Serum folate, total homocysteine levels and methylenetetrahydrofolate reductase 677C>T polymorphism in young healthy female Japanese

Asia Pacific Journal of Clinical Nutrition

Volumn 21, Issue 2, 2012, Pages 291-295

  Taguchi, Takashi ^a   Mori, Hideki ^a   Hamada, Atsumi ^a   Yamori, Yukio ^a   Mori, Mari ^a  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Folate; Homocysteine; MTHFR; Polymorphism; Young female

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PYRIDOXINE;

ADOLESCENT; AMPLIFIED FRAGMENT LENGTH POLYMORPHISM; ARTICLE; BLOOD; CHILD; DIET; ETHNOLOGY; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HEALTH SURVEY; HOMOZYGOTE; HUMAN; HYPERHOMOCYSTEINEMIA; JAPAN; METABOLISM; SINGLE NUCLEOTIDE POLYMORPHISM; VASCULAR DISEASE;

ADOLESCENT; AMPLIFIED FRAGMENT LENGTH POLYMORPHISM ANALYSIS; CHILD; DIET; FEMALE; FOLIC ACID; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HEALTH SURVEYS; HOMOCYSTEINE; HOMOZYGOTE; HUMANS; HYPERHOMOCYSTEINEMIA; JAPAN; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, SINGLE NUCLEOTIDE; VASCULAR DISEASES; VITAMIN B 12; VITAMIN B 6;

EID: 84861429226     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Ueland PM, Refsum H, Beresford SA, Vollset SE. The controversy over homocysteine and cardiovascular risk. Am J Clin Nutr. 2000;72:324-32.
2. Jamaluddin MS, Yang X, Wang H. Hyperhomocysteinemia, DNA methylation and vascular disease. Clin Chem Lab Med. 2007;45:1660-6.
3. Selhub J, Jacques PF, Bostom AG, D'Agostino RB, Wilson PW, Belanger AJ et al. Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis. N Engl J Med. 1995;332:286-91.
4. Marcus J, Sarnak MJ, Menon V. Homocysteine lowering and cardiovascular disease risk: lost in translation. Can J Cardiol. 2007;23:707-10.
5. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr. 2001;73:613-21.
6. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetra-hydrofolate reductase. Nat Genet. 1995;10:111-3.
7. Van der Put NM, Steegers-Theunissen RP, Frosst P, Trijbels FJ, Eskes TK, van den Heuvel LP, Mariman EC, den Heyer M, Rozen R, Blom HJ. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet. 1995;346: 1070-1.
8. Brattström L, Wilcken DE, Ohrvik J, Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation. 1998;98:2520-6.
9. Botto LD, Yang Q. 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol. 2000;151:862-77.
10. Kluijtmans LA, van den Heuvel LP, Boers GH, Frosst P, Stevens EM, van Oost BA et al. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet. 1996; 58:35-41.
11. Gallagher PM, Meleady R, Shields DC, Tan KS, McMaster D, Rozen R, Evans A, Graham IM, Whitehead AS. Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation. Circulation. 1996; 94:2154-8.
12. Muntjewerff JW, Kahn RS, Blom HJ, den Heijer M. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis. Mol Psychiatry. 2006;11: 143-9.
13. Blom HJ. Genetic determinants of hyperhomocysteinaemia: the roles of cystathionine beta-synthase and 5,10- methylenetetrahydrofolate reductase. Eur J Pediatr. 2000; 159:S208-12.
14. Mager A, Lalezari S, Shohat T, Birnbaum Y, Adler Y, Magal N, Shohat M. Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease. Circulation. 1999;100:2406-10.
15. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-19.
16. Takahashi K, Yoshimura Y, Kaimoto T, Kunii D, Komatsu T, Yamamoto S. Validation of a food frequency questionnaire based on food groups for estimating individual nutrient intake. Jpn J Nutr. 2001;59:221-32.
17. Resources Council of the Science and Technology Agency (ed.): The 5th Revised Edition of Tables of Japanese Foodstuff Composition. Tokyo: Ishiyaku Press; 2001.
18. Frederiksen J, Juul K, Grande P, Jensen GB, Schroeder TV, Tybjaerg-Hansen A, Nordestgaard BG. Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study. Blood. 2004; 104:3046-51.
19. Kauwell GP, Wilsky CE, Cerda JJ, Herrlinger-Garcia K, Hutson AD, Theriaque DW, Boddie A, Rampersaud GC, Bailey LB. Methylenetetrahydrofolate reductase mutation (677C-->T) negatively influences plasma homocysteine response to marginal folate intake in elderly women. Metabolism. 2000;49:1440-3.
20. Brouwer IA, van Dusseldorp M, West CE, Meyboom S, Thomas CM, Duran M et al. Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. J Nutr. 1999;129:1135-9.
21. Silaste ML, Rantala M, Alfthan G, Aro A, Kesäniemi YA. Plasma homocysteine concentration is decreased by dietary intervention. Br J Nutr. 2003;89:295-301.
22. Adachi H, Hirai Y, Fujiura Y, Matsuoka H, Satoh A, Imaizumi T. Plasma homocysteine levels and athero-sclerosis in Japan: epidemiological study by use of carotid ultrasonography. Stroke. 2002;33:2177-81.
23. Kim HJ, Kim MK, Kim JU, Ha HY, Choi BY. Major determinants of serum homocysteine concentrations in a Korean population. J Korean Med Sci. 2010;25:509-16.
24. Kageyama M, Hiraoka M, Kagawa Y. Relationship between genetic polymorphism, serum folate and homocysteine in Alzheimer's disease. Asia Pac J Public Health. 2008;20:111-7.
25. Papoutsakis C, Yiannakouris N, Manios Y, Papaconstantinou E, Magkos F, Schulpis KH, Zampelas A, Matalas AL. Plasma homocysteine concentrations in Greek children are influenced by an interaction between the methylenetetrahydrofolate reductase C677T genotype and folate status. J Nutr. 2005;135:383-8.
26. Berry RJ, Li Z, Erickson JD, Li S, Moore CA, Wang H et al. Prevention of neural-tube defects with folic acid in China. China-U.S. Collaborative Project for Neural Tube Defect Prevention. N Engl J Med. 1999;341:1485-90.
27. Rao S, Yajnik CS, Kanade A, Fall CH, Margetts BM, Jackson AA et al. Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune Maternal Nutrition Study. J Nutr. 2001;131: 1217-24.