Ether-à-go-go 1 (Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion

Neurotoxicity Research

Volumn 21, Issue 3, 2012, Pages 317-333

  Ferreira, N R ^a   Mitkovski, M ^b   Stuhmer W ^b   Pardo, L A ^b   Del Bel, E A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

6 OHDA; Basal ganglia; Dopamine; Eag1; Potassium channels

Indexed keywords

APOMORPHINE; OXIDOPAMINE; SODIUM CHLORIDE; TYROSINE 3 MONOOXYGENASE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ETHER A GO GO 1 GENE; FOREBRAIN; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE LOCATION; IMMUNOREACTIVITY; MALE; NERVE CELL LESION; NEUROMODULATION; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; ROTATION;

ANIMALS; BASAL GANGLIA; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; ETHER-A-GO-GO POTASSIUM CHANNELS; GLOBUS PALLIDUS; IMMUNOHISTOCHEMISTRY; MALE; NERVE DEGENERATION; NUCLEUS ACCUMBENS; OXIDOPAMINE; PARKINSONIAN DISORDERS; RATS; RATS, WISTAR; SUBSTANTIA NIGRA; SYMPATHOLYTICS; TYROSINE 3-MONOOXYGENASE;

RATTUS; RATTUS NORVEGICUS;

EID: 84861454382     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-011-9286-3     Document Type: Article

References (79)

