Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: Involvement of adenosine and dopamine receptors

Pharmacology Biochemistry and Behavior

Volumn 102, Issue 2, 2012, Pages 241-248

  Feduccia, Allison A ^a   Wang, Yuanyuan ^a,b,c   Simms, Jeffrey A ^a   Yi, Henry Y ^a   Li, Rui ^a   Bjeldanes, Leonard ^c   Ye, Chuangxing ^b   Bartlett, Selena E ^a  

^a UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenosine; Dopamine; Locomotor activity; Microinfusion; Nucleus accumbens; Sensitization; Theacrine

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 6 N CYCLOPENTYLADENOSINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ADENOSINE RECEPTOR; ALKALOID; CAFFEINE; DOPAMINE RECEPTOR; ETICLOPRIDE; THEACRINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG STRUCTURE; LOCOMOTION; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT;

ANIMALS; LOCOMOTION; NUCLEUS ACCUMBENS; RATS; RATS, LONG-EVANS; RECEPTORS, DOPAMINE; RECEPTORS, PURINERGIC P1; URIC ACID;

ANIMALIA; CAMELLIA; RATTUS; RODENTIA;

EID: 84861421469     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.04.014     Document Type: Article

References (49)

1. Antoniou K, Papadopoulou-Daifoti Z, Hyphantis T, Papathanasiou G, Bekris E, Marselos M, et al. A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A1 and A2A receptors. Psychopharmacology (Berl) 2005;183:154-62.
2. Borycz J, Pereira MF, Melani A, Rodrigues RJ, Kofalvi A, Panlilio L, et al. Differential glutamate-dependent and glutamate-independent adenosine A1 receptor-mediated modulation of dopamine release in different striatal compartments. J Neurochem 2007;101:355-63.
3. Brundege JM, Williams JT. Differential modulation of nucleus accumbens synapses. J Neurophysiol 2002;88:142-51.
4. Cauli O, Morelli M. Subchronic caffeine administration sensitizes rats to the motoractivating effects of dopamine D(1) and D(2) receptor agonists. Psychopharmacology (Berl) 2002;162:246-54.
5. Cauli O, Pinna A, Valentini V, Morelli M. Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release. Neuropsychopharmacology 2003;28:1752-9.
6. Ciruela F, Gómez-Soler M, Guidolin D, Borroto-Escuela DO, Agnati LF, Fuxe K, et al. Adenosine receptor containing oligomers: their role in the control of dopamine and glutamate neurotransmission in the brain. Biochim Biophys Acta 2011;1808:1245-55.
7. Committee NRCU. Guide for the care and use of laboratory animals. In: Health NIo, editor. 2011/05/20 ed. Washington D.C: National Academies Press; 2011.
8. Daly JW, Butts-Lamb P, Padgett W. Subclasses of adenosine receptors in the central nervous system: interaction with caffeine and related methylxanthines. Cell Mol Neurobiol 1983;3:69-80.
9. Di Chiara G, Bassareo V, Fenu S, De Luca MA, Spina L, Cadoni C, et al. Dopamine and drug addiction: the nucleus accumbens shell connection. Neuropharmacology 2004;47(Suppl. 1):227-41.
10. Ferre S. An update on the mechanisms of the psychostimulant effects of caffeine. J Neurochem 2008;105:1067-79.
11. Ferre S, FredholmBB, Morelli M, Popoli P, Fuxe K. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci 1997;20:482-7.
12. Fisone G, Borgkvist A, Usiello A. Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci 2004;61:857-72.
13. Fredholm BB, Battig K, Holmen J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 1999;51:83-133.
14. Fredholm BB, AP IJ, Jacobson KA, Klotz KN, Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 2001;53:527-52.
15. Garrett BE, Holtzman SG. D1 and D2 dopamine receptor antagonists block caffeineinduced stimulation of locomotor activity in rats. Pharmacol Biochem Behav 1994;47:89-94.
16. Gasior M, Jaszyna M, Peters J, Goldberg SR. Changes in the ambulatory activity and discriminative stimulus effects of psychostimulant drugs in rats chronically exposed to caffeine: effect of caffeine dose. J Pharmacol Exp Ther 2000;295:1101-11.
17. Hamamura T, Akiyama K, Akimoto K, Kashihara K, Okumura K, Ujike H, et al. Coadministration of either a selective D1 or D2 dopamine antagonist with methamphetamine prevents methamphetamine-induced behavioral sensitization and neurochemical change, studied by in vivo intracerebral dialysis. Brain Res 1991;546:40-6.
18. Jarvis MF, Williams M. Direct autoradiographic localization of adenosine A2 receptors in the rat brain using the A2-selective agonist, [3H]CGS 21680. Eur J Pharmacol 1989;168:243-6.
19. Joyce EM, Koob GF. Amphetamine-, scopolamine- and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system. Psychopharmacology 1981;73:311-3.
20. Karcz-Kubicha M, Antoniou K, Terasmaa A, Quarta D, Solinas M, Justinova Z, et al. Involvement of adenosine A1 and A2A receptors in the motor effects of caffeine after its acute and chronic administration. Neuropsychopharmacology 2003;28: 1281-91.
21. Kull B, Svenningsson P, Fredholm BB. Adenosine A(2A) receptors are colocalized with and activate g(olf) in rat striatum. Mol Pharmacol 2000;58:771-7.
