The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys

Pediatric Research

Volumn 71, Issue 6, 2012, Pages 713-719

  Damsgaard, Camilla T ^a   Mølgaard, Christian ^a   Matthiessen, Jeppe ^b   Gyldenløve, Sedsel N ^a   Lauritzen, Lotte ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DOCOSAHEXAENOIC ACID; FISH OIL; GROWTH FACTOR; NUMEGA; OMEGA 3 FATTY ACID; OSTEOCALCIN; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ADOLESCENCE; ADOLESCENT; ARTICLE; BONE AREA; BONE DENSITY; BONE GROWTH; BONE MASS; BONE MINERAL; CELL LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET SUPPLEMENTATION; DIETARY INTAKE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; ERYTHROCYTE; FATTY ACID BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; MALE; MUSCULOSKELETAL SYSTEM PARAMETERS; NORMAL HUMAN; OBESITY; OSSIFICATION; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; BONE DENSITY; CARDIOVASCULAR DISEASES; DOCOSAHEXAENOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FATTY ACIDS, OMEGA-3; FISH OILS; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; OSTEOCALCIN; OSTEOGENESIS; OVERWEIGHT; RISK FACTORS;

EID: 84861369583     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2012.28     Document Type: Article

References (40)

1. MacKelvie KJ, Khan KM, McKay HA. Is there a critical period for bone response to weight-bearing exercise in children and adolescents? a systematic review. Br J Sports Med 2002;36:250-7; discussion 257. (Pubitemid 34833116)
2. Bailey DA. The Saskatchewan Pediatric Bone Mineral Accrual Study: bone mineral acquisition during the growing years. Int J Sports Med 1997;18:Suppl 3:S191-4.
3. Eisman JA. Genetics of osteoporosis. Endocr Rev 1999;20:788-804. (Pubitemid 30647074)
4. Salari P, Rezaie A, Larijani B, Abdollahi M. A systematic review of the impact of n-3 fatty acids in bone health and osteoporosis. Med Sci Monit 2008;14:RA37-44. (Pubitemid 351457420)
5. Watkins BA, Li Y, Seifert MF. Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats. J Nutr Biochem 2006;17:282-9.
6. Sun D, Krishnan A, Zaman K, Lawrence R, Bhattacharya A, Fernandes G. Dietary n-3 fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. J Bone Miner Res 2003;18:1206-16. (Pubitemid 37294913)
7. Shen CL, Yeh JK, Rasty J, et al. Improvement of bone quality in gonadintact middle-aged male rats by long-chain n-3 polyunsaturated fatty acid. Calcif Tissue Int 2007;80:286-93. (Pubitemid 46675251)
8. Shen CL, Yeh JK, Rasty J, Li Y, Watkins BA. Protective effect of dietary long-chain n-3 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats. Br J Nutr 2006;95:462-8.
9. Watkins BA, Shen CL, McMurtry JP, et al. Dietary lipids modulate bone prostaglandin E2 production, insulin-like growth factor-I concentration and formation rate in chicks. J Nutr 1997;127:1084-91. (Pubitemid 27242105)
10. Cohen SL, Ward WE. Flaxseed oil and bone development in growing male and female mice. J Toxicol Environ Health Part A 2005;68:1861-70. (Pubitemid 41783261)
11. Weiler HA, Fitzpatrick-Wong S. Dietary long-chain polyunsaturated fatty acids minimize dexamethasone-induced reductions in arachidonic acid status but not bone mineral content in piglets. Pediatr Res 2002;51:282-9. (Pubitemid 34174962)
12. Kelly O, Cusack S, Jewell C, Cashman KD. The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats. Br J Nutr 2003;90:743-50. (Pubitemid 37270756)
13. Mollard RC, Kovacs HR, Fitzpatrick-Wong SC, Weiler HA. Low levels of dietary arachidonic and docosahexaenoic acids improve bone mass in neonatal piglets, but higher levels provide no benefit. J Nutr 2005;135:505-12. (Pubitemid 40365210)
14. Kruger MC, Coetzer H, de Winter R, Gericke G, van Papendorp DH. Calcium, gamma-linolenic acid and eicosapentaenoic acid supplementation in senile osteoporosis. Aging (Milano) 1998;10:385-94.
15. Bassey EJ, Littlewood JJ, Rothwell MC, Pye DW. Lack of effect of supplementation with essential fatty acids on bone mineral density in healthy preand postmenopausal women: two randomized controlled trials of Efacal v. calcium alone. Br J Nutr 2000;83:629-35. (Pubitemid 30392103)
