Research chemicals marketed as legal highs: The case of pipradrol derivatives

Toxicology Letters

Volumn 212, Issue 1, 2012, Pages 57-60

  Coppola, M ^a   Mondola, R ^b  

^a ASL CN2   (Italy)

^b ASL CN1   (Italy)

Author keywords

2 DPMP; D2PM; Designer drug; Diphenylmethylpyrrolidine; Pipradrol

Indexed keywords

AMPHETAMINE; COCAINE; DEOXYPIPRADOL; DIPHENYLMETHYLPYRROLIDINE; DIPHENYLPROLINOL; DOPAMINE; ILLICIT DRUG; LEGAL HIGH; PIPERIDINE DERIVATIVE; PIPRADOL; RECREATIONAL DRUG; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANESTHESIA; ATTENTION DEFICIT DISORDER; CHEMISTRY; CORPUS STRIATUM; DEPRESSION; DRUG ABUSE; DRUG EFFECT; DRUG MARKETING; DRUG USE; HUMAN; HYPOTHALAMUS; LEGAL ASPECT; MOLECULAR WEIGHT; NARCOLEPSY; NUCLEUS ACCUMBENS; OBESITY; PHARMACOLOGY; PRIORITY JOURNAL; REVIEW; TOXICOLOGY; TREATMENT INDICATION;

HUMANS; PIPERIDINES; STREET DRUGS;

EID: 84861446932     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.04.019     Document Type: Review

References (17)

1. Belucci G. (2-Diphenylmethyl-piperidine hydrochloride and the methyl ester of 2-chloro-2-phenyl-2-(2-piperidyl)-acetic acid), drugs with waking effect in anesthesia. Minerva Anestesiologica 1955, 21:125-128.
2. Davidson C., Ramsey J. Desoxypipradrol is more potent than cocaine on evoked dopamine efflux in the nucleus accumbens. Journal of Psychopharmacology 2011, 10.1177/0269881111430733.
3. Enyedy I.J., Sakamuri S., Zaman W.A., Johnson K.M., Wang S. Pharmacophore-based discovery of substituted pyridines as novel dopamine transporter inhibitors. Bioorganic & Medicinal Chemistry Letters 2003, 13:513-517.
4. Ferris R.M., Tang F.L. Comparison of the effects of the isomers of amphetamine, methylphenidate and deoxypipradrol on the uptake of l-[3H]norepinephrine and [3H]dopamine by synaptic vesicles from rat whole brain, striatum and hypothalamus. Journal of Pharmacology and Experimental Therapeutics 1979, 210:422-428.
5. Gibbons S. 'Legal highs' - novel and emerging psychoactive drugs: a chemical overview for the toxicologist. Clinical Toxicology (Philadelphia) 2012, 50:15-24.
6. Jones A.L. Legal 'highs' available through the Internet-implications and solutions?. QJM 2010, 103:535-536.
7. Lidder S., Dargan P., Sexton M., Button J., Ramsey J., Holt D., et al. Cardiovascular toxicity associated with recreational use of diphenylprolinol (diphenyl-2-pyrrolidinemethanol[D2PM]). Journal of Medical Toxicology 2008, 4:167-169.
8. Murray B.L., Murphy C.M., Beuhler M.C. Death following recreational use of designer drug bath salts containing 3,4-methylenedioxypyrovalerone (MDPV). Journal of Medical Toxicology 2012, 8:69-75.
9. Murray D.B., Potts S., Haxton C., Jackson G., Sandilands E.A., Ramsey J., et al. 'Ivory wave' toxicity in recreational drug users; integration of clinical and poisons information services to manage legal high poisoning. Clinical Toxicology (Philadelphia) 2012, 50:108-113.
10. Robbins T.W., Watson B.A., Gaskin M., Ennis C. Contrasting interactions of pipradrol, d-amphetamine, cocaine, cocaine analogues, apomorphine and other drugs with conditioned reinforcement. Psychopharmacology (Berlin) 1983, 80:113-119.
11. Shanks K.G., Dahn T., Terrell A.R. Detection of JWH-018 and JWH-073 by UPLC-MS-MS in postmortem whole blood casework. Journal of Analytical Toxicology 2012, 36:145-152.
12. Vardakou I., Pistos C., Spiliopoulou C.h. Drugs for youth via Internet and the example of mephedrone. Toxicology Letters 2011, 201:291-295.
13. Wood D.M., Ramsey J., Dargan P.I. Detecting novel and emerging recreational drugs on the club scene. Irish Psychiatrists 2008, 9:223-228.
14. Wood D.M., Davies S., Greene S.L., Button J., Holt D.W., Ramsey J., Dargan P.I. Case series of individuals with analytically confirmed acute mephedrone toxicity. Clinical Toxicology (Philadelphia) 2010, 48:924-927.
15. Wood D.M., Davies S., Puchnarewicz M., Johnston A., Dargan P.I. Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine. European Journal of Clinical Pharmacology 2011, 10.1007/s00228-011-1199-9.
16. Wood D.M., Puchnarewicz M., Johnston A., Dargan P.I. A case series of individuals with analytically confirmed acute diphenyl-2-pyrrolidinemethanol (D2PM) toxicity. European Journal of Clinical Pharmacology 2011, 10.1007/s00228-011-1142-0.
17. Zawilska J.B. Legal highs - new players in the old drama. Current Drug Abuse Reviews 2011, 4:122-130.