메뉴 건너뛰기




Volumn 5, Issue , 2012, Pages 59-65

The effect of anti-VEGF drugs (bevacizumab and aflibercept) on the survival of patients with metastatic colorectal cancer (mCRC)

Author keywords

Antiangiogenic; Chemotherapy; Tumors

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PLACEBO; TRASTUZUMAB;

EID: 84861369217     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S29719     Document Type: Review
Times cited : (20)

References (63)
  • 1
    • 74749085829 scopus 로고    scopus 로고
    • Current progress in targeted therapy for colorectal cancer
    • Ortega J, Vigil CE, Chodkiewicz C. Current progress in targeted therapy for colorectal cancer. Cancer Control. 2010;17(1):7-15.
    • (2010) Cancer Control , vol.17 , Issue.1 , pp. 7-15
    • Ortega, J.1    Vigil, C.E.2    Chodkiewicz, C.3
  • 3
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350(23):2335-2342.
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 4
    • 49149124199 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Karamysheva AF. Mechanisms of angiogenesis. Biochemistry (Mosc). 2008;73(7):751-762.
    • (2008) Biochemistry (Mosc) , vol.73 , Issue.7 , pp. 751-762
    • Karamysheva, A.F.1
  • 5
    • 33847048710 scopus 로고    scopus 로고
    • Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications
    • Döme B, Hendrix MJ, Paku S, Tóvári J, Tímár J. Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications. Am J Pathol. 2007;170(1):1-15.
    • (2007) Am J Pathol , vol.170 , Issue.1 , pp. 1-15
    • Döme, B.1    Hendrix, M.J.2    Paku, S.3    Tóvári, J.4    Tímár, J.5
  • 6
    • 33846018408 scopus 로고    scopus 로고
    • Is angiogenesis an organizing principle in biology and medicine?
    • Folkman J. Is angiogenesis an organizing principle in biology and medicine? J Pediatr Surg. 2007;42(1):1-11.
    • (2007) J Pediatr Surg , vol.42 , Issue.1 , pp. 1-11
    • Folkman, J.1
  • 7
    • 84861382251 scopus 로고    scopus 로고
    • ZALTRAP™ (aflibercept) Significantly Improved Survival in Previously Treated Metastatic Colorectal Cancer Patients
    • Van Cutsem E, Tabernero J, Lakomy R, et al. ZALTRAP™ (aflibercept) Significantly Improved Survival in Previously Treated Metastatic Colorectal Cancer Patients. Annals of Oncology. 2011;22(Suppl 5):v18.
    • (2011) Annals of Oncology , vol.22 , Issue.SUPPL. 5
    • van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 8
    • 84975525035 scopus 로고
    • Clinical Applications of Research on Angiogenesis
    • Folkman J. Clinical Applications of Research on Angiogenesis. N Engl J Med. 1995;333(26):1757-1763.
    • (1995) N Engl J Med , vol.333 , Issue.26 , pp. 1757-1763
    • Folkman, J.1
  • 9
    • 0031969264 scopus 로고    scopus 로고
    • Angiogenesis and tumor metastasis
    • Zetter BR. Angiogenesis and tumor metastasis. Annu Rev Med. 1998;49:407-424.
    • (1998) Annu Rev Med , vol.49 , pp. 407-424
    • Zetter, B.R.1
  • 10
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 2003;3(6):401-410.
    • (2003) Nat Rev Cancer , vol.3 , Issue.6 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 11
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005;23(5):1011-1027.
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 12
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • Ferrara N. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist. 2004; 9 Suppl 1: 2-10.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 1 , pp. 2-10
    • Ferrara, N.1
  • 13
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005;23(5):1011-1027.
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 14
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov. 2004;3(5):391-400.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.5 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 16
    • 0031789314 scopus 로고    scopus 로고
    • Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer
    • Ishigami SI, Arii S, Furutani M, et al. Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer. Br J Cancer. 1998;78(10):1379-1384.
    • (1998) Br J Cancer , vol.78 , Issue.10 , pp. 1379-1384
    • Ishigami, S.I.1    Arii, S.2    Furutani, M.3
  • 17
    • 0033010512 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is up-regulated in the early pre-malignant stage of colorectal tumour progression
    • Wong MP, Cheung N, Yuen ST, Leung SY, Chung LP. Vascular endothelial growth factor is up-regulated in the early pre-malignant stage of colorectal tumour progression. Int J Cancer. 1999;81(6): 845-850.
