메뉴 건너뛰기




Volumn 13, Issue 9, 2012, Pages 1299-1307

Pharmacogenomics of third-generation aromatase inhibitors

Author keywords

Anastrozole; CYP19A1; Exemestane; Letrozole; Pharmacogenomics; Polymorphism

Indexed keywords

ANASTROZOLE; AROMATASE; CYTOCHROME P450 3A4; CYTOCHROME P450 4A11; EXEMESTANE;

EID: 84861392012     PISSN: 14656566     EISSN: 17447666     Source Type: Journal    
DOI: 10.1517/14656566.2012.687721     Document Type: Review
Times cited : (20)

References (56)
  • 1
    • 77951999444 scopus 로고    scopus 로고
    • American Cancer Society. Available from: Last accessed 1 March
    • Breast cancer statistics. American Cancer Society. Available from: www.cancer.org [Last accessed 1 March 2012]
    • (2012) Breast Cancer Statistics
  • 2
    • 77951999444 scopus 로고    scopus 로고
    • Canadian Cancer Society. Available from: Last accessed 1 March
    • Breast cancer statistics. Canadian Cancer Society. Available from: www.cancer.ca [Last accessed 1 March 2012]
    • (2012) Breast Cancer Statistics
  • 3
    • 1942518397 scopus 로고    scopus 로고
    • Organization of the human aromatase p450 (CYP19) gene
    • Bulun SE, Takayama K, Suzuki T, et al. Organization of the human aromatase p450 (CYP19) gene. Semin Reprod Med 2004;22:5-9
    • (2004) Semin. Reprod Med. , vol.22 , pp. 5-9
    • Bulun, S.E.1    Takayama, K.2    Suzuki, T.3
  • 9
    • 0026808704 scopus 로고
    • Immunohistochemical distribution of aromatase and 3B-hydroxysteroid dehydrogenase in human hair follicle and sebaceous gland
    • Sawaya ME, Penneys NS. Immunohistochemical distribution of aromatase and 3B-hydroxysteroid dehydrogenase in human hair follicle and sebaceous gland. J Cutan Pathol 1992;19:309-14
    • (1992) J. Cutan. Pathol. , vol.19 , pp. 309-314
    • Sawaya, M.E.1    Penneys, N.S.2
  • 10
    • 0029918463 scopus 로고    scopus 로고
    • Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast
    • Bulun SE, Sharda G, Rink J, et al. Distribution of aromatase P450 transcripts and adipose fibroblasts in the human breast. J Clin Endocrinol Metab 1996;81:1273-7
    • (1996) J. Clin. Endocrinol. Metab. , vol.81 , pp. 1273-277
    • Bulun, S.E.1    Sharda, G.2    Rink, J.3
  • 11
    • 0018686827 scopus 로고
    • Subcellular distribution of aromatase in human placenta and ovary
    • Thompson EA Jr, Siiteri PK. Subcellular distribution of aromatase in human placenta and ovary. Horm Res 1979;11:179-85
    • (1979) Horm. Res. , vol.11 , pp. 179-185
    • Thompson Jr., E.A.1    Siiteri, P.K.2
  • 12
    • 78149479235 scopus 로고    scopus 로고
    • Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C] vorozole
    • Biegon A, Kim SW, Alexoff DL, et al. Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C] vorozole. Synapse 2010;64:801-7
    • (2010) Synapse , vol.64 , pp. 801-807
    • Biegon, A.1    Kim, S.W.2    Alexoff, D.L.3
  • 13
    • 1842505162 scopus 로고    scopus 로고
    • Aromatase inhibitors for breast cancer in postmenopausal women
    • Campos SM. Aromatase inhibitors for breast cancer in postmenopausal women. Oncologist 2004;9:126-36
    • (2004) Oncologist , vol.9 , pp. 126-136
    • Campos, S.M.1
  • 14
    • 15544379599 scopus 로고    scopus 로고
    • Estrogen-receptor biology: Continuing progress and therapeutic implications
    • Osborne CK, Schiff R. Estrogen-receptor biology: continuing progress and therapeutic implications. J Clin Oncol 2005;23:1616-22
