Total thyroidectomy with ultrasonic scalpel: A multicenter, randomized controlled trial

Head and Neck

Volumn 34, Issue 6, 2012, Pages 805-812

  Kowalski, Luiz P ^a   Sanabria, Alvaro ^b   Vartanian, José Guilherme ^a   Lima, Roberto Araujo ^c   Toscano De Mendonca, Ullianov Bezerra ^c   Roberto Dos Santos, Carlos ^d   Boldrini Júnior, Domingos ^d   Barbalho De Mello, Luis Eduardo ^e   Pinto, Fernando Paiva ^e   Lehn, Carlos Neutzling ^f   Correa, Luiz Artur Costa ^f   Dedivitis, Rogério A ^g   Guimarães, André Vicente ^g   Pedruzzi, Paola Andrea Galbiatti ^h   Ramos, Gyl Henrique Albrecht ^h   Gonçalves, Antonio José ⁱ   Suehara, Alexandre Babá ⁱ   Kanda, Jossi Ledo ^j   De Castro Capuzzo, Renato ^j   Carlos De Oliveira, José ^k   Curado, Maria Paula ^k   Francisco De Gõis Filho, José ^l   Fukuyama, Erica ^l   Beserra Júnior, Ivo Marquis ^e   Bentes De Carvalho Neto, Paulo ^e   Carvalho, André Lopes ^d   more..

^a A C CAMARGO CANCER CENTER   (Brazil)

^b UNIVERSIDAD DE LA SABANA   (Colombia)

^c INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^d BARRETOS CANCER HOSPITAL   (Brazil)

^e Liga Norte Riograndense Contra O Câncer ^*  (Brazil)

^f HOSPITAL HELIÓPOLIS   (Brazil)

^g HOSPITAL ANA COSTA   (Brazil)

^h Erasto Gaertner Hospital   (Brazil)

ⁱ FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO   (Brazil)

^j FACULDADE DE MEDICINA DO ABC   (Brazil)

^k Araujo Jorge Hospital   (Brazil)

^l Instituto do Cancer Dr Arnaldo   (Brazil)

more..

Author keywords

cost effectiveness; randomized controlled trial; thyroid gland; thyroidectomy; ultrasonic scalpel

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; FEMALE; HEALTH CARE COST; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPEN STUDY; OPERATION DURATION; OUTCOME ASSESSMENT; PATIENT SAFETY; POSTOPERATIVE PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCALPEL; THYROID TUMOR; THYROIDECTOMY; TREATMENT OUTCOME; ULTRASONIC SCALPEL; ULTRASOUND SURGERY;

CARCINOMA; DRAINAGE; FEMALE; GOITER; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; THYROID NEOPLASMS; THYROIDECTOMY; TIME FACTORS; ULTRASONIC SURGICAL PROCEDURES;

EID: 84861335933     PISSN: 10433074     EISSN: 10970347     Source Type: Journal    
DOI: 10.1002/hed.21815     Document Type: Article

References (41)