    • (1999) Int J Cancer , vol.81 , Issue.6 , pp. 845-850
    • Wong, M.P.1    Cheung, N.2    Yuen, S.T.3    Leung, S.Y.4    Chung, L.P.5
  • 18
    • 80053960981 scopus 로고    scopus 로고
    • Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies
    • Martins SF, Reis RM, Rodrigues AM, Baltazar F, Filho AL. Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies. World J Clin Oncol. 2011;2(6): 272-280.
    • (2011) World J Clin Oncol , vol.2 , Issue.6 , pp. 272-280
    • Martins, S.F.1    Reis, R.M.2    Rodrigues, A.M.3    Baltazar, F.4    Filho, A.L.5
  • 19
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005;307(5706):58-62.
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 20
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
    • Kerbel RS. Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science. 2006;312(5777):1171-1175.
    • (2006) Science , vol.312 , Issue.5777 , pp. 1171-1175
    • Kerbel, R.S.1
  • 21
    • 50349097617 scopus 로고    scopus 로고
    • Rapid chemotherapyinduced acute endothelial progenitor cell mobilization: Implications for antiangiogenic drugs as chemosensitizing agents
    • Shaked Y, Henke E, Roodhart JM, et al. Rapid chemotherapyinduced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents. Cancer Cell. 2008;14(3):263-273.
    • (2008) Cancer Cell , vol.14 , Issue.3 , pp. 263-273
    • Shaked, Y.1    Henke, E.2    Roodhart, J.M.3
  • 22
    • 0035253739 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
    • Gordon MS, Margolin K, Talpaz M, et al. Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol. 2001;19(3):843-850.
    • (2001) J Clin Oncol , vol.19 , Issue.3 , pp. 843-850
    • Gordon, M.S.1    Margolin, K.2    Talpaz, M.3
  • 23
    • 68149165603 scopus 로고    scopus 로고
    • Bevacizumab plus oxaliplatin-based regimens for the treatment of colorectal cancer
    • Scheithauer W, Schmiegel W. Bevacizumab plus oxaliplatin-based regimens for the treatment of colorectal cancer. Onkologie. 2009; 32(7):431-439.
    • (2009) Onkologie , vol.32 , Issue.7 , pp. 431-439
    • Scheithauer, W.1    Schmiegel, W.2
  • 24
    • 36048960109 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Results from the BICC-C Study
    • Fuchs CS, Marshall J, Mitchell E, et al. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol. 2007;25(30):4779-4786.
    • (2007) J Clin Oncol , vol.25 , Issue.30 , pp. 4779-4786
    • Fuchs, C.S.1    Marshall, J.2    Mitchell, E.3
  • 25
    • 39149108869 scopus 로고    scopus 로고
    • Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: Updated results from the BICC-C study
    • Fuchs CS, Marshall J, Barrueco J. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: updated results from the BICC-C study. J Clin Oncol. 2008;26(4):689-690.
    • (2008) J Clin Oncol , vol.26 , Issue.4 , pp. 689-690
    • Fuchs, C.S.1    Marshall, J.2    Barrueco, J.3
  • 26
    • 79959740774 scopus 로고    scopus 로고
    • XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer: NO16966 updated results
    • June 28
    • Cassidy J, Clarke S, Diaz-Rubio E, et al. XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer: NO16966 updated results. Br J Cancer. June 28, 2011;105(1):58-64.
    • (2011) Br J Cancer , vol.105 , Issue.1 , pp. 58-64
    • Cassidy, J.1    Clarke, S.2    Diaz-Rubio, E.3
  • 27
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 2007;25(12):1539-1544.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 28
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar FF, Hambleton J, Mass RD, Hurwitz HI, Bergsland E, Sarkar S. Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol. 2005;23(16):3706-3712.