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1616-1622
    • Osborne, C.K.1    Schiff, R.2
  • 15
    • 0035345731 scopus 로고    scopus 로고
    • Aromatase inhibition and antiestrogen therapy in early breast cancer treatment and chemoprevention
    • Ingle JN. Aromatase inhibition and antiestrogen therapy in early breast cancer treatment and chemoprevention. Oncology (Williston Park) 2001;15:28-34
    • (2001) Oncology (Williston Park , vol.15 , pp. 28-34
    • Ingle, J.N.1
  • 16
    • 33645459056 scopus 로고    scopus 로고
    • Tamoxifen after adjuvant chemotherapy for premenopausal women with lymph node-positive breast cancer: International breast cancer study group trial 13-93
    • Colleoni M, Gelber S, Goldhirsch A, et al. Tamoxifen after adjuvant chemotherapy for premenopausal women with lymph node-positive breast cancer: international Breast Cancer Study Group Trial 13-93. J Clin Oncol 2006;24:1332e41
    • (2006) J. Clin. Oncol. , vol.24
    • Colleoni, M.1    Gelber, S.2    Goldhirsch, A.3
  • 17
    • 37849052460 scopus 로고    scopus 로고
    • The breast cancer continuum in hormone-receptor-positive breast cancer in postmenopausal women: Evolving management options focusing on aromatase inhibitors
    • Rugo HS. The breast cancer continuum in hormone-receptor-positive breast cancer in postmenopausal women: evolving management options focusing on aromatase inhibitors. Ann Oncol 2008;19:16-27
    • (2008) Ann. Oncol. , vol.19 , pp. 16-27
    • Rugo, H.S.1
  • 18
    • 74549188670 scopus 로고    scopus 로고
    • Potential role of UGT pharmacogenetics in cancer treatment and prevention: Focus on tamoxifen and aromatase inhibitors
    • Lazarus P, Sun D. Potential role of UGT pharmacogenetics in cancer treatment and prevention: focus on tamoxifen and aromatase inhibitors. Drug Metab Rev 2010;42:182-94
    • (2010) Drug. Metab. Rev. , vol.42 , pp. 182-194
    • Lazarus, P.1    Sun, D.2
  • 19
    • 0026446844 scopus 로고
    • Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women
    • Evans TR, Di Salle E, Ornati G, et al. Phase I and endocrine study of exemestane (FCE 24304), a new aromatase inhibitor, in postmenopausal women. Cancer Res 1992;52:5933-9
    • (1992) Cancer Res. , vol.52 , pp. 5933-939
    • Evans, T.R.1    Di Salle, E.2    Ornati, G.3
  • 20
    • 0030040104 scopus 로고    scopus 로고
    • Arimidex (ZD1033): A selective, potent inhibitor of aromatase in postmenopausal female volunteers
    • Yates RA, Dowsett M, Fisher GV, et al. Arimidex (ZD1033): a selective, potent inhibitor of aromatase in postmenopausal female volunteers. Br J Cancer 1996;73:543-8
    • (1996) Br. J. Cancer , vol.73 , pp. 543-548
    • Yates, R.A.1    Dowsett, M.2    Fisher, G.V.3
  • 21
    • 0028943384 scopus 로고
    • Letrozole (CGS 20267) A phase I study of a new potent oral aromatase inhibitor of breast cancer
    • Lipton A, Demers LM, Harvey HA, et al. Letrozole (CGS 20267). A phase I study of a new potent oral aromatase inhibitor of breast cancer. Cancer 1995;75:2132-8
    • (1995) Cancer , vol.75 , pp. 2132-138
    • Lipton, A.1    Demers, L.M.2    Harvey, H.A.3
  • 22
    • 38549180762 scopus 로고    scopus 로고
    • Safety profiles of tamoxifen and the aromatase inhibitors in adjuvant therapy of hormone-responsive early breast cancer
