Effect of silencing HIF-1α on expressions of VEGF and CXCR4 in nasopharyngeal carcinoma cell line

Chinese Journal of Cancer Prevention and Treatment

Volumn 15, Issue 3, 2008, Pages 170-173

  Wu, De Hua ^a   Zhu, Xiao Xia ^a   Zhang, Hong Bo ^a   Li, Gao Feng ^a   Chen, Long Hua ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Genes; Nasopharyngeal neoplasms; RNA interference

Indexed keywords

EID: 84861435639     PISSN: 16735269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Semenza G L, Wang G L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation[J]. Mol Cell Biol, 1992, 12(12): 5447-5454.
2. Brahimi-Horn C, Pouyssegur J. The role of the hypoxia-inducible factor in tumor metabolism growth and invasion [J]. Bull Cancer, 2006, 93(8):E73-80.
3. Vaupel P. The role of hypoxia-induced factors in tumor progression[J]. Oncologist, 2004, 9(Suppl5): 10-17.
4. Livak K J, Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method[J]. Methods, 2001, 25(4): 402-408.
5. Song X, Liu X, Chi W, et al. Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1alpha gene[J]. Cancer Chemother Pharmacol, 2006, 58(6):776-784.
6. 2007, 14 (18): 1392-1395.
7. Brahimi-Horn C, Pouyssegur J. The role of the hypoxia-inducible factor in tumor metabolism growth and invasion [J]. Bull Cancer, 2006, 93(8):E73-80.
8. Tamamura H, Tsutsumi H, Fujii N. The chemokine receptor CXCR4 as a therapeutic target for several diseases[J]. Mini Rev Med Chem, 2006, 6(9):989-995.
9. Sshioppa T, Uranchimeg B, Saccani A, et al. Regulation of the chemokine receptor CXCR4 by hypoxia[J]. J Exp Med, 2003, 198(9): 1391-1402.