Investigation of polymorphic variants of PPARD and APOE genes in turkish coronary heart disease patients

DNA and Cell Biology

Volumn 31, Issue 5, 2012, Pages 867-875

  Yilmaz Aydogan, Hulya ^a   Kucukhuseyin, Ozlem ^a   Kurnaz, Ozlem ^a   Akadam Teker, Basak ^a   Kurt, Ozlem ^a   Tekeli, Atike ^b   Ozturk, Oguz ^a   Isbir, Turgay ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b MARMARA UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ALLELE; APOLIPOPROTEIN E GENE; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DNA POLYMORPHISM; FEMALE; GENE; GENE FUNCTION; GENE INTERACTION; GENETIC VARIABILITY; GENOTYPE; HEART LEFT VENTRICLE HYPERTROPHY; HOMOZYGOSITY; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA GENE; POPULATION GENETICS; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; TURKEY (BIRD);

APOLIPOPROTEINS E; CASE-CONTROL STUDIES; CORONARY DISEASE; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEART; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PPAR DELTA; PROGNOSIS; RISK FACTORS; TURKEY;

EID: 84861355899     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2011.1464     Document Type: Article

References (36)

1. Aberle, J., Hopfer, I., Beil, F.U., and Seedorf, U. (2006a). Association of the T + 294C polymorphism in PPAR d with low HDL cholesterol and coronary heart disease risk in women. IntJ Med Sci 3, 108-111. (Pubitemid 44035233)
2. Aberle, J., Hopfer, I., Beil, F.U., and Seedorf, U. (2006b). Association of peroxisome proliferator-activated receptor delta + 294T/C with body mass index and interaction with peroxisome proliferator-activated receptor alpha L162V. Int J Obes (Lond) 30, 1709-1713. (Pubitemid 44863401)
3. Ashavaid, T.F., Todur, S.P., and Nair, K.G. (2003). Apolipoprotein E polymorphism and coronary heart disease. J AssocPhysicians India 51, 784-788. (Pubitemid 41315502)
4. Balakumar, P., Rose, M., and Singh, M. (2007). PPAR ligands: are they potential agents for cardiovascular disorders? Pharmacology 80, 1-10. (Pubitemid 47013361)
5. Chen, S., Tsybouleva, N., Ballantyne, C.M., Gotto, A.M., and Marian, A.J. (2004). Effects of PPARa, g and d haplotypes on plasma levels of lipids and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. Pharmacogenet 14, 61-71. (Pubitemid 38183963)
6. Dressel, U., Allen, T.L., Pippal, J.B., Rohde, P.R., Lau, P., andMuscat, G.E. (2003). The peroxisome proliferator-activated receptor d/b agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells. Mol Endocrinol 17, 2477-2493. (Pubitemid 37542211)
7. Dupont, W.D., and Plummer, W.D. (2009). Ps: Power and Sample Size Calculation. Available at http://biostat.mc.vanderbilt.edu/wiki/Main/ PowerSampleSize Department of Biostatistics, Vanderbilt University Medical School Homepage.
8. Duval, C., Chinetti, G., Trottein, F., Fruchart, J.C., and Staels, B. (2002). The role of PPARs in atherosclerosis. Trends Mol Med 8, 422-430. (Pubitemid 34975988)
9. Gilde, A.J., van der Lee, K.A., Willemsen, P.H., Chinetti, G., van der Leij, F.R., van der Vusse G.J., Staels, B., and van Bilsen, M. (2003). Peroxisome proliferator-activated receptor (PPAR)a and PPARb/d, but not PPARg, modulate the expression of genes involved in cardiac lipid metabolism. Circ Res 92, 518-524. (Pubitemid 36368664)
10. Gouni-Berthold, I., Giannakidou, E., Faust, M., Berthold, H.K., and Krone, W. (2005). The peroxisome proliferator-activated receptor delta + 294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls. Atherosclerosis 183, 336-341. (Pubitemid 41579286)
11. Grundy, S.M. (2004). Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 89, 2595-2600. (Pubitemid 38766337)
12. Jguirim-Souissi, I., Jelassi, A., Hrira, Y., Najah, M., Slimani, A., Addad, F., Hassine, M., Hamda, K.B., Maatouk, F., Rouis, M., and Slimane, M.N. (2010). + 294T/C polymorphism in the PPAR- d gene is associated with risk of coronary artery disease in normolipidemic Tunisians. Genet Mol Res 9, 1326-1333.
13. Kontula, K., Aalto-Setälä, K., Kuusi, T., Hämälä inen, L., and Syvänen, A.C. (1990). Apolipoprotein E polymorphism determined by restriction enzyme analysis of DNA amplified by polymerase chain reaction: convenient alternative to phenotyping by isoelectric focusing. Clin Chem 36, 2087-2092. (Pubitemid 120000542)
14. Kota, B.P., Huang, T.H.W., and Roufogalis, B.D. (2005). An overview on biological mechanisms of PPARs. Pharmacol Res 51, 85-94. (Pubitemid 40040538)
15. Lahoz, C., Schaefer, E.J., Cupples, L.A., Wilson, P.W., Levy, D., Osgood, D., Parpos, S., Pedro-Botet, J., Daly, J.A., and Ordovas, J.M. (2001). Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis 154, 529-537. (Pubitemid 32232149)