    • Perez EA. Safety profiles of tamoxifen and the aromatase inhibitors in adjuvant therapy of hormone-responsive early breast cancer. Ann Oncol 2007;18(Suppl 8):26-35
    • (2007) Ann. Oncol. , vol.18 , Issue.SUPPL. 8 , pp. 26-35
    • Perez, E.A.1
  • 23
    • 33748084685 scopus 로고    scopus 로고
    • Incidence and management of side effects associated with aromatase inhibitors in the adjuvant treatment of breast cancer in postmenopausal women
    • Mouridsen HT. Incidence and management of side effects associated with aromatase inhibitors in the adjuvant treatment of breast cancer in postmenopausal women. Curr Med Res Opin 2006;22:1609-21
    • (2006) Curr. Med. Res. Opin. , vol.22 , pp. 1609-1621
    • Mouridsen, H.T.1
  • 24
    • 79960491885 scopus 로고    scopus 로고
    • Aromatase inhibitor-associated bone and musculoskeletal effects: New evidence defining etiology and strategies for management
    • Gaillard S, Stearns V. Aromatase inhibitor-associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management. Breast Cancer Res 2011;13:205
    • (2011) Breast Cancer Res. , vol.13 , pp. 205
    • Gaillard, S.1    Stearns, V.2
  • 25
    • 24944494988 scopus 로고    scopus 로고
    • The effects of aromatase inhibitors on lipids and thrombosis
    • Bundred NJ. The effects of aromatase inhibitors on lipids and thrombosis. Br J Cancer 2005;93:23-7
    • (2005) Br. J. Cancer , vol.93 , pp. 23-7
    • Bundred, N.J.1
  • 26
    • 60749114852 scopus 로고    scopus 로고
    • Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer
    • Gonnelli S, Petrioli R. Aromatase inhibitors, efficacy and metabolic risk in the treatment of postmenopausal women with early breast cancer. Clin Interv Aging 2008;3:647-57
    • (2008) Clin. Interv. Aging , vol.3 , pp. 647-657
    • Gonnelli, S.1    Petrioli, R.2
  • 27
    • 79954613338 scopus 로고    scopus 로고
    • Aromatase inhibitor-induced skin adverse reactions: Exemestane-related cutaneous vasculitis
    • Santoro S, Santini M, Pepe C, et al. Aromatase inhibitor-induced skin adverse reactions: exemestane-related cutaneous vasculitis. J Eur Acad Dermatol Venereol 2011;25:596-8
    • (2011) J. Eur. Acad. Dermatol. Venereol. , vol.25 , pp. 596-598
    • Santoro, S.1    Santini, M.2    Pepe, C.3
  • 28
    • 65649108908 scopus 로고    scopus 로고
    • Aromatase inhibitor-related musculoskeletal symptoms: Is preventing osteoporosis the key to eliminating these symptoms
    • Muslimani AA, Spiro TP, Chaudhry AA, et al. Aromatase inhibitor-related musculoskeletal symptoms: is preventing osteoporosis the key to eliminating these symptoms? Clin Breast Cancer 2009;9:34-8
    • (2009) Clin. Breast Cancer , vol.9 , pp. 34-38
    • Muslimani, A.A.1    Spiro, T.P.2    Chaudhry, A.A.3
  • 29
    • 38749113914 scopus 로고    scopus 로고
    • Pharmacogenomics of tamoxifen and aromatase inhibitors
    • Ingle JN. Pharmacogenomics of tamoxifen and aromatase inhibitors. Cancer 2008;112:695-9
    • (2008) Cancer , vol.112 , pp. 695-699
    • Ingle, J.N.1
  • 30
    • 49649086756 scopus 로고    scopus 로고
    • Pharmacogenomics of endocrine therapy in breast cancer
    • Weinshilboum R. Pharmacogenomics of endocrine therapy in breast cancer. Adv Exp Med Biol 2008;630:220-31
    • (2008) Adv. Exp. Med. Biol. , vol.630 , pp. 220-231
    • Weinshilboum, R.1
  • 31
    • 28244452912 scopus 로고    scopus 로고
    • Human aromatase: Gene resequencing and functional genomics