1. Agid Y (1991) Parkinson's disease: pathophysiology. Lancet 337:1321-1324
2. Angulo E, Noe V, Casado V, Mallol J, Gomez-Isla T, Lluis C, Ferrer I, Ciudad CJ, Franco R (2004) Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease. J Neurochem 91(3):547-557 (Pubitemid 39431150)
3. Ariano MA, Cepeda C, Calvert CR, Flores-Hernandez J, Hernandez- Echeagaray E, Klapstein GJ, Chandler SH, Aronin N, DiFiglia M, Levine MS (2005) Striatal potassium channel dysfunction in Huntington's disease transgenic mice. J Neurophysiol 93(5): 2565-2574 (Pubitemid 40570839)
4. Bajaj A, Driver JA, Schernhammer ES (2010) Parkinson's disease and cancer risk: a systematic review and meta-analysis. Cancer Causes Control 21:697-707
5. 2 elevation, not ATP depletion. J Neurosci 25:10029-10040 (Pubitemid 41528042)
6. Baranauskas G, Tkatch T, Surmeier DJ (1999) Delayed rectifier currents in rat globus pallidus neurons are attributable to Kv2.1 and Kv3.1/3.2 K(+) channels. J Neurosci 19(15):6394-6404 (Pubitemid 29347439)
7. Barnéoud P, Parmentier S, Mazadier M, Miquet JM, Boireau A, Dubedat P, Blanchard JC (1995) Effects of complete and partial lesions of the dopaminergic mesotelencephalic system on skilled forelimb use in rat. Neuroscience 67(4):837-848
8. Becker C, Brobert GP, Johansson S, Jick SS, Meier CR (2010) Cancer risk in association with Parkinson disease: a population-based study. Parkinsonism Relat Disord 16:186-190
9. Betarbet R, Sherer TB, Greenamyre JT (2002) Animal models of Parkinson's disease. Bioessays 24(4):308-318 (Pubitemid 34305686)
10. Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ, Steinlein OK (1998) A potassium channel mutation in neonatal human epilepsy. Science 279(5349):403-406 (Pubitemid 28063379)
11. +-evoked release of [3H]dopamine from synaptosomes. J Pharmacol Exp Ther 248(2):514-520 (Pubitemid 19090217)
12. Browne DL, Gancher ST, Nutt JG, Brunt ER, Smith EA, Kramer P, Litt M (1994) Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. Nat Genet 8(2):136-140 (Pubitemid 24308360)
13. Cass WA, Zahniser NR (1991) Potassium channel blockers inhibit D2 dopamine, but not A1 adenosine, receptor-mediated inhibition of striatal dopamine release. J Neurochem 57(1):147-152
14. Chung YH, Shin CM, Kim MJ, Cha CI (2000) Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat basal ganglia. Brain Res 875(1-2):164-170
15. + channels. J Neurophysiol 87(2):1046-1056 (Pubitemid 34670866)
16. Deumens R, Blokland A, Prickaerts J (2002) Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway. Exp Neurol 175(2):303-317 (Pubitemid 34634286)
17. Douhou A, Debeir T, Murer MG, Do L, Dufour N, Blanchard V, Moussaoui S, Bohme GA, Agid Y, Raisman-Vozari R (2002) Effect of chronic treatment with riluzole on the nigrostriatal dopaminergic system in weaver mutant mice. Exp Neurol 176: 247-253 (Pubitemid 34762125)
18. Eulitz D, Prüss H, Derst C, Veh RW (2007) Heterogeneous distribution of Kir3 potassium channel proteins within dopaminergic neurons in the mesencephalon of the rat brain. Cell Mol Neurobiol 27(3):285-302 (Pubitemid 46763877)
19. Ganetzky B, Wu CF (1983) Neurogenetic analysis of potassium currents in Drosophila: synergistic effects on neuromuscular transmission in double mutants. J Neurogenet 1(1):17-28 (Pubitemid 14165888)
20. Gao X, Ning Y (2011) Cancer and Parkinson's disease: the odd couple. Drugs Today 47(3):215-222
21. Gomes MZ, Del Bel EA (2003) Effects of electrolytic and 6-hydroxydopamine lesions of rat nigrostriatal pathway on nitric oxide synthase and nicotinamide adenine dinucleotide phosphate diaphorase. Brain Res Bull 62:107-115 (Pubitemid 37443656)
22. Gómez-Varela D, Zwick-Wallasch E, Knötgen H, Sánchez A, Hettmann T, Ossipov D, Weseloh R, Contreras-Jurado C, Rothe M, Stühmer W, Pardo LA (2007) Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity. Cancer Res 67(15):7343-7349 (Pubitemid 47206564)
23. Greif GJ, Lin YJ, Liu JC, Freedman JE (1995a) Dopamine-modulated potassium channels on rat striatal neurons: specific activation and cellular expression. J Neurosci 15(6):4533-4544
24. GreifGJ, LinYJ, Freedman JE (1995b) Role of cyclicAMP in dopamine modulation of potassiumchannels on rat striatal neurons: regulation of a subconductance state. Synapse 21(3):275-277
25. Groenewegen HJ (2003) The basal ganglia and motor control. Neural Plast 10:107-120
26. Hansen HH, Ebbesen C, Mathiesen C, Weikop P, Ronn LC, Waroux O, Scuvee-Moreau J, Seutin V, Mikkelsen JD (2006) The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat. J Pharmacol Exp Ther 318:1006-1019 (Pubitemid 44268305)
