011, 704:287-313.
5. 2+ signaling with implications for polycystic kidney disease. J. Biol. Chem. 2009, 284:36431-36441.
6. 2+ release through the PI3K/Akt pathway. Cell. Physiol. Biochem. 2011, 27:715-726.
7. Nauli S.M., Alenghat F.J., Luo Y., et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 2003, 33:129-137.
8. Yamaguchi T., Hempson S.J., Reif G.A., Hedge A.M., Wallace D.P. Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells. J. Am. Soc. Nephrol. 2006, 17:178-187.
9. Ahrabi A.K., Terryn S., Valenti G., et al. PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice. J. Am. Soc. Nephrol. 2007, 18:740-753.
10. Weber K.H., Lee E.K., Basavanna U., et al. Heterologous expression of polycystin-1 inhibits endoplasmic reticulum calcium leak in stably transfected MDCK cells. Am. J. Physiol. Renal Physiol. 2008, 294:F1279-F1286.
11. Morel N., Vandenberg G., Ahrabi A.K., et al. PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta. Pflugers Arch. 2009, 457:845-856.
12. 2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci. J. Gen. Physiol. 1990, 95:1103-1122.
13. 3- and calcium-gated channels from endoplasmic reticulum of cerebellum. Nature 1991, 351:751-754.
14. Finch E.A., Turner T.J., Goldin S.M. Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release. Science 1991, 252:443-446.
15. Hooper K.M., Boletta A., Germino G.G., Hu Q., Ziegelstein R.C., Sutters M. Expression of polycystin-1 enhances endoplasmic reticulum calcium uptake and decreases capacitative calcium entry in ATP-stimulated MDCK cells. Am. J. Physiol. Renal Physiol. 2005, 289:F521-F530.
16. 2+ signaling. J. Biol. Chem. 2005, 280:41298-41306.
17. 2+ entry via association with TRPC3 and TRPC7. J. Biol. Chem. 2009, 284:34400-34412.
18. 2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain. J. Biol. Chem. 2010, 285:18794-18805.
19. Sammels E., Devogelaere B., Mekahli D., et al. Unraveling the role of polycystin-2/inositol 1,4,5-trisphosphate receptor interaction in Ca signaling. Commun. Integr. Biol. 2010, 3:530-532.
20. Anyatonwu G.I., Estrada M., Tian X., Somlo S., Ehrlich B.E. Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:6454-6459.
21. 2+ in permeabilized cells. Nature 1992, 357:599-602.
22. Ong A.C., Ward C.J., Butler R.J., et al. Coordinate expression of the autosomal dominant polycystic kidney disease proteins, polycystin-2 and polycystin-1, in normal and cystic tissue. Am. J. Pathol. 1999, 154:1721-1729.
23. Sun D., Melegari M., Sridhar S., Rogler C.E., Zhu L. Multi-miRNA hairpin method that improves gene knockdown efficiency and provides linked multi-gene knockdown. Biotechniques 2006, 41:59-63.
24. Iyer S., Deutsch K., Yan X., Lin B. Batch RNAi selector: a standalone program to predict specific siRNA candidates in batches with enhanced sensitivity. Comput. Methods Prog. Biomed. 2007, 85:203-209.
25. Schrijvers R., De Rijck J., Demeulemeester J., et al. LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs. PLoS Pathog. 2012, 8:e1002558.
26. Gijsbers R., Ronen K., Vets S., et al. LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin. Mol. Ther. 2010, 18:552-560.
27. Ibrahimi A., Vande Velde G., Reumers V., et al. Highly efficient multicistronic lentiviral vectors with peptide 2A sequences. Hum. Gene Ther. 2009, 20:845-860.
28. Geraerts M., Michiels M., Baekelandt V., Debyser Z., Gijsbers R. Upscaling of lentiviral vector production by tangential flow filtration. J. Gene Med. 2005, 7:1299-1310.
29. Geraerts M., Willems S., Baekelandt V., Debyser Z., Gijsbers R. Comparison of lentiviral vector titration methods. BMC Biotechnol. 2006, 6:34.
30. Wilmer M.J., de Graaf-Hess A., Blom H.J., et al. Elevated oxidized glutathione in cystinotic proximal tubular epithelial cells. Biochem. Biophys. Res. Commun. 2005, 337:610-614.
31. Wilmer M.J., Saleem M.A., Masereeuw R., et al. Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters. Cell Tissue Res. 2010, 339:449-457.
32. Fabiato A., Fabiato F. Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J. Physiol. (Paris) 1979, 75:463-505.
33. Hanaoka K., Qian F., Boletta A., et al. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 2000, 408:990-994.
34. Delmas P., Nauli S.M., Li X., et al. Gating of the polycystin ion channel signaling complex in neurons and kidney cells. FASEB J. 2004, 18:740-752.
35. Tsiokas L., Kim S., Ong E.C. Cell biology of polycystin-2. Cell. Signal. 2007, 19:444-453.
36. Cai Y., Maeda Y., Cedzich A., et al. Identification and characterization of polycystin-2, the PKD2 gene product. J. Biol. Chem. 1999, 274:28557-28565.
37. Koulen P., Cai Y., Geng L., et al. Polycystin-2 is an intracellular calcium release channel. Nat. Cell Biol. 2002, 4:191-197.
38. Newby L.J., Streets A.J., Zhao Y., Harris P.C., Ward C.J., Ong A.C. Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. J. Biol. Chem. 2002, 277:20763-20773.
39. Woodward O.M., Li Y., Yu S., et al. Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1. PLoS ONE 2010, 5:e12305.
40. Spirli C., Locatelli L., Fiorotto R., et al. Altered store operated calcium entry increases cAMP production and ERK1/2 phosphorylation in polycystin-2 defective cholangiocytes. Hepatology 2012, 55:856-868.
41. 2+ concentration in the endoplasmic reticulum. EMBO J. 2009, 28:490-499.