    • Ma CX, Adjei AA, Salavaggione OE, et al. Human aromatase: gene resequencing and functional genomics. Cancer Res 2005;65:11071-82
    • (2005) Cancer Res. , vol.65 , pp. 11071-1082
    • Ma, C.X.1    Adjei, A.A.2    Salavaggione, O.E.3
  • 32
    • 79551604866 scopus 로고    scopus 로고
    • Pharmacogenetics of endocrine therapy for breast cancer
    • Higgins MJ, Stearns V. Pharmacogenetics of endocrine therapy for breast cancer. Annu Rev Med 2011;62:281-93
    • (2011) Annu. Rev. Med. , vol.62 , pp. 281-293
    • Higgins, M.J.1    Stearns, V.2
  • 33
    • 78349260513 scopus 로고    scopus 로고
    • In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole
    • Kamdem LK, Liu Y, Stearns V, et al. In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole. Br J Clin Pharmacol 2010;70:854-69
    • (2010) Br. J. Clin. Pharmacol. , vol.70 , pp. 854-869
    • Kamdem, L.K.1    Liu, Y.2    Stearns, V.3
  • 34
    • 77951050920 scopus 로고    scopus 로고
    • Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer
    • Ingle JN, Buzdar AU, Schaid DJ, et al. Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer. Cancer Res 2010;70:3278-86
    • (2010) Cancer Res. , vol.70 , pp. 3278-3286
    • Ingle, J.N.1    Buzdar, A.U.2    Schaid, D.J.3
  • 35
    • 0842325733 scopus 로고    scopus 로고
    • Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone glucuronidation phenotype in human liver microsomes
    • Wiener D, Fang JL, Dossett N, Lazarus P. Correlation between UDP-glucuronosyltransferase genotypes and 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone glucuronidation phenotype in human liver microsomes. Cancer Res 2004;64:1190-6
    • (2004) Cancer Res. , vol.64 , pp. 1190-1196
    • Wiener, D.1    Fang, J.L.2    Dossett, N.3    Lazarus, P.4
  • 36
    • 1842532189 scopus 로고    scopus 로고
    • Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4
    • Ehmer U, Vogel A, Schutte JK, et al. Variation of hepatic glucuronidation: novel functional polymorphisms of the UDP- glucuronosyltransferase UGT1A4. Hepatology 2004;39:970-7
    • (2004) Hepatology , vol.39 , pp. 970-977
    • Ehmer, U.1    Vogel, A.2    Schutte, J.K.3
  • 37
    • 78650725834 scopus 로고    scopus 로고
    • In vitro cytochrome P450-mediated metabolism of exemestane
    • Kamdem LK, Flockhart DA, Desta Z. In vitro cytochrome P450-mediated metabolism of exemestane. Drug Metab Dispos 2011;39:98-105
    • (2011) Drug. Metab. Dispos. , vol.39 , pp. 98-105
    • Kamdem, L.K.1    Flockhart, D.A.2    Desta, Z.3
  • 38
    • 0037239228 scopus 로고    scopus 로고
    • Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: Allele frequencies, linkage disequilibrium and influence on caffeine metabolism
    • Sachse C, Bhambra U, Smith G, et al. Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism. Br J Clin Pharmacol 2003;55:68-76
    • (2003) Br. J. Clin. Pharmacol. , vol.55 , pp. 68-76
    • Sachse, C.1    Bhambra, U.2    Smith, G.3
  • 39
    • 12544249249 scopus 로고    scopus 로고
    • Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density
    • Napoli N, Villareal DT, Mumm S, et al. Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res 2005;20:232-9
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 232-239
    • Napoli, N.1    Villareal, D.T.2    Mumm, S.3
  • 40
    • 7244250183 scopus 로고    scopus 로고