22. Le AD, Kiianmaa K, Cunningham CL, Engel JA, Ericson M, Soderpalm B, et al. Neurobiological processes in alcohol addiction. Alcohol Clin Exp Res 2001;25: 144S-51S.
23. MacDonald RL, Skerritt JH, Werz MA. Adenosine agonists reduce voltage-dependent calcium conductance of mouse sensory neurones in cell culture. J Physiol 1986;370:75-90.
24. Paxinos G, Watson C. The rat brain: in stereotaxic coordinates (Atlas & Computer Graphics Files). 3rd ed. San Diego: Academic Press, Inc.; 1997.
25. Pinna A, di Chiara G, Wardas J, Morelli M. Blockade of A2a adenosine receptors positively modulates turning behaviour and c-Fos expression induced by D1 agonists in dopamine-denervated rats. Eur J Neurosci 1996;8:1176-81.
26. Pollack AE, Fink JS. Synergistic interaction between an adenosine antagonist and a D1 dopamine agonist on rotational behavior and striatal c-Fos induction in 6- hydroxydopamine-lesioned rats. Brain Res 1996;743:124-30.
27. Porkka-Heiskanen T, Strecker RE, McCarley RW. Brain site-specificity of extracellular adenosine concentration changes during sleep deprivation and spontaneous sleep: an in vivo microdialysis study. Neuroscience 2000;99:507-17.
28. Prediger RD. Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms. J Alzheimers Dis 2010;20(Suppl. 1): S205-20.
29. Quarta D, Borycz J, Solinas M, Patkar K, Hockemeyer J, Ciruela F, et al. Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation. J Neurochem 2004a;91:873-80.
30. Quarta D, Ferre S, Solinas M, You ZB, Hockemeyer J, Popoli P, et al. Opposite modulatory roles for adenosine A1 and A2A receptors on glutamate and dopamine release in the shell of the nucleus accumbens. Effects of chronic caffeine exposure. J Neurochem 2004b;88:1151-8.
31. Ramsay DS, Woods SC. Biological consequences of drug administration: implications for acute and chronic tolerance. Psychol Rev 1997;104:170-93.
32. Rivkees SA, Price SL, Zhou FC. Immunohistochemical detection of A1 adenosine receptors in rat brain with emphasis on localization in the hippocampal formation, cerebral cortex, cerebellum, and basal ganglia. Brain Res 1995;677:193-203.
33. Siegel S. Tolerance: role of conditioning processes. NIDA Res Monogr 1991:213-29.
34. Simola N, Cauli O, Morelli M. Sensitization to caffeine and cross-sensitization to amphetamine: influence of individual response to caffeine. Behav Brain Res 2006;172:72-9.
35. Snyder SH, Katims JJ, Annau Z, Bruns RF, Daly JW. Adenosine receptors and behavioral actions of methylxanthines. Proc Natl Acad Sci 1981;78:3260-4.
36. Solinas M, Ferre S, You ZB, Karcz-Kubicha M, Popoli P, Goldberg SR. Caffeine induces dopamine and glutamate release in the shell of the nucleus accumbens. J Neurosci 2002;22:6321-4.
37. Solinas M, Ferre S, Antoniou K, Quarta D, Justinova Z, Hockemeyer J, et al. Involvement of adenosine A1 receptors in the discriminative-stimulus effects of caffeine in rats. Psychopharmacology (Berl) 2005;179:576-86.
38. Svenningsson P, Nomikos GG, Fredholm BB. Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration. J Neurosci 1995;15:7612-24.
39. Svenningsson P, Nomikos GG, Ongini E, Fredholm BB. Antagonism of adenosine A2A receptors underlies the behavioural activating effect of caffeine and is associated with reduced expression of messenger RNA for NGFI-A and NGFI-B in caudate-putamen and nucleus accumbens. Neuroscience 1997;79:753-64.
40. Svenningsson P, Nomikos GG, Fredholm BB. The stimulatory action and the development of tolerance to caffeine is associated with alterations in gene expression in specific brain regions. J Neurosci 1999;19:4011-22.
41. van Calker D, Muller M, Hamprecht B. Adenosine regulates via two different types of receptors, the accumulation of cyclic AMP in cultured brain cells. J Neurochem 1979;33:999-1005.
42. Vanderschuren LJ, Pierce RC. Sensitization processes in drug addiction. Curr Top Behav Neurosci 2010;3:179-95.
43. Wang Y, Yang X, Zheng X, Li J, Ye C, Song X. Theacrine, a purine alkaloid with antiinflammatory and analgesic activities. Fitoterapia 2010;81:627-31.
44. Wise RA. Dopamine, learning and motivation. Nat Rev Neurosci 2004;5:483-94.
45. Wise RA, Bozarth MA. A psychomotor stimulant theory of addiction. Psychol Rev 1987;94:469-92.
46. Xie G, Wu M, Huang Y, Cao Y, Lai-dong L, He-liangl Z, et al. Experimental study of theacrine on antidepressant effects. Chin Pharmacol Bull 2009;9:13.
47. Xu J-K, Kurihara H, Zhao L, Yao X-S. Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice. J Asian Nat Prod Res 2007;9:665-72.
48. Xu K, Xu YH, Chen JF, Schwarzschild MA. Neuroprotection by caffeine: time course and role of its metabolites in the MPTP model of Parkinson's disease. Neuroscience 2010;167:475-81.
49. Yacoubi ME, Ledent C, Ménard JF, Parmentier M, Costentin J, Vaugeois JM. The stimulant effects of caffeine on locomotor behaviour inmice are mediated through its blockade of adenosine A2A receptors. Br J Pharmacol 2000;129:1465-73.