16. Griel AE, Kris-Etherton PM, Hilpert KF, Zhao G, West SG, Corwin RL. An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. Nutr J 2007;6:2.
17. Högström M, Nordström P, Nordström A. n-3 Fatty acids are positively associated with peak bone mineral density and bone accrual in healthy men: the NO2 Study. Am J Clin Nutr 2007;85:803-7. (Pubitemid 46393513)
18. National Food Institute. Dietary habits in Denmark 2003-2008-Main Results [Danskernes Kostvaner 2003-2008-Hovedresultater]. Sørg, Denmark: Rosendahls-Schultz Grafisk, 2010:1-196.
19. Szulc P, Seeman E, Delmas PD. Biochemical measurements of bone turnover in children and adolescents. Osteoporos Int 2000;11:281-94. (Pubitemid 30417180)
20. Juul A. Serum levels of insulin-like growth factor I and its binding proteins in health and disease. Growth Horm IGF Res 2003;13:113-70. (Pubitemid 36986557)
21. Yakar S, Canalis E, Sun H, et al. Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions. J Bone Miner Res 2009;24:1481-92.
22. Juul A, Dalgaard P, Blum WF, et al. Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation. J Clin Endocrinol Metab 1995;80:2534-42.
23. Pedersen MH, Mgaard C, Hellgren LI, Lauritzen L. Effects of fish oil supplementation on markers of the metabolic syndrome. J Pediatr 2010;157:395-400, 400.e1.
24. Nordic Council of Ministers. Nordic Nutrition Recommendations 2004. Copenhagen, Denmark: Norden, 2004:1-436.
25. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M; Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008;122: 398-417.
26. Wharton B, Bishop N. Rickets. Lancet 2003;362:1389-400. (Pubitemid 37338342)
27. Katan MB, Deslypere JP, van Birgelen AP, Penders M, Zegwaard M. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. J Lipid Res 1997;38:2012-22. (Pubitemid 27468010)
28. Appleton KM, Fraser WD, Rogers PJ, Ness AR, Tobias JH. Supplementation with a low-moderate dose of n-3 long-chain PUFA has no short-term effect on bone resorption in human adults. Br J Nutr 2011;105:1145-9.
29. Davies JH, Evans BA, Gregory JW. Bone mass acquisition in healthy children. Arch Dis Child 2005;90:373-8. (Pubitemid 40488675)
30. Green KH, Wong SC, Weiler HA. The effect of dietary n-3 long-chain polyunsaturated fatty acids on femur mineral density and biomarkers of bone metabolism in healthy, diabetic and dietary-restricted growing rats. Prostaglandins Leukot Essent Fatty Acids 2004;71:121-30. (Pubitemid 38881251)
31. McCarthy TL, Centrella M, Raisz LG, Canalis E. Prostaglandin E2 stimulates insulin-like growth factor I synthesis in osteoblast-enriched cultures from fetal rat bone. Endocrinology 1991;128:2895-900.
32. Sijben JW, Calder PC. Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. Proc Nutr Soc 2007;66:237-59. (Pubitemid 46684976)
33. Vidgren HM, Agren JJ, Schwab U, Rissanen T, Hänninen O, Uusitupa MI. Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. Lipids 1997;32:697-705. (Pubitemid 27328050)
34. Stevens L, Zhang W, Peck L, et al. EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids 2003;38:1007-21. (Pubitemid 37444624)
35. Andersen E, Hutchings B, Jansen J, Nyholm M. [Heights and weights of Danish children]. Ugeskr Laeg 1982;144:1760-5. (Pubitemid 12084645)
36. The Danish Nutrition Council and National Food Institute. National Danish Dietary Guidelines [Kostréne 2005]. Report no. 36. Sørg, Denmark: Boje & Mobeck, 2011:1-88.
37. Williams JE, Wells JC, Wilson CM, Haroun D, Lucas A, Fewtrell MS. Evaluation of Lunar Prodigy dual-energy X-ray absorptiometry for assessing body composition in healthy persons and patients by comparison with the criterion 4-component model. Am J Clin Nutr 2006;83:1047-54. (Pubitemid 44713103)
38. Prentice A, Parsons TJ, Cole TJ. Uncritical use of bone mineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants. Am J Clin Nutr 1994;60:837-42.
39. Wagner D, Hanwell HE, Vieth R. An evaluation of automated methods for measurement of serum 25-hydroxyvitamin D. Clin Biochem 2009;42:1549-56.
40. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000;320:1240-3. (Pubitemid 30240471)