    • CYP3A4 polymorphisms - Potential risk factors for breast and prostate cancer: A HuGE review
    • Keshava C, McCanlies EC, Weston A. CYP3A4 polymorphisms - potential risk factors for breast and prostate cancer: a HuGE review. Am J Epidemiol 2004;160:825-41
    • (2004) Am. J. Epidemiol. , vol.160 , pp. 825-841
    • Keshava, C.1    McCanlies, E.C.2    Weston, A.3
  • 41
    • 21544469981 scopus 로고    scopus 로고
    • Highly polymorphic human CYP4A11 gene
    • Cho BH, Park BL, Kim LH, et al. Highly polymorphic human CYP4A11 gene. J Hum Genet 2005;50:259-63
    • (2005) J. Hum. Genet. , vol.50 , pp. 259-263
    • Cho, B.H.1    Park, B.L.2    Kim, L.H.3
  • 42
    • 33744523603 scopus 로고    scopus 로고
    • Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk
    • Mikhailova ON, Gulyaeva LF, Prudnikov AV, et al. Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk. Pharmacogenomics J 2006;6:189-93
    • (2006) Pharmacogenomics. J. , vol.6 , pp. 189-193
    • Mikhailova, O.N.1    Gulyaeva, L.F.2    Prudnikov, A.V.3
  • 43
    • 77957243014 scopus 로고    scopus 로고
    • Characterization of 17-dihydroexemestane glucuronidation: Potential role of the UGT2B17 deletion in exemestane pharmacogenetics
    • Sun D, Chen G, Dellinger RW, et al. Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics. Pharmacogenet Genomics 2010;20:575-85
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 575-585
    • Sun, D.1    Chen, G.2    Dellinger, R.W.3
  • 44
    • 4744338923 scopus 로고    scopus 로고
    • Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15
    • Wilson W III, Pardo-Manuel de Villena F, Lyn-Cook BD, et al. Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15. Genomics 2004; 84:707-14
    • (2004) Genomics , vol.84 , pp. 707-714
    • Wilson III, W.1    Pardo-Manuel De Villena, F.2    Lyn-Cook, B.D.3
  • 45
    • 0038190942 scopus 로고    scopus 로고
    • A human minor histocompatibility antigen resulting from differential expression due to a gene deletion
    • Murata M, Warren EH, Riddell SR. A human minor histocompatibility antigen resulting from differential expression due to a gene deletion. J Exp Med 2003;197:1279-8
    • (2003) J. Exp. Med. , vol.197 , pp. 1279-278
    • Murata, M.1    Warren, E.H.2    Riddell, S.R.3
  • 46
    • 69049103060 scopus 로고    scopus 로고
    • Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'- methanolbisbenzonitrile in vitro
    • Jeong S, Woo MM, Flockhart DA, Desta Z. Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanolbisbenzonitrile in vitro. Cancer Chemother Pharmacol 2009;64:867-75
    • (2009) Cancer Chemother. Pharmacol. , vol.64 , pp. 867-875
    • Jeong, S.1    Woo, M.M.2    Flockhart, D.A.3    Desta, Z.4
  • 47
    • 70350315907 scopus 로고    scopus 로고
    • Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes
    • Murai K, Yamazaki H, Nakagawa K, et al. Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes. Xenobiotica 2009;39:795-802
    • (2009) Xenobiotica , vol.39 , pp. 795-802
    • Murai, K.1    Yamazaki, H.2    Nakagawa, K.3
  • 48
    • 80055021257 scopus 로고    scopus 로고
    • Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age
    • Desta Z, Kreutz Y, Nguyen AT, et al. Plasma letrozole concentrations in postmenopausal women with breast cancer are associated with CYP2A6 genetic variants, body mass index, and age. Clin Pharmacol Ther 2011;90:693-700