    • (2005) J Clin Oncol , vol.23 , Issue.16 , pp. 3706-3712
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3    Hurwitz, H.I.4    Bergsland, E.5    Sarkar, S.6
  • 29
    • 27944458472 scopus 로고    scopus 로고
    • Bevacizumab combined with standard fluoropyrimidine-based chemotherapy regimens to treat colorectal cancer
    • Hurwitz H, Kabbinavar F. Bevacizumab combined with standard fluoropyrimidine-based chemotherapy regimens to treat colorectal cancer. Oncology. 2005;69 Suppl 3:17-24.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 17-24
    • Hurwitz, H.1    Kabbinavar, F.2
  • 30
    • 84861539889 scopus 로고    scopus 로고
    • An Update on the Current and Emerging Targeted Agents in Metastatic Colorectal Cancer
    • Chu E. An Update on the Current and Emerging Targeted Agents in Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2012; 11(1):1-13.
    • (2012) Clin Colorectal Cancer , vol.11 , Issue.1 , pp. 1-13
    • Chu, E.1
  • 31
    • 70349413045 scopus 로고    scopus 로고
    • Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: The BRiTE observational cohort study
    • Kozloff M, Yood MU, Berlin J, et al. Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: the BRiTE observational cohort study. Oncologist. 2009;14(9): 862-870.
    • (2009) Oncologist , vol.14 , Issue.9 , pp. 862-870
    • Kozloff, M.1    Yood, M.U.2    Berlin, J.3
  • 32
    • 84857660379 scopus 로고    scopus 로고
    • The Continuation of Bevacizumab Following Disease Progression in Patients with Metastatic Colorectal Cancer Offers a Survival Benefit
    • Samelis GF, Ekmektzoglou KA, Tsiakou A, Konstadoulakis M. The Continuation of Bevacizumab Following Disease Progression in Patients with Metastatic Colorectal Cancer Offers a Survival Benefit. Hepatogastroenterology. 2011;58(112):1968-1971.
    • (2011) Hepatogastroenterology , vol.58 , Issue.112 , pp. 1968-1971
    • Samelis, G.F.1    Ekmektzoglou, K.A.2    Tsiakou, A.3    Konstadoulakis, M.4
  • 33
    • 17944370631 scopus 로고    scopus 로고
    • Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
    • Shaheen RM, Ahmad SA, Liu W, et al. Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors. Br J Cancer. 2001;85(4):584-589.
    • (2001) Br J Cancer , vol.85 , Issue.4 , pp. 584-589
    • Shaheen, R.M.1    Ahmad, S.A.2    Liu, W.3
  • 34
    • 5044236157 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in tumor angiogenesis
    • Ellis LM. Epidermal growth factor receptor in tumor angiogenesis. Hematol Oncol Clin North Am. 2004;18(5):1007-1021.
    • (2004) Hematol Oncol Clin North Am , vol.18 , Issue.5 , pp. 1007-1021
    • Ellis, L.M.1
  • 35
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol. 2009;27(5):672-680.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 36
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N Engl J Med. 2009; 360(6):563-572.
    • (2009) N Engl J Med , vol.360 , Issue.6 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 37
    • 84861394418 scopus 로고    scopus 로고
    • Phase III Trial of Cetuximab, Bevacizumab, and 5-Fluorouracil/Leucovorin vs FOLFOX-Bevacizumab in Colorectal Cancer
    • Epub ahead of print
    • Saltz L, Badarinath S, Dakhil S, et al. Phase III Trial of Cetuximab, Bevacizumab, and 5-Fluorouracil/Leucovorin vs FOLFOX-Bevacizumab in Colorectal Cancer. Clin Colorectal Cancer. 2011. [Epub ahead of print.]
    • (2011) Clin Colorectal Cancer
    • Saltz, L.1    Badarinath, S.2    Dakhil, S.3
  • 38
    • 79953236184 scopus 로고    scopus 로고
    • AVANT: Results from a randomized, three-arm multinational phase III study to investigate bevacizumab with either XELOX or FOLFOX4 versus FOLFOX4 alone as adjuvant treatment for colon cancer
    • February 3
    • De Gramont A, Van Cutsem E, Tabernero J, et al. AVANT: Results from a randomized, three-arm multinational phase III study to investigate bevacizumab with either XELOX or FOLFOX4 versus FOLFOX4 alone as adjuvant treatment for colon cancer. ASCO Meeting Abstracts. February 3, 2011;29(Suppl 4):362.
