Artemether-lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania

Malaria Journal

Volumn 11, Issue , 2012, Pages

  Färnert, Anna ^a,b   Ursing, Johan ^a,b   Tolfvenstam, Thomas ^a,b   Rono, Josea ^a   Karlsson, Lillemor ^b   Sparrelid, Elda ^b   Lindegårdh, Niklas ^c,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c MAHIDOL UNIVERSITY   (Thailand)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Artemisinin; Lumefantrine; Malaria; non immune; P. falciparum; Sensitivity

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; ATOVAQUONE PLUS PROGUANIL; BILIRUBIN; C REACTIVE PROTEIN; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; GENTAMICIN; HEMOGLOBIN; MEFLOQUINE; MEROZOITE SURFACE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 1; PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE PROTEIN; PLASMODIUM FALCIPARUM MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE;

ADULT; ANTIBIOTIC THERAPY; ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; BACTEREMIA; BILIRUBIN BLOOD LEVEL; CASE REPORT; CHEMOPROPHYLAXIS; CHILL; CONSCIOUSNESS DISORDER; DRUG BLOOD LEVEL; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; ERYTHROCYTE; FEVER; FOLLOW UP; GENOTYPE; HEADACHE; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOTENSION; INTRAVENOUS ADMINISTRATION; JAUNDICE; LOOSE FECES; MALARIA CONTROL; MALARIA FALCIPARUM; MALE; MULTIDRUG RESISTANCE; PLASMODIUM FALCIPARUM; PROTEIN BLOOD LEVEL; SINGLE DRUG DOSE; SWEDEN; TANZANIA; THROMBOCYTE COUNT; TRAVEL; TREATMENT DURATION; CLASSIFICATION; DRUG COMBINATION; DRUG EFFECT; DRUG RESISTANCE; GENETICS; ISOLATION AND PURIFICATION; MIDDLE AGED; RECURRENT DISEASE; TREATMENT FAILURE;

ANTIMALARIALS; ARTEMISININS; DRUG COMBINATIONS; DRUG RESISTANCE; ETHANOLAMINES; FLUORENES; GENOTYPE; HUMANS; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; PLASMODIUM FALCIPARUM; RECURRENCE; TANZANIA; TRAVEL; TREATMENT FAILURE;

EID: 84861366881     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-11-176     Document Type: Article

References (17)

1. World Health Organization, Guidelines for the treatment of malaria http://whqlibdoc.who.int/publications/2010/9789241547925-eng.pdf
2. Optimization and validation of multi-coloured capillary electrophoresis for genotyping of Plasmodium falciparum merozoite surface proteins (msp1 and 2). Liljander A, Wiklund L, Falk N, Kweku M, Martensson A, Felger I, Färnert A, Malar J 2009 8 78 10.1186/1475-2875-8-78 19386138
3. A clinical and pharmacokinetic trial of six doses of artemether- lumefantrine for multidrug-resistant Plasmodium falciparum malaria in Thailand. Lefevre G, Looareesuwan S, Treeprasertsuk S, Krudsood S, Silachamroon U, Gathmann I, Mull R, Bakshi R, AmJTrop Med Hyg 2001 64 247 256
4. Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria. Price RN, Uhlemann AC, van Vugt M, Brockman A, Hutagalung R, Nair S, Nash D, Singhasivanon P, Anderson TJ, Krishna S, White NJ, Nosten F, Clin Infect Dis 2006 42 1570 1577 10.1086/503423 16652314
5. Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: a pooled analysis. Makanga M, Bassat Q, Falade CO, Premji ZG, Krudsood S, Hunt P, Walter V, Beck HP, Marrast AC, Cousin M, Rosenthal PJ, AmJTrop Med Hyg 2011 85 793 804
6. First case of treatment failure of artemether-lumefantrine in a Japanese traveler with imported falciparum malaria. Mizuno Y, Kato Y, Kudo K, Kano S, Jpn J Infect Dis 2009 62 139 141 19305055
7. Possible clinical failure of artemether-lumefantrine in an italian traveler with uncomplicated falciparum malaria. Repetto EC, Traverso A, Giacomazzi CG, Mediterr J Hematol Infect Dis 2011 3 2011041 22084655
8. Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria. Ezzet F, van Vugt M, Nosten F, Looareesuwan S, White NJ, Antimicrob Agents Chemother 2000 44 697 704 10.1128/AAC.44.3.697-704.2000 10681341
9. Methods and techniques for assessing exposure to antimalarial drugs in clinical field studies http://www.wwarn.org/sites/default/files/ AssessingExposureToAntimalarials.pdf
10. Desbutyl-lumefantrine is a metabolite of lumefantrine with potent in vitro antimalarial activity that may influence artemether-lumefantrine treatment outcome. Wong RP, Salman S, Ilett KF, Siba PM, Mueller I, Davis TM, Antimicrob Agents Chemother 2011 55 1194 1198 10.1128/AAC.01312-10 21199927
11. Artemisinin resistance in Plasmodium falciparum malaria. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, Lwin KM, Ariey F, Hanpithakpong W, Lee SJ, Ringwald P, Silamut K, Imwong M, Chotivanich K, Lim P, Herdman T, An SS, Yeung S, Singhasivanon P, Day NP, Lindegårdh N, Socheat D, White NJ, N Engl J Med 2009 361 455 467 10.1056/NEJMoa0808859 19641202
12. Reduced in vitro susceptibility to artemisinin derivatives associated with multi-resistance in a traveller returning from South-East Asia. Pradines B, Bertaux L, Pomares C, Delaunay P, Marty P, Malar J 2011 10 268 10.1186/1475-2875-10-268 21923936
13. In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1. Mwai L, Kiara SM, Abdirahman A, Pole L, Rippert A, Diriye A, Bull P, Marsh K, Borrmann S, Nzila A, Antimicrob Agents Chemother 2009 53 5069 5073 10.1128/AAC.00638-09 19770282
14. In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem). Sisowath C, Strömberg J, Mårtensson A, Msellem M, Obondo C, Björkman A, Gil JP, J Infect Dis 2005 191 1014 1017 10.1086/427997 15717281
15. Interaction trial between artemether-lumefantrine (Riamet) and quinine in healthy subjects. Lefevre G, Carpenter P, Souppart C, Schmidli H, Martin JM, Lane A, Ward C, Amakye D, J Clin Pharmacol 2002 42 1147 1158 12362930
16. The effects of anti-bacterials on the malaria parasite Plasmodium falciparum. Goodman CD, Su V, McFadden GI, Mol Biochem Parasitol 2007 152 181 191 10.1016/j.molbiopara.2007.01.005 17289168
17. Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast. Borrmann S, Sasi P, Mwai L, Bashraheil M, Abdallah A, Muriithi S, Fruhauf H, Schaub B, Pfeil J, Peshu J, Hanpithakpong W, Rippert A, Juma E, Tsofa M, Mosobo M, Lowe B, Osier F, Fegan G, Lindegardh N, Nzila A, Peshu N, Mackinnon M, Marsh K, PLoS One 2011 6 26005 10.1371/journal.pone.0026005 22102856