Acute traumatic spinal cord injury induces glial activation in the cynomolgus macaque (Macaca fascicularis)

Journal of Medical Primatology

Volumn 41, Issue 3, 2012, Pages 202-209

  Miller, A D ^a   Westmoreland, S V ^a   Evangelous, N R ^a   Graham, A ^b   Sledge, J ^c   Nesathurai, S ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MCMASTER UNIVERSITY   (Canada)

^c Sports Medicine North   (United States)

Author keywords

Immunohistochemistry; Inducible nitric oxide synthase; Macrophage related protein 8; Trauma

Indexed keywords

BIOLOGICAL MARKER; CD16 ANTIGEN; CD163 ANTIGEN; GELATINASE B; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE TRANSPORTER 1; INDUCIBLE NITRIC OXIDE SYNTHASE; MACROPHAGE RELATED PROTEIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELIN BASIC PROTEIN; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE ANTIBODY; PROTEIN IBA 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BALLOON CATHETER; BLEEDING; CELL ACTIVATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GLIA CELL; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MACACA FASCICULARIS; MACROPHAGE; MALE; MICROGLIA; NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD INJURY;

ACUTE DISEASE; ANIMALS; ANTIGENS, CD; BIOLOGICAL MARKERS; CATHETERIZATION; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGES; MALE; MICROGLIA; SPINAL CORD; SPINAL CORD INJURIES; WOUNDS AND INJURIES;

MACACA FASCICULARIS; PRIMATES; RODENTIA;

EID: 84861475047     PISSN: 00472565     EISSN: 16000684     Source Type: Journal    
DOI: 10.1111/j.1600-0684.2012.00542.x     Document Type: Article

References (15)

1. Auld GC, Ritchie H, Robbie LA, Booth NA: Thrombin upregulates tissue transglutaminase in endothelial cells: a potential role for tissue transglutaminase in stability of atherosclerotic plaque. Arterioscler Thromb Vasc Biol 2001; 21:1689-94.
2. Brown GC, Neher JJ: Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 2010; 41:242-7.
3. Carlson SL, Parrish ME, Springer JE, Doty K, Dossett L: Acute inflammatory response in spinal cord following impact injury. Exp Neurol 1998; 151:77-88.
4. Conti A, Miscusi M, Cardali S, Germano A, Suzuki H, Cuzzocrea S, Tomasello F: Nitric oxide in the injured spinal cord: synthases cross-talk, oxidative stress and inflammation. Brain Res Rev 2007; 54:205-18.
5. Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS: Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 1997; 3:73-6.
6. Fleming JC, Norenberg MD, Ramsay DA, Dekaban GA, Marcillo AE, Saenz AD, Pasquale-Styles M, Dietrich WD, Weaver LC: The cellular inflammatory response in human spinal cords after injury. Brain 2006; 129:3249-69.
7. Hessian PA, Edgeworth J, Hogg N: MRP-8 and MRP-14, two abundant Ca(2+)-binding proteins of neutrophils and monocytes. J Leukoc Biol 1993; 53:197-204.
8. Imai Y, Kohsaka S: Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia 2002; 40:164-74.
9. Kigerl KA, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, Popovich PG: Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 2009; 29:13435-44.
10. Nesathurai S, Graham WA, Mansfield K, Magill D, Sehgal P, Westmoreland SV, Prusty S, Rosene DL, Sledge JB: Model of traumatic spinal cord injury in Macaca fascicularis: similarity of experimental lesions created by epidural catheter to human spinal cord injury. J Med Primatol 2006; 35:401-4.
11. Popovich PG, Wei P, Stokes BT: Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neurol 1997; 377:443-64.
12. Schwab JM, Brechtel K, Nguyen TD, Schluesener HJ: Persistent accumulation of cyclooxygenase-1 (COX-1) expressing microglia/macrophages and upregulation by endothelium following spinal cord injury. J Neuroimmunol 2000; 111:122-30.
13. Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen MA, Nacken W, Foell D, van der Poll T, Sorg C, Roth J: Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 2007; 13:1042-9.
14. Wu D, Miyamoto O, Shibuya S, Okada M, Igawa H, Janjua NA, Norimatsu H, Itano T: Different expression of macrophages and microglia in rat spinal cord contusion injury model at morphological and regional levels. Acta Med Okayama 2005; 59:121-7.
15. Young W: Spinal cord contusion models. Prog Brain Res 2002; 137:231-55.