    • (2011) ASCO Meeting Abstracts , vol.29 , Issue.SUPPL. 4 , pp. 362
    • de Gramont, A.1    van Cutsem, E.2    Tabernero, J.3
  • 39
    • 69549147378 scopus 로고    scopus 로고
    • A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: Results of NSABP Protocol C-08. ASCO Meeting Abstracts
    • Wolmark N, Yothers G, O'Connell MJ, et al. A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: Results of NSABP Protocol C-08. ASCO Meeting Abstracts. June 8, 2009;27(15S):A4.
    • (2009) June 8 , vol.27 , Issue.15 S
    • Wolmark, N.1    Yothers, G.2    O'Connell, M.J.3
  • 40
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A. 2002;99(17):11393-11398.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.17 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 41
    • 81155126233 scopus 로고    scopus 로고
    • Aflibercept (VEGF-TRAP): The Next Anti-VEGF Drug
    • Stewart MW. Aflibercept (VEGF-TRAP): The Next Anti-VEGF Drug. Inflamm Allergy Drug Targets. 2011;10(6):497-508.
    • (2011) Inflamm Allergy Drug Targets , vol.10 , Issue.6 , pp. 497-508
    • Stewart, M.W.1
  • 42
    • 11144355004 scopus 로고    scopus 로고
    • VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment
    • Cursiefen C, Chen L, Borges LP, et al. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest. 2004;113(7): 1040-1050.
    • (2004) J Clin Invest , vol.113 , Issue.7 , pp. 1040-1050
    • Cursiefen, C.1    Chen, L.2    Borges, L.P.3
  • 43
    • 0037143739 scopus 로고    scopus 로고
    • Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma
    • Kim ES, Serur A, Huang J, et al. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc Natl Acad Sci U S A. 2002;99(17):11399-11404.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.17 , pp. 11399-11404
    • Kim, E.S.1    Serur, A.2    Huang, J.3
  • 44
    • 77957083400 scopus 로고    scopus 로고
    • Clinical applications of VEGF-trap (aflibercept) in cancer treatment
    • Teng LS, Jin KT, He KF, Zhang J, Wang HH, Cao J. Clinical applications of VEGF-trap (aflibercept) in cancer treatment. J Chin Med Assoc. 2010;73(9):449-456.
    • (2010) J Chin Med Assoc , vol.73 , Issue.9 , pp. 449-456
    • Teng, L.S.1    Jin, K.T.2    He, K.F.3    Zhang, J.4    Wang, H.H.5    Cao, J.6
  • 45
    • 77958061434 scopus 로고    scopus 로고
    • Aflibercept exerts antivascular effects and enhances levels of anthracycline chemotherapy in vivo in human acute myeloid leukemia models
    • Lal D, Park JA, Demock K, et al. Aflibercept exerts antivascular effects and enhances levels of anthracycline chemotherapy in vivo in human acute myeloid leukemia models. Mol Cancer Ther. 2010;9(10):2737-2751.
    • (2010) Mol Cancer Ther , vol.9 , Issue.10 , pp. 2737-2751
    • Lal, D.1    Park, J.A.2    Demock, K.3
  • 46
    • 26444484355 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap combined with paclitaxel trikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model
    • Hu L, Hofmann J, Holash J, Yancopoulos GD, Sood AK, Jaffe RB. Vascular endothelial growth factor trap combined with paclitaxel trikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model. Clin Cancer Res. 2005;11(19 Pt 1): 6966-6971.
    • (2005) Clin Cancer Res , vol.11 , Issue.19 PT. 1 , pp. 6966-6971
    • Hu, L.1    Hofmann, J.2    Holash, J.3    Yancopoulos, G.D.4    Sood, A.K.5    Jaffe, R.B.6
  • 47
    • 74949119167 scopus 로고    scopus 로고
    • Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors
    • Lockhart AC, Rothenberg ML, Dupont J, et al. Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol. 2010;28(2):207-214.
