Nuclear export and expression of human T-cell leukemia virus type 1 tax/rex mRNA Are RxRE/rex Dependent

Journal of Virology

Volumn 86, Issue 8, 2012, Pages 4559-4565

  Bai, X T ^a   Sinha Datta, U ^a   Ko, N L ^a   Bellon, M ^a   Nicot, C ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXPORTIN 1; LEPTOMYCIN B; MESSENGER RNA; PROTEIN P30; REV PROTEIN; REX PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE LOCATION; GENE TRANSLOCATION; GENETIC TRANSFECTION; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; IMMUNOPRECIPITATION; INTRACELLULAR TRANSPORT; NONHUMAN; NUCLEIC ACID STRUCTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN RNA BINDING; REX GENE; REX RESPONSIVE ELEMENT; TAX GENE; VIRAL GENETICS; VIRUS GENE; VIRUS REPLICATION;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE; CELL NUCLEOLUS; GENE EXPRESSION REGULATION, VIRAL; GENE ORDER; GENE PRODUCTS, REX; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; RNA, VIRAL;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 84861396425     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06361-11     Document Type: Article

References (36)

1. Adachi Y, et al. 1992. Phosphorylation of the Rex protein of human T-cell leukemia virus type I. J. Biol. Chem. 267:21977-21981.
2. Adachi Y, Nosaka T, Hatanaka M. 1990. Protein kinase inhibitor H-7 blocks accumulation of unspliced mRNA of human T-cell leukemia virus type I (HTLV-I). Biochem. Biophys. Res. Commun. 169:469-475. doi: 0006-291X(90)90355-Q.
3. Ahmed YF, Gilmartin GM, Hanly SM, Nevins JR, Greene WC. 1991. The HTLV-I Rex response element mediates a novel form of mRNA polyadenylation. Cell 64:727-737. doi:0092-8674(91)90502-P.
4. Ballaun C, et al. 1991. Functional analysis of human T-cell leukemia virus type I Rex-response element: directRNAbinding of Rex protein correlates with in vivo activity. J. Virol. 65:4408-4413.
5. Bindhu M, Nair A, Lairmore MD. 2004. Role of accessory proteins of HTLV-1 in viral replication, T cell activation, and cellular gene expression. Front. Biosci. 9:2556-2576.
6. Bogerd H, Greene WC. 1993. Dominant negative mutants of human T-cell leukemia virus type I Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo. J. Virol. 67:2496-2502.
7. Bogerd HP, Echarri A, Ross TM, Cullen BR. 1998. Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. J. Virol. 72: 8627-8635.
8. Bogerd HP, Huckaby GL, Ahmed YF, Hanly SM, Greene WC. 1991. The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements. Proc. Natl. Acad. Sci. U. S. A. 88:5704-5708.
9. Bogerd HP, Tiley LS, Cullen BR. 1992. Specific binding of the human T-cell leukemia virus type I Rex protein to a short RNA sequence located within the Rex-response element. J. Virol. 66:7572-7575.
10. Copeland KF, Haaksma AG, Derse D, Heeney JL. 1994. Detection of human T-cell leukaemia virus 1 permissive cells using cell lines producing selectable recombinant virions. J. Virol. Methods 50:219-225.
11. Cullen BR. 2003. Nuclear mRNA export: insights from virology. Trends Biochem. Sci. 28:419-424. doi:S0968000403001427
12. D'Agostino DM, Ciminale V, Zotti L, Rosato A, Chieco-Bianchi L. 1997. The human T-cell lymphotropic virus type 1 Tof protein contains a bipartite nuclear localization signal that is able to functionally replace the amino-terminal domain of Rex. J. Virol. 71:75-83.
13. Delamarre L, Rosenberg AR, Pique C, Pham D, Dokhelar MC. 1997. A novel human T-leukemia virus type 1 cell-to-cell transmission assay permits definition of SU glycoprotein amino acids important for infectivity. J. Virol. 71:259-266.
14. Franchini G, Nicot C, Johnson JM. 2003. Seizing of T cells by human T-cell leukemia/lymphoma virus type 1. Adv. Cancer Res. 89:69-132.
15. Giebler HA, et al. 1997. Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: a molecular mechanism of Tax transactivation. Mol. Cell. Biol. 17:5156-5164.
