Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model

Biochemical and Biophysical Research Communications

Volumn 422, Issue 1, 2012, Pages 22-27

  Oishi, Toshiyuki ^a   Terai, Shuji ^a   Kuwashiro, Shinya ^a   Fujisawa, Koichi ^a   Matsumoto, Toshihiko ^a   Nishina, Hiroshi ^b   Sakaida, Isao ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Ezetimibe; Inflammation; Medaka; NASH

Indexed keywords

CHOLESTEROL; EZETIMIBE; FATTY ACID; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; FATTY ACID ANALYSIS; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HISTOPATHOLOGY; INFLAMMATORY CELL; LIVER CELL; NONALCOHOLIC FATTY LIVER; NONHUMAN; ORYZIAS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; AZETIDINES; DISEASE MODELS, ANIMAL; FATTY ACIDS; FATTY LIVER; INFLAMMATION; LIVER; ORYZIAS;

ORYZIINAE;

EID: 84861456262     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.04.087     Document Type: Article

References (21)

1. Ludwig J., Viggiano T.R., McGill D.B., Oh B.J. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin. Proc. 1980, 55(7):434-438.
2. Day C.P., James O.F. Steatohepatitis: a tale of two "hits" ?. Gastroenterology 1998, 114(4):842-845.
3. Masahito P., Aoki K., Egami N., Ishikawa T., Sugano H. Life-span studies on spontaneous tumor development in the medaka (Oryzias latipes). Jpn. J. Cancer Res. 1989, 80(11):1058-1065.
4. Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T., Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A., Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S., Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S., Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K., Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y. The medaka draft genome and insights into vertebrate genome evolution. Nature 2007, 447(7145):714-719.
5. Sadler K.C., Amsterdam A., Soroka C., Boyer J., Hopkins N. A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. Development 2005, 132(15):3561-3572.
6. Watanabe T., Asaka S., Kitagawa D., Saito K., Kurashige R., Sasado T., Morinaga C., Suwa H., Niwa K., Henrich T., Hirose Y., Yasuoka A., Yoda H., Deguchi T., Iwanami N., Kunimatsu S., Osakada M., Loosli F., Quiring R., Carl M., Grabher C., Winkler S., Del Bene F., Wittbrodt J., Abe K., Takahama Y., Takahashi K., Katada T., Nishina H., Kondoh H., Furutani-Seiki M. Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria. Mech. Dev. 2004, 121(7-8):791-802.
7. Shieh Y.S., Chang Y.S., Hong J.R., Chen L.J., Jou L.K., Hsu C.C., Her G.M. Increase of hepatic fat accumulation by liver specific expression of Hepatitis B virus X protein in zebrafish. Biochim. Biophys. Acta 2010, 1801(7):721-730.
8. Matsumoto T., Terai S., Oishi T., Kuwashiro S., Fujisawa K., Yamamoto N., Fujita Y., Hamamoto Y., Furutani-Seiki M., Nishina H., Sakaida I. Medaka as a model for human nonalcoholic steatohepatitis. Dis. Model Mech. 2010, 3(7-8):431-440.
9. Kuwashiro S., Terai S., Oishi T., Fujisawa K., Matsumoto T., Nishina H., Sakaida I. Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. Cell Tissue Res. 2011, 344(1):125-134.
10. Kleiner D.E., Brunt E.M., Van Natta M., et al. Design and validation of a histologic scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41:1313-1321.
11. Folch J., Lees M. Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 1957, 226(1):497-509.
12. Oishi T., Terai S., Iwamoto T., Takami T., Yamamoto N., Sakaida I. Splenectomy reduces fibrosis and preneoplastic lesions with increased triglycerides and essential fatty acids in rat liver cirrhosis induced by a choline-deficient l-amino acid-defined diet. Hepatol. Res. 2011, 41(5):463-474.
13. Altmann S.W., Davis H.R., Zhu L.J., Yao X., Hoos L.M., Tetzloff G., et al. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 2004, 303:1201-1204.
14. Deushi M., Nomura M., Kawakami A., Haraguchi M., Ito M., Okazaki M., et al. Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome. FEBS Lett. 2007, 581:5664-5670.
15. Labonté E.D., Camarota L.M., Rojas J.C., Jandacek R.J., Gilham D.E., Davies J.P., et al. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295:776-783.
16. Assy N., Grozovski M., Bersudsky I., Szvalb S., Hussein O. Effect of insulin-sensitizing agents in combination with ezetimibe, and valsartan in rats with non-alcoholic fatty liver disease. World J. Gastroenterol. 2006, 12:4369-4376.
17. Zheng S., Hoos L., Cook J., Tetzloff G., Davis H., van Heek M., et al. Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice Eur. J. Pharmacol. 2008, 584:118-124.
18. Weisberg S.P., McCann D., Desai M., Rosenbaum M., Leibel R.L., Ferrante A.W. Obesity is associated with macrophage accumulation in adipose tissue. J. Clin. Invest. 2003, 112(12):1796-1808.
19. Labonté E.D., Camarota L.M., Rojas J.C., Jandacek R.J., Gilham D.E., Davies J.P., Ioannou Y.A., Tso P., Hui D.Y., Howles P.N. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295(4):G776-G783.
20. Westerbacka J., Kolak M., Kiviluoto T., Arkkila P., Sirén J., Hamsten A., Fisher R.M., Yki-Järvinen H. Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes 2007, 56(11):2759-2765.
21. Ishibashi M., Hiasa K., Zhao Q., Inoue S., Ohtani K., Kitamoto S., Tsuchihashi M., Sugaya T., Charo I.F., Kura S., Tsuzuki T., Ishibashi T., Takeshita A., Egashira K. Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling. Circ. Res. 2004, 94(9):1203-1210.