    • (2010) J Clin Oncol , vol.28 , Issue.2 , pp. 207-214
    • Lockhart, A.C.1    Rothenberg, M.L.2    Dupont, J.3
  • 48
    • 74949101370 scopus 로고    scopus 로고
    • Phase 1study of aflibercept administered subcutaneously to patients with advanced solid tumors
    • Tew WP, Gordon M, Murren J, et al. Phase 1study of aflibercept administered subcutaneously to patients with advanced solid tumors. Clin Cancer Res. 2010;16(1):358-366.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 358-366
    • Tew, W.P.1    Gordon, M.2    Murren, J.3
  • 49
    • 79960111080 scopus 로고    scopus 로고
    • Phase II study of aflibercept in recurrent malignant glioma: A North American Brain Tumor Consortium study
    • de Groot JF, Lamborn KR, Chang SM, et al. Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol. 2011;29(19):2689-2695.
    • (2011) J Clin Oncol , vol.29 , Issue.19 , pp. 2689-2695
    • de Groot, J.F.1    Lamborn, K.R.2    Chang, S.M.3
  • 50
    • 77958198446 scopus 로고    scopus 로고
    • Aflibercept (VEGF Trap): One more double-edged sword of anti-VEGF therapy for cancer?
    • Jin K, Shen Y, He K, Xu Z, Li G, Teng L. Aflibercept (VEGF Trap): one more double-edged sword of anti-VEGF therapy for cancer? Clin Transl Oncol. 2010;12(8):526-532.
    • (2010) Clin Transl Oncol , vol.12 , Issue.8 , pp. 526-532
    • Jin, K.1    Shen, Y.2    He, K.3    Xu, Z.4    Li, G.5    Teng, L.6
  • 51
    • 36749040908 scopus 로고    scopus 로고
    • VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
    • Rudge JS, Holash J, Hylton D, et al. VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc Natl Acad Sci U S A. 2007;104(47):18363-18370.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.47 , pp. 18363-18370
    • Rudge, J.S.1    Holash, J.2    Hylton, D.3
  • 52
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • Reichert JM. Antibody-based therapeutics to watch in 2011. MAbs. 2011;3(1):76-99.
    • (2011) MAbs , vol.3 , Issue.1 , pp. 76-99
    • Reichert, J.M.1
  • 53
    • 84861413530 scopus 로고    scopus 로고
    • Regeneron Pharmaceuticals Inc. Press Release Reporting Two Year Results of Phase 3 Studies with ELYEA™ (aflibercept) Injection in wet AMD Show Sustained Improvement in Visual Acuity [press release]. Tarrytown, NY: Regeneron; December 5
    • Regeneron Pharmaceuticals Inc. Press Release Reporting Two Year Results of Phase 3 Studies with ELYEA™ (aflibercept) Injection in wet AMD Show Sustained Improvement in Visual Acuity [press release]. Tarrytown, NY: Regeneron; December 5, 2000.
    • (2000)
  • 54
    • 84861369715 scopus 로고    scopus 로고
    • Sanofi-Aventis; Regenreron Pharmaceuticals. Study of Intravenous Aflibercept in Combination With FOLFIRI in Japanese Patients With Metastatic Colorectal Cancer. In: ClinicalTrials.gov [Internet]. Bethesda, MD: National Library of Medicine (US). June 15, 2009 [last updated on November 2, 2011]. Available from, NLM Identifier: NCT00921661
    • Sanofi-Aventis; Regenreron Pharmaceuticals. Study of Intravenous Aflibercept in Combination With FOLFIRI in Japanese Patients With Metastatic Colorectal Cancer. In: ClinicalTrials.gov [Internet]. Bethesda, MD: National Library of Medicine (US). June 15, 2009 [last updated on November 2, 2011]. Available from: http://clinicaltrials.gov/ct2/show/NCT00921661. NLM Identifier: NCT00921661.
  • 55
    • 56749169353 scopus 로고    scopus 로고
    • Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: Results from a large observational cohort study (BRiTE)
    • Grothey A, Sugrue MM, Purdie DM, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol. 2008;26(33):5326-5334.
    • (2008) J Clin Oncol , vol.26 , Issue.33 , pp. 5326-5334
    • Grothey, A.1    Sugrue, M.M.2    Purdie, D.M.3
  • 56
    • 33746571577 scopus 로고    scopus 로고
    • Clinical benefit from bevacizumab (BV) in responding (R) and non-responding (NR) patients (pts) with metastatic colorectal cancer (mCRC)
    • May 28
    • Mass RD, Sarkar S, Holden SN, Hurwitz H. Clinical benefit from bevacizumab (BV) in responding (R) and non-responding (NR) patients (pts) with metastatic colorectal cancer (mCRC). ASCO Meeting Abstracts. May 28, 2005;23(Suppl 16):3514.