27. Harik SI, Schmidley JW, Iacofano LA, Blue P, Arora PK, Sayre LM (1987) On the mechanisms underlying 1-methyl-4phenyl-1,2,3,6- tetrahydropiridine neurotoxicity: the effect of perinigral infusion of 1-methyl-4phenyl-1,2,3,6- tetrahydropiridine, its metabolite and their analogs in rat. J Pharmacol Exp Ther 241:669-676 (Pubitemid 17111579)
28. + channels. Proc Natl Acad Sci USA 103(8):289-2886
29. Heim C, Sova L, Kurz T, Kolasiewicz W, Schwegler H, Sontag K-H (2002) Partial loss of dopaminergic neurons in the substantia nigra, ventrotegmental area and the retrorubral area-model of the early beginning of Parkinson's symptomatology? J Neural Transm 109:691-709 (Pubitemid 34810767)
30. Hemmerlein B, Weseloh RM, Mello de Queiroz F, Knotgen H, Sanchez A, Rubio ME, Martin S, Schliephacke T, Jenke M, Radzun HJ, Stühmer W, Pardo LA (2006) B Overexpression of Eag1 potassium channels in clinical tumours. Mol Cancer 5:41
31. Hille B (2001) Ionic channels of excitable membranes, 3rd edn. Sinauer Assoc, Sunderland, MA
32. Inzelberg R, Jankovi CJ (2007) Are Parkinson disease patients protected from some but not all cancers? Neurology 69: 1542-1550 (Pubitemid 47537862)
33. Jellinger K (1987) The pathology of parkinsonism. In: Marsden CD, Fahn S (eds) Movement disorders, vol 2. Butterworths, London, pp 124-165
34. + sensitivity of SK channels. Eur J Neurosci 29(9):1883-1895
35. Ju M, Wray D (2002) Molecular identification and characterisation of the human eag2 potassium channel. FEBS Lett 524(1-3):204-210 (Pubitemid 34804861)
36. Kaczmarek LK (2006) Non-conducting functions of voltage-gated ion channels. Nat Rev Neurosci 7(10):761-771 (Pubitemid 44435259)
37. Kaplan WD, Trout WE (1969) The behavior of four neurological mutants of Drosophila. Genetics 61(2):399-409
38. Kitai ST, Surmeier DJ (1993) Cholinergic and dopaminergic modulation of potassium conductances in neostriatal neurons. Adv Neurol 60:40-52
39. Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El-Amraoui A, Marlin S, Petit C, Jentsch TJ (1999) KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96(3):437-446 (Pubitemid 29077597)
40. Lacey MG, Mercuri NB, North RA (1987) Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta. J Physiol 392:397-416 (Pubitemid 18014315)
41. Lamensdorf I, Meiri N, Harvey-White J, Jacobowitz DM, Kopin IJ (1999) Kir6.2 oligoantisense administered into the globus pallidus reduces apomorphineinduced turning in 6-OHDA hemiparkinsonian rats. Brain Res 818:275-284 (Pubitemid 29229941)
42. Liss B, Roeper J (2001) ATP-sensitive potassium channels in dopaminergic neurons: transducers of mitochondrial dysfunction. News Physiol Sci 16:214-217 (Pubitemid 33712826)
43. Liss B, Roeper J (2008) Individual dopamine midbrain neurons: functional diversity and flexibility in health and disease. Brain Res Rev 58(2):314-321
44. Liss B, Haeckel O, Wildmann J, Miki T, Seino S, Roeper J (2005) K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nat Neurosci 8:1742-1751 (Pubitemid 41683203)
45. Ludwig J, Terlau H, Wunder F, Brüggemann A, Pardo LA, Marquardt A, Stühmer W, Pong O (1994) Functional expression of a rat homologue of the voltage gated ether-à-go-go potassium channel reveals differences in selectivity and activation kinetics between the Drosophila channel and its mammalian counterpart. EMBO J 13(19):4451-4458
46. Ludwig J, Weseloh R, Karschin C, Liu Q, Netzer R, Engeland B, Stansfeld C, Pongs O (2000) Cloning and functional expression of rat eag2, a new member of the ether-à-go-go family of potassium channels and comparison of its distribution with that of eag1. Mol Cell Neurosci 16(1):59-70 (Pubitemid 30616558)
47. Luján R, de la Vega C, Dominguez del Toro E, Ballesta JJ, Criado M, Juiz JM (2003) Immunohistochemical localization of the voltage- gated potassium channel subunit Kv1.4 in the central nervous system of the adult rat. J Chem Neuroanat 26(3): 209-224 (Pubitemid 38112736)
48. Martin S, Lino De Oliveira C, Mello de Queiroz F, Pardo LA, Stühmer W, Del Bel E (2008) Eag1 potassium channel immunohistochemistry in the CNS of adult rat and selected regions of human brain. Neuroscience 155(3):833-844
49. Minami Y, Yamamoto R, Nishikouri M, Fukao A, Hisamichi S (2000) Mortality and cancer incidence in patients with Parkinson's disease. J Neurol 247(6):429-434 (Pubitemid 30433556)
50. Missale C, Nash SR, Robinson SW, Jaber M, Caron MG (1998) Dopamine receptors: from structure to function. Physiol Rev 78(1):189-225 (Pubitemid 28070979)
