Allogeneic stromal cell implantation in brain tissue leads to robust microglial activation

Immunology and Cell Biology

Volumn 87, Issue 4, 2009, Pages 267-273

  Tambuyzer, Bart R ^a   Bergwerf, Irene ^a   De Vocht, Nathalie ^a   Reekmans, Kristien ^a,b   Daans, Jasmijn ^a   Jorens, Philippe G ^b   Goossens, Herman ^a   Ysebaert, Dirk K ^a,b   Chatterjee, Shyama ^a   Van Marck, Eric ^a   Berneman, Zwi N ^a,b   Ponsaerts, Peter ^a,b  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Graft rejection; Microglia; Neuroimmunology; Stromal cells; Transplantation

Indexed keywords

ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL ACTIVATION; CONTROLLED STUDY; GRAFT REJECTION; IMMUNOREACTIVITY; MICROGLIA; MOUSE; NEUROIMMUNOLOGY; NONHUMAN; STROMA CELL; T LYMPHOCYTE;

ANIMALS; BONE MARROW TRANSPLANTATION; BRAIN; CELLS, CULTURED; COCULTURE TECHNIQUES; GRAFT REJECTION; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROGLIA; NITRIC OXIDE; STEM CELL TRANSPLANTATION; STROMAL CELLS; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE; MUS;

EID: 67349194971     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2009.12     Document Type: Article

References (28)

1. Hyder AA, Wunderlich CA, Puvanachandra P, Gururaj G, Kobusingye OC. The impact of traumatic brain injuries: a global perspective. Neuro Rehabilitation 2007; 22: 341-353.
2. Reilly P. The impact of neurotrauma on society: an international perspective. Prog Brain Res 2007; 161:3-9.
3. Rossnagel K, Nolte CH, Muller-Nordhorn J, Jungehulsing GJ, Selim D, Bruggenjurgen B et al. Medical resource use and costs of health care after acute stroke in Germany. Eur J Neurol 2005; 12: 862-868.
4. Dheen ST, Kaur C, Ling EA. Microglial activation and its implications in the brain diseases. Curr Med Chem 2007; 14: 1189-1197.
5. Parr AM, Tator CH, Keating A. Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury. Bone Marrow Transplant 2007; 40: 609-619.
6. Ronsyn MW, Berneman ZN, Van Tendeloo VF, Jorens PG, Ponsaerts P. Can cell therapy heal a spinal cord injury? Spinal Cord 2008; 46:532-539.
7. Keyser KA, Beagles KE, Kiem HP. Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation. Cell Transplant 2007; 16:555-562.
8. Zheng ZH, Li XY, Ding J, Jia JF, Zhu P. Allogeneic mesenchymal stem cell and mesenchymal stem cell-differentiated chondrocyte suppress the responses of type II collagen-reactive T-cells in rheumatoid arthritis. Rheumatology (Oxford) 2008; 47: 22-30.
9. Ryan JM, Barry FP, Murphy JM, Mahon BP. Mesenchymal stem cells avoid allogeneic rejection. J Inflamm (Lond) 2005; 2:8.
10. Eliopoulos N, Stagg J, Lejeune L, Pommey S, Galipeau J. Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice. Blood 2005; 106: 4057-4065.
11. Coyne TM, Marcus AJ, WoodburyD, Black IB. Marrowstromal cells transplanted to the adult brain are rejected by an inflammatory response and transfer donor labels to host neurons and glia. Stem Cells 2006; 24: 2483-2492.
12. Krystkowiak P, Gaura V, Labalette M, Rialland A, Remy P, Peschanski M et al. Alloimmunisation to donor antigens and immunerejection following foet al neural grafts to the brain in patients with Huntington's disease. PLoS ONE 2007; 2:e166.
13. Bradbury MS, Panagiotakos G, Chan BK, Tomishima M, Zanzonico P, Vider J et al. Optical bioluminescence imaging of human ES cell progeny in the rodent CNS. J Neurochem 2007; 102: 2029-2039.
14. Isakova IA, Baker K, DuTreil M, Dufour J, Gaupp D, PhinneyDG. Age- and dose-related effects on MSC engraftment levels and anatomical distribution in the central nervous systems of nonhuman primates: identification of novel MSC subpopulations that respond to guidance cues in brain. Stem Cells 2007; 25: 3261-3270.
15. Hayashi Y, Shumsky JS, Connors T, Otsuka T, Fischer I, Tessler A et al. Immunosup- pression with either cyclosporine a or FK50supports survival of transplanted fibroblasts and promotes growth of host axons into the transplant after spinal cord injury. JNeurotrauma 2005; 22: 1267-1281.
16. Swanger SA, Neuhuber B, Himes BT, Bakshi A, Fischer I. Analysis of allogeneic and syngeneic bone marrow stromal cell graft survival in the spinal cord. Cell Transplant 2005; 14: 775-786.
17. Ponsaerts P, Van Tendeloo VFI, Jorens PG, Berneman ZN, Van Bockstaele DR. Current challenges in human embryonic stem cell research: directed differentiation and immune tolerance. J Biol Regul Homeost Agent 2004; 18: 347-351.
18. Ronsyn MW, Daans J, Spaepen G, Chatterjee S, Vermeulen K, D'Haese P et al. Plasmid- based genetic modification of human bone marrow-derived stromal cells: analysis of cell survival and transgene survival after transplantation in rat spinal cord. BMC Biotechnol 2007; 7:90.
19. Ambrosini E, Aloisi F. Chemokines and glial cells: a complex network in the central nervous system. Neurochem Res 2004; 29: 1017-1038.
20. Guillemin GJ, Brew BJ. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. JLeukoc Biol 2004; 75: 388-397.
21. Peister A, Mellad JA, Larson BL, Hall BM, Gibson LF, Prockop DJ. Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood 2004; 103: 1662-1668.
22. Nakamura Y. Regulating factors for microglial activation. Biol Pharm Bul 2002; 25: 945-953.
23. Mais A, Klein T, Ullrich V, Schudt C, Lauer G. Prostanoid pattern and iNOS expression during chondrogenic differentiation of human mesenchymal stem cells. JCell Biochem 2006; 98: 798-809.
24. Pevsner-Fischer M, Morad V, Cohen-SfadyM, Rousso-Noori L, Zanin-ZhorovA, Cohen S et al. Toll-like receptors and their ligands control mesenchymal stem cell functions. Blood 2007; 109: 1422-1432.
25. Carson MJ, DooseJM, Melchior B, Schmid CD, Ploix CC. CNS immune privilege: hiding in plain sight. Immunol Rev 2006; 213:48-65.
26. Tambuyzer BR, Ponsaerts P, Nouwen EJ. Microglia: gatekeepers of central nervous system immunology. J Leukoc Biol 2009; 85: 352-370.
27. Bergwerf I, De Vocht N, Tambuyzer B, Verschueren J, Reekmans K, Daans J et al. Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice. BMC Biotechnol 2009; 9:1.
28. Tambuyzer BR, Nouwen EJ. Inhibition of microglia multinucleated giant cell formation and induction of differentiation by GM-CSF using a porcine in vitro model. Cytokine 2005; 31: 270-279.