    • (2005) ASCO Meeting Abstracts , vol.23 , Issue.SUPPL. 16 , pp. 3514
    • Mass, R.D.1    Sarkar, S.2    Holden, S.N.3    Hurwitz, H.4
  • 57
    • 75749096309 scopus 로고    scopus 로고
    • Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: Efficacy and circulating angiogenic biomarkers associated with therapeutic resistance
    • Kopetz S, Hoff PM, Morris JS, et al. Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol. 2010;28(3):453-459.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 453-459
    • Kopetz, S.1    Hoff, P.M.2    Morris, J.S.3
  • 58
    • 84861387458 scopus 로고    scopus 로고
    • Groupe Cooperateur Multidisciplinaire en Oncologie (GERCOR). Combination Chemotherapy and Bevacizumab With or Without Erlotinib in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery. In: ClinicalTrials.gov [Internet]. Bethesda, MD: National Library of Medicine (US). December 14, 2005 [last updated February 6, 2009]. Avaialble from, NLM identifier: NCT00265824
    • Groupe Cooperateur Multidisciplinaire en Oncologie (GERCOR). Combination Chemotherapy and Bevacizumab With or Without Erlotinib in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery. In: ClinicalTrials.gov [Internet]. Bethesda, MD: National Library of Medicine (US). December 14, 2005 [last updated February 6, 2009]. Avaialble from: http://clinicaltrials.gov/ct/show/NCT00265824. NLM identifier: NCT00265824.
  • 59
    • 33745135802 scopus 로고    scopus 로고
    • Current development status of small-molecule vascular disrupting agents
    • Chaplin DJ, Horsman MR, Siemann DW. Current development status of small-molecule vascular disrupting agents. Curr Opin Investig Drugs. 2006;7(6):522-528.
    • (2006) Curr Opin Investig Drugs , vol.7 , Issue.6 , pp. 522-528
    • Chaplin, D.J.1    Horsman, M.R.2    Siemann, D.W.3
  • 60
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer. 2004;4(6):423-436.
    • (2004) Nat Rev Cancer , vol.4 , Issue.6 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 61
    • 80053527559 scopus 로고    scopus 로고
    • Biomarkers of anti-angiogenic therapy in metastatic colorectal cancer (mCRC): Original data and review of the literature
    • Pohl M, Werner N, Munding J, et al. Biomarkers of anti-angiogenic therapy in metastatic colorectal cancer (mCRC): original data and review of the literature. Z Gastroenterol. 2011;49(10):1398-1406.
    • (2011) Z Gastroenterol , vol.49 , Issue.10 , pp. 1398-1406
    • Pohl, M.1    Werner, N.2    Munding, J.3
  • 62
    • 77950390607 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor pathway in first-line treatment of metastatic colorectal cancer: State-of-the-art and future perspectives in clinical and molecular selection of patients
    • Loupakis F, Bocci G, Pasqualetti G, et al. Targeting vascular endothelial growth factor pathway in first-line treatment of metastatic colorectal cancer: state-of-the-art and future perspectives in clinical and molecular selection of patients. Curr Cancer Drug Targets. 2010;10(1): 37-45.
    • (2010) Curr Cancer Drug Targets , vol.10 , Issue.1 , pp. 37-45
    • Loupakis, F.1    Bocci, G.2    Pasqualetti, G.3
  • 63
    • 80054691724 scopus 로고    scopus 로고
    • Circulating endothelial cells predict for response to bevacizumab-based chemotherapy in metastatic colorectal cancer
    • Matsusaka S, Suenaga M, Mishima Y, et al. Circulating endothelial cells predict for response to bevacizumab-based chemotherapy in metastatic colorectal cancer. Cancer Chemother Pharmacol. 2011;68(3):763-768.
    • (2011) Cancer Chemother Pharmacol , vol.68 , Issue.3 , pp. 763-768
    • Matsusaka, S.1    Suenaga, M.2    Mishima, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.