1. Kunde D, Welch C,. Ultracision in gynaecological laparoscopic surgery. J Obstet Gynaecol 2003; 23: 347-352.
2. Msika S, Deroide G, Kianmanesh R, et al. Harmonic scalpel in laparoscopic colorectal surgery. Dis Colon Rectum 2001; 44: 432-436.
3. Sietses C, Eijsbouts QAJ, von Blomberg BM, Cuesta MA,. Ultrasonic energy vs monopolar electrosurgery in laparoscopic cholecystectomy: influence on the postoperative systemic immune response. Surg Endosc 2001; 15: 69-71.
4. Underwood RA, Dunnegan DL, Soper NJ,. Prospective, randomized trial of bipolar electrosurgery vs ultrasonic coagulation for division of short gastric vessels during laparoscopic Nissen fundoplication. Surg Endosc 1999; 13: 763-768.
5. Miccoli P, Berti P, Raffaelli M, Materazzi G, Conte M, Galleri D,. Impact of harmonic scalpel on operative time during video-assisted thyroidectomy. Surg Endosc 2002; 16: 663-666.
6. Jackson LL, Gourin CG, Thomas DS, Porubsky ES, Klippert FN, Terris DJ,. Use of the harmonic scalpel in superficial and total parotidectomy for benign and malignant disease. Laryngoscope 2005; 115: 1070-1073.
7. Markkanen-Leppanen M, Pitkaranta A,. Parotidectomy using the harmonic scalpel. Laryngoscope 2004; 114: 381-382.
8. Miccoli P, Materazzi G, Fregoli L, Panicucci E, Kunz-Martinez W, Berti P,. Modified lateral neck lymphadenectomy: prospective randomized study comparing harmonic scalpel with clamp-and-tie technique. Otolaryngol Head Neck Surg 2009; 140: 61-64.
9. Voutilainen PE, Haapiainen RK, Haglund CH,. Ultrasonically activated shears in thyroid surgery. Am J Surg 1998; 175: 491-493.
10. Shemen L,. Thyroidectomy using the harmonic scalpel: analysis of 105 consecutive cases. Otolaryngol Head Neck Surg 2002; 127: 284-288.
11. Siperstein AE, Berber E, Morkoyun E,. The use of the harmonic scalpel vs conventional knot tying for vessel ligation in thyroid surgery. Arch Surg 2002; 137: 137-142.
12. Voutilainen PE, Haglund CH,. Ultrasonically activated shears in thyroidectomies: a randomized trial. Ann Surg 2000; 231: 322-328.
13. Defechereux T, Rinken F, Maweja S, Hamoir E, Meurisse M,. Evaluation of the ultrasonic dissector in thyroid surgery. A prospective randomised study. Acta Chir Belg 2003; 103: 274-277.
14. Cordon C, Fajardo R, Ramirez J, Herrera MF,. A randomized, prospective, parallel group study comparing the Harmonic Scalpel to electrocautery in thyroidectomy. Surgery 2005; 137: 337-341.
15. Miccoli P, Berti P, Dionigi G, D'Agostino J, Orlandini C, Donatini G,. Randomized controlled trial of harmonic scalpel use during thyroidectomy. Arch Otolaryngol Head Neck Surg 2006; 132: 1069-1073.
16. Kilic M, Keskek M, Ertan T, Yoldas O, Bilgin A, Koc M,. A prospective randomized trial comparing the harmonic scalpel with conventional knot tying in thyroidectomy. Adv Ther 2007; 24: 632-638.
17. Yildirim O, Umit T, Ebru M, et al. Ultrasonic harmonic scalpel in total thyroidectomies. Adv Ther 2008; 25: 260-265.
18. Leonard DS, Timon C,. Prospective trial of the ultrasonic dissector in thyroid surgery. Head Neck 2008; 30: 904-908.
19. Lombardi CP, Raffaelli M, Cicchetti A, et al. The use of "harmonic scalpel" versus "knot tying" for conventional "open" thyroidectomy: results of a prospective randomized study. Langenbecks Arch Surg 2008; 393: 627-631.
20. Hallgrimsson P, Loven L, Westerdahl J, Bergenfelz A,. Use of the harmonic scalpel versus conventional haemostatic techniques in patients with Grave disease undergoing total thyroidectomy: a prospective randomised controlled trial. Langenbecks Arch Surg 2008; 393: 675-680.
21. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. ICH Guidelines. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. 2009. May be accessed at
22. Pons Y, Gauthier J, Ukkola-Pons E, et al. Comparison of LigaSure vessel sealing system, harmonic scalpel, and conventional hemostasis in total thyroidectomy. Otolaryngol Head Neck Surg 2009; 141: 496-501.
23. Laster LL, Johnson MF, Kotler ML,. Non-inferiority trials: the "at least as good as" criterion with dichotomous data. Stat Med 2006; 25: 1115-1130.
24. Sanabria A, Dominguez LC, Vega V, Osorio C, Duarte D,. Routine postoperative administration of vitamin D and calcium after total thyroidectomy: a meta-analysis. Int J Surg 2011; 9: 46-51.
25. Miccoli P, Berti P, Frustaci GL, Ambrosini CE, Materazzi G,. Video-assisted thyroidectomy: indications and results. Langenbecks Arch Surg 2006; 391: 68-71.
26. Terris DJ, Seybt MW, Gourin CG, Chin E,. Ultrasonic technology facilitates minimal access thyroid surgery. Laryngoscope 2006; 116: 851-854.
27. van der Linden W,. Pitfalls in randomized surgical trials. Surgery 1980; 87: 258-262.
28. McLeod RS,. Issues in surgical randomized controlled trials. World J Surg 1999; 23: 1210-1214.
29. Paradis C,. Bias in surgical research. Ann Surg 2008; 248: 180-188.
30. Chiang FY, Lee KW, Huang YF, Wang LF, Kuo WR,. Risk of vocal palsy after thyroidectomy with identification of the recurrent laryngeal nerve. Kaohsiung J Med Sci 2004; 20: 431-436.
31. Rosato L, Avenia N, Bernante P, et al. Complications of thyroid surgery: analysis of a multicentric study on 14,934 patients operated on in Italy over 5 years. World J Surg 2004; 28: 271-276.
32. Zambudio AR, Rodriguez J, Riquelme J, Soria T, Canteras M, Parrilla P,. Prospective study of postoperative complications after total thyroidectomy for multinodular goiters by surgeons with experience in endocrine surgery. Ann Surg 2004; 240: 18-25.
33. de Pedro Netto I, Fae A, Vartanian JG, et al. Voice and vocal self-assessment after thyroidectomy. Head Neck 2006; 28: 1106-1114.
34. Farrag TY, Samlan RA, Lin FR, Tufano RP,. The utility of evaluating true vocal fold motion before thyroid surgery. Laryngoscope 2006; 116: 235-238.
35. Stojadinovic A, Shaha AR, Orlikoff RF, et al. Prospective functional voice assessment in patients undergoing thyroid surgery. Ann Surg 2002; 236: 823-832.
36. Ortega J, Sala C, Flor B, Lledo S,. Efficacy and cost-effectiveness of the UltraCision harmonic scalpel in thyroid surgery: an analysis of 200 cases in a randomized trial. J Laparoendosc Adv Surg Tech A 2004; 14: 9-12.
37. Frazzetta M, Furgiuele G, Raimondo D, et al. Ultrasonic dissector for total thyroidectomy: results of prospective randomized study [in Italian]. G Chir 2005; 26: 295-301.
38. Koh YW, Park JH, Lee SW, Choi EC,. The harmonic scalpel technique without supplementary ligation in total thyroidectomy with central neck dissection: a prospective randomized study. Ann Surg 2008; 247: 945-949.
39. Meurisse M, Defechereux T, Maweja S, Degauque C, Vandelaer M, Hamoir E,. Evaluation of the Ultracision ultrasonic dissector in thyroid surgery. Prospective randomized study [in French]. Ann Chir 2000; 125: 468-472.
40. Weinbroum AA, Ekstein P, Ezri T,. Efficiency of the operating room suite. Am J Surg 2003; 185: 244-250.
41. Bridges M, Diamond DL,. The financial impact of teaching surgical residents in the operating room. Am J Surg 1999; 177: 28-32.