Safety and efficacy of antioxidants-loaded nanoparticles for an anti-aging application

Journal of Biomedical Nanotechnology

Volumn 8, Issue 2, 2012, Pages 316-321

  Felippi, Cândice C ^a   Oliveira, Dileusa ^a   Ströher, Alessandra ^a   Carvalho, Anderson R ^a   Aquino Van Etten, Eliana A M ^a   Bruschi, Márcia ^a   Raffin, Renata P ^a  

^a Inventiva Indústria e Inovação Ltda   (Brazil)

Author keywords

Alternative methods; Antioxidants; Efficacy; Nanoparticles; Photoprotection; Safety; Wrinkles

Indexed keywords

ALTERNATIVE METHODS; ANTIOXIDANTS; EFFICACY; PHOTOPROTECTION; WRINKLES;

ACCIDENT PREVENTION; DRYING OILS; OILS AND FATS; SUSPENSIONS (FLUIDS);

NANOPARTICLES;

ANTIOXIDANT; NANOAGING REVERSE; NANOPARTICLE; TROLOX C; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG SAFETY; HUMAN; HUMAN EXPERIMENT; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PH MEASUREMENT; PHOTOTOXICITY; SKIN IRRITATION; ULTRAVIOLET A RADIATION;

ADULT; ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; CHICKENS; CHROMANS; COSMETICS; HUMANS; HYDROGEN-ION CONCENTRATION; LINSEED OIL; MICE; MICE, INBRED BALB C; MIDDLE AGED; NANOPARTICLES; NIH 3T3 CELLS; PARTICLE SIZE; SKIN; SKIN AGING; SKIN IRRITANCY TESTS; SUNSCREENING AGENTS; TOCOPHEROLS; UBIQUINONE; VITAMIN A;

EID: 84861472045     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2012.1379     Document Type: Article

References (26)

1. C. Battie and M. Verschoore, Dermatology, cosmetic and well-being. Ann. Dermatol. Vener. 138, 294 (2011).
2. S. Magdassi, Delivery Systems in Cosmetics. Col. Surf. 123-124, 671 (1997).
3. M. M. Jiménez, J. Pelletier, M. F. Bobin, and M. C. Martini, Influence of encapsulation on the in vitro percutaneous absorption of octyl methoxycinnamate. Int. J. Pharm. 272, 45 (2004).
4. A. S. Wissing, R. H. Müller, Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration, J. Control. Rel. 81, 225 (2002).
5. K. Paese, A. Jäger, F. S. Poletto, E. F. Pinto, B. Rossi-Bergmann, A. R. Pohlmann, and S. S. Guterres, Semisolid Formulation Containing a Nanoencapsulated Sunscreen: Effectiveness, In vitro Photostability and Immune Response. J. Biomed. Nanotechnol. 5, 1 (2009).
6. E. B. Souto and R. H. Muller, Cosmetic features and applications of lipid nanoparticles (SLN, NLC), Int. J. Cosm. Sci. 30, 157 (2008).
7. E. B. Souto, A. J. Almeida, and R. H. Müller, Lipid nanoparticles (SLN,® NLC®) for cutaneous drug delivery: Structure, protection and skin effect. J. Biomed. Nanotech. 3, 1 (2007).
8. P. Somasundaran, S. C. Mehta, L. Rhein, and S. Chakraborty, Nanotechnology and related safety issues for delivery of active ingredients in cosmetics, MRS Bulletin. 32, 779 (2007).
9. V. Weiss-Angeli, F. S. Poletto, L. R. Zancan, F. Baldasso, A. R. Pohlmann, and S. S. Guterres, nanocapsules of octyl methoxycinnamate containing quercetin delayed the photodegradation of both components under ultraviolet A radition. J. Biomed. Nanotechnol. 4, 1 (2008).
10. R. H. Muller, M. Radtke, and S. A. Wissing, Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Del. Rev. 54, S131 (2002).
11. P. Batheja, L. Sheihet, J. Kohn, A. J. Singer, and B. Michniak-Kohn, Topical drug delivery by a polymeric nanosphere gel: Formulation optimization and in vitro and in vivo skin distribution studies. J. Control. Rel. 149, 159 (2011).
12. F. Marquele-Oliveiraa, D. C. A. Santana, S. F. Taveira, D. M. Vermeulen, A. R. M. Oliveira, R. S. Silva, and R. F. V. Lopez, Development of nitrosyl ruthenium complex-loaded lipid carriers for topical administration: Improvement in skin stability and in nitric oxide release by visible light irradiation, J. Pharm. Biomed. Anal. 53, 843 (2010).
13. K. A. Shah, A. A. Date, M. D. Joshi, and V. B. Patravale, Solid lipid nanoparticles (SLN) of tretinoin: Potential in topical delivery. Int. J. Pharm. 345, 163 (2007).
14. Y. Agrawal, K. C. Petkar, and K. K. Sawant, Development, evaluation and clinical studies of Acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis. Int. J. Pharm. 401, 93 (2010).
15. SCCP (Scientific Committee on Consumer Products), Safety of nanomaterials in cosmetic products (2007).
16. M. Pauwels and V. Rogiers, EU legislations affecting safety data availability of cosmetic ingredients. Reg. Toxicol. Pharmacol. 49, 308 (2007).
17. ECVAM-European Centre for the Validation of Alternative Methods. Technical Report on the Status of Alternative Methods for Cosmetics Testing (2009).
18. M. P. Vinardell and M. Mitjans, Alternative methods for eye and skin irritation tests: An overview, J. Pharm. Sci. 97, 46 (2008).
19. Guidelines for the Safety Evaluation of Cosmetic Products published by the Brazilian Sanitary Surveillance Agency, Brasilia (2003).
20. D. S. Wilkinson, S. Fregert, B. Magnusson, H. J. Bandmann, C. D. Calnan, E. Cronin, N. Hjorth, H. J. Maibach, K. E. Malalten, C. L. Meneghini, and T. Pirilä, Terminology of contact dermatitis. Acta Dermato-Venereol. 50, 287 (1970).
21. R. G. Glogau, Physiologic and structural changes associated with aging skin. Dermatol. Clin. 15, 555 (1997).
22. M. Bracher, C. Faller, J. Spengler, and C. A. Reinhardt, Comparison of in vitro cell toxicity with in vivo eye irritation. Mol. Toxicol. 1, 561 (1987).
23. J. Araújo, E. Vega, C. Lopes, M. A. Egea, M. L. Garcia, and E. B. Souto, Effect of polymer viscosity on physicochemical properties and ocular tolerance of FB-loaded PLGA nanospheres. Colloid Surface B 72, 48 (2009).
24. H. Gupta, M. Aqil, R. K. Khar, A. Ali, A. Bhatnagar, and G. Mittal, Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery. Nanomed-Nanotechnol. 6, 324 (2010).
25. U. Ruktanonchai, P. Bejrapha, U. Sakulkhu, P. Opanasopit, N. Bunyapraphatsara, V. Junyaprasert, and S. Puttipipatkhachorn, Physicochemical characteristics, cytotoxicity, and antioxidant activity of three lipid nanoparticulate formulations of alpha-lipoic acid. AAPS Pharmscitech. 10, 227 (2009).
26. W. Weyenberg, P. Filev, D. Van den Plas, J. Vandervoort, K. De Smet, P. Sollie, and A. Ludwiga, Cytotoxicity of submicron emulsions and solid lipid nanoparticles for dermal application. Int. J. Pharm. 337, 291 (2007).