16. Leibowitz, M.D., Fievet, C., Hennuyer, N., Peinado-Onsurbe, J., Duez, H., Bergera, J., Cullinan, C.A., Sparrow, C.P., Baffic, J., Berger, G.D., Santini, C., Marquis, R.W., Tolman, R.L., Smith, R.G., Moller, D.E., and Auwerx, J. (2000). Activation of PPAR delta alters lipid metabolism in db/db mice. FEBS Lett 473, 333-336. (Pubitemid 30249149)
17. Libby, P., and Plutzky, J. (2007). Inflammation in diabetes mellitus: role of peroxisome proliferator-activated receptor-a and peroxisome proliferator-activated receptor-g agonists. Am Cardiol 99, 27B-40B.
18. Loew, M., Hoffmann, M.M., Hahmann, H., März, W., Rothenbacher, D., and Brenner, H. (2005). Smoking, apolipoprotein E genotype, and early onset of coronary heart disease. Eur J Cardiovasc Prev Rehabil 12, 268-270. (Pubitemid 40910855)
19. Mahley, R.W. (1988). Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science. 240, 622-630.
20. Marenberg, M.E., Risch, N., Berkman, L.F., Floderus, B., and De Faire, U. (1994). Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 330, 1041-1046. (Pubitemid 24106561)
21. Marx, N., Duez, H., Fruchart, J.C., and Staels, B. (2004). Peroxisome proliferator- activated receptors and atherogenesis: regulators of gene expression in vascular cells. Circ Res 94, 1168-1178. (Pubitemid 38656403)
22. Nikitin, A.G., Chistiakov, D.A., Minushkina, L.O., Zateyshchikov, D.A., and Nosikov, V.V. (2010). Association of the CYBA, PPARGC1A, PPARG3, and PPARD gene variants with coronary artery disease and metabolic risk factors of coronary atherosclerosis in a Russian population. Heart Vessels 25, 229-236.
23. Pedersen, J.C., and Berg, K. (1989). Interaction between low density lipoprotein receptor (LDLR) and apolipoprotein E (apoE) alleles contributes to normal variation in lipid level. Clin Genet 35, 331-337. (Pubitemid 19128521)
24. Peng, D.Q., Zhao, S.P., Nie, S., and Li, J. (2003). Gene-gene interaction of PPARW and ApoE affects coronary heart disease risk. Int J Cardiol 92, 257-263. (Pubitemid 37509991)
25. Robitaille, J., Gaudet, D., Pérusse, L., and Vohl, M.C. (2007). Features of the metabolic syndrome are modulated by an interaction between the peroxisome proliferatoractivated receptor-delta - 87T >C polymorphism and dietary fat in French-Canadians. Int J Obes (Lond) 31, 411-417.
26. Ross, R. (1993). The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362, 801-809. (Pubitemid 23132154)
27. Sahn, D.J., De Maria, A., Kisslo, J., and Weyman, A. (1978). Recommendations regarding quantitation in M-mode echocardiography: result of a survey of echocardiographic measurements. Circulation 58, 1072-1083. (Pubitemid 9091990)
28. Skogsberg, J., Kannisto, K., Cassel, T.N., Hamsten, A., Eriksson, P., and Ehrenborg, E. (2003a). Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men. Arterioscler Thromb Vasc Biol 23, 637-643. (Pubitemid 36438077)
29. Skogsberg, J., McMahon, A.D., Karpe, F., Hamsten, A., Packard, C.J., and Ehrenborg, E. (2003b). West of Scotland Coronary Prevention Study, Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men. J Intern Med 254, 597-604. (Pubitemid 37521857)
30. Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R.X., Tachibana, K., Watanabe, Y., Uchiyama, Y., Sumi, K., Iguchi, H., Ito, S.,Doi, T., Hamakubo, T., Naito, M., Auwerx, J., Yanagisawa, M., Kodama, T., and Sakai, J. (2003) Activation of peroxisome proliferator-activated receptor delta induces fatty acid betaoxidation in skeletal muscle and attenuates metabolic syndrome. Proc Natl Acad Sci USA 100, 15924-15929. (Pubitemid 38021091)
31. Tesse, A., Andriantsitohaina, R., and Ragot, T. (2009). PPARdelta activity in cardiovascular diseases: a potential pharmacological target. PPAR Res 2009, 1-9.
32. Wilson, P.W., D'Agostino, R.B., Levy, D., Belanger, A.M., Silbershatz, H., and Kannel, W.B. (1998). Prediction of coronary heart disease using risk factor categories. Circulation 97, 1837-1847. (Pubitemid 28213628)
33. Wilson, P.W.F., Schaefer, E.J., Larson, M.G., and Ordovas, J.M. (1996). Apolipoprotein E alleles and risk of coronary disease-A meta-analysis. Arterioscler Thromb Vasc Biol 16, 1250-1255. (Pubitemid 26339712)
34. Yan, Z.C., Shen, C.Y., Zhong, J., Wang, L., Ni, Y.X., Nie, H., and Zhu, Z.M. (2005). PPARdelta + 294T/C gene polymorphism related to plasma lipid, obesity and left ventricular hypertrophy in subjects with metabolic syndrome. Zhonghua Xin Xue Guan Bing Za Zhi 33, 529-533. (Pubitemid 41135742)
35. Yilmaz-Aydogan, H., Kurnaz, O., Kurt, O., Akadam-Teker, B., Kucukhuseyin, O., Tekeli, A., and Isbir, T. (2011). Effects of the PPARG P12A and C161T gene variants on serum lipids in coronary heart disease patients with and without Type 2 diabetes. Mol Cell Biochem 358, 355-363.
36. Yilmaz, H., Isbir, T., Agachan, B., and Aydin, M. (2001). Is E4 allele of apolipoprotein E associated with more severe endorgan damage in essential hypertension? Cell Biochem Func 19, 191-195. (Pubitemid 32768768)