Interferon-γ modulates the functional profile of in-vitro-cultured porcine microglia

NeuroReport

Volumn 23, Issue 9, 2012, Pages 519-524

  Tambuyzer, Bart R ^a   Casteleyn, Christophe ^a   Van Cruchten, Steven ^a   Ponsaerts, Peter ^a   Van Ginneken, Chris ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

hydroethidine; in vitro; interferon c; microglia

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE DEXTRAN; GAMMA INTERFERON; HYDROETHIDINE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL PHAGOCYTOSIS; FLOW CYTOMETRY; IN VITRO STUDY; MICROGLIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ANTIVIRAL AGENTS; CARCINOGENS; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; FLOW CYTOMETRY; INTERFERON-GAMMA; MICROGLIA; PHAGOCYTOSIS; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; SWINE; TETRADECANOYLPHORBOL ACETATE;

EID: 84861456259     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32835349e4     Document Type: Article

References (19)

1. Tambuyzer B, Ponsaerts P, Nouwen EJ Microglia: gatekeepers of central nervous system immunology J Leukoc Biol 2009; 85:352-370
2. Lipovsky MM, Gekker G, Anderson WR, Molitor TW, Peterson PK, Hoepelman AI Phagocytosis of nonopsonized Cryptococcus neoformans by swine microglia involves CD14 receptors Clin Immunol Immunopathol 1997; 84:208-211 (Pubitemid 27353474)
3. Kadiu I, Glanzer JG, Kipnis J, Gendelman HE, Thomas MP Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases Neurotox Res 2005; 8:25-50
4. Tambuyzer BR, Nouwen EJ Inhibition of microglia multinucleated giant cell formation and induction of differentiation by GM-CSF using a porcine in vitro model Cytokine 2005; 31:270-279 (Pubitemid 41097363)
5. Tambuyzer BR, Bergwerf I, De Vocht N, Reekmans K, Daans J, Jorens PG, et al Allogeneic stromal cell implantation in brain tissue leads to robust microglial activation Immunol Cell Biol 2009; 87:267-273
6. Ueyama T, Lennartz MR, Noda Y, Kobayashi T, Shirai Y, Rikitake K, et al Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia J Immunol 2004; 173:4582-4589 (Pubitemid 39280691)
7. Block ML, Zecca L, Hong JS Microglia-mediated neurotoxicity: uncovering the molecular mechanisms Nat Rev Neurosci 2007; 8:57-69 (Pubitemid 46011999)
8. Castellano B, Gonzá lez B, Jensen MB, Pedersen EB, Finsen BR, Zimmer J A double staining technique for simultaneous demonstration of astrocytes and microglia in brain sections and astroglial cell cultures J Histochem Cytochem 1991; 39:561-568
9. Tambuyzer BR, Lambrichts I, Lenjou M, Nouwen EJ Effects of the pig renal epithelial cell line LLC-PK1 and its conditioned medium on the phenotype of porcine microglia in vitro Eur J Cell Biol 2007; 86:221-232 (Pubitemid 46420141)
10. Perticarari S, Presani G, Mangiarotti MA, Banfi E Simultaneous flow cytometric method to measure phagocytosis and oxidative products by neutrophils Cytometry 1991; 12:687-893
11. Chan A, Magnus T, Gold R Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: mechanism for removal of apoptotic cells in the inflamed nervous system Glia 2001; 33:87-95 (Pubitemid 32102819)
12. Smith ME, van der Maesen K, Somera FP Macrophage and microglial responses to cytokines in vitro: phagocytic activity, proteolytic enzyme release, and free radical production J Neurosci Res 1998; 54:68-78 (Pubitemid 28447190)
13. Chao CC, Hu S, Peterson PK Modulation of human microglial cell superoxide roduction by cytokines J Leukoc Biol 1995; 58:65-70
14. Colton CA, Yao J, Keri JE, Gilbert D Regulation of microglial function by interferons J Neuroimmunol 1992; 40:89-98
15. Broderick C, Duncan L, Taylor N, Dick AD IFN-gamma and LPS-mediated IL-10-dependent suppression of retinal microglial activation Invest Ophthalmol Vis Sci 2000; 41:2613-2622 (Pubitemid 30624390)
16. Butovsky O, Talpalar AE, Ben Yaakov K, Schwartz M Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective Mol Cell Neurosci 2005; 29:381-393 (Pubitemid 40799211)
17. Correale J, Villa A The neuroprotective role of inflammation in nervous system injuries J Neurol 2004; 251:1304-1316
18. Furlan R, Brambilla E, Ruffini F, Poliani PL, Bergami A, Marconi PC, et al Intrathecal delivery of IFN-gamma protects C57BL/6 mice from chronicprogressive experimental autoimmune encephalomyelitis by increasing apoptosis of central nervous system-infiltrating lymphocytes J Immunol 2001; 167:1821-1829 (Pubitemid 32703187)
19. Panitch HS, Hirsch RL, Haley AS, Johnson KP Exacerbations of multiple sclerosis in patients treated with gamma interferon Lancet 1987; 1:893-895