Alveolar Macrophage-Derived Vascular Endothelial Growth Factor Contributes to Allergic Airway Inflammation in a Mouse Asthma Model

Scandinavian Journal of Immunology

Volumn 75, Issue 6, 2012, Pages 599-605

  Song, C ^a   Ma, H ^a   Yao, C ^a   Tao, X ^a   Gan, H ^a  

^a BENGBU MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MICRORNA 20B; NEUTRALIZING ANTIBODY; OVALBUMIN; VASCULOTROPIN; VASCULOTROPIN ANTIBODY;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; INFLAMMATORY INFILTRATE; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT ALLERGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; ASTHMA; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; HYPERSENSITIVITY; INFLAMMATION; LUNG; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED BALB C; MICRORNAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84861465443     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2012.02693.x     Document Type: Article

References (39)

1. Locksley RM. Asthma and allergic inflammation. Cell 2010;140:777-83.
2. Holt PG, Strickland DH, Bosco A, Jahnsen FL. Pathogenic mechanisms of allergic inflammation: atopic asthma as a paradigm. Adv Immunol 2009;104:51-113.
3. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004;59:469-78.
4. Bossé Y, Paré PD, Seow CY. Airway wall remodeling in asthma: from the epithelial layer to the adventitia. Curr Allergy Asthma Rep 2008;8:357-66.
5. Hirashima M. Regulation of endothelial cell differentiation and arterial specification by VEGF and Notch signaling. Anat Sci Int 2009;84:95-101.
6. Maniscalco WM, Watkins RH, D'Angio CT, Ryan RM. Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung. Am J Respir Cell Mol Biol 1997;16:557-67.
7. Kristan SS, Malovrh MM, Silar M et al. Airway angiogenesis in patients with rhinitis and controlled asthma. Clin Exp Allergy 2009;39:354-60.
8. Lee CG, Link H, Baluk P et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 2004;10:1095-103.
9. Kanazawa H. VEGF, angiopoietin-1 and -2 in bronchial asthma: new molecular targets in airway angiogenesis and microvascular remodeling. Recent Pat Inflamm Allergy Drug Discov 2007;1:1-8.
10. Yao JS, Shen F, Young WL, Yang GY. Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smoothmuscle cell migration. Neurochem Int 2007;50:524-30.
11. Bieri M, Oroszlan M, Farkas A, Ligeti N, Bieri J, Mohacsi P. Anti-HLA I antibodies induce VEGF production by endothelial cells, which increases proliferation and paracellular permeability. Int J Biochem Cell Biol 2009;41:2422-30.
12. Marek N, Myśliwiec M, Raczyńska K, Zorena K, Myśliwska J, Trzonkowski P. Increased spontaneous production of VEGF by CD4+ T cells in type 1 diabetes. Clin Immunol 2010;137:261-70.
13. Wu WK, Llewellyn OP, Bates DO, Nicholson LB, Dick AD. IL-10 regulation of macrophage VEGF production is dependent on macrophagepolarisation and hypoxia. Immunobiology 2010;215:796-803.
14. Song C, Luo L, Lei Z et al. IL-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. J Immunol 2008;181:6117-24.
15. Medford AR, Douglas SK, Godinho SI et al. Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury. Respir Res 2009;10:27.
16. Takeda K, Hamelmann E, Joetham A et al. Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice. J Exp Med 1997;186:449-54.
17. Song C, Wang C, Huang L. Human neonatal neutrophils are resistant to apoptosis with lower caspase-3 activity. Tohoku J Exp Med 2011;225:59-63.
18. + TREGcells by targeting AC9 mRNA. EMBO Rep 2009;10:180-5.
19. Lei Z, Li B, Yang Z et al. Regulation of HIF-1alpha and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS ONE 2009;4:e7629.
20. Jiang X. The emerging role of microRNAs in asthma. Mol Cell Biochem 2011;353:35-40.
21. Hua Z, Lv Q, Ye W et al. MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS ONE 2006;1:e116.
22. Saetta M, Turato G. Airway pathology in asthma. Eur Respir J Suppl 2001;34:18s-23s.
23. Lee KS, Kim SR, Park HS et al. Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression. J Allergy Clin Immunol 2004;114:1093-9.
24. Lee KS, Min KH, Kim SR et al. Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma. Am J Respir Crit Care Med Med 2006;174:161-70.
25. Lee YC, Kwak YG, Song CH. Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma. J Immunol 2002;168:3595-600.
26. Choi JH, Suh YJ, Lee SK et al. Acute and chronic changes of vascular endothelial growth factor (VEGF) in induced sputum of toluene diisocyanate (TDI)-induced asthma patients. J Korean Med Sci 2004;19:359-63.
27. Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001;107:295-301.
28. Bae YJ, Kim TB, Moon KA et al. Vascular endothelial growth factor levels in induced sputum and emphysematous changes in smoking asthmatic patients. Ann Allergy Asthma Immunol 2009;103:51-6.
29. Lohmann-Matthes ML, Steinmüller C, Franke-Ullmann G. Pulmonary macrophages. Eur Respir J 1994;7:1678-89.
30. Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003;3:23-35.
31. Mantovani A, Sica A, Locati M. Macrophage polarization comes of age. Immunity 2005;23:344-6.
32. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76.
33. Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signaling-in control of vascular function. Nat Rev Mol Cell Biol 2006;7:359-71.
34. Lu TX, Munitz A, Rothenberg ME. Microrna-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol 2009;182:4994-5002.
35. Ambros V. microRNAs: tiny regulators with great potential. Cell 2001;107:823-6.
36. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004;5:522-31.
37. Miska EA. How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev 2005;15:563-8.
38. Shivdasani RA. MicroRNAs: regulators of gene expression and cell differentiation. Blood 2006;108:3646-53.
39. Hobert O. Gene regulation by transcription factors and microRNAs. Science 2008;319:1785-6.