51. Morris BJ, Simpson CS, Mundell S, Maceachern K, Johnston HM, Nolan AM (1997) Dynamic changes in NADPH-diaphorase staining reflect activity of nitric oxide synthase: evidence for a dopaminergic regulation of striatal nitric oxide release. Neuropharmacology 36(11-12):1589-1599 (Pubitemid 28085919)
52. Morris LG, Veeriah S, Chan TA (2010) Genetic determinants at the interface of cancer and neurodegenerative disease. Oncogene 29:3453-3464
53. Nair-Roberts RG, Chatelain-Badie SD, Benson E, White-Cooper H, Bolam JP, Ungless MA (2008) Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat. Neuroscience 152(4):1024-1031
54. Occhiodoro T, Bernheim L, Liu JH, Bijlenga P, Sinnreich M, Bader CR, Fischer-Lougheed J (1998) Cloning of a human ether-à-gogo potassium channel expressed in myoblasts at the onset of fusion. FEBS Lett 434(1-2):177-182 (Pubitemid 28404684)
55. Olsen JH, Friis S, Frederiksen K, Mclaughlin JK, Mellemkjaer L, Moller H (2005) Atypical cancer pattern in patients with Parkinson's disease. Br J Cancer 92(1):201-205 (Pubitemid 40188456)
56. Pardo LA (2004) Voltage-gated potassium channels in cell proliferation. Physiology 19:285-292 (Pubitemid 39472640)
57. + channels. EMBO J 18(20):5540-5547 (Pubitemid 29486373)
58. Pardo LA, Contreras-Jurado C, Zientkowska M, Alves F, Stuhmer W (2005) Role of voltage-gated potassium channels in cancer. J Memb Biol 205:115-124 (Pubitemid 41803688)
59. Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic Press, San Diego
60. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22(2):153-183 (Pubitemid 32458157)
61. Perese DA, Ulman J, Viola J, Ewing SE, Bankiewicz KS (1989) A 6-hydroxydopamine-induced selective parkinsonian rat model. Brain Res 494:285-293 (Pubitemid 19194542)
62. + channel activity regulates excitability of nucleus accumbens neurons at different membrane potentials. J Neurophysiol 96(5):217-2228
63. Preisig-Muller R, Schlichthorl G, Goerge T, Heinen S, Brüggemann A, Rajan S, Derst C, Veh RW, Daut J (2002) Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. Proc Natl Acad Sci USA 99(11):7774-7779 (Pubitemid 34568767)
64. Prüss H, Wenzel M, Eulitz D, Thomzig A, Karschin A, Veh RW (2003) Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Brain Res Mol Brain Res 110(2):203-219 (Pubitemid 36184694)
65. Rasband WS (1997-2009) ImageJ, US National Institutes of Health, Bethesda, MD, USA, http://rsb.info.nih.gov/ij/
66. Redman PT, Jefferson BS, Ziegler CB, Mortensen OV, Torres GE, Levitan ES, Aizenman E (2006) A vital role for voltagedependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience 143:1-6 (Pubitemid 44667319)
67. + channels in brain. J Neurosci 21(13):4609-4624 (Pubitemid 32565620)
68. Salthun-Lassalle B, Hirsch EC, Wolfart J, Ruberg M, Michel PP (2004) Rescue of mesencephalic dopaminergic neurons in culture by low-level stimulation of voltage-gated sodium channels. J Neurosci 24(26):5922-5930 (Pubitemid 38859390)
69. Sánchez Sorzano CÓ , Thévenaz P, Unser M (2005) Elastic registration of biological images using vector-spline regularization. IEEE Trans Biomed Eng 52(4):652-663 (Pubitemid 40477175)
70. Sanguinetti MC, Spector PS (1997) Potassium channelopathies. Neuropharmacology 36(6):755-762 (Pubitemid 27286728)
71. Shieh CC, Coghlan M, Sullivan JP, Gopalakrishnan M (2000) Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev 52(4):557-594
72. Sutton KG, McRory JE, Guthrie H, Murphy TH, Snutch TP (1999) P/Q-type calcium channels mediate the activity-dependent feedback of syntaxin-1A. Nature 401(67550):800-804
73. Thévenaz P, Unser M (2007) User-friendly semiautomated assembly of accurate image mosaics in microscopy. Microsc Res Tech 70(2):135-146 (Pubitemid 46292248)
74. Truong L, Allbutt H, Kassiou M, Henderson JM (2006) Developing a preclinical model of Parkinson's disease: a study of behaviour in rats with graded 6-OHDA lesions. Behav Brain Res 169(1):1-9 (Pubitemid 43277465)
75. + channel in acutely dissociated rat substantia nigra neurones. Neuropharmacology 39(2):191-201 (Pubitemid 30009813)
76. Wang Y, Yang PL, Tang JF, Lin JF, Cai XH, Wang XT, Zheng GQ (2008) Potassium channels: possible new therapeutic targets in Parkinson's disease. Med Hypotheses 71(4):546-550
77. Warmke JW, Ganetzky B (1994) A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci USA 91(8):3438-3442 (Pubitemid 24130252)
78. Warmke J, Drysdale R, Ganetzky B (1991) A distinct potassium channel polypeptide encoded by the Drosophila eag locus. Science 252(5012):1560-1562 (Pubitemid 21917078)
79. Weber C, Mello de Queiroz F, Downie BR, Suckow A, Stühmer W, Pardo LA (2006) Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference. J Biol Chem 281(19):13030-13037 (Pubitemid 43855212)