Two mechanistically distinct effects of dihydropyridine nifedipine on Ca V1.2 L-type Ca 2+ channels revealed by Timothy syndrome mutation

European Journal of Pharmacology

Volumn 685, Issue 1-3, 2012, Pages 15-23

  Sheng, Xiaona ^a,b,c   Nakada, Tsutomu ^a   Kobayashi, Motohiro ^b   Kashihara, Toshihide ^a   Shibazaki, Toshihide ^a,d   Horiuchi Hirose, Miwa ^a   Gomi, Simmon ^a   Hirose, Masamichi ^e   Aoyama, Toshifumi ^b   Yamada, Mitsuhiko ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c HEBEI MEDICAL UNIVERSITY   (China)

^d KISSEI PHARMACEUTICAL CO LTD   (Japan)

^e IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Allosteric model; Ca V1.2 L type Ca 2+ channel; Dihydropyridine; Nifedipine; Timothy syndrome; Voltage dependent inactivation

Indexed keywords

BARIUM ION; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL L TYPE CAV 1.2; NIFEDIPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AUTOSOMAL DOMINANT DISORDER; BLOCKING FACTOR; CALCIUM CURRENT; CALCIUM DEPLETION; CALCIUM TRANSPORT; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; GENE MUTATION; GENE SEQUENCE; MEMBRANE POTENTIAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PREPULSE INHIBITION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TIMOTHY SYNDROME; TRANSPORT KINETICS;

ALLOSTERIC REGULATION; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; HEK293 CELLS; HUMANS; LONG QT SYNDROME; MEMBRANE POTENTIALS; MUTATION; NIFEDIPINE; RABBITS; RATS; SYNDACTYLY;

EID: 84861339908     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.04.029     Document Type: Article

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