16. Grone M, Koch C, Grassmann R. 1996. The HTLV-1 Rex protein induces nuclear accumulation of unspliced viral RNA by avoiding intron excision and degradation. Virology 218:316-325
17. Hakata Y, Umemoto T, Matsushita S, Shida H. 1998. Involvement of human CRM1 (exportin 1) in the export and multimerization of the Rex protein of human T-cell leukemia virus type 1. J. Virol. 72:6602-6607.
18. Hakata Y, Yamada M, Shida H. 2001. Rat CRM1 is responsible for the poor activity of human T-cell leukemia virus type 1 Rex protein in rat cells. J. Virol. 75:11515-11525. doi:10.1128/JVI.75.23.11515-11525.2001.
19. Hakata Y, Yamada M, Shida H. 2003. A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. Mol. Cell. Biol. 23:8751-8761.
20. Hamaia S, Casse H, Gazzolo L, Duc DM. 1997. The human T-cell leukemia virus type 1 Rex regulatory protein exhibits an impaired functionality in human lymphoblastoid Jurkat T cells. J. Virol. 71:8514-8521.
21. Hammes SR, Greene WC. 1993. Multiple arginine residues within the basic domain of HTLV-I Rex are required for specific RNA binding and function. Virology 193:41-49. doi:S0042-6822(83)71101-3.
22. Hanly SM, et al. 1989. Comparative analysis of the HTLV-I Rex andHIV-1 Rev trans-regulatory proteins and their RNA response elements. Genes Dev. 3:1534-1544.
23. Harrod R, et al. 1998. An exposed KID-like domain in human T-cell lymphotropic virus type 1 Tax is responsible for the recruitment of coactivators CBP/p300. Mol. Cell. Biol. 18:5052-5061.
24. Heger P, Rosorius O, Hauber J, Stauber RH. 1999. Titration of cellular export factors, but not heteromultimerization, is the molecular mechanism of trans-dominant HTLV-1 Rex mutants. Oncogene 18:4080-4090. doi:10.1038/sj.onc.1202762.
25. Hidaka M, Inoue J, Yoshida M, Seiki M. 1988. Post-transcriptional regulator (Rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins. EMBO J. 7:519-523.
26. Jiang H, et al. 1999. PCAF interacts with Tax and stimulates Tax transactivation in a histone acetyltransferase-independent manner. Mol. Cell. Biol. 19:8136-8145.
27. Kashanchi F, Brady JN. 2005. Transcriptional and post-transcriptional gene regulation of HTLV-1. Oncogene 24:5938-5951.
28. King JA, et al. 1998. Nucleocytoplasmic transport of HTLV-1 RNA is regulated by two independent LTR encoded nuclear retention elements. Oncogene 16:3309-3316. doi:10.1038/sj.onc.1201884.
29. Kudo N, et al. 1998. Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242:540-547. doi:S0014-4827(98)94136-2.
30. Lemasson I, Polakowski NJ, Laybourn PJ, Nyborg JK. 2004. Transcription regulatory complexes bind the human T-cell leukemia virus 5= and 3= long terminal repeats to control gene expression. Mol. Cell. Biol. 24:6117-6126. doi:10.1128/MCB.24.14.6117-6126.2004.
31. Nicot C, et al. 2004. HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication. Nat. Med. 10:197-201. doi:10.1038/ nm984.
32. Nicot C, Harrod RL, Ciminale V, Franchini G. 2005. Human T-cell leukemia/lymphoma virus type 1 nonstructural genes and their functions. Oncogene 24:6026-6034.
33. Otero GC, Harris ME, Donello JE, Hope TJ. 1998. Leptomycin B inhibits equine infectious anemia virus Rev and feline immunodeficiency virus Rev function but not the function of the hepatitis B virus posttranscriptional regulatory element. J. Virol. 72:7593-7597.
34. Schwartz S, Felber BK, Pavlakis GN. 1991. Expression of human immunodeficiency virus type 1 Vif and Vpr mRNAs is Rev-dependent and regulated by splicing. Virology 183:677-686. doi:0042-6822(91)90996-O.
35. Sinha-Datta U, Datta A, Ghorbel S, Dodon MD, Nicot C. 2007. Human T-cell lymphotrophic virus type I Rex and p30 interactions govern the switch between virus latency and replication. J. Biol. Chem. 282:14608-14615. doi:10.1074/jbc.M611219200.
36. Smith MR, Greene WC. 1990. Identification of HTLV-I Tax transactivator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 4:1875-1885.