    • (2011) Clin. Pharmacol. Ther. , vol.90 , pp. 693-700
    • Desta, Z.1    Kreutz, Y.2    Nguyen, A.T.3
  • 49
    • 38949105895 scopus 로고    scopus 로고
    • A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma
    • Colomer R, Monzo M, Tusquets I, et al. A single-nucleotide polymorphism in the aromatase gene is associated with the efficacy of the aromatase inhibitor letrozole in advanced breast carcinoma. Clin Cancer Res 2008;14:811-16
    • (2008) Clin. Cancer Res. , vol.14 , pp. 811-816
    • Colomer, R.1    Monzo, M.2    Tusquets, I.3
  • 50
    • 77649178123 scopus 로고    scopus 로고
    • A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole
    • Garcia-Casado Z, Guerrero-Zotano A, Llombart-Cussac A, et al. A polymorphism at the 3'-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole. BMC Cancer 2010;10:36
    • (2010) BMC Cancer , vol.10 , pp. 36
    • Garcia-Casado, Z.1    Guerrero-Zotano, A.2    Llombart-Cussac, A.3
  • 51
    • 52949088650 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/ neu status, and prognosis in breast cancer patients
    • Fasching PA, Loehberg CR, Strissel PL, et al. Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/ neu status, and prognosis in breast cancer patients. Breast Cancer Res Treat 2008;112:89-98
    • (2008) Breast Cancer Res. Treat. , vol.112 , pp. 89-98
    • Fasching, P.A.1    Loehberg, C.R.2    Strissel, P.L.3
  • 52
    • 75149159605 scopus 로고    scopus 로고
    • Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors
    • Wang L, Ellsworth KA, Moon I, et al. Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors. Cancer Res 2010;70:319-28
    • (2010) Cancer Res. , vol.70 , pp. 319-328
    • Wang, L.1    Ellsworth, K.A.2    Moon, I.3
  • 53
    • 84860389786 scopus 로고    scopus 로고
    • Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors
    • Mao JJ, Su HI, Feng R, et al. Association of functional polymorphisms in CYP19A1 with aromatase inhibitor associated arthralgia in breast cancer survivors. Breast Cancer Res 2011;13:R8
    • (2011) Breast Cancer Res. , vol.13
    • Mao, J.J.1    Su, H.I.2    Feng, R.3
  • 54
    • 0034662307 scopus 로고    scopus 로고
    • A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk
    • Haiman CA, Hankinson SE, Spiegelman D, et al. A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk. Int J Cancer 2000;87:204-10
    • (2000) Int. J. Cancer , vol.87 , pp. 204-210
    • Haiman, C.A.1    Hankinson, S.E.2    Spiegelman, D.3
  • 55
    • 2942699898 scopus 로고    scopus 로고
    • A common polymorphism in the 5'-untranslated region of the aromatase gene influences bone mass and fracture risk
    • Zarrabeitia MT, Hernandez JL, Valero C, et al. A common polymorphism in the 5'-untranslated region of the aromatase gene influences bone mass and fracture risk. Eur J Endocrinol 2004;150:699-704
    • (2004) Eur. J. Endocrinol. , vol.150 , pp. 699-704
    • Zarrabeitia, M.T.1    Hernandez, J.L.2    Valero, C.3
  • 56
    • 78149250018 scopus 로고    scopus 로고
    • Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors
    • Ingle JN, Schaid DJ, Goss PE, et al. Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. J Clin Oncol 2010;28:4674-82
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4674-4682
    • Ingle, J.N.1    Schaid, D.J.2    Goss, P.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.