The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells

International Immunology

Volumn 24, Issue 6, 2012, Pages 389-400

  Nagai, Yoshinori ^a   Yanagibashi, Tsutomu ^a   Watanabe, Yasuharu ^a   Ikutani, Masashi ^a   Kariyone, Ai ^a   Ohta, Shoichiro ^b   Hirai, Yoshikatsu ^a   Kimoto, Masao ^b   Miyake, Kensuke ^c   Takatsu, Kiyoshi ^a,d  

^a UNIVERSITY OF TOYAMA   (Japan)

^b SAGA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d Toyama Prefectural Institute for Pharmaceutical Research   (Japan)

Author keywords

Innate immunity; LPS; T cell independent immune response

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; IMMUNOGLOBULIN M; LIPID A; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTEIN BCL XL; TOLL LIKE RECEPTOR 4; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL SURVIVAL; CROSS LINKING; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; ONCOGENE C MYC; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION PROTECTION; UPREGULATION;

EID: 84861467917     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxs040     Document Type: Article

References (35)

1. Kawai, T. and Akira, S. 2011. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637.
2. Shimazu, R., Akashi, S., Ogata, H. et al. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189:1777.
3. Akashi, S., Shimazu, R., Ogata, H. et al. 2000. Cutting edge: cell surface expression and lipopolysaccharide signaling via the tolllike receptor 4-MD-2 complex on mouse peritoneal macrophages. J. Immunol. 164:3471.
4. Hoshino, K., Takeuchi, O., Kawai, T. et al. 1999. Cutting edge: Tolllike receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162:3749.
5. Nagai, Y., Akashi, S., Nagafuku, M. et al. 2002. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3:667.
6. Ohto, U., Fukase, K., Miyake, K. and Satow, Y. 2007. Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa. Science 316:1632.
7. Kim, H. M., Park, B. S., Kim, J. I. et al. 2007. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130:906.
8. Miyake, K., Yamashita, Y., Ogata, M., Sudo, T. and Kimoto, M. 1995. RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J. Immunol. 154:3333.
9. Yamashita, Y., Miyake, K., Miura, Y. et al. 1996. Activation mediated by RP105 but not CD40 makes normal B cells susceptible to anti-IgM-induced apoptosis: a role for Fc receptor coligation. J. Exp. Med. 184:113.
10. Nagai, Y., Shimazu, R., Ogata, H. et al. 2002. Requirement for MD-1 in cell surface expression of RP105/CD180 and B-cell responsiveness to lipopolysaccharide. Blood 99:1699.
11. Yazawa, N., Fujimoto, M., Sato, S. et al. 2003. CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. Blood 102:1374.
12. Stephenson, L. M., Miletic, A. V., Kloeppel, T., Kusin, S. and Swat, W. 2006. Vav proteins regulate the plasma cell program and secretory Ig production. J. Immunol. 177:8620.
13. Chan, V. W., Mecklenbrauker, I., Su, I. et al. 1998. The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J. Exp. Med. 188:93.
14. Miyake, K., Shimazu, R., Kondo, J. et al. 1998. Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J. Immunol. 161:1348.
15. Ogata, H., Su, I., Miyake, K. et al. 2000. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192:23.
16. Nagai, Y., Kobayashi, T., Motoi, Y. et al. 2005. The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes. J. Immunol. 174:7043.
17. Yoon, S. I., Hong, M., Han, G. W. and Wilson, I. A. 2010. Crystal structure of soluble MD-1 and its interaction with lipid IVa. Proc. Natl Acad. Sci. USA 107:10990.
18. Harada, H., Ohto, U. and Satow, Y. 2010. Crystal structure of mouse MD-1 with endogenous phospholipid bound in its cavity. J. Mol. Biol. 400:838.
19. Oliver, A. M., Martin, F., Gartland, G. L., Carter, R. H. and Kearney, J. F. 1997. Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses. Eur. J. Immunol. 27:2366.
20. Oliver, A. M., Martin, F. and Kearney, J. F. 1999. IgMhighCD21high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells. J. Immunol. 162:7198.
21. Lopes-Carvalho, T. and Kearney, J. F. 2004. Development and selection of marginal zone B cells. Immunol. Rev. 197:192.
22. Gunn, K. E. and Brewer, J. W. 2006. Evidence that marginal zone B cells possess an enhanced secretory apparatus and exhibit superior secretory activity. J. Immunol. 177:3791.
23. Meyer-Bahlburg, A., Khim, S. and Rawlings, D. J. 2007. B cell intrinsic TLR signals amplify but are not required for humoral immunity. J. Exp. Med. 204:3095.
24. Yamashita, Y., Miyake, K., Kikuchi, Y. et al. 1995. A monoclonal antibody against a murine CD38 homologue delivers a signal to B cells for prolongation of survival and protection against apoptosis in vitro: unresponsiveness of X-linked immunodeficient B cells. Immunology 85:248.
25. Ohta, S., Bahrun, U., Shimazu, R., Matsushita, H., Fukudome, K. and Kimoto, M. 2006. Induction of long-term lipopolysaccharide tolerance by an agonistic monoclonal antibody to the toll-like receptor 4/MD-2 complex. Clin. Vaccine Immunol. 13:1131.
26. Shapiro-Shelef, M., Lin, K. I., McHeyzer-Williams, L. J., Liao, J., McHeyzer-Williams, M. G. and Calame, K. 2003. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19:607.
27. Shapiro-Shelef, M. and Calame, K. 2005. Regulation of plasmacell development. Nat. Rev. Immunol. 5:230.
28. Martins, G. and Calame, K. 2008. Regulation and functions of Blimp-1 in T and B lymphocytes. Annu. Rev. Immunol. 26:133.
29. Grumont, R. J., Rourke, I. J. and Gerondakis, S. 1999. Reldependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev. 13:400.
30. Grumont, R. J., Strasser, A. and Gerondakis, S. 2002. B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-kappaB regulated c-myc transcription. Mol. Cell 10:1283.
31. Lee, H., Arsura, M., Wu, M., Duyao, M., Buckler, A. J. and Sonenshein, G. E. 1995. Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line. J. Exp. Med. 181:1169.
32. Hebeis, B., Vigorito, E., Kovesdi, D. and Turner, M. 2005. Vav proteins are required for B-lymphocyte responses to LPS. Blood 106:635.
33. Meyer-Bahlburg, A., Bandaranayake, A. D., Andrews, S. F. and Rawlings, D. J. 2009. Reduced c-myc expression levels limit follicular mature B cell cycling in response to TLR signals. J. Immunol. 182:4065.
34. Divanovic, S., Trompette, A., Atabani, S. F. et al. 2005. Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat. Immunol. 6:571.
35. Yoon, S. I., Hong, M. and Wilson, I. A. 2011. An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1. Nat. Struct. Mol. Biol. 18:1028.